GREMLIN Database
YQEI - Uncharacterized protein YqeI
UniProt: Q46942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13100
Length: 269 (226)
Sequences: 797 (721)
Seq/√Len: 48.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_Q72_Y5.0031.00
11_F35_S4.9921.00
195_C224_C4.6541.00
71_L101_F3.7621.00
51_Q68_T3.2491.00
34_A70_T3.0491.00
31_T70_T2.9511.00
73_Q82_F2.8061.00
101_F195_C2.7661.00
40_L54_F2.5231.00
94_A102_K2.4961.00
58_V76_S2.4461.00
31_T71_L2.3251.00
56_T61_E2.1411.00
37_C49_V2.1221.00
44_A47_D2.0991.00
31_T67_P2.0411.00
71_L76_S2.0221.00
101_F224_C2.0190.99
55_F67_P1.8910.99
51_Q76_S1.8060.99
31_T34_A1.7550.99
37_C74_N1.7450.99
36_R62_E1.7380.98
141_G160_L1.7120.98
76_S224_C1.6860.98
31_T35_S1.6830.98
37_C72_Y1.6710.98
72_Y101_F1.6700.98
76_S80_R1.6420.98
37_C41_L1.5850.97
146_N149_I1.5640.97
11_F18_L1.5520.97
40_L57_R1.5270.96
40_L44_A1.5110.96
41_L75_I1.5050.96
195_C246_C1.4660.96
34_A69_N1.4510.95
37_C73_Q1.4370.95
33_P70_T1.4360.95
73_Q232_F1.4260.95
32_T62_E1.4120.95
66_V101_F1.4030.94
51_Q74_N1.4000.94
77_I80_R1.3980.94
33_P36_R1.3900.94
37_C58_V1.3860.94
66_V70_T1.3790.94
58_V97_P1.3760.94
153_I156_H1.3710.94
127_P137_E1.3590.93
69_N72_Y1.3490.93
46_P73_Q1.3470.93
69_N97_P1.3460.93
159_M162_A1.3440.93
41_L49_V1.3340.93
84_A87_D1.3240.92
12_W15_H1.3170.92
74_N77_I1.3130.92
72_Y195_C1.3110.92
51_Q60_E1.2980.92
145_F151_K1.2960.92
148_K152_H1.2820.91
50_A53_D1.2730.91
157_L173_L1.2600.90
101_F246_C1.2510.90
140_G147_N1.2410.90
51_Q70_T1.2330.89
143_K162_A1.2230.89
38_L97_P1.2180.89
71_L224_C1.2100.88
16_R35_S1.2060.88
84_A90_H1.2010.88
31_T77_I1.1980.88
155_S169_S1.1970.88
12_W17_K1.1920.88
69_N246_C1.1770.87
138_S170_A1.1750.87
32_T98_R1.1750.87
32_T73_Q1.1730.87
72_Y76_S1.1710.87
33_P69_N1.1510.86
74_N231_Y1.1510.86
31_T73_Q1.1480.86
162_A170_A1.1470.86
31_T76_S1.1460.86
73_Q240_G1.1440.86
11_F33_P1.1410.85
9_I87_D1.1400.85
40_L49_V1.1370.85
138_S149_I1.1360.85
165_I172_W1.1210.84
55_F74_N1.1160.84
154_K159_M1.1060.84
113_V137_E1.1030.83
69_N74_N1.0990.83
152_H174_W1.0880.82
136_K157_L1.0860.82
150_L170_A1.0780.82
63_G199_V1.0710.81
31_T66_V1.0650.81
57_R61_E1.0600.81
37_C71_L1.0600.81
154_K161_S1.0590.81
141_G161_S1.0560.81
74_N239_P1.0520.80
67_P74_N1.0450.80
9_I224_C1.0390.79
38_L82_F1.0390.79
11_F42_L1.0300.79
54_F58_V1.0230.78
9_I85_V1.0200.78
37_C101_F1.0160.78
73_Q99_R1.0090.77
163_F168_Y1.0070.77
