GUDX - ECOLI - GREMLIN Contacts

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GUDX - Glucarate dehydratase-related protein

UniProt:	Q46915	Sequences: MATQSSPVITDMKVIPVAGHDSMLLNIGGAHNAYFTRNIVVLTDNAGHTGIGEAPGGDVIYQTLVDAIPMVLGQEVARLNKVVQQVHKGNQAADFDTFGKGAWTFELRVNAVAALEAALLDLLGKALNVPVCELLGPGKQREAITVLGYLFYIGDRTKTDLPYVENTPGNHEWYQLRHQKAMNSEAVVRLAEASQDRYGFKDFKLKGGVLPGEQEIDTVRALKKRFPDARITVDPNGAWLLDEAISLCKGLNDVLTYAEDPCGAEQGFSGREVMAEFRRATGLPVATNMIATNWREMGHAVMLNAVDIPLADPHFWTLSGAVRVAQLCDDWGLTWGCHSNNHFDISLAMFTHVGAAAPGNPTAIDTHWIWQEGDCRLTQNPLEIKNGKIAVPDAPGLGVELDWEQVQKAHEAYKRLPGGARNDAGPMQYLIPGWTFDRKRPVFGRH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13168
Length:	446 (356)
Sequences:	6803 (4165)
Seq/√Len:	220.8

ECOLI - GUDX GUDD RHMD RSPA DGOD AEEP MENC
BACSU - GUDD YITF AEEP MENC
HALSA - Q9HS20 Q9HP25 Q9HQN7
SULSO - GAD Q97VG1 Q97YL9 ARAD Q97YR3 Q97UK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
143_A	388_K	3.926	1.00
278_R	307_D	3.620	1.00
74_Q	85_Q	3.350	1.00
48_H	122_L	3.343	1.00
275_A	279_R	2.758	1.00
13_K	41_V	2.747	1.00
192_E	225_R	2.681	1.00
41_V	403_W	2.632	1.00
301_V	333_L	2.629	1.00
240_L	243_E	2.584	1.00
124_G	131_V	2.492	1.00
44_D	122_L	2.483	1.00
248_C	258_A	2.447	1.00
43_T	49_T	2.400	1.00
51_I	401_L	2.370	1.00
248_C	281_T	2.338	1.00
13_K	43_T	2.325	1.00
294_W	320_G	2.314	1.00
11_D	43_T	2.303	1.00
245_I	280_A	2.272	1.00
249_K	252_N	2.255	1.00
270_G	273_V	2.239	1.00
44_D	48_H	2.231	1.00
276_E	279_R	2.218	1.00
48_H	126_A	2.213	1.00
116_E	319_S	2.207	1.00
316_W	324_V	2.205	1.00
252_N	282_G	2.204	1.00
184_S	188_V	2.136	1.00
145_T	201_K	2.130	1.00
272_E	303_L	2.111	1.00
41_V	49_T	2.045	1.00
8_V	45_N	2.023	1.00
379_Q	400_E	2.002	1.00
298_G	302_M	1.966	1.00
188_V	225_R	1.965	1.00
12_M	42_L	1.927	1.00
275_A	303_L	1.922	1.00
195_Q	229_A	1.909	1.00
125_K	400_E	1.901	1.00
276_E	280_A	1.896	1.00
220_R	224_K	1.868	1.00
241_L	277_F	1.867	1.00
262_C	277_F	1.851	1.00
192_E	196_D	1.834	1.00
302_M	331_W	1.831	1.00
220_R	254_V	1.805	1.00
139_K	142_E	1.794	1.00
183_N	186_A	1.792	1.00
247_L	251_L	1.782	1.00
385_K	390_A	1.781	1.00
78_R	81_K	1.774	1.00
252_N	283_L	1.736	1.00
15_I	41_V	1.717	1.00
250_G	253_D	1.675	1.00
216_I	250_G	1.674	1.00
223_K	227_P	1.674	1.00
297_M	324_V	1.663	1.00
42_L	119_L	1.649	1.00
