GREMLIN Database
KDUI - 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
UniProt: Q46938 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13096
Length: 278 (275)
Sequences: 721 (449)
Seq/√Len: 27.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D53_I4.1091.00
129_N258_G3.7791.00
27_E235_Q3.7781.00
87_G126_F3.4951.00
91_V110_A3.4521.00
11_H15_L3.4461.00
71_Y74_E3.0271.00
148_S165_K2.8151.00
106_V139_T2.7861.00
125_K234_E2.7231.00
83_I206_F2.7181.00
12_A20_L2.6170.99
91_V106_V2.5870.99
16_D19_G2.4760.99
78_L106_V2.4760.99
273_A276_D2.4570.99
181_L254_T2.4250.99
31_V34_E2.3820.99
215_C232_H2.3610.99
100_H209_N2.3210.98
88_T116_A2.3130.98
217_F230_V2.1900.98
117_S123_P2.1650.98
229_I237_V2.1590.97
78_L128_Y2.1220.97
18_Q22_N2.1190.97
65_K68_G2.1090.97
189_L248_V2.0510.97
37_M128_Y2.0240.96
156_L186_P2.0230.96
158_S189_L2.0180.96
15_L19_G1.9870.96
149_P164_N1.9810.96
90_T116_A1.9680.96
37_M46_I1.9680.96
160_R185_A1.9180.95
35_Y57_V1.9070.95
150_V165_K1.9060.95
210_M214_A1.8790.94
50_I57_V1.8330.93
117_S124_A1.8290.93
8_H11_H1.7990.93
119_D122_T1.7940.93
19_G23_E1.7790.92
70_S74_E1.7490.92
167_F174_T1.7460.92
37_M48_G1.7440.92
142_V172_L1.7340.91
33_D56_T1.7100.91
73_L78_L1.7070.91
26_V238_I1.6910.90
107_G138_P1.6820.90
56_T116_A1.6450.89
14_T19_G1.6410.89
86_A99_G1.6380.89
26_V47_V1.6260.88
168_V171_V1.6130.88
154_D157_T1.5910.87
154_D160_R1.5810.87
135_T173_E1.5790.87
45_I204_V1.5660.86
8_H23_E1.5440.86
33_D54_T1.5280.85
86_A118_I1.5150.85
79_G179_M1.4830.83
131_A260_V1.4790.83
51_M125_K1.4520.82
13_K16_D1.4370.81
88_T118_I1.4330.81
155_N160_R1.4160.80
231_M235_Q1.3810.79
33_D51_M1.3770.78
95_C116_A1.3740.78
6_S42_I1.3530.77
58_S112_E1.3420.77
45_I260_V1.3400.76
151_T160_R1.3250.76
150_V267_D1.3240.76
181_L256_I1.3210.75
25_L231_M1.3160.75
156_L188_N1.3140.75
143_T146_E1.3130.75
30_F206_F1.3080.75
81_I256_I1.2900.74
7_I12_A1.2860.73
142_V171_V1.2830.73
88_T95_C1.2820.73
41_H241_S1.2550.71
28_K31_V1.2320.70
51_M206_F1.2310.70
40_S238_I1.2280.70
266_F269_M1.2180.69
28_K235_Q1.2170.69
2_D38_V1.2060.68
148_S170_D1.1960.68
18_Q225_E1.1950.68
165_K170_D1.1910.67
83_I256_I1.1880.67
215_C230_V1.1740.66
5_Q222_Q1.1690.66
103_A171_V1.1690.66
80_V104_L1.1680.66
140_K174_T1.1670.66
98_I102_D1.1640.66
211_D251_K1.1620.65
30_F51_M1.1570.65
186_P252_A1.1500.65
107_G139_T1.1470.64
266_F271_H1.1440.64
149_P166_Y1.1440.64
90_T95_C1.1420.64
167_F171_V1.1380.64
103_A166_Y1.1300.63
42_I241_S1.1230.63
91_V139_T1.1210.63
164_N183_E1.1090.62
137_Y173_E1.1070.62
192_T246_S1.1070.62
98_I104_L1.1070.62
102_D144_P1.1000.61
165_K168_V1.1000.61
86_A97_E1.0880.60
12_A24_F1.0870.60
7_I24_F1.0660.59
155_N188_N1.0640.58
98_I141_K1.0640.58
97_E118_I1.0600.58
10_A22_N1.0530.58
27_E49_G1.0530.58
108_K136_T1.0480.57
80_V89_I1.0400.57
32_A51_M1.0280.56
178_S266_F1.0170.55
33_D55_K1.0140.55
102_D143_T1.0050.54
58_S62_E1.0020.54
4_R238_I0.9890.53
103_A172_L0.9800.52
