GREMLIN Database
GUDX - Glucarate dehydratase-related protein
UniProt: Q46915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13168
Length: 446 (356)
Sequences: 6803 (4165)
Seq/√Len: 220.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_A388_K3.9261.00
278_R307_D3.6201.00
74_Q85_Q3.3501.00
48_H122_L3.3431.00
275_A279_R2.7581.00
13_K41_V2.7471.00
192_E225_R2.6811.00
41_V403_W2.6321.00
301_V333_L2.6291.00
240_L243_E2.5841.00
124_G131_V2.4921.00
44_D122_L2.4831.00
248_C258_A2.4471.00
43_T49_T2.4001.00
51_I401_L2.3701.00
248_C281_T2.3381.00
13_K43_T2.3251.00
294_W320_G2.3141.00
11_D43_T2.3031.00
245_I280_A2.2721.00
249_K252_N2.2551.00
270_G273_V2.2391.00
44_D48_H2.2311.00
276_E279_R2.2181.00
48_H126_A2.2131.00
116_E319_S2.2071.00
316_W324_V2.2051.00
252_N282_G2.2041.00
184_S188_V2.1361.00
145_T201_K2.1301.00
272_E303_L2.1111.00
41_V49_T2.0451.00
8_V45_N2.0231.00
379_Q400_E2.0021.00
298_G302_M1.9661.00
188_V225_R1.9651.00
12_M42_L1.9271.00
275_A303_L1.9221.00
195_Q229_A1.9091.00
125_K400_E1.9011.00
276_E280_A1.8961.00
220_R224_K1.8681.00
241_L277_F1.8671.00
262_C277_F1.8511.00
192_E196_D1.8341.00
302_M331_W1.8311.00
220_R254_V1.8051.00
139_K142_E1.7941.00
183_N186_A1.7921.00
247_L251_L1.7821.00
385_K390_A1.7811.00
78_R81_K1.7741.00
252_N283_L1.7361.00
15_I41_V1.7171.00
250_G253_D1.6751.00
216_I250_G1.6741.00
223_K227_P1.6741.00
297_M324_V1.6631.00
42_L119_L1.6491.00
143_A390_A1.6441.00
299_H303_L1.6431.00
129_V133_E1.6411.00
131_V397_L1.6211.00
379_Q402_D1.6071.00
74_Q81_K1.5961.00
226_F231_I1.5931.00
48_H125_K1.5871.00
10_T45_N1.5781.00
10_T43_T1.5601.00
186_A189_R1.5411.00
217_D220_R1.5291.00
301_V327_L1.5281.00
355_A391_V1.5271.00
300_A306_V1.5231.00
123_L127_L1.5071.00
15_I410_H1.5021.00
221_A224_K1.4961.00
241_L276_E1.4911.00
74_Q82_V1.4841.00
323_R329_D1.4791.00
326_Q329_D1.4741.00
62_Q65_V1.4711.00
82_V86_V1.4681.00
403_W407_Q1.4561.00
321_A353_V1.4541.00
80_N323_R1.4541.00
203_F229_A1.4511.00
18_A34_Y1.4481.00
77_A126_A1.4461.00
189_R192_E1.4271.00
220_R253_D1.4231.00
44_D126_A1.4211.00
211_P214_Q1.4161.00
380_N394_A1.3981.00
245_I277_F1.3931.00
206_K236_N1.3931.00
75_E78_R1.3901.00
40_V114_A1.3831.00
322_V326_Q1.3731.00
116_E120_L1.3561.00
39_I406_V1.3521.00
262_C273_V1.3461.00
124_G134_L1.3461.00
54_A114_A1.3451.00
191_A226_F1.3411.00
12_M68_I1.3411.00
77_A123_L1.3311.00
320_G323_R1.3281.00
46_A126_A1.3271.00
80_N322_V1.3231.00
297_M309_P1.3181.00
131_V318_L1.3161.00
299_H302_M1.3141.00
39_I345_I1.3101.00
195_Q203_F1.3041.00
252_N281_T1.3041.00
191_A203_F1.2941.00
233_V255_L1.2921.00
249_K280_A1.2861.00
217_D221_A1.2721.00
405_Q408_K1.2691.00
205_L222_L1.2641.00
230_R256_T1.2631.00
287_T300_A1.2561.00
26_N31_H1.2541.00
86_V112_V1.2521.00
82_V85_Q1.2461.00
11_D68_I1.2451.00
232_T256_T1.2441.00
74_Q78_R1.2391.00
286_A310_L1.2371.00
