GREMLIN Database
CSDA - Cysteine desulfurase CsdA
UniProt: Q46925 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13082
Length: 401 (323)
Sequences: 41146 (28309)
Seq/√Len: 1575.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_E138_V3.6681.00
307_L386_D3.4951.00
311_A389_V3.4371.00
183_I193_V3.3721.00
111_E158_T3.2681.00
307_L382_K3.1421.00
178_D181_R3.1051.00
154_P188_S2.9251.00
111_E136_K2.9101.00
168_Q200_G2.6761.00
348_Y394_R2.6241.00
207_D210_Q2.5701.00
152_L155_E2.4971.00
154_P185_F2.4761.00
116_V141_P2.4661.00
315_R393_D2.4571.00
111_E161_S2.4251.00
197_G216_Y2.3761.00
284_A287_E2.3501.00
186_A191_M2.3491.00
71_K287_E2.3031.00
183_I187_H2.3011.00
307_L311_A2.1891.00
164_L186_A2.1721.00
275_N278_G2.1511.00
218_F231_V2.1481.00
180_A184_T2.1381.00
311_A314_K2.1301.00
311_A386_D2.1151.00
184_T188_S2.1061.00
152_L156_L2.0751.00
348_Y391_A2.0481.00
319_R332_D1.9851.00
187_H214_D1.9481.00
94_I121_A1.9461.00
387_A391_A1.9081.00
149_D152_L1.8981.00
374_A388_L1.8961.00
306_T310_D1.8941.00
111_E160_R1.8861.00
110_D162_R1.8721.00
319_R334_A1.8591.00
303_S382_K1.8131.00
186_A193_V1.8111.00
180_A210_Q1.7971.00
163_I194_M1.7941.00
77_N207_D1.7841.00
154_P189_A1.7781.00
138_V156_L1.7661.00
140_L156_L1.7611.00
141_P152_L1.7471.00
300_W304_L1.7321.00
309_E329_L1.7241.00
299_S303_S1.7111.00
311_A393_D1.6781.00
150_V185_F1.6631.00
181_R184_T1.6521.00
150_V181_R1.6461.00
88_R92_E1.6361.00
344_L395_A1.6351.00
343_T347_E1.6001.00
166_L193_V1.5671.00
308_A376_F1.5581.00
70_E74_Q1.5521.00
72_V231_V1.5451.00
157_I185_F1.5371.00
185_F189_A1.5311.00
74_Q290_A1.5271.00
321_F332_D1.5241.00
87_T93_S1.5031.00
151_D154_P1.4951.00
332_D370_G1.4941.00
83_T236_S1.4891.00
97_V215_F1.4681.00
344_L347_E1.4621.00
300_W303_S1.4611.00
195_V213_I1.4521.00
143_N147_L1.4481.00
330_A371_T1.4351.00
166_L182_A1.4301.00
295_N299_S1.4281.00
337_H340_D1.4221.00
110_D160_R1.4001.00
107_Q110_D1.3871.00
151_D155_E1.3831.00
302_R306_T1.3751.00
382_K386_D1.3711.00
187_H212_D1.3561.00
213_I216_Y1.3561.00
158_T161_S1.3461.00
381_T384_D1.3461.00
314_K393_D1.3401.00
154_P181_R1.3291.00
67_A71_K1.3281.00
113_I161_S1.3281.00
113_I156_L1.3121.00
114_V126_W1.3091.00
305_A309_E1.2991.00
311_A315_R1.2841.00
207_D211_L1.2811.00
307_L385_V1.2751.00
71_K283_S1.2681.00
164_L191_M1.2541.00
153_L182_A1.2541.00
206_A210_Q1.2351.00
138_V158_T1.2091.00
183_I212_D1.2061.00
71_K290_A1.2021.00
94_I194_M1.2001.00
391_A394_R1.2001.00
90_T198_A1.1971.00
220_G282_L1.1911.00
101_Y192_V1.1791.00
136_K158_T1.1781.00
310_D313_A1.1771.00
98_A126_W1.1771.00
70_E73_A1.1751.00
116_V139_K1.1751.00