92_D111_K0.9790.52
147_V162_T0.9780.52
83_I234_E0.9690.51
223_P272_V0.9650.51
15_L23_E0.9640.51
144_P183_E0.9600.51
13_K225_E0.9480.50
101_R183_E0.9480.50
96_Y139_T0.9480.50
140_K146_E0.9410.49
171_V178_S0.9390.49
46_I72_F0.9380.49
11_H19_G0.9380.49
70_S265_V0.9350.49
178_S264_Q0.9350.49
79_G167_F0.9320.49
81_I179_M0.9310.49
78_L89_I0.9290.48
63_V69_V0.9290.48
155_N158_S0.9150.47
151_T185_A0.9130.47
107_G136_T0.9110.47
151_T162_T0.9060.47
241_S267_D0.9050.47
46_I67_L0.9000.46
68_G169_P0.8990.46
183_E254_T0.8990.46
211_D214_A0.8910.46
7_I23_E0.8880.45
89_I106_V0.8830.45
5_Q199_E0.8810.45
94_Q110_A0.8740.44
92_D110_A0.8730.44
8_H15_L0.8710.44
140_K173_E0.8640.43
29_V86_A0.8590.43
217_F265_V0.8590.43
35_Y50_I0.8560.43
101_R181_L0.8510.43
62_E67_L0.8500.42
41_H199_E0.8470.42
199_E241_S0.8440.42
192_T216_V0.8380.42
12_A131_A0.8370.42
90_T112_E0.8330.41
81_I103_A0.8300.41
51_M57_V0.8270.41
28_K36_T0.8240.41
149_P165_K0.8230.40
46_I260_V0.8220.40
33_D57_V0.8170.40
4_R38_V0.8150.40
142_V169_P0.8140.40
197_T241_S0.8140.40
162_T185_A0.8140.40
42_I264_Q0.8130.40
25_L235_Q0.8110.40
35_Y108_K0.8090.39
157_T187_G0.8070.39
43_D202_M0.8060.39
119_D123_P0.8050.39
165_K169_P0.8040.39
68_G265_V0.8030.39
168_V174_T0.8030.39
266_F270_D0.8030.39
231_M237_V0.8010.39
24_F42_I0.7980.39
150_V266_F0.7980.39
91_V104_L0.7920.38
106_V113_V0.7890.38
96_Y227_R0.7880.38
32_A56_T0.7870.38
11_H14_T0.7850.38
71_Y111_K0.7840.38
152_L163_I0.7740.37
134_H176_Q0.7730.37
204_V238_I0.7670.36
57_V63_V0.7660.36
7_I15_L0.7660.36
43_D197_T0.7640.36
132_P206_F0.7610.36
230_V274_V0.7580.36
174_T178_S0.7580.36
10_A23_E0.7530.36
53_I123_P0.7460.35
131_A202_M0.7430.35
103_A168_V0.7420.35
13_K254_T0.7390.35
62_E69_V0.7390.35
169_P178_S0.7310.34
17_T226_T0.7300.34
232_H274_V0.7290.34
99_G102_D0.7240.34
24_F83_I0.7210.33
25_L229_I0.7210.33
32_A53_I0.7170.33
85_G117_S0.7160.33
154_D189_L0.7160.33
156_L187_G0.7110.33
42_I204_V0.7070.32
67_L262_E0.7070.32
244_I277_L0.7040.32
114_V118_I0.7040.32
53_I85_G0.7040.32
68_G264_Q0.6990.32
185_A269_M0.6980.32
10_A19_G0.6960.32
126_F204_V0.6940.32
195_C274_V0.6870.31
150_V171_V0.6830.31
101_R106_V0.6770.30
212_D275_K0.6770.30
69_V264_Q0.6750.30
110_A136_T0.6700.30
102_D166_Y0.6700.30
117_S125_K0.6680.30
53_I56_T0.6640.30
165_K267_D0.6600.29
33_D206_F0.6590.29
216_V231_M0.6580.29
142_V167_F0.6570.29
223_P244_I0.6560.29
103_A129_N0.6510.29
18_Q122_T0.6510.29
57_V206_F0.6500.29
157_T188_N0.6470.29
197_T267_D0.6460.29
107_G110_A0.6440.28
219_M229_I0.6410.28
192_T231_M0.6400.28
152_L266_F0.6390.28
109_G136_T0.6370.28
133_A175_C0.6350.28
195_C272_V0.6340.28
178_S197_T0.6340.28
148_S267_D0.6330.28
168_V267_D0.6320.28
168_V264_Q0.6290.27
69_V78_L0.6280.27
5_Q9_S0.6270.27
11_H23_E0.6270.27
31_V49_G0.6260.27
206_F237_V0.6250.27
6_S37_M0.6250.27
9_S48_G0.6230.27
132_P157_T0.6230.27
158_S187_G0.6210.27
113_V278_R0.6210.27
158_S278_R0.6200.27
89_I92_D0.6200.27
