GREMLIN Database
TCDA - tRNA threonylcarbamoyladenosine dehydratase
UniProt: Q46927 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13084
Length: 268 (239)
Sequences: 4348 (2839)
Seq/√Len: 183.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A101_R4.4891.00
90_A94_R3.9901.00
79_D95_Q3.6441.00
83_L91_E3.6251.00
32_H58_T3.6031.00
56_A103_T3.4331.00
45_A126_I3.3331.00
125_V142_C3.2201.00
255_H258_K3.0531.00
17_A22_E2.8401.00
165_Q207_T2.8131.00
84_A106_D2.6691.00
32_H56_A2.6561.00
35_V46_A2.6061.00
87_E106_D2.5831.00
152_T252_A2.4961.00
46_A93_I2.4941.00
126_I256_A2.4571.00
34_C122_Y2.4111.00
90_A104_V2.2621.00
124_Y256_A2.2251.00
139_I149_L2.2171.00
50_A93_I2.1851.00
83_L87_E2.1431.00
93_I100_C2.0151.00
84_A87_E2.0011.00
58_T122_Y1.9831.00
86_A104_V1.9741.00
16_T25_L1.8971.00
87_E104_V1.8311.00
184_R188_D1.8301.00
28_F257_L1.8281.00
75_H89_M1.8131.00
34_C60_I1.7431.00
120_V145_N1.7381.00
26_Q30_D1.7081.00
139_I201_V1.6911.00
64_D84_A1.6811.00
202_D255_H1.6701.00
183_E187_S1.6571.00
163_Q207_T1.6541.00
129_I134_P1.6111.00
138_L149_L1.6001.00
80_N83_L1.5851.00
38_I89_M1.5641.00
58_T105_V1.5531.00
140_A144_R1.5521.00
14_G18_R1.5321.00
141_Y145_N1.5101.00
198_K202_D1.5041.00
172_T175_D1.5001.00
36_V60_I1.4991.00
167_T171_K1.4931.00
86_A106_D1.4851.00
52_T242_T1.4811.00
93_I102_V1.4521.00
12_R78_R1.4391.00
58_T103_T1.4131.00
63_D85_K1.4071.00
109_V114_V1.3931.00
22_E26_Q1.3851.00
127_D138_L1.3721.00
249_G253_V1.3601.00
31_A260_M1.3541.00
69_N85_K1.3531.00
20_Y25_L1.3461.00
247_T251_V1.3241.00
44_W47_E1.3191.00
70_T81_V1.3171.00
87_E91_E1.2801.00
35_V49_L1.2441.00
43_S75_H1.2321.00
202_D206_S1.2301.00
246_A250_F1.1971.00
43_S74_I1.1921.00
183_E186_K1.1821.00
46_A59_L1.1801.00
17_A25_L1.1791.00
23_K27_L1.1731.00
137_A141_Y1.1711.00
160_D163_Q1.1611.00
193_K200_G1.1591.00
150_V252_A1.1561.00
184_R187_S1.1461.00
109_V137_A1.1271.00
141_Y144_R1.1241.00
65_V75_H1.1181.00
77_L92_R1.1151.00
57_I100_C1.1051.00
173_I207_T1.1041.00
181_L186_K1.0881.00
26_Q29_A1.0771.00
20_Y241_A1.0681.00
188_D192_V1.0591.00
83_L88_V1.0501.00
187_S190_G1.0501.00
127_D130_D1.0481.00
50_A57_I1.0471.00
136_A140_A1.0431.00
27_L31_A1.0391.00
32_H103_T1.0341.00
46_A89_M1.0331.00
124_Y259_K1.0291.00
229_P232_M1.0251.00
206_S210_L1.0251.00
217_G220_C1.0180.99
126_I252_A1.0120.99
40_G245_T1.0080.99
45_A252_A1.0050.99
94_R100_C1.0030.99
118_M147_I1.0000.99
201_V208_E0.9930.99
50_A100_C0.9910.99
159_I241_A0.9840.99
97_N100_C0.9720.99
91_E95_Q0.9650.99
36_V138_L0.9570.99
207_T210_L0.9520.99
177_L180_K0.9410.99
38_I59_L0.9410.99