401_L406_V1.2281.00
312_D338_H1.2121.00
216_I254_V1.2111.00
249_K282_G1.2081.00
405_Q409_A1.2081.00
192_E195_Q1.2081.00
193_A198_Y1.1961.00
272_E299_H1.1951.00
145_T388_K1.1891.00
219_V233_V1.1871.00
185_E189_R1.1791.00
68_I72_L1.1711.00
12_M71_V1.1681.00
301_V331_W1.1671.00
130_P133_E1.1591.00
349_M397_L1.1551.00
45_N76_V1.1551.00
255_L283_L1.1541.00
77_A127_L1.1531.00
188_V226_F1.1501.00
120_L319_S1.1441.00
325_A357_A1.1411.00
402_D405_Q1.1291.00
306_V309_P1.1271.00
223_K231_I1.1261.00
42_L71_V1.1251.00
226_F229_A1.1221.00
129_V134_L1.1211.00
117_A349_M1.1201.00
81_K85_Q1.1191.00
329_D358_P1.1151.00
292_T296_E1.1141.00
214_Q217_D1.1141.00
260_D310_L1.0981.00
67_A115_L1.0971.00
246_S250_G1.0821.00
79_L123_L1.0811.00
351_T391_V1.0751.00
274_M287_T1.0671.00
311_A321_A1.0651.00
223_K228_D1.0651.00
191_A222_L1.0631.00
216_I220_R1.0621.00
277_F285_V1.0591.00
194_S198_Y1.0551.00
222_L226_F1.0551.00
293_N296_E1.0541.00
133_E393_D1.0531.00
188_V224_K1.0531.00
278_R304_N1.0521.00
239_W247_L1.0511.00
316_W321_A1.0501.00
322_V356_A1.0431.00
202_D232_T1.0401.00
235_P258_A1.0381.00
271_R300_A1.0371.00
143_A386_N1.0271.00
404_E407_Q1.0231.00
212_G247_L1.0231.00
41_V51_I1.0191.00
188_V192_E1.0181.00
301_V309_P1.0141.00
128_N395_P1.0111.00
139_K393_D1.0071.00
208_G215_E1.0031.00
219_V254_V1.0001.00
64_L68_I0.9931.00
39_I51_I0.9911.00
313_P321_A0.9891.00
189_R193_A0.9881.00
67_A86_V0.9851.00
82_V119_L0.9841.00
127_L134_L0.9811.00
286_A308_I0.9801.00
132_C391_V0.9741.00
216_I253_D0.9711.00
132_C139_K0.9641.00
184_S221_A0.9611.00
83_V319_S0.9601.00
298_G331_W0.9561.00
221_A225_R0.9521.00
207_G235_P0.9491.00
219_V251_L0.9461.00
262_C274_M0.9441.00
203_F226_F0.9391.00
213_E217_D0.9371.00
188_V221_A0.9341.00
348_A399_V0.9230.99
125_K394_A0.9190.99
276_E304_N0.9180.99
323_R326_Q0.9180.99
205_L219_V0.9150.99
407_Q410_H0.9120.99
70_M85_Q0.9090.99
184_S217_D0.9050.99
384_I389_I0.9020.99
64_L115_L0.9000.99
148_G200_F0.8960.99
291_A297_M0.8950.99
245_I276_E0.8930.99
64_L69_P0.8870.99
189_R225_R0.8860.99
123_L134_L0.8850.99
296_E299_H0.8820.99
213_E250_G0.8820.99
76_V119_L0.8800.99
239_W258_A0.8790.99
235_P239_W0.8790.99
355_A392_P0.8790.99
245_I281_T0.8770.99
71_V82_V0.8700.99
309_P328_C0.8630.99
193_A196_D0.8620.99
119_L123_L0.8620.99
245_I249_K0.8610.99
232_T257_Y0.8590.99
241_L273_V0.8580.99
135_L318_L0.8580.99
14_V64_L0.8550.99
241_L262_C0.8540.99
294_W327_L0.8530.99
281_T285_V0.8530.99
385_K388_K0.8500.99
298_G327_L0.8470.99
75_E133_E0.8450.99
327_L331_W0.8440.99
271_R305_A0.8440.99
394_A400_E0.8370.99
78_R133_E0.8360.99
288_N312_D0.8300.99
291_A296_E0.8260.99
43_T46_A0.8230.99
202_D230_R0.8220.99
318_L353_V0.8200.99
15_I407_Q0.8190.99
83_V116_E0.8160.99
121_D125_K0.8150.99
313_P350_F0.8120.99
143_A385_K0.8120.99
261_P285_V0.8090.99
191_A225_R0.8080.99
345_I399_V0.8070.99