18_L69_N0.9980.77
117_S127_P0.9910.76
93_I109_I0.9650.74
116_S151_K0.9630.74
157_L166_G0.9620.74
42_L48_V0.9560.73
139_I147_N0.9550.73
70_T73_Q0.9550.73
48_V99_R0.9540.73
103_I109_I0.9530.73
154_K158_I0.9480.73
170_A174_W0.9420.72
128_A167_A0.9410.72
77_I82_F0.9400.72
11_F73_Q0.9360.72
37_C54_F0.9350.72
37_C186_Y0.9350.72
11_F91_S0.9340.72
37_C51_Q0.9330.72
70_T76_S0.9300.71
70_T94_A0.9300.71
144_N161_S0.9240.71
82_F85_V0.9210.71
59_W79_R0.9150.70
66_V242_I0.9070.69
128_A147_N0.9010.69
37_C97_P0.9000.69
5_I103_I0.8990.69
228_P240_G0.8920.68
164_V185_D0.8910.68
33_P74_N0.8880.68
60_E65_R0.8830.67
152_H162_A0.8740.67
156_H165_I0.8690.66
34_A77_I0.8680.66
34_A73_Q0.8650.66
32_T58_V0.8600.65
34_A101_F0.8590.65
19_I210_F0.8570.65
41_L103_I0.8550.65
66_V74_N0.8550.65
139_I159_M0.8530.65
137_E168_Y0.8530.65
75_I101_F0.8520.65
145_F149_I0.8500.64
33_P97_P0.8500.64
51_Q58_V0.8450.64
138_S146_N0.8420.64
146_N168_Y0.8400.64
31_T74_N0.8400.64
128_A141_G0.8400.64
68_T74_N0.8370.63
150_L154_K0.8350.63
154_K157_L0.8320.63
52_Q61_E0.8260.62
33_P246_C0.8250.62
66_V72_Y0.8240.62
117_S160_L0.8200.62
138_S157_L0.8180.61
43_E161_S0.8170.61
33_P58_V0.8170.61
30_L81_G0.8160.61
159_M171_Y0.8130.61
198_N229_W0.8120.61
54_F80_R0.8100.61
82_F242_I0.8100.61
159_M167_A0.8070.60
147_N153_I0.7950.59
155_S173_L0.7920.59
147_N156_H0.7900.59
150_L160_L0.7890.59
23_N26_L0.7870.58
7_D108_N0.7860.58
18_L38_L0.7830.58
146_N157_L0.7770.57
146_N163_F0.7750.57
72_Y102_K0.7720.57
17_K27_N0.7720.57
55_F77_I0.7710.57
154_K168_Y0.7680.57
39_S43_E0.7670.56
148_K168_Y0.7670.56
113_V160_L0.7670.56
117_S128_A0.7650.56
149_I153_I0.7630.56
139_I157_L0.7620.56
15_H27_N0.7610.56
64_M74_N0.7610.56
38_L78_I0.7590.56
60_E63_G0.7580.56
146_N150_L0.7560.55
172_W175_N0.7560.55
153_I160_L0.7510.55
160_L170_A0.7500.55
57_R103_I0.7490.55
33_P94_A0.7480.55
162_A185_D0.7450.54
162_A169_S0.7450.54
139_I146_N0.7370.54
137_E146_N0.7360.53
137_E142_A0.7340.53
116_S145_F0.7330.53
115_N155_S0.7300.53
54_F100_G0.7290.53
64_M101_F0.7280.53
138_S168_Y0.7260.52
51_Q62_E0.7260.52
192_I197_F0.7250.52
75_I111_N0.7210.52
157_L164_V0.7190.52
137_E154_K0.7190.52
146_N170_A0.7190.52
73_Q97_P0.7180.52
146_N171_Y0.7180.52
5_I46_P0.7130.51
139_I144_N0.7130.51
163_F207_L0.7130.51
117_S146_N0.7100.51
165_I181_P0.7080.51
79_R100_G0.7050.50
199_V203_T0.7040.50
44_A53_D0.7020.50
36_R58_V0.6980.50
146_N159_M0.6900.49
87_D92_L0.6900.49
