GREMLIN Database
YQEJ - Uncharacterized protein YqeJ
UniProt: Q46943 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13101
Length: 160 (149)
Sequences: 111 (95)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_I19_I4.2730.98
141_Q145_A3.5130.94
109_E127_Y2.9660.86
114_V119_L2.5000.74
67_V127_Y2.4530.73
85_R112_D2.2990.68
107_K112_D2.2760.67
100_L131_E2.2400.66
84_R89_Y2.2320.65
102_S124_P2.1160.61
89_Y126_F2.0220.57
96_D100_L2.0020.56
127_Y145_A1.9130.53
145_A148_L1.9010.52
14_F95_Y1.8800.52
74_Q81_K1.8790.51
126_F154_A1.8650.51
48_G156_M1.8640.51
7_N11_I1.7570.47
58_Y91_W1.7460.46
141_Q146_F1.7010.44
102_S126_F1.6620.43
20_L117_D1.6590.43
42_V119_L1.6460.42
37_C158_C1.6240.41
90_T103_K1.5860.40
63_K91_W1.5790.40
66_T144_H1.5610.39
58_Y89_Y1.5420.38
78_R89_Y1.5190.37
10_F95_Y1.4990.36
39_A132_K1.4900.36
51_N68_A1.4860.36
138_I146_F1.4680.35
39_A54_I1.4680.35
103_K127_Y1.4580.35
73_W145_A1.4430.34
85_R157_H1.4090.33
135_S157_H1.4040.33
70_S86_N1.3930.33
69_L112_D1.3920.33
87_I154_A1.3710.32
139_L149_S1.3580.31
37_C71_G1.3560.31
38_T92_I1.3510.31
35_E93_E1.3510.31
37_C65_G1.3500.31
58_Y93_E1.3270.30
74_Q147_I1.3240.30
7_N47_Q1.3040.30
66_T131_E1.2730.28
92_I109_E1.2610.28
8_L33_Y1.2270.27
30_K87_I1.2230.27
14_F140_K1.2050.26
65_G89_Y1.2020.26
10_F35_E1.2000.26
8_L29_E1.1980.26
16_S19_I1.1900.26
82_S147_I1.1780.25
91_W153_R1.1730.25
30_K133_S1.1650.25
19_I138_I1.1650.25
65_G126_F1.1450.24
86_N113_Q1.1380.24
38_T138_I1.1380.24
83_I86_N1.1220.24
41_W107_K1.1150.24
11_I133_S1.1110.23
20_L115_D1.1080.23
83_I142_G1.0960.23
66_T151_G1.0950.23
93_E153_R1.0940.23
39_A99_H1.0920.23
89_Y99_H1.0920.23
109_E139_L1.0910.23
127_Y150_I1.0890.23
154_A158_C1.0820.23
35_E58_Y1.0810.23
8_L102_S1.0540.22
50_A91_W1.0490.22
113_Q133_S1.0300.21
13_V19_I1.0210.21
49_R121_Q1.0150.21
46_D134_V1.0130.21
29_E131_E1.0090.21
107_K116_D1.0080.21
43_I151_G0.9940.20
65_G158_C0.9890.20
71_G158_C0.9870.20
82_S90_T0.9810.20
84_R151_G0.9760.20
34_N100_L0.9740.20
22_T27_T0.9500.19
13_V87_I0.9500.19
50_A152_N0.9400.19
35_E86_N0.9360.19
60_K63_K0.9230.18
67_V142_G0.9210.18
9_L41_W0.9190.18
19_I41_W0.9180.18
53_T127_Y0.9070.18
102_S130_P0.9060.18
47_Q148_L0.8960.18
59_N89_Y0.8920.18
33_Y64_T0.8850.18
36_T134_V0.8850.18
56_F92_I0.8750.17
39_A72_T0.8650.17
139_L146_F0.8610.17
94_N136_Y0.8410.17
67_V85_R0.8390.16
123_I146_F0.8370.16
90_T140_K0.8150.16
86_N91_W0.8120.16
107_K127_Y0.7950.16
58_Y128_V0.7850.15
100_L157_H0.7790.15
69_L105_V0.7780.15
