QUEF - ECOLI - GREMLIN Contacts

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QUEF - NADPH-dependent 7-cyano-7-deazaguanine reductase

UniProt:	Q46920	Sequences: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13173
Length:	282 (270)
Sequences:	731 (441)
Seq/√Len:	26.8

ECOLI - QUEF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
178_E	206_R	4.625	1.00
241_L	269_N	4.118	1.00
105_F	111_V	3.932	1.00
148_T	212_R	3.766	1.00
84_S	125_G	3.734	1.00
227_E	235_R	3.224	1.00
88_I	123_A	3.172	1.00
85_V	124_Q	3.166	1.00
157_I	220_V	2.866	1.00
210_I	244_C	2.809	1.00
68_K	154_D	2.800	1.00
62_L	115_L	2.703	0.99
191_L	226_N	2.633	0.99
22_R	26_D	2.551	0.99
78_V	93_F	2.519	0.99
70_L	153_Q	2.477	0.99
250_S	268_S	2.450	0.99
38_N	41_P	2.441	0.99
191_L	227_E	2.435	0.99
58_T	276_T	2.394	0.99
149_C	184_H	2.378	0.99
13_L	31_Q	2.378	0.99
201_L	219_L	2.375	0.99
102_Q	224_H	2.370	0.99
23_D	224_H	2.360	0.99
36_S	40_D	2.275	0.98
233_V	253_A	2.250	0.98
68_K	156_T	2.236	0.98
145_F	200_S	2.230	0.98
59_L	78_V	2.145	0.97
80_L	123_A	2.136	0.97
93_F	115_L	2.114	0.97
159_N	163_T	2.046	0.96
66_N	154_D	2.021	0.96
39_R	256_T	1.960	0.95
240_L	244_C	1.951	0.95
10_L	38_N	1.930	0.95
240_L	246_P	1.911	0.95
179_E	212_R	1.908	0.95
248_K	270_S	1.883	0.94
59_L	97_L	1.854	0.94
182_V	202_Q	1.846	0.94
186_L	255_Y	1.829	0.93
31_Q	37_L	1.758	0.92
201_L	236_I	1.746	0.91
98_N	101_N	1.735	0.91
14_T	31_Q	1.654	0.89
100_F	114_T	1.647	0.89
219_L	236_I	1.646	0.89
38_N	231_Q	1.627	0.88
166_Y	214_K	1.626	0.88
175_K	209_Q	1.611	0.88
206_R	248_K	1.579	0.87
114_T	117_R	1.572	0.86
62_L	76_G	1.549	0.86
179_E	205_Y	1.547	0.86
146_N	182_V	1.529	0.85
237_F	269_N	1.516	0.84
145_F	182_V	1.508	0.84
169_N	214_K	1.491	0.83
10_L	13_L	1.478	0.83
67_A	106_N	1.461	0.82
145_F	202_Q	1.458	0.82
11_A	199_G	1.443	0.81
106_N	110_E	1.435	0.81
149_C	182_V	1.400	0.79
33_V	192_I	1.394	0.79
77_H	130_A	1.377	0.78
163_T	166_Y	1.376	0.78
214_K	243_F	1.358	0.77
58_T	77_H	1.356	0.77
33_V	37_L	1.354	0.77
147_G	182_V	1.330	0.75
159_N	166_Y	1.324	0.75
38_N	227_E	1.318	0.75
59_L	76_G	1.317	0.75
81_D	125_G	1.300	0.74
77_H	266_W	1.280	0.73
146_N	202_Q	1.276	0.72
42_L	238_N	1.267	0.72
88_I	203_I	1.267	0.72
134_L	280_V	1.241	0.70
13_L	33_V	1.230	0.70
137_L	280_V	1.227	0.69
117_R	121_T	1.215	0.69
224_H	279_L	1.212	0.68
78_V	115_L	1.209	0.68
222_F	235_R	1.208	0.68
109_D	112_R	1.173	0.66
32_G	122_C	1.171	0.66
79_E	128_S	1.170	0.66
145_F	279_L	1.167	0.65
70_L	220_V	1.157	0.65
78_V	97_L	1.144	0.64
41_P	231_Q	1.143	0.64
