GREMLIN Database
YAJL - Chaperone protein YajL
UniProt: Q46948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13272
Length: 196 (168)
Sequences: 15185 (10337)
Seq/√Len: 797.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_W171_L2.8151.00
4_S31_K2.7171.00
6_L67_Y2.6791.00
167_K170_D2.5331.00
6_L35_A2.4421.00
122_G148_A2.4071.00
33_T67_Y2.3641.00
123_N140_L2.3081.00
44_A54_L2.2001.00
122_G147_D2.1561.00
4_S33_T2.1501.00
119_F124_M2.1031.00
123_N138_Q2.0191.00
33_T57_A2.0131.00
175_R179_H1.9811.00
146_W167_K1.9271.00
24_L169_I1.8681.00
28_G169_I1.8121.00
96_H151_K1.7871.00
22_I26_V1.7351.00
122_G152_L1.6821.00
148_A151_K1.6791.00
95_F100_R1.6221.00
170_D175_R1.5971.00
38_A43_L1.5931.00
44_A52_K1.5871.00
13_S47_C1.5661.00
96_H102_V1.5651.00
143_R163_D1.5541.00
131_K135_P1.5421.00
146_W153_L1.5351.00
123_N147_D1.5191.00
177_K180_E1.5021.00
58_P61_E1.4981.00
104_A154_T1.4951.00
101_I171_L1.4821.00
37_V85_S1.4781.00
46_T52_K1.4551.00
173_V177_K1.4351.00
15_E19_V1.4251.00
30_I172_L1.3971.00
91_T95_F1.3911.00
7_V71_V1.3731.00
103_A168_I1.3661.00
60_V87_L1.3661.00
122_G151_K1.3591.00
7_V22_I1.3371.00
90_E94_Q1.3361.00
104_A113_L1.3181.00
167_K171_L1.3161.00
142_K163_D1.3091.00
52_K56_D1.3051.00
89_V93_K1.3001.00
11_P46_T1.2741.00
155_S160_T1.2671.00
25_L165_G1.2661.00
86_T90_E1.2631.00
94_Q98_S1.2611.00
96_H152_L1.2551.00
69_V101_I1.2361.00
103_A164_F1.2331.00
57_A61_E1.2331.00
96_H118_I1.2301.00
90_E93_K1.2241.00
153_L171_L1.2171.00
174_G177_K1.2121.00
13_S18_A1.2091.00
133_K137_E1.2001.00
5_A69_V1.1991.00
87_L90_E1.1881.00
18_A34_T1.1791.00
146_W151_K1.1781.00
23_D27_R1.1771.00
9_L34_T1.1751.00
99_G102_V1.1531.00
99_G151_K1.1511.00
89_V116_H1.1501.00
30_I173_V1.1421.00
63_A66_E1.1421.00
20_T162_I1.1321.00
16_T20_T1.1311.00
84_D115_P1.1231.00
101_I172_L1.0991.00
22_I34_T1.0921.00
117_D120_P1.0871.00
115_P137_E1.0721.00
8_C88_L1.0711.00
94_Q97_R1.0661.00
110_A133_K1.0491.00
36_S42_N1.0471.00
134_I139_W1.0441.00
96_H99_G1.0441.00
9_L18_A1.0431.00
123_N145_V1.0281.00
144_V167_K1.0261.00
71_V164_F1.0221.00
20_T23_D1.0141.00
107_A130_L1.0091.00
20_T165_G1.0081.00
93_K97_R0.9931.00
35_A57_A0.9891.00
127_F157_G0.9841.00
30_I169_I0.9671.00
68_D100_R0.9641.00
7_V32_V0.9631.00
72_L92_V0.9511.00
101_I151_K0.9511.00
153_L164_F0.9461.00
15_E51_V0.9461.00
37_V87_L0.9391.00
155_S164_F0.9351.00
123_N142_K0.9281.00
95_F98_S0.9251.00
83_R115_P0.9201.00
36_S55_A0.9071.00
20_T161_A0.9001.00
38_A42_N0.8921.00
24_L165_G0.8891.00
176_E180_E0.8851.00
57_A62_V0.8841.00
104_A109_P0.8841.00
37_V59_L0.8811.00
72_L108_A0.8751.00
23_D26_V0.8721.00
42_N58_P0.8711.00
69_V172_L0.8631.00
125_T145_V0.8571.00
72_L112_V0.8551.00
153_L168_I0.8511.00
71_V103_A0.8501.00
89_V115_P0.8431.00
130_L133_K0.8431.00