143_A	390_A	1.644	1.00
299_H	303_L	1.643	1.00
129_V	133_E	1.641	1.00
131_V	397_L	1.621	1.00
379_Q	402_D	1.607	1.00
74_Q	81_K	1.596	1.00
226_F	231_I	1.593	1.00
48_H	125_K	1.587	1.00
10_T	45_N	1.578	1.00
10_T	43_T	1.560	1.00
186_A	189_R	1.541	1.00
217_D	220_R	1.529	1.00
301_V	327_L	1.528	1.00
355_A	391_V	1.527	1.00
300_A	306_V	1.523	1.00
123_L	127_L	1.507	1.00
15_I	410_H	1.502	1.00
221_A	224_K	1.496	1.00
241_L	276_E	1.491	1.00
74_Q	82_V	1.484	1.00
323_R	329_D	1.479	1.00
326_Q	329_D	1.474	1.00
62_Q	65_V	1.471	1.00
82_V	86_V	1.468	1.00
403_W	407_Q	1.456	1.00
321_A	353_V	1.454	1.00
80_N	323_R	1.454	1.00
203_F	229_A	1.451	1.00
18_A	34_Y	1.448	1.00
77_A	126_A	1.446	1.00
189_R	192_E	1.427	1.00
220_R	253_D	1.423	1.00
44_D	126_A	1.421	1.00
211_P	214_Q	1.416	1.00
380_N	394_A	1.398	1.00
245_I	277_F	1.393	1.00
206_K	236_N	1.393	1.00
75_E	78_R	1.390	1.00
40_V	114_A	1.383	1.00
322_V	326_Q	1.373	1.00
116_E	120_L	1.356	1.00
39_I	406_V	1.352	1.00
262_C	273_V	1.346	1.00
124_G	134_L	1.346	1.00
54_A	114_A	1.345	1.00
191_A	226_F	1.341	1.00
12_M	68_I	1.341	1.00
77_A	123_L	1.331	1.00
320_G	323_R	1.328	1.00
46_A	126_A	1.327	1.00
80_N	322_V	1.323	1.00
297_M	309_P	1.318	1.00
131_V	318_L	1.316	1.00
299_H	302_M	1.314	1.00
39_I	345_I	1.310	1.00
195_Q	203_F	1.304	1.00
252_N	281_T	1.304	1.00
191_A	203_F	1.294	1.00
233_V	255_L	1.292	1.00
249_K	280_A	1.286	1.00
217_D	221_A	1.272	1.00
405_Q	408_K	1.269	1.00
205_L	222_L	1.264	1.00
230_R	256_T	1.263	1.00
287_T	300_A	1.256	1.00
26_N	31_H	1.254	1.00
86_V	112_V	1.252	1.00
82_V	85_Q	1.246	1.00
11_D	68_I	1.245	1.00
232_T	256_T	1.244	1.00
74_Q	78_R	1.239	1.00
286_A	310_L	1.237	1.00
401_L	406_V	1.228	1.00
312_D	338_H	1.212	1.00
216_I	254_V	1.211	1.00
249_K	282_G	1.208	1.00
405_Q	409_A	1.208	1.00
192_E	195_Q	1.208	1.00
193_A	198_Y	1.196	1.00
272_E	299_H	1.195	1.00
145_T	388_K	1.189	1.00
219_V	233_V	1.187	1.00
185_E	189_R	1.179	1.00
68_I	72_L	1.171	1.00
12_M	71_V	1.168	1.00
301_V	331_W	1.167	1.00
130_P	133_E	1.159	1.00
349_M	397_L	1.155	1.00
45_N	76_V	1.155	1.00
255_L	283_L	1.154	1.00
77_A	127_L	1.153	1.00
188_V	226_F	1.150	1.00
120_L	319_S	1.144	1.00
325_A	357_A	1.141	1.00
402_D	405_Q	1.129	1.00
306_V	309_P	1.127	1.00
223_K	231_I	1.126	1.00
42_L	71_V	1.125	1.00
226_F	229_A	1.122	1.00
129_V	134_L	1.121	1.00