67_A	104_R	1.142	0.64
109_D	113_Q	1.139	0.63
32_G	166_Y	1.135	0.63
34_P	86_N	1.134	0.63
75_V	133_R	1.124	0.62
189_N	255_Y	1.124	0.62
210_I	240_L	1.113	0.62
39_R	227_E	1.107	0.61
248_K	269_N	1.092	0.60
22_R	191_L	1.090	0.60
105_F	114_T	1.086	0.60
19_T	199_G	1.086	0.60
20_D	184_H	1.080	0.59
107_N	110_E	1.073	0.59
187_K	255_Y	1.070	0.59
85_V	125_G	1.064	0.58
204_Q	270_S	1.062	0.58
147_G	202_Q	1.059	0.58
112_R	116_E	1.055	0.57
199_G	255_Y	1.049	0.57
39_R	42_L	1.043	0.57
87_L	199_G	1.040	0.56
66_N	72_Q	1.037	0.56
38_N	235_R	1.030	0.56
22_R	266_W	1.029	0.56
74_A	108_W	1.028	0.55
181_L	205_Y	1.022	0.55
45_K	48_N	1.022	0.55
58_T	75_V	1.015	0.54
54_T	79_E	1.011	0.54
157_I	217_R	1.007	0.54
80_L	199_G	1.003	0.54
222_F	226_N	1.000	0.53
81_D	134_L	0.999	0.53
174_E	209_Q	0.999	0.53
37_L	192_I	0.999	0.53
31_Q	122_C	0.989	0.53
78_V	122_C	0.989	0.53
77_H	276_T	0.983	0.52
14_T	122_C	0.978	0.52
208_R	245_Q	0.972	0.51
42_L	184_H	0.971	0.51
266_W	270_S	0.969	0.51
19_T	192_I	0.969	0.51
14_T	58_T	0.967	0.51
39_R	226_N	0.966	0.51
144_H	279_L	0.963	0.51
153_Q	213_E	0.955	0.50
33_V	162_F	0.955	0.50
187_K	191_L	0.952	0.50
226_N	231_Q	0.945	0.49
186_L	199_G	0.941	0.49
165_D	243_F	0.935	0.48
231_Q	235_R	0.933	0.48
170_A	174_E	0.932	0.48
32_G	219_L	0.920	0.47
81_D	124_Q	0.920	0.47
266_W	271_D	0.919	0.47
42_L	202_Q	0.912	0.47
27_A	111_V	0.910	0.47
75_V	132_Y	0.909	0.47
40_D	226_N	0.902	0.46
150_I	215_L	0.901	0.46
72_Q	108_W	0.899	0.46
164_T	214_K	0.896	0.46
123_A	261_L	0.892	0.45
33_V	122_C	0.885	0.45
18_S	22_R	0.885	0.45
102_Q	115_L	0.876	0.44
13_L	38_N	0.870	0.44
176_V	247_E	0.865	0.43
205_Y	210_I	0.863	0.43
76_G	237_F	0.863	0.43
87_L	261_L	0.859	0.43
168_E	214_K	0.857	0.43
76_G	82_Y	0.856	0.43
150_I	212_R	0.856	0.43
93_F	261_L	0.847	0.42
58_T	252_Y	0.847	0.42
31_Q	192_I	0.843	0.42
33_V	76_G	0.841	0.41
97_L	115_L	0.836	0.41
106_N	174_E	0.835	0.41
150_I	181_L	0.833	0.41
178_E	204_Q	0.832	0.41
145_F	252_Y	0.829	0.41
278_R	281_R	0.824	0.40
149_C	152_D	0.822	0.40
233_V	261_L	0.818	0.40
204_Q	240_L	0.816	0.40
67_A	213_E	0.814	0.40
225_H	235_R	0.810	0.39
101_N	187_K	0.810	0.39
63_S	198_W	0.793	0.38
206_R	247_E	0.793	0.38
205_Y	244_C	0.792	0.38
179_E	207_G	0.792	0.38
254_R	264_N	0.784	0.37
150_I	219_L	0.774	0.37
227_E	256_T	0.773	0.37
133_R	136_E	0.773	0.37
170_A	209_Q	0.772	0.37
180_T	204_Q	0.769	0.36
33_V	191_L	0.762	0.36
158_D	217_R	0.760	0.36
123_A	157_I	0.757	0.36
278_R	282_Q	0.757	0.36
75_V	280_V	0.754	0.35
105_F	121_T	0.754	0.35
237_F	278_R	0.745	0.35
155_I	217_R	0.745	0.35
