GREMLIN Database
QUEF - NADPH-dependent 7-cyano-7-deazaguanine reductase
UniProt: Q46920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13173
Length: 282 (270)
Sequences: 731 (441)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_E206_R4.6251.00
241_L269_N4.1181.00
105_F111_V3.9321.00
148_T212_R3.7661.00
84_S125_G3.7341.00
227_E235_R3.2241.00
88_I123_A3.1721.00
85_V124_Q3.1661.00
157_I220_V2.8661.00
210_I244_C2.8091.00
68_K154_D2.8001.00
62_L115_L2.7030.99
191_L226_N2.6330.99
22_R26_D2.5510.99
78_V93_F2.5190.99
70_L153_Q2.4770.99
250_S268_S2.4500.99
38_N41_P2.4410.99
191_L227_E2.4350.99
58_T276_T2.3940.99
149_C184_H2.3780.99
13_L31_Q2.3780.99
201_L219_L2.3750.99
102_Q224_H2.3700.99
23_D224_H2.3600.99
36_S40_D2.2750.98
233_V253_A2.2500.98
68_K156_T2.2360.98
145_F200_S2.2300.98
59_L78_V2.1450.97
80_L123_A2.1360.97
93_F115_L2.1140.97
159_N163_T2.0460.96
66_N154_D2.0210.96
39_R256_T1.9600.95
240_L244_C1.9510.95
10_L38_N1.9300.95
240_L246_P1.9110.95
179_E212_R1.9080.95
248_K270_S1.8830.94
59_L97_L1.8540.94
182_V202_Q1.8460.94
186_L255_Y1.8290.93
31_Q37_L1.7580.92
201_L236_I1.7460.91
98_N101_N1.7350.91
14_T31_Q1.6540.89
100_F114_T1.6470.89
219_L236_I1.6460.89
38_N231_Q1.6270.88
166_Y214_K1.6260.88
175_K209_Q1.6110.88
206_R248_K1.5790.87
114_T117_R1.5720.86
62_L76_G1.5490.86
179_E205_Y1.5470.86
146_N182_V1.5290.85
237_F269_N1.5160.84
145_F182_V1.5080.84
169_N214_K1.4910.83
10_L13_L1.4780.83
67_A106_N1.4610.82
145_F202_Q1.4580.82
11_A199_G1.4430.81
106_N110_E1.4350.81
149_C182_V1.4000.79
33_V192_I1.3940.79
77_H130_A1.3770.78
163_T166_Y1.3760.78
214_K243_F1.3580.77
58_T77_H1.3560.77
33_V37_L1.3540.77
147_G182_V1.3300.75
159_N166_Y1.3240.75
38_N227_E1.3180.75
59_L76_G1.3170.75
81_D125_G1.3000.74
77_H266_W1.2800.73
146_N202_Q1.2760.72
42_L238_N1.2670.72
88_I203_I1.2670.72
134_L280_V1.2410.70
13_L33_V1.2300.70
137_L280_V1.2270.69
117_R121_T1.2150.69
224_H279_L1.2120.68
78_V115_L1.2090.68
222_F235_R1.2080.68
109_D112_R1.1730.66
32_G122_C1.1710.66
79_E128_S1.1700.66
145_F279_L1.1670.65
70_L220_V1.1570.65
78_V97_L1.1440.64
41_P231_Q1.1430.64
67_A104_R1.1420.64
109_D113_Q1.1390.63
32_G166_Y1.1350.63
34_P86_N1.1340.63
75_V133_R1.1240.62
189_N255_Y1.1240.62
210_I240_L1.1130.62
39_R227_E1.1070.61
248_K269_N1.0920.60
22_R191_L1.0900.60
105_F114_T1.0860.60
19_T199_G1.0860.60
20_D184_H1.0800.59
107_N110_E1.0730.59
187_K255_Y1.0700.59
85_V125_G1.0640.58
204_Q270_S1.0620.58
147_G202_Q1.0590.58
112_R116_E1.0550.57
199_G255_Y1.0490.57
39_R42_L1.0430.57
87_L199_G1.0400.56
66_N72_Q1.0370.56
38_N235_R1.0300.56
22_R266_W1.0290.56
74_A108_W1.0280.55
181_L205_Y1.0220.55
45_K48_N1.0220.55
58_T75_V1.0150.54
54_T79_E1.0110.54
157_I217_R1.0070.54
80_L199_G1.0030.54
222_F226_N1.0000.53
81_D134_L0.9990.53
174_E209_Q0.9990.53
37_L192_I0.9990.53
31_Q122_C0.9890.53
78_V122_C0.9890.53
77_H276_T0.9830.52
14_T122_C0.9780.52
208_R245_Q0.9720.51