101_I153_L0.8421.00
70_I95_F0.8391.00
156_Q160_T0.8381.00
13_S53_L0.8331.00
170_D178_A0.8301.00
21_T71_V0.8291.00
35_A62_V0.8281.00
132_D136_A0.8271.00
162_I166_L0.8261.00
5_A30_I0.8191.00
33_T56_D0.8171.00
21_T161_A0.8131.00
22_I32_V0.8081.00
109_P126_G0.8061.00
72_L88_L0.8051.00
9_L13_S0.7911.00
24_L166_L0.7821.00
91_T94_Q0.7781.00
67_Y95_F0.7701.00
85_S88_L0.7601.00
153_L167_K0.7541.00
18_A22_I0.7441.00
7_V18_A0.7441.00
133_K136_A0.7371.00
11_P38_A0.7361.00
44_A55_A0.7291.00
25_L168_I0.7281.00
6_L62_V0.7231.00
69_V168_I0.7211.00
131_K139_W0.7151.00
69_V103_A0.7131.00
30_I69_V0.7061.00
15_E47_C0.7051.00
96_H122_G0.6951.00
75_G78_G0.6921.00
105_I161_A0.6921.00
161_A165_G0.6871.00
140_L145_V0.6871.00
46_T50_G0.6811.00
143_R146_W0.6801.00
104_A108_A0.6771.00
77_K81_C0.6771.00
93_K116_H0.6751.00
13_S73_P0.6741.00
26_V32_V0.6711.00
143_R160_T0.6701.00
5_A25_L0.6641.00
12_G46_T0.6581.00
15_E49_R0.6581.00
128_P157_G0.6501.00
101_I168_I0.6501.00
86_T89_V0.6461.00
25_L30_I0.6441.00
7_V21_T0.6401.00
29_G177_K0.6361.00
43_L54_L0.6331.00
43_L55_A0.6301.00
30_I68_D0.6281.00
24_L27_R0.6261.00
35_A67_Y0.6231.00
92_V116_H0.6231.00
163_D166_L0.6201.00
176_E179_H0.6191.00
114_V119_F0.6141.00
114_V134_I0.6121.00
66_E98_S0.6021.00
114_V124_M0.6001.00
89_V92_V0.6001.00
62_V67_Y0.5991.00
63_A94_Q0.5961.00
132_D135_P0.5961.00
126_G139_W0.5961.00
92_V112_V0.5951.00
77_K80_E0.5941.00
4_S68_D0.5921.00
141_D145_V0.5921.00
43_L46_T0.5861.00
8_C35_A0.5851.00
124_M134_I0.5851.00
105_I164_F0.5821.00
24_L28_G0.5821.00
78_G82_F0.5801.00
14_E23_D0.5731.00
8_C70_I0.5731.00
102_V151_K0.5661.00
89_V112_V0.5641.00
102_V152_L0.5591.00
84_D89_V0.5541.00
62_V91_T0.5531.00
28_G177_K0.5531.00
103_A153_L0.5521.00
163_D167_K0.5521.00
57_A63_A0.5511.00
35_A91_T0.5501.00
67_Y70_I0.5501.00
24_L162_I0.5501.00
81_C84_D0.5481.00
102_V113_L0.5481.00
79_A83_R0.5461.00
6_L33_T0.5451.00
93_K118_I0.5441.00
110_A130_L0.5421.00
22_I51_V0.5421.00
17_E158_P0.5411.00
17_E74_G0.5291.00
47_C51_V0.5271.00
38_A58_P0.5251.00
92_V118_I0.5251.00
82_F85_S0.5251.00
14_E48_S0.5231.00
102_V118_I0.5221.00
113_L116_H0.5161.00
6_L91_T0.5151.00
42_N55_A0.5111.00
72_L113_L0.5041.00
19_V53_L0.5041.00
18_A73_P0.5031.00
9_L45_I0.5021.00
71_V155_S0.5021.00
20_T24_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ot1A 2 0.9847 100 0.16 Contact Map
2ab0A 2 0.9745 100 0.161 Contact Map
2rk3A 2 0.9286 100 0.177 Contact Map
4k2hA 4 0.9388 100 0.178 Contact Map
4e08A 2 0.9388 100 0.18 Contact Map
3ewnA 2 0.9643 100 0.183 Contact Map
4xllA 2 0.9286 100 0.184 Contact Map
3noqA 2 0.9541 100 0.187 Contact Map
3mgkA 2 0.949 100 0.19 Contact Map
3graA 2 0.8929 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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