GREMLIN Database
YGCU - Uncharacterized FAD-linked oxidoreductase YgcU
UniProt: Q46911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13128
Length: 484 (425)
Sequences: 18236 (13633)
Seq/√Len: 661.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_E218_E3.9641.00
60_T179_E3.9601.00
71_N471_N3.7361.00
156_V219_V3.4601.00
107_Q121_Q3.3651.00
176_V222_K3.1751.00
74_K471_N3.0691.00
112_D115_N2.9741.00
106_N128_V2.9701.00
240_D243_T2.9211.00
179_E189_R2.9171.00
132_A135_E2.9001.00
119_T220_T2.8561.00
119_T218_E2.8411.00
58_G104_A2.8201.00
55_V66_V2.7301.00
138_Y223_I2.7211.00
180_A206_I2.6341.00
358_C361_E2.5721.00
63_V217_T2.5711.00
121_Q218_E2.4491.00
64_S187_V2.4361.00
182_L186_T2.4271.00
177_G189_R2.3391.00
124_V129_L2.3391.00
67_L77_G2.2811.00
183_A474_M2.2411.00
177_G220_T2.2261.00
127_E131_N2.1741.00
113_I136_K2.1671.00
365_S431_R2.0951.00
108_I124_V2.0351.00
182_L188_T2.0211.00
61_E64_S2.0141.00
69_F73_H2.0121.00
299_E303_E1.9851.00
60_T187_V1.9701.00
125_P128_V1.9621.00
242_K364_E1.9551.00
195_R198_A1.9471.00
179_E187_V1.9321.00
118_A129_L1.9301.00
60_T64_S1.9191.00
60_T217_T1.9141.00
61_E65_R1.8971.00
56_K104_A1.8951.00
180_A214_C1.8681.00
178_L206_I1.8651.00
100_L215_Y1.8531.00
105_M121_Q1.8511.00
24_D27_V1.8491.00
63_V215_Y1.8451.00
110_N119_T1.8421.00
133_L223_I1.8331.00
58_G62_Q1.8191.00
80_R83_A1.8161.00
117_Q220_T1.8091.00
64_S68_N1.8011.00
368_N372_T1.7841.00
117_Q176_V1.7781.00
116_M138_Y1.7681.00
428_E431_R1.7641.00
365_S368_N1.7411.00
67_L474_M1.7331.00
102_G215_Y1.7321.00
157_A209_N1.7231.00
59_S62_Q1.7051.00
65_R68_N1.6951.00
463_G467_Q1.6891.00
79_P215_Y1.6861.00
128_V131_N1.6741.00
111_I132_A1.6631.00
120_A152_M1.6591.00
205_I464_L1.6361.00
118_A221_V1.6331.00
156_V175_V1.6321.00
70_M98_V1.6001.00
116_M225_K1.5971.00
179_E217_T1.5961.00
68_N71_N1.5771.00
427_E431_R1.5761.00
459_A462_E1.5751.00
291_P295_K1.5711.00
459_A463_G1.5451.00
451_K456_S1.5451.00
22_I27_V1.5321.00
102_G105_M1.5261.00
365_S428_E1.5261.00
466_K472_G1.5251.00
372_T424_I1.5201.00
132_A136_K1.5201.00
157_A216_I1.5081.00
181_V217_T1.5041.00
243_T246_N1.5001.00
367_I371_R1.4921.00
63_V181_V1.4921.00
427_E452_L1.4791.00
242_K246_N1.4731.00
250_E254_E1.4701.00
22_I56_K1.4641.00
112_D117_Q1.4631.00
206_I214_C1.4591.00
174_M224_F1.4551.00
460_L463_G1.4541.00
108_I132_A1.4521.00
444_K478_T1.4461.00
67_L71_N1.4431.00
155_L171_I1.4431.00
156_V221_V1.4391.00
177_G195_R1.4361.00
361_E365_S1.4311.00
141_G174_M1.4281.00
120_A221_V1.4281.00
69_F75_I1.4241.00
420_P424_I1.4101.00
175_V178_L1.3981.00
94_V97_S1.3941.00
183_A468_F1.3841.00
55_V98_V1.3841.00
462_E466_K1.3741.00
63_V100_L1.3671.00
190_I199_G1.3651.00
121_Q124_V1.3611.00
195_R199_G1.3521.00
190_I203_R1.3451.00
290_N293_I1.3311.00
415_D420_P1.3291.00
187_V217_T1.3271.00
67_L215_Y1.3191.00