42_L184_H0.9710.51
266_W270_S0.9690.51
19_T192_I0.9690.51
14_T58_T0.9670.51
39_R226_N0.9660.51
144_H279_L0.9630.51
153_Q213_E0.9550.50
33_V162_F0.9550.50
187_K191_L0.9520.50
226_N231_Q0.9450.49
186_L199_G0.9410.49
165_D243_F0.9350.48
231_Q235_R0.9330.48
170_A174_E0.9320.48
32_G219_L0.9200.47
81_D124_Q0.9200.47
266_W271_D0.9190.47
42_L202_Q0.9120.47
27_A111_V0.9100.47
75_V132_Y0.9090.47
40_D226_N0.9020.46
150_I215_L0.9010.46
72_Q108_W0.8990.46
164_T214_K0.8960.46
123_A261_L0.8920.45
33_V122_C0.8850.45
18_S22_R0.8850.45
102_Q115_L0.8760.44
13_L38_N0.8700.44
176_V247_E0.8650.43
205_Y210_I0.8630.43
76_G237_F0.8630.43
87_L261_L0.8590.43
168_E214_K0.8570.43
76_G82_Y0.8560.43
150_I212_R0.8560.43
93_F261_L0.8470.42
58_T252_Y0.8470.42
31_Q192_I0.8430.42
33_V76_G0.8410.41
97_L115_L0.8360.41
106_N174_E0.8350.41
150_I181_L0.8330.41
178_E204_Q0.8320.41
145_F252_Y0.8290.41
278_R281_R0.8240.40
149_C152_D0.8220.40
233_V261_L0.8180.40
204_Q240_L0.8160.40
67_A213_E0.8140.40
225_H235_R0.8100.39
101_N187_K0.8100.39
63_S198_W0.7930.38
206_R247_E0.7930.38
205_Y244_C0.7920.38
179_E207_G0.7920.38
254_R264_N0.7840.37
150_I219_L0.7740.37
227_E256_T0.7730.37
133_R136_E0.7730.37
170_A209_Q0.7720.37
180_T204_Q0.7690.36
33_V191_L0.7620.36
158_D217_R0.7600.36
123_A157_I0.7570.36
278_R282_Q0.7570.36
75_V280_V0.7540.35
105_F121_T0.7540.35
237_F278_R0.7450.35
155_I217_R0.7450.35
162_F191_L0.7430.35
56_I276_T0.7420.35
176_V209_Q0.7410.34
101_N255_Y0.7410.34
14_T192_I0.7380.34
250_S269_N0.7370.34
20_D166_Y0.7360.34
194_H199_G0.7350.34
104_R156_T0.7310.34
134_L137_L0.7260.33
58_T264_N0.7160.33
58_T254_R0.7160.33
88_I141_P0.7160.33
162_F199_G0.7160.33
67_A135_D0.7130.33
135_D184_H0.7130.33
13_L231_Q0.7120.33
56_I252_Y0.7120.33
50_P62_L0.7080.32
183_S186_L0.7070.32
93_F187_K0.7070.32
159_N217_R0.7050.32
181_L186_L0.7050.32
88_I261_L0.6940.31
52_H269_N0.6930.31
227_E231_Q0.6920.31
191_L235_R0.6900.31
14_T19_T0.6890.31
22_R29_L0.6850.31
203_I219_L0.6840.31
13_L17_K0.6830.31
43_G206_R0.6830.31
203_I215_L0.6820.31
206_R270_S0.6820.31
93_F97_L0.6810.30
54_T202_Q0.6810.30
54_T274_P0.6790.30
23_D82_Y0.6730.30
75_V140_Q0.6730.30
100_F115_L0.6730.30
44_L49_L0.6700.30
159_N165_D0.6700.30
36_S130_A0.6690.30
64_W151_D0.6690.30
226_N235_R0.6680.30
39_R51_F0.6670.30
119_L123_A0.6670.30
113_Q117_R0.6650.29
70_L151_D0.6640.29
169_N208_R0.6600.29
87_L217_R0.6600.29
47_D121_T0.6590.29
20_D129_V0.6590.29
101_N191_L0.6580.29
44_L50_P0.6570.29
132_Y137_L0.6540.29
225_H239_D0.6530.29
11_A17_K0.6530.29
149_C279_L0.6500.29
18_S133_R0.6490.28
106_N109_D0.6480.28
10_L31_Q0.6480.28
191_L222_F0.6470.28
210_I219_L0.6470.28
237_F244_C0.6460.28
140_Q199_G0.6440.28
77_H254_R0.6440.28
50_P219_L0.6420.28
204_Q248_K0.6410.28
237_F241_L0.6390.28
20_D277_T0.6380.28
66_N155_I0.6380.28
98_N198_W0.6380.28
199_G219_L0.6370.28
152_D212_R0.6360.28
47_D87_L0.6320.27
226_N256_T0.6300.27