117_A	349_M	1.120	1.00
81_K	85_Q	1.119	1.00
329_D	358_P	1.115	1.00
292_T	296_E	1.114	1.00
214_Q	217_D	1.114	1.00
260_D	310_L	1.098	1.00
67_A	115_L	1.097	1.00
246_S	250_G	1.082	1.00
79_L	123_L	1.081	1.00
351_T	391_V	1.075	1.00
274_M	287_T	1.067	1.00
311_A	321_A	1.065	1.00
223_K	228_D	1.065	1.00
191_A	222_L	1.063	1.00
216_I	220_R	1.062	1.00
277_F	285_V	1.059	1.00
194_S	198_Y	1.055	1.00
222_L	226_F	1.055	1.00
293_N	296_E	1.054	1.00
133_E	393_D	1.053	1.00
188_V	224_K	1.053	1.00
278_R	304_N	1.052	1.00
239_W	247_L	1.051	1.00
316_W	321_A	1.050	1.00
322_V	356_A	1.043	1.00
202_D	232_T	1.040	1.00
235_P	258_A	1.038	1.00
271_R	300_A	1.037	1.00
143_A	386_N	1.027	1.00
404_E	407_Q	1.023	1.00
212_G	247_L	1.023	1.00
41_V	51_I	1.019	1.00
188_V	192_E	1.018	1.00
301_V	309_P	1.014	1.00
128_N	395_P	1.011	1.00
139_K	393_D	1.007	1.00
208_G	215_E	1.003	1.00
219_V	254_V	1.000	1.00
64_L	68_I	0.993	1.00
39_I	51_I	0.991	1.00
313_P	321_A	0.989	1.00
189_R	193_A	0.988	1.00
67_A	86_V	0.985	1.00
82_V	119_L	0.984	1.00
127_L	134_L	0.981	1.00
286_A	308_I	0.980	1.00
132_C	391_V	0.974	1.00
216_I	253_D	0.971	1.00
132_C	139_K	0.964	1.00
184_S	221_A	0.961	1.00
83_V	319_S	0.960	1.00
298_G	331_W	0.956	1.00
221_A	225_R	0.952	1.00
207_G	235_P	0.949	1.00
219_V	251_L	0.946	1.00
262_C	274_M	0.944	1.00
203_F	226_F	0.939	1.00
213_E	217_D	0.937	1.00
188_V	221_A	0.934	1.00
348_A	399_V	0.923	0.99
125_K	394_A	0.919	0.99
276_E	304_N	0.918	0.99
323_R	326_Q	0.918	0.99
205_L	219_V	0.915	0.99
407_Q	410_H	0.912	0.99
70_M	85_Q	0.909	0.99
184_S	217_D	0.905	0.99
384_I	389_I	0.902	0.99
64_L	115_L	0.900	0.99
148_G	200_F	0.896	0.99
291_A	297_M	0.895	0.99
245_I	276_E	0.893	0.99
64_L	69_P	0.887	0.99
189_R	225_R	0.886	0.99
123_L	134_L	0.885	0.99
296_E	299_H	0.882	0.99
213_E	250_G	0.882	0.99
76_V	119_L	0.880	0.99
239_W	258_A	0.879	0.99
235_P	239_W	0.879	0.99
355_A	392_P	0.879	0.99
245_I	281_T	0.877	0.99
71_V	82_V	0.870	0.99
309_P	328_C	0.863	0.99
193_A	196_D	0.862	0.99
119_L	123_L	0.862	0.99
245_I	249_K	0.861	0.99
232_T	257_Y	0.859	0.99
241_L	273_V	0.858	0.99
135_L	318_L	0.858	0.99
14_V	64_L	0.855	0.99
241_L	262_C	0.854	0.99
294_W	327_L	0.853	0.99
281_T	285_V	0.853	0.99
385_K	388_K	0.850	0.99
298_G	327_L	0.847	0.99
75_E	133_E	0.845	0.99
327_L	331_W	0.844	0.99