85_G123_P0.6190.27
103_A142_V0.6180.27
99_G145_D0.6170.27
103_A174_T0.6170.27
138_P206_F0.6160.27
170_D231_M0.6140.27
89_I122_T0.6140.27
59_V63_V0.6130.27
9_S222_Q0.6110.26
87_G117_S0.6100.26
5_Q135_T0.6100.26
155_N163_I0.6090.26
209_N231_M0.6080.26
50_I170_D0.6070.26
117_S120_T0.6030.26
65_K148_S0.6030.26
189_L222_Q0.6030.26
150_V162_T0.6020.26
13_K227_R0.6020.26
32_A54_T0.6020.26
167_F179_M0.6010.26
42_I260_V0.5980.26
165_K171_V0.5980.26
211_D215_C0.5980.26
56_T90_T0.5970.26
45_I129_N0.5970.26
49_G256_I0.5940.25
169_P172_L0.5940.25
93_G110_A0.5930.25
80_V115_F0.5870.25
155_N186_P0.5860.25
45_I202_M0.5850.25
155_N185_A0.5840.25
148_S168_V0.5810.25
18_Q224_Q0.5780.25
144_P166_Y0.5760.24
53_I120_T0.5750.24
120_T123_P0.5720.24
75_R108_K0.5710.24
73_L202_M0.5710.24
38_V235_Q0.5700.24
22_N88_T0.5690.24
183_E209_N0.5680.24
29_V36_T0.5680.24
12_A223_P0.5670.24
65_K169_P0.5600.24
89_I139_T0.5590.23
171_V174_T0.5590.23
197_T270_D0.5590.23
48_G215_C0.5570.23
171_V271_H0.5560.23
210_M254_T0.5560.23
168_V178_S0.5550.23
131_A174_T0.5540.23
18_Q278_R0.5530.23
112_E210_M0.5510.23
68_G199_E0.5500.23
141_K146_E0.5480.23
14_T35_Y0.5480.23
274_V277_L0.5470.23
106_V143_T0.5460.23
37_M170_D0.5460.23
272_V276_D0.5450.23
150_V163_I0.5450.23
29_V54_T0.5430.23
179_M269_M0.5420.23
35_Y46_I0.5420.23
74_E110_A0.5420.23
73_L106_V0.5410.23
214_A274_V0.5400.22
68_G217_F0.5380.22
21_R25_L0.5380.22
71_Y108_K0.5370.22
8_H166_Y0.5360.22
213_D230_V0.5340.22
231_M249_G0.5330.22
35_Y179_M0.5330.22
158_S248_V0.5330.22
140_K172_L0.5320.22
128_Y154_D0.5300.22
151_T219_M0.5300.22
88_T114_V0.5300.22
150_V189_L0.5300.22
37_M78_L0.5290.22
101_R129_N0.5290.22
129_N142_V0.5280.22
86_A121_G0.5280.22
31_V36_T0.5270.22
47_V204_V0.5260.22
136_T210_M0.5250.22
80_V126_F0.5250.22
172_L178_S0.5220.22
144_P164_N0.5220.22
217_F228_H0.5220.22
197_T264_Q0.5220.22
102_D272_V0.5220.22
59_V69_V0.5210.21
139_T236_A0.5200.21
168_V215_C0.5190.21
41_H131_A0.5170.21
89_I98_I0.5160.21
129_N206_F0.5160.21
169_P266_F0.5160.21
24_F249_G0.5150.21
184_L252_A0.5150.21
236_A256_I0.5130.21
43_D226_T0.5110.21
41_H247_G0.5110.21
87_G124_A0.5100.21
56_T86_A0.5100.21
202_M260_V0.5100.21
3_V199_E0.5090.21
102_D168_V0.5080.21
210_M251_K0.5080.21
22_N213_D0.5060.21
110_A139_T0.5060.21
183_E273_A0.5050.21
17_T195_C0.5040.21
88_T97_E0.5040.21
13_K278_R0.5030.21
6_S19_G0.5010.20
197_T269_M0.5000.20
104_L110_A0.5000.20
43_D150_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ywkA 1 0.9101 100 0.298 Contact Map
1xruA 3 0.9928 100 0.3 Contact Map
2qjvA 4 0.8201 100 0.611 Contact Map
2vqaA 3 0.8957 96.5 0.955 Contact Map
3rnsA 1 0.7266 96.2 0.956 Contact Map
1sefA 5 0.8237 95.8 0.958 Contact Map
1sq4A 5 0.8921 95.7 0.958 Contact Map
1uijA 3 0.8849 95.7 0.958 Contact Map
1rc6A 4 0.8022 95.5 0.958 Contact Map
3h7jA 1 0.7878 95.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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