39_G129_I0.9410.99
185_L190_G0.9370.99
186_K190_G0.9310.99
244_V247_T0.9290.99
25_L29_A0.9290.99
94_R101_R0.9260.99
24_A31_A0.9210.99
152_T248_F0.9160.99
193_K201_V0.9120.99
62_M108_F0.9070.99
180_K183_E0.9070.99
162_T251_V0.9060.99
77_L95_Q0.9060.99
65_V76_A0.9000.99
20_Y159_I0.9000.99
200_G207_T0.8960.99
77_L80_N0.8960.99
139_I151_T0.8950.99
181_L184_R0.8930.99
205_F209_A0.8810.99
177_L182_R0.8790.99
78_R95_Q0.8770.99
38_I86_A0.8760.98
33_I124_Y0.8730.98
205_F208_E0.8650.98
114_V141_Y0.8650.98
242_T245_T0.8630.98
57_I93_I0.8600.98
52_T257_L0.8560.98
167_T205_F0.8500.98
230_K233_D0.8490.98
36_V109_V0.8490.98
47_E51_R0.8470.98
200_G206_S0.8460.98
111_P137_A0.8430.98
105_V117_Y0.8420.98
178_A182_R0.8420.98
44_W74_I0.8400.98
131_S134_P0.8310.98
211_V215_S0.8280.98
20_Y24_A0.8280.98
193_K198_K0.8230.98
161_P254_S0.8210.98
67_V81_V0.8210.98
139_I143_R0.8200.98
207_T211_V0.8200.98
39_G42_G0.8180.98
186_K191_V0.8110.98
200_G208_E0.8060.97
39_G63_D0.8050.97
114_V137_A0.8040.97
49_L57_I0.8030.97
118_M145_N0.8030.97
186_K192_V0.8020.97
140_A188_D0.8000.97
80_N92_R0.7950.97
91_E94_R0.7940.97
134_P137_A0.7840.97
200_G203_C0.7740.97
115_A141_Y0.7700.97
203_C206_S0.7700.97
42_G73_Q0.7700.97
62_M106_D0.7700.97
230_K234_C0.7700.97
211_V214_Q0.7590.96
90_A102_V0.7550.96
28_F261_M0.7530.96
214_Q218_T0.7530.96
251_V254_S0.7520.96
141_Y147_I0.7510.96
159_I248_F0.7470.96
109_V141_Y0.7380.96
59_L104_V0.7360.96
162_T165_Q0.7340.96
44_W246_A0.7310.95
11_Q68_T0.7300.95
208_E212_Y0.7300.95
39_G128_A0.7280.95
127_D135_K0.7260.95
187_S191_V0.7210.95
198_K206_S0.7210.95
203_C207_T0.7190.95
87_E90_A0.7170.95
216_D219_V0.7160.95
21_G24_A0.7150.95
216_D220_C0.7120.95
203_C208_E0.7100.95
135_K151_T0.7070.95
31_A54_I0.7070.95
184_R191_V0.7050.94
63_D68_T0.7050.94
43_S89_M0.7040.94
180_K184_R0.7040.94
14_G17_A0.7040.94
202_D208_E0.7030.94
202_D211_V0.6970.94
177_L181_L0.6970.94
203_C214_Q0.6920.94
212_Y217_G0.6920.94
208_E217_G0.6870.94
59_L89_M0.6870.94
24_A28_F0.6870.94
45_A49_L0.6860.94
200_G204_V0.6860.94
227_E231_R0.6850.94
63_D130_D0.6840.94
80_N91_E0.6830.93
11_Q17_A0.6830.93
227_E232_M0.6800.93
70_T80_N0.6750.93
199_L208_E0.6730.93
167_T170_A0.6730.93
206_S214_Q0.6720.93
211_V217_G0.6700.93
13_F97_N0.6700.93
72_R130_D0.6690.93
208_E211_V0.6690.93
69_N73_Q0.6690.93
199_L203_C0.6680.93
78_R81_V0.6640.92
36_V127_D0.6630.92
63_D69_N0.6600.92
115_A144_R0.6600.92
48_A250_F0.6590.92
124_Y260_M0.6570.92
142_C149_L0.6560.92
202_D205_F0.6550.92
150_V255_H0.6500.92
35_V42_G0.6480.92
46_A75_H0.6480.92
28_F54_I0.6430.91
177_L185_L0.6430.91