271_R	305_A	0.844	0.99
394_A	400_E	0.837	0.99
78_R	133_E	0.836	0.99
288_N	312_D	0.830	0.99
291_A	296_E	0.826	0.99
43_T	46_A	0.823	0.99
202_D	230_R	0.822	0.99
318_L	353_V	0.820	0.99
15_I	407_Q	0.819	0.99
83_V	116_E	0.816	0.99
121_D	125_K	0.815	0.99
313_P	350_F	0.812	0.99
143_A	385_K	0.812	0.99
261_P	285_V	0.809	0.99
191_A	225_R	0.808	0.99
345_I	399_V	0.807	0.99
132_C	352_H	0.807	0.99
304_N	333_L	0.805	0.99
58_D	62_Q	0.804	0.99
313_P	353_V	0.803	0.99
403_W	406_V	0.803	0.99
124_G	127_L	0.801	0.99
14_V	61_Y	0.801	0.99
278_R	285_V	0.791	0.98
76_V	122_L	0.791	0.98
271_R	299_H	0.786	0.98
18_A	36_T	0.783	0.98
318_L	322_V	0.783	0.98
103_W	106_E	0.783	0.98
366_T	369_I	0.781	0.98
71_V	115_L	0.780	0.98
9_I	42_L	0.780	0.98
329_D	359_G	0.779	0.98
195_Q	225_R	0.772	0.98
279_R	304_N	0.770	0.98
59_V	62_Q	0.770	0.98
242_D	246_S	0.769	0.98
287_T	306_V	0.769	0.98
188_V	191_A	0.768	0.98
192_E	226_F	0.763	0.98
122_L	126_A	0.759	0.98
188_V	222_L	0.757	0.98
201_K	386_N	0.756	0.98
148_G	194_S	0.755	0.98
195_Q	226_F	0.754	0.98
291_A	300_A	0.753	0.98
43_T	51_I	0.752	0.98
124_G	129_V	0.752	0.98
87_H	320_G	0.750	0.98
272_E	302_M	0.749	0.98
83_V	87_H	0.749	0.98
58_D	65_V	0.749	0.98
83_V	86_V	0.748	0.98
132_C	393_D	0.747	0.98
49_T	400_E	0.747	0.98
133_E	139_K	0.746	0.98
62_Q	66_D	0.744	0.98
371_Q	374_D	0.744	0.98
260_D	288_N	0.739	0.98
310_L	338_H	0.739	0.98
311_A	335_W	0.737	0.97
190_L	193_A	0.734	0.97
52_G	114_A	0.734	0.97
380_N	400_E	0.731	0.97
375_C	408_K	0.731	0.97
146_V	389_I	0.731	0.97
275_A	305_A	0.731	0.97
54_A	110_N	0.731	0.97
153_I	186_A	0.730	0.97
10_T	44_D	0.728	0.97
191_A	221_A	0.727	0.97
56_G	59_V	0.725	0.97
390_A	393_D	0.723	0.97
369_I	372_E	0.723	0.97
201_K	228_D	0.723	0.97
383_E	390_A	0.723	0.97
130_P	352_H	0.721	0.97
348_A	351_T	0.717	0.97
241_L	245_I	0.717	0.97
16_P	36_T	0.716	0.97
8_V	75_E	0.712	0.97
351_T	389_I	0.709	0.97
16_P	61_Y	0.706	0.97
66_D	69_P	0.706	0.97
150_L	194_S	0.706	0.97
49_T	125_K	0.704	0.97
365_D	368_W	0.703	0.97
124_G	395_P	0.702	0.97
195_Q	227_P	0.700	0.97
243_E	246_S	0.699	0.97
322_V	357_A	0.699	0.97
271_R	303_L	0.698	0.97
215_E	239_W	0.697	0.96
65_V	68_I	0.694	0.96
145_T	230_R	0.694	0.96
57_G	60_I	0.689	0.96
123_L	126_A	0.688	0.96
233_V	251_L	0.687	0.96
67_A	90_N	0.682	0.96
142_E	393_D	0.678	0.96