106_L135_A1.1711.00
154_P158_T1.1701.00
208_V211_L1.1651.00
327_S330_A1.1581.00
143_N149_D1.1551.00
309_E313_A1.1551.00
298_E302_R1.1541.00
226_P281_G1.1441.00
344_L348_Y1.1371.00
293_D296_Q1.1361.00
386_D390_N1.1321.00
308_A385_V1.1271.00
389_V393_D1.1251.00
205_P209_Q1.1231.00
340_D344_L1.1221.00
310_D314_K1.1221.00
79_P236_S1.1201.00
245_W249_G1.1191.00
173_T366_L1.1161.00
345_L352_L1.1081.00
387_A390_N1.1001.00
247_G250_K1.0971.00
47_A51_H1.0941.00
246_L249_G1.0931.00
179_L195_V1.0911.00
296_Q299_S1.0871.00
71_K74_Q1.0811.00
205_P208_V1.0781.00
341_M395_A1.0741.00
63_A67_A1.0731.00
390_N394_R1.0721.00
187_H193_V1.0681.00
383_S386_D1.0671.00
106_L110_D1.0601.00
168_Q179_L1.0541.00
185_F188_S1.0401.00
293_D297_A1.0401.00
93_S217_A1.0381.00
311_A390_N1.0361.00
66_E70_E1.0301.00
194_M217_A1.0291.00
150_V154_P1.0291.00
64_R280_I1.0161.00
248_G251_M1.0131.00
77_N209_Q1.0061.00
114_V139_K1.0001.00
280_I283_S0.9971.00
223_L282_L0.9961.00
215_F234_G0.9951.00
339_S343_T0.9891.00
79_P235_K0.9831.00
106_L109_G0.9821.00
151_D181_R0.9801.00
248_G252_V0.9791.00
350_I391_A0.9771.00
99_Q247_G0.9771.00
87_T96_M0.9631.00
169_M200_G0.9601.00
124_V127_L0.9601.00
158_T189_A0.9581.00
123_L139_K0.9541.00
224_Y377_A0.9531.00
283_S287_E0.9461.00
249_G252_V0.9461.00
304_L385_V0.9441.00
94_I217_A0.9441.00
68_A283_S0.9431.00
153_L164_L0.9421.00
296_Q300_W0.9401.00
168_Q216_Y0.9391.00
157_I189_A0.9371.00
246_L250_K0.9341.00
243_S247_G0.9331.00
145_Q323_C0.9321.00
79_P209_Q0.9321.00
282_L286_L0.9311.00
157_I161_S0.9241.00
287_E291_D0.9131.00
245_W252_V0.9131.00
246_L251_M0.9041.00
307_L310_D0.9031.00
166_L179_L0.9021.00
352_L372_L0.9021.00
95_N99_Q0.8981.00
140_L152_L0.8981.00
317_G334_A0.8971.00
350_I388_L0.8961.00
245_W251_M0.8901.00
47_A50_V0.8881.00
109_G162_R0.8871.00
264_S267_W0.8841.00
263_Q267_W0.8801.00
331_F374_A0.8791.00
342_V352_L0.8781.00
308_A374_A0.8781.00
247_G251_M0.8771.00
214_D235_K0.8721.00
385_V389_V0.8711.00
350_I387_A0.8701.00
177_P182_A0.8651.00
284_A288_W0.8651.00
341_M392_V0.8631.00
112_I126_W0.8621.00
128_M247_G0.8621.00
271_A274_P0.8621.00
165_A194_M0.8611.00
308_A388_L0.8611.00
239_L242_M0.8601.00
303_S307_L0.8571.00
184_T212_D0.8531.00
113_I140_L0.8501.00
126_W137_V0.8491.00
205_P211_L0.8491.00
186_A189_A0.8471.00
247_G252_V0.8451.00
289_L292_Y0.8391.00
201_A218_F0.8361.00
48_G51_H0.8351.00
167_G171_N0.8341.00
343_T346_A0.8311.00
342_V354_A0.8281.00
312_L392_V0.8241.00
183_I211_L0.8221.00
73_A81_D0.8191.00
157_I191_M0.8171.00
164_L182_A0.8131.00
105_R108_P0.8061.00
194_M215_F0.8061.00
166_L177_P0.8021.00
246_L252_V0.7991.00
