GREMLIN Database
YQEF - Probable acetyl-CoA acetyltransferase
UniProt: Q46939 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13097
Length: 393 (375)
Sequences: 15219 (8368)
Seq/√Len: 432.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_S185_K3.4211.00
3_D261_E3.4141.00
174_L328_K3.3261.00
263_K267_L3.3081.00
107_A110_V2.9461.00
180_L225_A2.8261.00
95_L358_L2.7721.00
36_A39_E2.7661.00
261_E265_R2.6821.00
175_Q240_S2.6641.00
188_A192_A2.6561.00
181_S184_Q2.6361.00
166_R236_D2.5871.00
263_K266_A2.5861.00
191_D221_T2.5321.00
361_L373_G2.4601.00
299_C388_T2.3681.00
9_A359_V2.3651.00
102_I258_M2.3491.00
34_V111_I2.3291.00
5_V264_A2.3081.00
10_L40_R2.2811.00
299_C303_V2.2601.00
196_K214_D2.2351.00
37_L257_M2.1771.00
109_I259_M2.1221.00
171_S174_L2.1081.00
98_A110_V2.0821.00
273_A362_V2.0671.00
365_M370_A2.0531.00
190_I219_P2.0481.00
277_A303_V2.0431.00
30_G53_L1.9841.00
305_W372_K1.9771.00
274_R390_E1.9741.00
312_L339_V1.9651.00
102_I260_S1.9311.00
7_V259_M1.9241.00
44_P47_A1.9221.00
32_L202_V1.9151.00
3_D274_R1.9141.00
218_Q248_S1.9131.00
272_L366_V1.8931.00
311_D370_A1.8171.00
173_Q177_A1.8171.00
187_R219_P1.8011.00
47_A267_L1.7851.00
254_A355_C1.7761.00
187_R191_D1.7341.00
20_A213_V1.7331.00
164_L170_I1.7281.00
327_G334_E1.7261.00
190_I199_I1.7241.00
228_L244_G1.7231.00
277_A299_C1.7151.00
259_M263_K1.7041.00
108_D260_S1.6921.00
196_K215_T1.6661.00
259_M264_A1.6621.00
327_G337_V1.6571.00
297_R301_E1.6471.00
296_T376_T1.6451.00
307_L313_I1.6361.00
190_I215_T1.6291.00
260_S263_K1.6261.00
194_R340_N1.6251.00
364_E368_R1.6121.00
108_D263_K1.6101.00
180_L184_Q1.6071.00
340_N364_E1.6061.00
53_L113_G1.6041.00
167_E287_L1.5961.00
305_W310_V1.5941.00
100_Q106_E1.5921.00
101_A107_A1.5871.00
310_V388_T1.5851.00
82_I97_L1.5801.00
36_A200_V1.5731.00
158_G235_F1.5691.00
32_L200_V1.5691.00
181_S334_E1.5621.00
227_G230_R1.5591.00
310_V313_I1.5521.00
256_V355_C1.5511.00
37_L41_T1.5411.00
197_D366_V1.5281.00
8_G41_T1.5101.00
28_E72_K1.5101.00
294_Y297_R1.4991.00
30_G69_S1.4981.00
312_L364_E1.4941.00
98_A258_M1.4891.00
276_R390_E1.4831.00
117_N120_R1.4821.00
35_K39_E1.4821.00
370_A373_G1.4781.00
177_A225_A1.4771.00
34_V69_S1.4601.00
177_A181_S1.4551.00
194_R364_E1.4341.00
364_E367_K1.4321.00
109_I263_K1.4281.00
305_W388_T1.4111.00
33_V255_A1.4081.00
33_V253_A1.4061.00
184_Q188_A1.4001.00
5_V274_R1.3951.00
358_L389_I1.3921.00
184_Q222_D1.3861.00
371_R390_E1.3741.00
300_L307_L1.3701.00
279_A298_R1.3411.00
21_L213_V1.3361.00
96_H387_L1.3201.00
36_A40_R1.3081.00
77_N284_D1.3001.00
333_D336_R1.3001.00
65_P115_Q1.2991.00
124_V142_S1.2971.00
310_V372_K1.2951.00
313_I374_L1.2891.00
24_H32_L1.2881.00
18_R130_T1.2851.00
174_L177_A1.2821.00
298_R301_E1.2741.00
194_R367_K1.2641.00
262_A266_A1.2601.00
8_G37_L1.2561.00
279_A299_C1.2511.00
187_R222_D1.2451.00
96_H278_F1.2411.00
55_Q58_T1.2411.00
4_V258_M1.2391.00
172_R242_T1.2381.00
14_I352_A1.2291.00
49_D107_A1.2291.00
369_N373_G1.2241.00