162_F	191_L	0.743	0.35
56_I	276_T	0.742	0.35
176_V	209_Q	0.741	0.34
101_N	255_Y	0.741	0.34
14_T	192_I	0.738	0.34
250_S	269_N	0.737	0.34
20_D	166_Y	0.736	0.34
194_H	199_G	0.735	0.34
104_R	156_T	0.731	0.34
134_L	137_L	0.726	0.33
58_T	264_N	0.716	0.33
58_T	254_R	0.716	0.33
88_I	141_P	0.716	0.33
162_F	199_G	0.716	0.33
67_A	135_D	0.713	0.33
135_D	184_H	0.713	0.33
13_L	231_Q	0.712	0.33
56_I	252_Y	0.712	0.33
50_P	62_L	0.708	0.32
183_S	186_L	0.707	0.32
93_F	187_K	0.707	0.32
159_N	217_R	0.705	0.32
181_L	186_L	0.705	0.32
88_I	261_L	0.694	0.31
52_H	269_N	0.693	0.31
227_E	231_Q	0.692	0.31
191_L	235_R	0.690	0.31
14_T	19_T	0.689	0.31
22_R	29_L	0.685	0.31
203_I	219_L	0.684	0.31
13_L	17_K	0.683	0.31
43_G	206_R	0.683	0.31
203_I	215_L	0.682	0.31
206_R	270_S	0.682	0.31
93_F	97_L	0.681	0.30
54_T	202_Q	0.681	0.30
54_T	274_P	0.679	0.30
23_D	82_Y	0.673	0.30
75_V	140_Q	0.673	0.30
100_F	115_L	0.673	0.30
44_L	49_L	0.670	0.30
159_N	165_D	0.670	0.30
36_S	130_A	0.669	0.30
64_W	151_D	0.669	0.30
226_N	235_R	0.668	0.30
39_R	51_F	0.667	0.30
119_L	123_A	0.667	0.30
113_Q	117_R	0.665	0.29
70_L	151_D	0.664	0.29
169_N	208_R	0.660	0.29
87_L	217_R	0.660	0.29
47_D	121_T	0.659	0.29
20_D	129_V	0.659	0.29
101_N	191_L	0.658	0.29
44_L	50_P	0.657	0.29
132_Y	137_L	0.654	0.29
225_H	239_D	0.653	0.29
11_A	17_K	0.653	0.29
149_C	279_L	0.650	0.29
18_S	133_R	0.649	0.28
106_N	109_D	0.648	0.28
10_L	31_Q	0.648	0.28
191_L	222_F	0.647	0.28
210_I	219_L	0.647	0.28
237_F	244_C	0.646	0.28
140_Q	199_G	0.644	0.28
77_H	254_R	0.644	0.28
50_P	219_L	0.642	0.28
204_Q	248_K	0.641	0.28
237_F	241_L	0.639	0.28
20_D	277_T	0.638	0.28
66_N	155_I	0.638	0.28
98_N	198_W	0.638	0.28
199_G	219_L	0.637	0.28
152_D	212_R	0.636	0.28
47_D	87_L	0.632	0.27
226_N	256_T	0.630	0.27
155_I	159_N	0.627	0.27
13_L	235_R	0.624	0.27
111_V	115_L	0.622	0.27
227_E	255_Y	0.620	0.27
222_F	227_E	0.619	0.27
112_R	131_L	0.618	0.27
192_I	228_F	0.613	0.26
101_N	222_F	0.611	0.26
127_I	233_V	0.610	0.26
144_H	280_V	0.609	0.26
232_C	253_A	0.609	0.26
161_E	250_S	0.607	0.26
49_L	219_L	0.607	0.26
168_E	211_D	0.605	0.26
106_N	113_Q	0.605	0.26
130_A	170_A	0.604	0.26
208_R	241_L	0.603	0.26
134_L	142_I	0.600	0.26
154_D	174_E	0.599	0.26
27_A	100_F	0.599	0.26
179_E	210_I	0.597	0.25
50_P	244_C	0.595	0.25
13_L	37_L	0.593	0.25
71_P	207_G	0.592	0.25
38_N	199_G	0.592	0.25
103_T	111_V	0.589	0.25
137_L	192_I	0.589	0.25
75_V	250_S	0.589	0.25
49_L	115_L	0.587	0.25
208_R	247_E	0.585	0.25
153_Q	220_V	0.581	0.25
70_L	78_V	0.581	0.25
77_H	140_Q	0.579	0.24