132_C352_H0.8070.99
304_N333_L0.8050.99
58_D62_Q0.8040.99
313_P353_V0.8030.99
403_W406_V0.8030.99
124_G127_L0.8010.99
14_V61_Y0.8010.99
278_R285_V0.7910.98
76_V122_L0.7910.98
271_R299_H0.7860.98
18_A36_T0.7830.98
318_L322_V0.7830.98
103_W106_E0.7830.98
366_T369_I0.7810.98
71_V115_L0.7800.98
9_I42_L0.7800.98
329_D359_G0.7790.98
195_Q225_R0.7720.98
279_R304_N0.7700.98
59_V62_Q0.7700.98
242_D246_S0.7690.98
287_T306_V0.7690.98
188_V191_A0.7680.98
192_E226_F0.7630.98
122_L126_A0.7590.98
188_V222_L0.7570.98
201_K386_N0.7560.98
148_G194_S0.7550.98
195_Q226_F0.7540.98
291_A300_A0.7530.98
43_T51_I0.7520.98
124_G129_V0.7520.98
87_H320_G0.7500.98
272_E302_M0.7490.98
83_V87_H0.7490.98
58_D65_V0.7490.98
83_V86_V0.7480.98
132_C393_D0.7470.98
49_T400_E0.7470.98
133_E139_K0.7460.98
62_Q66_D0.7440.98
371_Q374_D0.7440.98
260_D288_N0.7390.98
310_L338_H0.7390.98
311_A335_W0.7370.97
190_L193_A0.7340.97
52_G114_A0.7340.97
380_N400_E0.7310.97
375_C408_K0.7310.97
146_V389_I0.7310.97
275_A305_A0.7310.97
54_A110_N0.7310.97
153_I186_A0.7300.97
10_T44_D0.7280.97
191_A221_A0.7270.97
56_G59_V0.7250.97
390_A393_D0.7230.97
369_I372_E0.7230.97
201_K228_D0.7230.97
383_E390_A0.7230.97
130_P352_H0.7210.97
348_A351_T0.7170.97
241_L245_I0.7170.97
16_P36_T0.7160.97
8_V75_E0.7120.97
351_T389_I0.7090.97
16_P61_Y0.7060.97
66_D69_P0.7060.97
150_L194_S0.7060.97
49_T125_K0.7040.97
365_D368_W0.7030.97
124_G395_P0.7020.97
195_Q227_P0.7000.97
243_E246_S0.6990.97
322_V357_A0.6990.97
271_R303_L0.6980.97
215_E239_W0.6970.96
65_V68_I0.6940.96
145_T230_R0.6940.96
57_G60_I0.6890.96
123_L126_A0.6880.96
233_V251_L0.6870.96
67_A90_N0.6820.96
142_E393_D0.6780.96
61_Y65_V0.6780.96
45_N48_H0.6780.96
274_M285_V0.6760.96
51_I345_I0.6760.96
127_L130_P0.6700.96
382_L389_I0.6700.96
82_V115_L0.6660.95
187_V218_T0.6650.95
318_L349_M0.6590.95
213_E246_S0.6580.95
68_I115_L0.6540.95
207_G233_V0.6540.95
51_I403_W0.6500.95
120_L131_V0.6500.95
364_I367_H0.6480.95
368_W375_C0.6470.95
255_L258_A0.6460.95
86_V115_L0.6430.95
76_V126_A0.6420.94
58_D61_Y0.6390.94
10_T46_A0.6370.94
46_A76_V0.6340.94
87_H112_V0.6330.94
248_C283_L0.6320.94
56_G60_I0.6300.94
131_V322_V0.6280.94
274_M277_F0.6270.94
55_P314_H0.6220.94
404_E408_K0.6200.93
195_Q228_D0.6190.93
256_T284_P0.6180.93
63_T111_A0.6170.93
149_Y206_K0.6170.93
223_K254_V0.6130.93
222_L225_R0.6120.93
125_K397_L0.6110.93
354_G360_N0.6110.93
367_H371_Q0.6110.93
309_P333_L0.6110.93
117_A314_H0.6080.93
257_Y336_G0.6080.93
237_G264_A0.6070.93
275_A304_N0.6070.93
38_N61_Y0.6020.92
76_V79_L0.6020.92
260_D289_M0.5980.92
260_D290_I0.5960.92
40_V115_L0.5950.92
297_M328_C0.5930.92
213_E220_R0.5930.92
214_Q218_T0.5920.92
57_G61_Y0.5890.92
317_T320_G0.5890.92
84_Q140_Q0.5880.91
380_N383_E0.5870.91
216_I251_L0.5870.91
244_A258_A0.5870.91
71_V119_L0.5860.91
288_N310_L0.5850.91
201_K388_K0.5850.91