114_I144_N0.6870.48
33_P101_F0.6810.48
42_L224_C0.6810.48
96_V102_K0.6750.47
34_A51_Q0.6740.47
170_A176_N0.6650.46
171_Y175_N0.6640.46
138_S142_A0.6610.46
140_G230_L0.6570.45
152_H160_L0.6550.45
72_Y85_V0.6530.45
37_C70_T0.6420.44
149_I160_L0.6400.44
137_E161_S0.6390.44
141_G146_N0.6370.44
128_A136_K0.6360.43
194_G221_G0.6330.43
136_K153_I0.6320.43
31_T84_A0.6310.43
150_L156_H0.6280.43
196_H227_H0.6280.43
83_R217_I0.6250.42
33_P76_S0.6240.42
36_R230_L0.6240.42
145_F158_I0.6200.42
164_V171_Y0.6180.42
36_R63_G0.6170.42
60_E73_Q0.6160.41
70_T97_P0.6130.41
149_I152_H0.6100.41
35_S42_L0.6090.41
9_I90_H0.6050.40
34_A195_C0.6030.40
161_S168_Y0.6020.40
142_A169_S0.6010.40
142_A161_S0.5990.40
13_P35_S0.5950.39
141_G157_L0.5930.39
141_G155_S0.5880.39
99_R102_K0.5860.39
34_A81_G0.5860.39
86_G95_T0.5830.38
151_K166_G0.5820.38
136_K141_G0.5780.38
159_M175_N0.5750.38
169_S173_L0.5730.37
31_T72_Y0.5700.37
147_N164_V0.5700.37
17_K29_V0.5680.37
50_A201_E0.5670.37
3_W52_Q0.5650.37
10_E191_E0.5640.36
139_I160_L0.5640.36
171_Y215_T0.5640.36
36_R197_F0.5630.36
13_P39_S0.5610.36
32_T40_L0.5610.36
117_S136_K0.5600.36
32_T78_I0.5600.36
144_N151_K0.5590.36
146_N173_L0.5570.36
46_P80_R0.5540.36
152_H158_I0.5520.35
215_T218_L0.5520.35
198_N231_Y0.5500.35
155_S158_I0.5490.35
136_K144_N0.5470.35
6_N81_G0.5460.35
115_N159_M0.5450.35
138_S141_G0.5450.35
107_I111_N0.5440.35
15_H64_M0.5440.35
55_F72_Y0.5430.35
244_M249_N0.5400.34
31_T51_Q0.5400.34
63_G86_G0.5390.34
3_W38_L0.5360.34
150_L153_I0.5350.34
152_H170_A0.5350.34
145_F156_H0.5340.34
233_P244_M0.5320.34
32_T35_S0.5310.33
61_E96_V0.5280.33
30_L98_R0.5280.33
145_F226_K0.5270.33
153_I164_V0.5260.33
163_F225_K0.5250.33
136_K151_K0.5230.33
49_V55_F0.5230.33
65_R74_N0.5220.33
152_H176_N0.5190.32
6_N14_E0.5080.31
164_V181_P0.5080.31
110_Q169_S0.5040.31
93_I107_I0.5020.31
166_G189_V0.5020.31
149_I154_K0.5010.31
6_N33_P0.5000.31
128_A148_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ixaA 1 0.3792 99.8 0.65 Contact Map
4nhjA 2 0.3717 99.8 0.651 Contact Map
2k4jA 1 0.368 99.8 0.655 Contact Map
3q9vA 1 0.3643 99.8 0.655 Contact Map
2hwvA 1 0.3755 99.8 0.655 Contact Map
2jzyA 1 0.3755 99.8 0.656 Contact Map
2zxjA 1 0.3717 99.8 0.656 Contact Map
1opcA 1 0.368 99.8 0.657 Contact Map
3zq7A 1 0.368 99.8 0.658 Contact Map
2hqnA 1 0.3903 99.8 0.662 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.008 seconds.