38_N	82_Y	0.578	0.24
13_L	122_C	0.578	0.24
188_S	255_Y	0.578	0.24
116_E	209_Q	0.578	0.24
170_A	173_G	0.577	0.24
103_T	129_V	0.576	0.24
110_E	120_S	0.575	0.24
19_T	134_L	0.575	0.24
162_F	217_R	0.575	0.24
28_S	272_F	0.574	0.24
70_L	154_D	0.574	0.24
56_I	87_L	0.574	0.24
58_T	137_L	0.573	0.24
38_N	191_L	0.573	0.24
14_T	44_L	0.573	0.24
88_I	122_C	0.572	0.24
42_L	227_E	0.571	0.24
14_T	80_L	0.571	0.24
99_S	237_F	0.569	0.24
19_T	60_Y	0.568	0.24
10_L	41_P	0.568	0.24
213_E	217_R	0.568	0.24
199_G	256_T	0.567	0.24
43_G	214_K	0.564	0.24
134_L	144_H	0.562	0.23
106_N	158_D	0.559	0.23
77_H	132_Y	0.555	0.23
24_T	28_S	0.554	0.23
156_T	261_L	0.553	0.23
241_L	246_P	0.553	0.23
244_C	264_N	0.552	0.23
147_G	180_T	0.552	0.23
66_N	70_L	0.550	0.23
23_D	277_T	0.546	0.23
110_E	247_E	0.544	0.23
115_L	224_H	0.543	0.22
248_K	271_D	0.542	0.22
60_Y	103_T	0.542	0.22
77_H	250_S	0.541	0.22
73_V	111_V	0.540	0.22
60_Y	192_I	0.539	0.22
51_F	244_C	0.538	0.22
177_V	207_G	0.537	0.22
74_A	256_T	0.537	0.22
18_S	250_S	0.535	0.22
200_S	252_Y	0.535	0.22
132_Y	272_F	0.534	0.22
159_N	219_L	0.532	0.22
203_I	212_R	0.531	0.22
17_K	102_Q	0.528	0.22
31_Q	34_P	0.528	0.22
42_L	231_Q	0.527	0.22
63_S	98_N	0.526	0.22
131_L	253_A	0.524	0.21
52_H	268_S	0.523	0.21
62_L	97_L	0.523	0.21
17_K	87_L	0.522	0.21
178_E	269_N	0.522	0.21
24_T	104_R	0.522	0.21
122_C	194_H	0.520	0.21
238_N	276_T	0.520	0.21
74_A	201_L	0.520	0.21
38_N	42_L	0.520	0.21
24_T	201_L	0.519	0.21
181_L	222_F	0.519	0.21
34_P	88_I	0.517	0.21
238_N	241_L	0.517	0.21
59_L	93_F	0.517	0.21
122_C	279_L	0.516	0.21
121_T	165_D	0.516	0.21
58_T	142_I	0.516	0.21
93_F	253_A	0.516	0.21
87_L	181_L	0.514	0.21
183_S	198_W	0.514	0.21
112_R	134_L	0.513	0.21
151_D	183_S	0.513	0.21
134_L	149_C	0.512	0.21
86_N	123_A	0.512	0.21
38_N	192_I	0.512	0.21
254_R	261_L	0.508	0.21
50_P	238_N	0.508	0.21
24_T	32_G	0.503	0.20
23_D	276_T	0.503	0.20
122_C	192_I	0.502	0.20
107_N	175_K	0.502	0.20
34_P	222_F	0.501	0.20
180_T	202_Q	0.501	0.20
142_I	158_D	0.500	0.20
75_V	269_N	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3uxjA	2	0.922	100	0.181	Contact Map
4f8bA	5	0.4468	100	0.681	Contact Map
1wurA	6	0.578	97.3	0.944	Contact Map
2f62A	2	0.4149	63.7	0.971	Contact Map
3ceiA	2	0.3191	27.2	0.977	Contact Map
3ehdA	4	0.4043	25.6	0.977	Contact Map
3ak2A	4	0.3156	18.5	0.978	Contact Map
4jenA	2	0.344	12.7	0.98	Contact Map
1cojA	4	0.3191	11.8	0.98	Contact Map
1dt0A	2	0.2908	11.7	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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