364_E368_N1.3171.00
246_N250_E1.3161.00
295_K299_E1.3131.00
423_K427_E1.3121.00
107_Q124_V1.3031.00
195_R200_P1.2971.00
67_L181_V1.2941.00
413_E416_K1.2921.00
150_A155_L1.2831.00
465_K472_G1.2791.00
411_E415_D1.2781.00
57_L66_V1.2721.00
131_N135_E1.2721.00
262_R265_D1.2671.00
410_P413_E1.2651.00
320_E323_F1.2611.00
365_S432_L1.2561.00
355_C358_C1.2531.00
457_A460_L1.2451.00
68_N72_A1.2301.00
120_A129_L1.2211.00
70_M77_G1.2191.00
56_K101_D1.2161.00
169_G173_D1.2161.00
66_V98_V1.2101.00
57_L62_Q1.2091.00
62_Q65_R1.2071.00
322_W326_L1.2021.00
321_T325_N1.1891.00
25_E28_L1.1841.00
64_S181_V1.1811.00
111_I118_A1.1781.00
458_W462_E1.1781.00
118_A223_I1.1751.00
302_A306_A1.1731.00
181_V187_V1.1721.00
385_G388_S1.1701.00
299_E302_A1.1601.00
239_E243_T1.1521.00
24_D29_K1.1511.00
293_I296_V1.1481.00
106_N121_Q1.1411.00
188_T199_G1.1351.00
118_A133_L1.1301.00
412_E415_D1.1291.00
463_G466_K1.1241.00
369_R372_T1.1101.00
175_V207_I1.1091.00
130_E142_H1.1081.00
369_R428_E1.1051.00
71_N473_I1.1011.00
368_N371_R1.0991.00
156_V171_I1.0961.00
260_I267_E1.0891.00
111_I138_Y1.0851.00
206_I216_I1.0841.00
66_V100_L1.0841.00
332_K335_A1.0811.00
204_H460_L1.0801.00
321_T324_N1.0791.00
369_R424_I1.0761.00
53_A98_V1.0691.00
21_V55_V1.0681.00
440_H443_G1.0651.00
365_S369_R1.0651.00
182_L468_F1.0631.00
180_A188_T1.0571.00
439_H442_I1.0561.00
80_R99_V1.0521.00
77_G100_L1.0521.00
74_K473_I1.0471.00
438_H441_G1.0401.00
416_K420_P1.0401.00
128_V132_A1.0341.00
264_Y267_E1.0271.00
338_V341_L1.0211.00
250_E308_Y1.0151.00
362_I366_V1.0131.00
153_G219_V1.0111.00
81_T151_Q1.0051.00
201_D204_H1.0011.00
437_V442_I1.0001.00
141_G224_F0.9951.00
383_L386_H0.9891.00
68_N186_T0.9891.00
437_V440_H0.9871.00
76_N97_S0.9861.00
306_A309_P0.9851.00
178_L203_R0.9841.00
23_T53_A0.9831.00
411_E414_I0.9801.00
60_T121_Q0.9771.00
247_I250_E0.9751.00
300_G303_E0.9731.00
56_K103_S0.9711.00
250_E253_V0.9711.00
388_S391_Y0.9661.00
52_A96_N0.9661.00
209_N213_L0.9661.00
266_A270_T0.9641.00
418_H423_K0.9621.00
77_G473_I0.9601.00
102_G122_C0.9581.00
262_R267_E0.9581.00
296_V299_E0.9581.00
326_L329_G0.9541.00
138_Y225_K0.9531.00
439_H443_G0.9521.00
22_I28_L0.9491.00
255_G258_P0.9481.00
362_I432_L0.9431.00
184_D188_T0.9431.00
360_H364_E0.9421.00
450_S454_H0.9421.00
456_S459_A0.9381.00
258_P267_E0.9321.00
152_M221_V0.9321.00
60_T181_V0.9311.00
420_P423_K0.9291.00
298_G302_A0.9291.00
262_R266_A0.9231.00
428_E432_L0.9231.00
189_R220_T0.9201.00
258_P265_D0.9121.00
112_D119_T0.9091.00
205_I213_L0.9081.00
85_A89_G0.9081.00
441_G444_K0.9071.00
440_H444_K0.9041.00
174_M222_K0.9021.00
259_S262_R0.9021.00
126_L142_H0.9011.00
178_L219_V0.8981.00
190_I206_I0.8961.00
386_H390_S0.8961.00
323_F326_L0.8951.00
63_V105_M0.8921.00
361_E364_E0.8861.00
196_R200_P0.8831.00
28_L32_S0.8831.00
380_I385_G0.8821.00
63_V102_G0.8771.00