61_Y	65_V	0.678	0.96
45_N	48_H	0.678	0.96
274_M	285_V	0.676	0.96
51_I	345_I	0.676	0.96
127_L	130_P	0.670	0.96
382_L	389_I	0.670	0.96
82_V	115_L	0.666	0.95
187_V	218_T	0.665	0.95
318_L	349_M	0.659	0.95
213_E	246_S	0.658	0.95
68_I	115_L	0.654	0.95
207_G	233_V	0.654	0.95
51_I	403_W	0.650	0.95
120_L	131_V	0.650	0.95
364_I	367_H	0.648	0.95
368_W	375_C	0.647	0.95
255_L	258_A	0.646	0.95
86_V	115_L	0.643	0.95
76_V	126_A	0.642	0.94
58_D	61_Y	0.639	0.94
10_T	46_A	0.637	0.94
46_A	76_V	0.634	0.94
87_H	112_V	0.633	0.94
248_C	283_L	0.632	0.94
56_G	60_I	0.630	0.94
131_V	322_V	0.628	0.94
274_M	277_F	0.627	0.94
55_P	314_H	0.622	0.94
404_E	408_K	0.620	0.93
195_Q	228_D	0.619	0.93
256_T	284_P	0.618	0.93
63_T	111_A	0.617	0.93
149_Y	206_K	0.617	0.93
223_K	254_V	0.613	0.93
222_L	225_R	0.612	0.93
125_K	397_L	0.611	0.93
354_G	360_N	0.611	0.93
367_H	371_Q	0.611	0.93
309_P	333_L	0.611	0.93
117_A	314_H	0.608	0.93
257_Y	336_G	0.608	0.93
237_G	264_A	0.607	0.93
275_A	304_N	0.607	0.93
38_N	61_Y	0.602	0.92
76_V	79_L	0.602	0.92
260_D	289_M	0.598	0.92
260_D	290_I	0.596	0.92
40_V	115_L	0.595	0.92
297_M	328_C	0.593	0.92
213_E	220_R	0.593	0.92
214_Q	218_T	0.592	0.92
57_G	61_Y	0.589	0.92
317_T	320_G	0.589	0.92
84_Q	140_Q	0.588	0.91
380_N	383_E	0.587	0.91
216_I	251_L	0.587	0.91
244_A	258_A	0.587	0.91
71_V	119_L	0.586	0.91
288_N	310_L	0.585	0.91
201_K	388_K	0.585	0.91
339_S	347_L	0.584	0.91
131_V	135_L	0.583	0.91
65_V	69_P	0.583	0.91
277_F	280_A	0.582	0.91
15_I	51_I	0.580	0.91
139_K	391_V	0.580	0.91
270_G	332_G	0.579	0.91
190_L	194_S	0.579	0.91
117_A	345_I	0.577	0.91
79_L	82_V	0.577	0.91
153_I	190_L	0.577	0.91
297_M	311_A	0.577	0.91
295_R	299_H	0.576	0.91
150_L	153_I	0.572	0.90
310_L	336_G	0.572	0.90
328_C	333_L	0.572	0.90
185_E	188_V	0.571	0.90
12_M	115_L	0.570	0.90
301_V	328_C	0.569	0.90
345_I	401_L	0.569	0.90
207_G	239_W	0.569	0.90
278_R	305_A	0.568	0.90
240_L	334_T	0.568	0.90
223_K	229_A	0.568	0.90
120_L	124_G	0.568	0.90
310_L	337_C	0.567	0.90
23_M	190_L	0.567	0.90
216_I	219_V	0.566	0.90
79_L	119_L	0.565	0.90
344_D	378_T	0.565	0.90
70_M	89_G	0.564	0.90
11_D	45_N	0.563	0.90
201_K	387_G	0.560	0.89
291_A	309_P	0.560	0.89
368_W	371_Q	0.557	0.89
78_R	82_V	0.554	0.89
272_E	275_A	0.554	0.89
365_D	370_W	0.552	0.89
84_Q	88_K	0.551	0.89
117_A	397_L	0.550	0.89