10_L200_V1.2241.00
197_D367_K1.2231.00
359_V363_H1.2221.00
95_L256_V1.2141.00
339_V364_E1.2121.00
362_V366_V1.2111.00
111_I257_M1.2111.00
162_E236_D1.2061.00
31_S72_K1.2031.00
48_V109_I1.1971.00
297_R329_M1.1951.00
89_G385_V1.1851.00
374_L388_T1.1811.00
53_L255_A1.1811.00
293_V297_R1.1571.00
295_A386_A1.1531.00
306_Q309_E1.1431.00
5_V261_E1.1401.00
170_I175_Q1.1391.00
89_G379_I1.1381.00
159_V236_D1.1361.00
281_V294_Y1.1261.00
14_I346_L1.1251.00
283_V290_I1.1221.00
52_I110_V1.1111.00
168_Y290_I1.1041.00
198_E360_S1.1041.00
303_V388_T1.1031.00
178_Y323_A1.1011.00
47_A263_K1.1001.00
49_D108_D1.0981.00
361_L375_A1.0891.00
290_I293_V1.0791.00
204_T213_V1.0781.00
187_R221_T1.0771.00
103_Q106_E1.0761.00
276_R372_K1.0761.00
296_T374_L1.0741.00
372_K390_E1.0731.00
34_V75_L1.0731.00
9_A363_H1.0711.00
93_K97_L1.0711.00
163_N167_E1.0651.00
32_L36_A1.0611.00
98_A112_A1.0611.00
106_E302_R1.0581.00
92_L358_L1.0481.00
197_D363_H1.0401.00
170_I324_L1.0391.00
275_I387_L1.0351.00
225_A229_A1.0311.00
5_V259_M1.0311.00
369_N372_K1.0261.00
178_Y324_L1.0231.00
100_Q104_C1.0171.00
158_G234_S1.0161.00
281_V298_R1.0151.00
311_D336_R1.0131.00
51_V70_A1.0121.00
95_L258_M1.0061.00
223_A228_L1.0041.00
6_I389_I1.0031.00
312_L368_R0.9971.00
9_A362_V0.9961.00
167_E286_A0.9921.00
47_A266_A0.9911.00
231_L244_G0.9901.00
38_I75_L0.9871.00
287_L290_I0.9841.00
340_N367_K0.9811.00
10_L36_A0.9801.00
13_P213_V0.9801.00
8_G40_R0.9751.00
339_V368_R0.9751.00
311_D365_M0.9741.00
277_A302_R0.9701.00
307_L310_V0.9691.00
356_R360_S0.9631.00
149_W154_D0.9601.00
310_V374_L0.9581.00
54_G90_S0.9551.00
25_S28_E0.9481.00
180_L228_L0.9461.00
277_A388_T0.9451.00
31_S35_K0.9431.00
272_L362_V0.9351.00
162_E166_R0.9311.00
33_V36_A0.9291.00
254_A352_A0.9281.00
261_E274_R0.9271.00
312_L361_L0.9241.00
332_W337_V0.9211.00
3_D103_Q0.9131.00
190_I196_K0.9131.00
372_K388_T0.9121.00
313_I332_W0.9101.00
184_Q187_R0.9051.00
168_Y329_M0.9031.00
12_T33_V0.8961.00
7_V269_L0.8961.00
165_A321_A0.8951.00
15_G217_E0.8941.00
224_S227_G0.8911.00
298_R302_R0.8881.00
14_I250_N0.8861.00
357_I375_A0.8861.00
75_L79_V0.8851.00
52_I82_I0.8821.00
358_L387_L0.8801.00
52_I98_A0.8791.00
38_I43_V0.8791.00
180_L222_D0.8771.00
275_I278_F0.8761.00
259_M269_L0.8731.00
52_I94_A0.8721.00
186_A219_P0.8711.00
164_L325_S0.8681.00
232_N243_A0.8681.00
71_I77_N0.8681.00
99_T275_I0.8671.00
290_I325_S0.8651.00
254_A359_V0.8631.00
173_Q229_A0.8621.00
181_S335_R0.8601.00
379_I385_V0.8581.00
99_T103_Q0.8581.00
296_T330_L0.8571.00
164_L290_I0.8541.00
362_V389_I0.8521.00
190_I221_T0.8511.00
231_L242_T0.8511.00
290_I329_M0.8491.00
12_T29_L0.8491.00
192_A367_K0.8481.00
55_Q61_A0.8431.00
163_N166_R0.8431.00
4_V260_S0.8401.00
9_A256_V0.8391.00
13_P32_L0.8381.00
4_V99_T0.8371.00
37_L111_I0.8291.00
176_D245_N0.8251.00
86_D93_K0.8221.00
323_A327_G0.8211.00
16_C218_Q0.8211.00
47_A109_I0.8181.00
191_D215_T0.8101.00
51_V79_V0.8081.00
112_A256_V0.8071.00
185_K188_A0.8021.00