155_I159_N0.6270.27
13_L235_R0.6240.27
111_V115_L0.6220.27
227_E255_Y0.6200.27
222_F227_E0.6190.27
112_R131_L0.6180.27
192_I228_F0.6130.26
101_N222_F0.6110.26
127_I233_V0.6100.26
144_H280_V0.6090.26
232_C253_A0.6090.26
161_E250_S0.6070.26
49_L219_L0.6070.26
168_E211_D0.6050.26
106_N113_Q0.6050.26
130_A170_A0.6040.26
208_R241_L0.6030.26
134_L142_I0.6000.26
154_D174_E0.5990.26
27_A100_F0.5990.26
179_E210_I0.5970.25
50_P244_C0.5950.25
13_L37_L0.5930.25
71_P207_G0.5920.25
38_N199_G0.5920.25
103_T111_V0.5890.25
137_L192_I0.5890.25
75_V250_S0.5890.25
49_L115_L0.5870.25
208_R247_E0.5850.25
153_Q220_V0.5810.25
70_L78_V0.5810.25
77_H140_Q0.5790.24
38_N82_Y0.5780.24
13_L122_C0.5780.24
188_S255_Y0.5780.24
116_E209_Q0.5780.24
170_A173_G0.5770.24
103_T129_V0.5760.24
110_E120_S0.5750.24
19_T134_L0.5750.24
162_F217_R0.5750.24
28_S272_F0.5740.24
70_L154_D0.5740.24
56_I87_L0.5740.24
58_T137_L0.5730.24
38_N191_L0.5730.24
14_T44_L0.5730.24
88_I122_C0.5720.24
42_L227_E0.5710.24
14_T80_L0.5710.24
99_S237_F0.5690.24
19_T60_Y0.5680.24
10_L41_P0.5680.24
213_E217_R0.5680.24
199_G256_T0.5670.24
43_G214_K0.5640.24
134_L144_H0.5620.23
106_N158_D0.5590.23
77_H132_Y0.5550.23
24_T28_S0.5540.23
156_T261_L0.5530.23
241_L246_P0.5530.23
244_C264_N0.5520.23
147_G180_T0.5520.23
66_N70_L0.5500.23
23_D277_T0.5460.23
110_E247_E0.5440.23
115_L224_H0.5430.22
248_K271_D0.5420.22
60_Y103_T0.5420.22
77_H250_S0.5410.22
73_V111_V0.5400.22
60_Y192_I0.5390.22
51_F244_C0.5380.22
177_V207_G0.5370.22
74_A256_T0.5370.22
18_S250_S0.5350.22
200_S252_Y0.5350.22
132_Y272_F0.5340.22
159_N219_L0.5320.22
203_I212_R0.5310.22
17_K102_Q0.5280.22
31_Q34_P0.5280.22
42_L231_Q0.5270.22
63_S98_N0.5260.22
131_L253_A0.5240.21
52_H268_S0.5230.21
62_L97_L0.5230.21
17_K87_L0.5220.21
178_E269_N0.5220.21
24_T104_R0.5220.21
122_C194_H0.5200.21
238_N276_T0.5200.21
74_A201_L0.5200.21
38_N42_L0.5200.21
24_T201_L0.5190.21
181_L222_F0.5190.21
34_P88_I0.5170.21
238_N241_L0.5170.21
59_L93_F0.5170.21
122_C279_L0.5160.21
121_T165_D0.5160.21
58_T142_I0.5160.21
93_F253_A0.5160.21
87_L181_L0.5140.21
183_S198_W0.5140.21
112_R134_L0.5130.21
151_D183_S0.5130.21
134_L149_C0.5120.21
86_N123_A0.5120.21
38_N192_I0.5120.21
254_R261_L0.5080.21
50_P238_N0.5080.21
24_T32_G0.5030.20
23_D276_T0.5030.20
122_C192_I0.5020.20
107_N175_K0.5020.20
34_P222_F0.5010.20
180_T202_Q0.5010.20
142_I158_D0.5000.20
75_V269_N0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uxjA 2 0.922 100 0.181 Contact Map
4f8bA 5 0.4468 100 0.681 Contact Map
1wurA 6 0.578 97.3 0.944 Contact Map
2f62A 2 0.4149 63.7 0.971 Contact Map
3ceiA 2 0.3191 27.2 0.977 Contact Map
3ehdA 4 0.4043 25.6 0.977 Contact Map
3ak2A 4 0.3156 18.5 0.978 Contact Map
4jenA 2 0.344 12.7 0.98 Contact Map
1cojA 4 0.3191 11.8 0.98 Contact Map
1dt0A 2 0.2908 11.7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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