339_S347_L0.5840.91
131_V135_L0.5830.91
65_V69_P0.5830.91
277_F280_A0.5820.91
15_I51_I0.5800.91
139_K391_V0.5800.91
270_G332_G0.5790.91
190_L194_S0.5790.91
117_A345_I0.5770.91
79_L82_V0.5770.91
153_I190_L0.5770.91
297_M311_A0.5770.91
295_R299_H0.5760.91
150_L153_I0.5720.90
310_L336_G0.5720.90
328_C333_L0.5720.90
185_E188_V0.5710.90
12_M115_L0.5700.90
301_V328_C0.5690.90
345_I401_L0.5690.90
207_G239_W0.5690.90
278_R305_A0.5680.90
240_L334_T0.5680.90
223_K229_A0.5680.90
120_L124_G0.5680.90
310_L337_C0.5670.90
23_M190_L0.5670.90
216_I219_V0.5660.90
79_L119_L0.5650.90
344_D378_T0.5650.90
70_M89_G0.5640.90
11_D45_N0.5630.90
201_K387_G0.5600.89
291_A309_P0.5600.89
368_W371_Q0.5570.89
78_R82_V0.5540.89
272_E275_A0.5540.89
365_D370_W0.5520.89
84_Q88_K0.5510.89
117_A397_L0.5500.89
378_T381_P0.5500.89
110_N315_F0.5490.88
19_G343_F0.5490.88
294_W298_G0.5470.88
351_T392_P0.5470.88
24_L31_H0.5450.88
120_L318_L0.5440.88
244_A248_C0.5430.88
124_G397_L0.5400.88
119_L122_L0.5380.87
212_G216_I0.5380.87
63_T107_L0.5370.87
130_P134_L0.5360.87
244_A262_C0.5360.87
207_G251_L0.5350.87
327_L330_D0.5350.87
325_A359_G0.5320.87
265_E295_R0.5310.87
368_W384_I0.5300.87
321_A337_C0.5300.87
212_G243_E0.5290.87
348_A397_L0.5280.86
27_I32_N0.5270.86
90_N112_V0.5270.86
147_L311_A0.5270.86
27_I30_A0.5260.86
59_V66_D0.5260.86
219_V255_L0.5250.86
76_V123_L0.5250.86
288_N338_H0.5250.86
45_N126_A0.5250.86
352_H392_P0.5230.86
21_D35_F0.5220.86
326_Q330_D0.5220.86
20_H409_A0.5210.86
146_V200_F0.5200.86
144_I354_G0.5200.86
79_L319_S0.5190.86
205_L218_T0.5190.86
122_L125_K0.5190.86
123_L133_E0.5180.85
354_G363_A0.5170.85
369_I374_D0.5160.85
246_S249_K0.5150.85
334_T361_P0.5150.85
38_N54_A0.5150.85
147_L338_H0.5140.85
237_G290_I0.5140.85
117_A131_V0.5130.85
184_S187_V0.5130.85
348_A352_H0.5130.85
64_L71_V0.5120.85
314_H340_N0.5120.85
370_W373_G0.5120.85
366_T371_Q0.5120.85
294_W323_R0.5110.85
37_R343_F0.5100.85
185_E221_A0.5100.85
135_L356_A0.5090.84
288_N337_C0.5070.84
50_G118_A0.5070.84
152_Y218_T0.5070.84
150_L187_V0.5070.84
365_D372_E0.5070.84
241_L272_E0.5060.84
130_P394_A0.5060.84
312_D340_N0.5060.84
258_A283_L0.5060.84
51_I125_K0.5050.84
402_D406_V0.5040.84
24_L32_N0.5040.84
79_L86_V0.5030.84
328_C335_W0.5020.84
206_K234_D0.5020.84
220_R250_G0.5010.84
274_M306_V0.5000.83
262_C287_T0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mznA 2 0.9641 100 0.266 Contact Map
3pfrA 2 0.935 100 0.269 Contact Map
4hyrA 4 0.9596 100 0.272 Contact Map
3p0wA 2 0.9395 100 0.272 Contact Map
4it1A 3 0.9395 100 0.275 Contact Map
3vc5A 2 0.9193 100 0.275 Contact Map
3vdgA 2 0.9305 100 0.278 Contact Map
4g8tA 3 0.9641 100 0.281 Contact Map
3va8A 2 0.9283 100 0.288 Contact Map
3s5sA 2 0.7937 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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