340_N368_R0.8011.00
293_V329_M0.8011.00
261_E264_A0.7991.00
12_T32_L0.7981.00
14_I356_R0.7951.00
96_H385_V0.7951.00
233_P236_D0.7931.00
188_A194_R0.7921.00
343_A353_S0.7911.00
270_P366_V0.7891.00
38_I48_V0.7891.00
320_A344_I0.7881.00
173_Q225_A0.7871.00
48_V111_I0.7851.00
24_H28_E0.7821.00
188_A191_D0.7761.00
4_V103_Q0.7731.00
262_A265_R0.7721.00
94_A355_C0.7711.00
283_V294_Y0.7711.00
26_A115_Q0.7711.00
327_G332_W0.7701.00
106_E278_F0.7691.00
297_R330_L0.7641.00
119_S251_D0.7611.00
315_A376_T0.7591.00
97_L100_Q0.7581.00
49_D298_R0.7581.00
50_E101_A0.7541.00
186_A190_I0.7511.00
376_T379_I0.7481.00
379_I383_Q0.7471.00
245_N320_A0.7451.00
174_L324_L0.7451.00
236_D239_G0.7451.00
161_A321_A0.7441.00
223_A227_G0.7431.00
283_V291_A0.7431.00
365_M373_G0.7421.00
37_L255_A0.7401.00
97_L101_A0.7371.00
311_D372_K0.7361.00
136_N140_V0.7331.00
111_I255_A0.7311.00
33_V37_L0.7301.00
53_L66_A0.7291.00
132_A137_S0.7291.00
226_E230_R0.7231.00
308_A331_E0.7231.00
100_Q103_Q0.7221.00
133_Q136_N0.7211.00
296_T386_A0.7211.00
92_L375_A0.7181.00
101_A106_E0.7131.00
305_W309_E0.7121.00
30_G113_G0.7111.00
308_A336_R0.7081.00
92_L387_L0.7061.00
272_L363_H0.7051.00
49_D110_V0.7031.00
52_I97_L0.7021.00
125_L139_L0.7021.00
12_T202_V0.7021.00
180_L223_A0.7021.00
300_L305_W0.7011.00
315_A326_V0.7001.00
86_D280_S0.6951.00
38_I45_A0.6941.00
147_G151_A0.6911.00
50_E280_S0.6901.00
180_L227_G0.6881.00
180_L224_S0.6861.00
20_A217_E0.6851.00
223_A244_G0.6851.00
108_D302_R0.6841.00
307_L332_W0.6841.00
276_R303_V0.6831.00
32_L35_K0.6801.00
296_T315_A0.6791.00
234_S243_A0.6781.00
138_Q141_D0.6751.00
75_L111_I0.6741.00
55_Q65_P0.6731.00
280_S385_V0.6711.00
4_V102_I0.6711.00
193_G196_K0.6701.00
41_T257_M0.6691.00
325_S329_M0.6661.00
183_Q187_R0.6661.00
284_D287_L0.6641.00
84_I97_L0.6641.00
256_V359_V0.6631.00
133_Q137_S0.6621.00
35_K45_A0.6611.00
156_H159_V0.6601.00
56_V350_I0.6581.00
155_Y159_V0.6570.99
34_V73_G0.6570.99
285_P288_M0.6560.99
101_A110_V0.6560.99
218_Q250_N0.6550.99
183_Q218_Q0.6550.99
170_I174_L0.6540.99
25_S120_R0.6540.99
311_D371_R0.6520.99
241_V246_A0.6510.99
155_Y286_A0.6490.99
35_K74_G0.6480.99
129_R133_Q0.6450.99
10_L33_V0.6430.99
46_Y78_S0.6420.99
28_E31_S0.6420.99
170_I328_K0.6410.99
258_M275_I0.6400.99
50_E86_D0.6380.99
130_T133_Q0.6370.99
109_I267_L0.6350.99
6_I362_V0.6330.99
45_A76_P0.6300.99
353_S357_I0.6300.99
164_L168_Y0.6290.99
48_V75_L0.6290.99
108_D266_A0.6280.99
276_R305_W0.6240.99
69_S73_G0.6230.99
8_G272_L0.6230.99
29_L202_V0.6230.99
38_I42_G0.6220.99
296_T307_L0.6210.99
10_L37_L0.6210.99
24_H120_R0.6200.99
179_A183_Q0.6200.99
70_A81_A0.6180.99
98_A107_A0.6180.99
183_Q219_P0.6160.99
82_I93_K0.6150.99
5_V260_S0.6140.99
299_C374_L0.6130.99
6_I258_M0.6130.99
323_A337_V0.6130.99
187_R220_R0.6110.99
159_V163_N0.6110.99
80_S280_S0.6110.99
95_L112_A0.6110.99
64_N383_Q0.6100.99
38_I41_T0.6030.99
103_Q278_F0.6030.99
161_A241_V0.6020.99
288_M292_P0.6010.99
7_V264_A0.6010.99
27_V61_A0.6000.99