68_A83_I0.7750.15
21_F121_Q0.7670.15
65_G124_P0.7600.15
130_P151_G0.7600.15
47_Q76_G0.7540.15
112_D119_L0.7480.15
105_V124_P0.7410.14
40_N152_N0.7350.14
7_N146_F0.7270.14
100_L136_Y0.7250.14
16_S129_F0.7240.14
23_V96_D0.7220.14
105_V123_I0.7210.14
69_L85_R0.7210.14
24_Y66_T0.7130.14
37_C124_P0.7100.14
14_F75_Q0.7080.14
59_N96_D0.7080.14
57_M128_V0.7060.14
35_E56_F0.6990.14
49_R53_T0.6970.14
17_G94_N0.6940.14
54_I141_Q0.6920.13
35_E55_D0.6910.13
68_A102_S0.6900.13
64_T92_I0.6890.13
9_L28_A0.6880.13
96_D139_L0.6840.13
15_I130_P0.6800.13
108_F149_S0.6780.13
40_N79_E0.6710.13
90_T146_F0.6680.13
124_P138_I0.6630.13
137_N157_H0.6500.13
94_N148_L0.6480.13
148_L158_C0.6380.12
37_C126_F0.6370.12
51_N99_H0.6350.12
65_G102_S0.6340.12
36_T54_I0.6270.12
102_S132_K0.6220.12
85_R114_V0.6150.12
41_W48_G0.6130.12
37_C89_Y0.6130.12
13_V121_Q0.6130.12
25_S119_L0.6130.12
124_P155_I0.6030.12
14_F87_I0.6010.12
103_K117_D0.5950.12
105_V132_K0.5940.12
73_W84_R0.5870.12
122_L155_I0.5840.12
16_S101_T0.5810.12
55_D90_T0.5800.12
35_E89_Y0.5800.12
38_T137_N0.5800.12
74_Q149_S0.5790.11
17_G89_Y0.5790.11
50_A58_Y0.5780.11
136_Y141_Q0.5760.11
79_E122_L0.5760.11
45_N97_T0.5740.11
15_I46_D0.5740.11
82_S145_A0.5740.11
22_T118_R0.5730.11
24_Y116_D0.5720.11
22_T46_D0.5720.11
71_G154_A0.5680.11
13_V97_T0.5660.11
96_D118_R0.5650.11
31_M127_Y0.5610.11
118_R123_I0.5600.11
18_F75_Q0.5520.11
15_I90_T0.5520.11
70_S102_S0.5510.11
67_V155_I0.5480.11
15_I27_T0.5470.11
87_I138_I0.5470.11
65_G71_G0.5460.11
39_A64_T0.5440.11
119_L141_Q0.5430.11
40_N78_R0.5380.11
34_N111_M0.5370.11
25_S78_R0.5330.11
132_K148_L0.5320.11
29_E142_G0.5310.11
25_S98_A0.5250.11
86_N105_V0.5240.11
60_K120_A0.5230.11
81_K93_E0.5210.11
58_Y100_L0.5190.11
146_F150_I0.5190.11
34_N60_K0.5170.11
118_R149_S0.5150.10
56_F157_H0.5130.10
64_T139_L0.5120.10
12_L83_I0.5120.10
35_E95_Y0.5120.10
10_F34_N0.5110.10
57_M136_Y0.5110.10
14_F33_Y0.5100.10
75_Q98_A0.5090.10
20_L64_T0.5060.10
54_I147_I0.5010.10
10_F76_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q35A 1 0.8313 9.6 0.941 Contact Map
8tfvA 1 0.0813 8.1 0.943 Contact Map
3hvnA 1 0.6813 6.6 0.945 Contact Map
3da0A 3 0.6813 2.9 0.954 Contact Map
3qvcA 2 0.55 2.9 0.954 Contact Map
3ju0A 1 0.3 2.8 0.954 Contact Map
3jtzA 2 0.3 2.8 0.954 Contact Map
2mc7A 1 0.1875 2.7 0.955 Contact Map
1q15A 3 0.7875 2.4 0.956 Contact Map
2mfrA 1 0.2687 2.3 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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