32_H121_G0.6430.91
35_V126_I0.6430.91
193_K208_E0.6400.91
150_V166_V0.6380.91
229_P233_D0.6320.91
62_M86_A0.6320.91
211_V216_D0.6310.90
166_V204_V0.6300.90
51_R96_I0.6290.90
225_T229_P0.6270.90
39_G240_A0.6250.90
16_T52_T0.6250.90
166_V251_V0.6240.90
177_L184_R0.6210.90
88_V91_E0.6190.90
41_V45_A0.6190.90
45_A48_A0.6160.89
185_L188_D0.6150.89
184_R190_G0.6120.89
135_K153_G0.6110.89
115_A145_N0.6110.89
38_I46_A0.6090.89
14_G20_Y0.6040.88
31_A123_S0.6020.88
225_T228_G0.6020.88
72_R240_A0.6020.88
11_Q20_Y0.5990.88
228_G232_M0.5980.88
199_L210_L0.5980.88
214_Q219_V0.5970.88
13_F16_T0.5960.88
175_D181_L0.5960.88
70_T78_R0.5960.88
118_M121_G0.5940.88
124_Y202_D0.5940.88
125_V149_L0.5940.88
212_Y220_C0.5930.88
193_K199_L0.5890.87
32_H122_Y0.5880.87
140_A191_V0.5830.87
166_V255_H0.5830.87
64_D106_D0.5820.87
174_Q209_A0.5820.87
171_K176_P0.5820.87
16_T19_L0.5820.87
226_A230_K0.5800.86
41_V72_R0.5790.86
117_Y122_Y0.5790.86
202_D207_T0.5770.86
198_K203_C0.5770.86
243_M254_S0.5770.86
181_L185_L0.5750.86
57_I102_V0.5710.86
33_I49_L0.5690.85
12_R70_T0.5690.85
171_K175_D0.5680.85
200_G205_F0.5660.85
68_T72_R0.5650.85
233_D237_G0.5640.85
178_A181_L0.5620.85
33_I126_I0.5610.85
69_N72_R0.5610.85
209_A212_Y0.5580.84
41_V152_T0.5580.84
182_R185_L0.5550.84
172_T176_P0.5530.84
183_E188_D0.5530.84
170_A200_G0.5530.84
188_D191_V0.5510.84
72_R245_T0.5450.83
203_C210_L0.5420.83
44_W51_R0.5390.82
135_K160_D0.5390.82
34_C58_T0.5380.82
182_R186_K0.5370.82
204_V208_E0.5370.82
123_S147_I0.5360.82
155_A248_F0.5360.82
69_N130_D0.5340.82
177_L186_K0.5330.81
37_G42_G0.5330.81
42_G85_K0.5320.81
39_G73_Q0.5280.81
14_G67_V0.5270.81
25_L28_F0.5240.80
154_G245_T0.5230.80
45_A128_A0.5220.80
33_I256_A0.5220.80
242_T250_F0.5210.80
205_F210_L0.5150.79
213_P219_V0.5140.79
124_Y150_V0.5130.79
11_Q14_G0.5130.79
92_R95_Q0.5130.79
212_Y215_S0.5120.79
65_V88_V0.5110.79
44_W250_F0.5100.79
113_N116_Q0.5080.78
46_A57_I0.5080.78
175_D178_A0.5080.78
200_G210_L0.5070.78
232_M237_G0.5070.78
240_A245_T0.5070.78
231_R236_S0.5070.78
177_L190_G0.5010.77
47_E74_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y8qA 1 0.9627 100 0.238 Contact Map
4nnjA 2 0.959 100 0.244 Contact Map
4p22A 2 0.9366 100 0.245 Contact Map
4ii2A 1 0.9515 100 0.246 Contact Map
1tt5A 1 0.9851 100 0.254 Contact Map
1y8qB 1 0.9142 100 0.256 Contact Map
1tt5B 1 0.9701 100 0.287 Contact Map
4d79A 2 0.9216 100 0.313 Contact Map
2nvuB 1 0.9701 100 0.317 Contact Map
1zud1 2 0.7799 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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