383_S387_A0.7951.00
113_I138_V0.7941.00
208_V233_Y0.7901.00
340_D343_T0.7901.00
304_L382_K0.7891.00
244_P252_V0.7881.00
266_P269_L0.7851.00
84_I233_Y0.7841.00
300_W382_K0.7811.00
304_L376_F0.7811.00
386_D389_V0.7791.00
235_K238_L0.7771.00
65_Y279_V0.7771.00
79_P83_T0.7731.00
192_V215_F0.7721.00
240_E243_S0.7721.00
67_A283_S0.7711.00
297_A300_W0.7671.00
73_A78_A0.7631.00
315_R389_V0.7621.00
76_L233_Y0.7581.00
214_D219_S0.7561.00
265_A268_K0.7541.00
244_P250_K0.7501.00
380_N385_V0.7491.00
129_V135_A0.7451.00
380_N384_D0.7441.00
75_L201_A0.7431.00
184_T187_H0.7431.00
215_F238_L0.7431.00
214_D217_A0.7421.00
117_A177_P0.7401.00
309_E320_S0.7381.00
150_V153_L0.7381.00
180_A211_L0.7361.00
245_W248_G0.7341.00
186_A190_G0.7331.00
114_V118_E0.7321.00
305_A329_L0.7281.00
268_K274_P0.7281.00
376_F385_V0.7271.00
281_G285_A0.7241.00
71_K288_W0.7181.00
220_G225_G0.7181.00
153_L185_F0.7181.00
176_C204_F0.7171.00
122_N165_A0.7151.00
312_L331_F0.7131.00
99_Q128_M0.7121.00
200_G216_Y0.7111.00
76_L218_F0.7111.00
182_A193_V0.7101.00
244_P248_G0.7081.00
157_I164_L0.7071.00
287_E290_A0.7071.00
68_A71_K0.7041.00
217_A220_G0.7041.00
78_A233_Y0.7031.00
75_L295_N0.7011.00
81_D236_S0.6941.00
168_Q211_L0.6931.00
342_V346_A0.6911.00
349_G353_R0.6881.00
79_P237_E0.6861.00
67_A287_E0.6761.00
297_A378_P0.6751.00
265_A269_L0.6751.00
308_A329_L0.6741.00
264_S268_K0.6741.00
338_H354_A0.6731.00
245_W250_K0.6721.00
101_Y105_R0.6711.00
78_A83_T0.6711.00
206_A209_Q0.6701.00
98_A163_I0.6701.00
320_S332_D0.6691.00
282_L285_A0.6691.00
304_L308_A0.6681.00
273_T276_V0.6671.00
244_P247_G0.6661.00
391_A395_A0.6641.00
168_Q195_V0.6621.00
329_L332_D0.6621.00
352_L374_A0.6611.00
192_V214_D0.6571.00
64_R67_A0.6551.00
323_C326_S0.6551.00
205_P295_N0.6551.00
192_V238_L0.6551.00
206_A211_L0.6531.00
216_Y219_S0.6501.00
114_V137_V0.6501.00
138_V161_S0.6491.00
181_R185_F0.6481.00
313_A323_C0.6471.00
80_D237_E0.6451.00
112_I163_I0.6451.00
201_A223_L0.6441.00
301_S327_S0.6431.00
388_L392_V0.6421.00
244_P249_G0.6381.00
220_G229_I0.6371.00
123_L127_L0.6361.00
283_S286_L0.6351.00
214_D220_G0.6331.00
136_K160_R0.6331.00
197_G200_G0.6331.00
297_A301_S0.6321.00
75_L286_L0.6291.00
350_I353_R0.6291.00
285_A290_A0.6291.00
390_N393_D0.6271.00
97_V101_Y0.6261.00
321_F371_T0.6231.00
90_T94_I0.6221.00
55_F58_A0.6221.00
120_H124_V0.6191.00
388_L391_A0.6191.00
321_F330_A0.6181.00
66_E69_R0.6171.00
263_Q268_K0.6161.00
141_P156_L0.6141.00
212_D235_K0.6141.00
67_A70_E0.6111.00
56_A60_R0.6101.00
197_G201_A0.6091.00
263_Q266_P0.6081.00
307_L389_V0.6051.00
205_P210_Q0.6041.00
327_S332_D0.5951.00