145_H149_W0.6000.99
185_K334_E0.5980.99
31_S73_G0.5980.99
160_T288_M0.5970.99
194_R368_R0.5960.99
7_V263_K0.5960.99
70_A75_L0.5950.99
222_D227_G0.5950.99
176_D225_A0.5950.99
259_M267_L0.5930.99
53_L69_S0.5930.99
300_L303_V0.5910.99
271_V274_R0.5890.99
186_A345_A0.5880.99
358_L375_A0.5860.99
27_V72_K0.5860.99
186_A346_L0.5840.99
148_L151_A0.5840.99
136_N139_L0.5830.99
366_V369_N0.5830.99
297_R331_E0.5830.99
118_M350_I0.5800.99
301_E306_Q0.5790.99
201_P214_D0.5790.99
346_L356_R0.5780.99
183_Q344_I0.5780.99
34_V255_A0.5770.99
285_P289_G0.5770.99
5_V263_K0.5760.99
183_Q222_D0.5750.99
23_G120_R0.5740.99
34_V38_I0.5740.99
93_K280_S0.5730.99
139_L142_S0.5720.99
324_L328_K0.5710.99
18_R119_S0.5710.99
294_Y298_R0.5690.99
322_Q326_V0.5680.99
318_A348_H0.5680.99
35_K73_G0.5680.99
168_Y325_S0.5680.99
30_G115_Q0.5680.99
113_G255_A0.5680.99
24_H117_N0.5670.99
168_Y287_L0.5670.99
43_V257_M0.5650.98
198_E363_H0.5620.98
279_A302_R0.5610.98
275_I389_I0.5610.98
296_T300_L0.5590.98
93_K96_H0.5590.98
286_A289_G0.5580.98
352_A355_C0.5570.98
176_D229_A0.5550.98
95_L355_C0.5540.98
161_A165_A0.5540.98
268_N271_V0.5530.98
10_L41_T0.5520.98
65_P69_S0.5510.98
69_S115_Q0.5500.98
226_E229_A0.5500.98
328_K331_E0.5490.98
101_A104_C0.5460.98
51_V111_I0.5460.98
62_G68_Q0.5460.98
379_I384_G0.5460.98
58_T83_T0.5460.98
215_T221_T0.5460.98
155_Y163_N0.5440.98
146_D150_D0.5440.98
162_E239_G0.5430.98
179_A228_L0.5410.98
34_V51_V0.5400.98
32_L203_M0.5400.98
309_E372_K0.5390.98
313_I376_T0.5390.98
377_L380_G0.5380.98
225_A228_L0.5380.98
296_T326_V0.5380.98
132_A135_G0.5370.98
94_A112_A0.5360.98
52_I101_A0.5360.98
49_D79_V0.5360.98
5_V267_L0.5340.98
50_E110_V0.5340.98
135_G138_Q0.5340.98
140_V145_H0.5340.98
187_R190_I0.5330.98
126_T140_V0.5300.98
50_E107_A0.5300.98
147_G150_D0.5300.98
315_A323_A0.5300.98
321_A325_S0.5290.98
272_L276_R0.5280.98
312_L370_A0.5280.98
13_P199_I0.5270.98
60_G124_V0.5260.98
13_P214_D0.5240.98
203_M213_V0.5240.98
332_W335_R0.5220.97
57_L121_A0.5220.97
166_R238_L0.5210.97
121_A142_S0.5210.97
92_L385_V0.5200.97
67_R71_I0.5190.97
24_H202_V0.5170.97
137_S140_V0.5160.97
168_Y328_K0.5160.97
369_N374_L0.5150.97
93_K101_A0.5140.97
195_F346_L0.5140.97
177_A334_E0.5130.97
299_C310_V0.5120.97
178_Y342_G0.5120.97
132_A139_L0.5110.97
162_E241_V0.5070.97
327_G333_D0.5050.97
279_A303_V0.5040.97
318_A322_Q0.5030.97
378_C384_G0.5010.97
3_D390_E0.5010.97
164_L321_A0.5010.97
148_L152_F0.5000.97
355_C359_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.9949 100 0.242 Contact Map
2vu1A 4 0.9949 100 0.248 Contact Map
3ss6A 4 0.9949 100 0.252 Contact Map
4n46A 4 0.9975 100 0.253 Contact Map
4e1lA 4 0.9796 100 0.266 Contact Map
4c2jA 4 0.9898 100 0.268 Contact Map
2wu9A 2 0.972 100 0.271 Contact Map
4nzsA 4 0.9949 100 0.272 Contact Map
2ib8A 4 0.9873 100 0.273 Contact Map
4o9aA 4 0.9949 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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