378_T	381_P	0.550	0.89
110_N	315_F	0.549	0.88
19_G	343_F	0.549	0.88
294_W	298_G	0.547	0.88
351_T	392_P	0.547	0.88
24_L	31_H	0.545	0.88
120_L	318_L	0.544	0.88
244_A	248_C	0.543	0.88
124_G	397_L	0.540	0.88
119_L	122_L	0.538	0.87
212_G	216_I	0.538	0.87
63_T	107_L	0.537	0.87
130_P	134_L	0.536	0.87
244_A	262_C	0.536	0.87
207_G	251_L	0.535	0.87
327_L	330_D	0.535	0.87
325_A	359_G	0.532	0.87
265_E	295_R	0.531	0.87
368_W	384_I	0.530	0.87
321_A	337_C	0.530	0.87
212_G	243_E	0.529	0.87
348_A	397_L	0.528	0.86
27_I	32_N	0.527	0.86
90_N	112_V	0.527	0.86
147_L	311_A	0.527	0.86
27_I	30_A	0.526	0.86
59_V	66_D	0.526	0.86
219_V	255_L	0.525	0.86
76_V	123_L	0.525	0.86
288_N	338_H	0.525	0.86
45_N	126_A	0.525	0.86
352_H	392_P	0.523	0.86
21_D	35_F	0.522	0.86
326_Q	330_D	0.522	0.86
20_H	409_A	0.521	0.86
146_V	200_F	0.520	0.86
144_I	354_G	0.520	0.86
79_L	319_S	0.519	0.86
205_L	218_T	0.519	0.86
122_L	125_K	0.519	0.86
123_L	133_E	0.518	0.85
354_G	363_A	0.517	0.85
369_I	374_D	0.516	0.85
246_S	249_K	0.515	0.85
334_T	361_P	0.515	0.85
38_N	54_A	0.515	0.85
147_L	338_H	0.514	0.85
237_G	290_I	0.514	0.85
117_A	131_V	0.513	0.85
184_S	187_V	0.513	0.85
348_A	352_H	0.513	0.85
64_L	71_V	0.512	0.85
314_H	340_N	0.512	0.85
370_W	373_G	0.512	0.85
366_T	371_Q	0.512	0.85
294_W	323_R	0.511	0.85
37_R	343_F	0.510	0.85
185_E	221_A	0.510	0.85
135_L	356_A	0.509	0.84
288_N	337_C	0.507	0.84
50_G	118_A	0.507	0.84
152_Y	218_T	0.507	0.84
150_L	187_V	0.507	0.84
365_D	372_E	0.507	0.84
241_L	272_E	0.506	0.84
130_P	394_A	0.506	0.84
312_D	340_N	0.506	0.84
258_A	283_L	0.506	0.84
51_I	125_K	0.505	0.84
402_D	406_V	0.504	0.84
24_L	32_N	0.504	0.84
79_L	86_V	0.503	0.84
328_C	335_W	0.502	0.84
206_K	234_D	0.502	0.84
220_R	250_G	0.501	0.84
274_M	306_V	0.500	0.83
262_C	287_T	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mznA	2	0.9641	100	0.266	Contact Map
3pfrA	2	0.935	100	0.269	Contact Map
4hyrA	4	0.9596	100	0.272	Contact Map
3p0wA	2	0.9395	100	0.272	Contact Map
4it1A	3	0.9395	100	0.275	Contact Map
3vc5A	2	0.9193	100	0.275	Contact Map
3vdgA	2	0.9305	100	0.278	Contact Map
4g8tA	3	0.9641	100	0.281	Contact Map
3va8A	2	0.9283	100	0.288	Contact Map
3s5sA	2	0.7937	100	0.304	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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