303_S306_T0.5951.00
43_Y277_A0.5931.00
330_A333_F0.5921.00
288_W291_D0.5911.00
308_A312_L0.5871.00
286_L290_A0.5871.00
240_E244_P0.5871.00
54_Q58_A0.5821.00
125_P129_V0.5791.00
341_M372_L0.5751.00
101_Y215_F0.5751.00
236_S240_E0.5751.00
266_P273_T0.5741.00
308_A389_V0.5741.00
234_G239_L0.5741.00
97_V194_M0.5731.00
308_A311_A0.5711.00
319_R322_R0.5711.00
68_A86_W0.5711.00
183_I186_A0.5711.00
159_P189_A0.5701.00
341_M344_L0.5681.00
299_S302_R0.5671.00
94_I165_A0.5651.00
288_W292_Y0.5631.00
71_K292_Y0.5631.00
59_Q62_T0.5611.00
116_V142_L0.5601.00
336_V340_D0.5591.00
153_L157_I0.5551.00
71_K75_L0.5541.00
180_A206_A0.5541.00
126_W165_A0.5531.00
285_A289_L0.5531.00
224_Y378_P0.5521.00
72_V86_W0.5521.00
327_S331_F0.5501.00
155_E159_P0.5491.00
185_F191_M0.5491.00
179_L193_V0.5491.00
135_A162_R0.5441.00
115_S166_L0.5411.00
122_N126_W0.5391.00
60_R63_A0.5381.00
270_E273_T0.5381.00
278_G281_G0.5381.00
318_F323_C0.5371.00
127_L139_K0.5361.00
329_L333_F0.5361.00
95_N128_M0.5361.00
85_V96_M0.5361.00
117_A175_G0.5351.00
163_I192_V0.5341.00
111_E159_P0.5341.00
76_L208_V0.5331.00
208_V212_D0.5321.00
70_E81_D0.5311.00
274_P277_A0.5311.00
338_H342_V0.5301.00
91_T95_N0.5281.00
56_A346_A0.5281.00
179_L183_I0.5281.00
236_S239_L0.5271.00
114_V123_L0.5271.00
65_Y276_V0.5271.00
72_V286_L0.5251.00
222_K373_R0.5251.00
183_I195_V0.5241.00
83_T235_K0.5241.00
244_P251_M0.5241.00
156_L159_P0.5231.00
118_E123_L0.5231.00
70_E80_D0.5231.00
229_I278_G0.5221.00
217_A221_H0.5211.00
318_F333_F0.5201.00
205_P298_E0.5201.00
62_T66_E0.5191.00
377_A380_N0.5191.00
220_G223_L0.5191.00
229_I279_V0.5191.00
143_N152_L0.5181.00
51_H274_P0.5181.00
306_T309_E0.5181.00
198_A222_K0.5181.00
315_R318_F0.5171.00
336_V341_M0.5161.00
187_H190_G0.5161.00
327_S334_A0.5161.00
168_Q206_A0.5151.00
223_L286_L0.5141.00
348_Y395_A0.5121.00
295_N298_E0.5121.00
312_L318_F0.5111.00
154_P184_T0.5101.00
69_R86_W0.5101.00
90_T217_A0.5071.00
349_G352_L0.5071.00
320_S323_C0.5071.00
140_L153_L0.5051.00
97_V232_L0.5031.00
315_R390_N0.5021.00
150_V178_D0.5011.00
216_Y220_G0.5011.00
376_F380_N0.5001.00
98_A165_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kmjA 2 0.99 100 0.322 Contact Map
4lw2A 2 0.995 100 0.323 Contact Map
4q75A 2 0.995 100 0.333 Contact Map
4w91A 2 0.99 100 0.334 Contact Map
3e9kA 2 0.9501 100 0.336 Contact Map
1t3iA 2 0.985 100 0.336 Contact Map
3caiA 2 0.9352 100 0.366 Contact Map
1eluA 2 0.9202 100 0.385 Contact Map
3a9zA 2 0.9027 100 0.385 Contact Map
4isyA 2 0.8903 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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