80_R101_D0.8771.00
75_I98_V0.8761.00
303_E306_A0.8741.00
265_D268_D0.8741.00
349_T352_V0.8741.00
325_N329_G0.8721.00
258_P262_R0.8641.00
381_T384_G0.8631.00
286_M289_G0.8621.00
386_H389_H0.8621.00
29_K33_I0.8611.00
427_E430_I0.8601.00
65_R69_F0.8561.00
124_V128_V0.8531.00
258_P261_A0.8521.00
106_N124_V0.8521.00
424_I427_E0.8481.00
234_Y238_L0.8481.00
152_M219_V0.8471.00
189_R218_E0.8471.00
200_P212_A0.8461.00
118_A132_A0.8461.00
81_T102_G0.8441.00
327_N331_D0.8441.00
127_E148_P0.8421.00
260_I265_D0.8381.00
341_L347_G0.8381.00
353_S435_S0.8351.00
398_Y403_Y0.8341.00
364_E367_I0.8341.00
197_A200_P0.8321.00
81_T122_C0.8291.00
57_L104_A0.8241.00
175_V219_V0.8231.00
298_G305_V0.8231.00
127_E149_L0.8231.00
414_I417_Y0.8191.00
126_L155_L0.8181.00
52_A97_S0.8171.00
249_R253_V0.8141.00
178_L216_I0.8121.00
362_I370_I0.8121.00
386_H391_Y0.8121.00
319_I323_F0.8121.00
122_C219_V0.8111.00
103_S151_Q0.8101.00
26_T29_K0.8101.00
242_K360_H0.8091.00
346_M349_T0.8091.00
258_P264_Y0.8081.00
387_S390_S0.8061.00
82_G151_Q0.8051.00
216_I219_V0.8051.00
76_N475_N0.8041.00
361_E432_L0.8041.00
25_E29_K0.8041.00
326_L331_D0.8041.00
328_W331_D0.8021.00
266_A280_K0.8001.00
380_I384_G0.8001.00
245_F249_R0.7991.00
285_F288_E0.7951.00
57_L102_G0.7931.00
60_T105_M0.7931.00
385_G390_S0.7931.00
350_T353_S0.7881.00
248_L252_M0.7881.00
358_C432_L0.7881.00
246_N249_R0.7871.00
347_G351_E0.7851.00
318_L323_F0.7841.00
320_E324_N0.7821.00
270_T274_T0.7781.00
382_M388_S0.7771.00
117_Q222_K0.7751.00
339_Q345_N0.7721.00
436_M440_H0.7711.00
382_M386_H0.7711.00
302_A305_V0.7701.00
129_L152_M0.7671.00
382_M385_G0.7641.00
260_I264_Y0.7621.00
126_L129_L0.7601.00
293_I297_T0.7601.00
384_G388_S0.7571.00
438_H443_G0.7531.00
436_M439_H0.7521.00
297_T300_G0.7521.00
399_F402_D0.7511.00
319_I322_W0.7501.00
398_Y401_Y0.7501.00
60_T63_V0.7491.00
258_P263_L0.7461.00
380_I424_I0.7441.00
170_A173_D0.7431.00
156_V216_I0.7411.00
153_G157_A0.7411.00
24_D28_L0.7401.00
464_L468_F0.7391.00
263_L267_E0.7381.00
176_V220_T0.7371.00
437_V443_G0.7371.00
347_G350_T0.7371.00
183_A473_I0.7351.00
21_V53_A0.7341.00
430_I452_L0.7341.00
448_H451_K0.7331.00
30_K33_I0.7311.00
383_L388_S0.7301.00
31_N36_F0.7261.00
79_P102_G0.7261.00
257_R261_A0.7261.00
234_Y237_I0.7261.00
61_E187_V0.7241.00
71_N184_D0.7211.00
257_R260_I0.7181.00
126_L150_A0.7181.00
340_I345_N0.7161.00
437_V441_G0.7151.00
261_A264_Y0.7091.00
260_I266_A0.7071.00
259_S288_E0.7071.00
54_V99_V0.7071.00
131_N134_R0.7041.00
51_P99_V0.7031.00
318_L321_T0.7031.00
301_I305_V0.7011.00
62_Q66_V0.6991.00
339_Q342_K0.6981.00
199_G468_F0.6971.00
380_I383_L0.6971.00
201_D467_Q0.6971.00
260_I263_L0.6971.00
397_M402_D0.6961.00
412_E416_K0.6951.00
67_L183_A0.6951.00
459_A466_K0.6931.00
395_T398_Y0.6911.00
326_L330_P0.6881.00
259_S265_D0.6871.00
140_T223_I0.6851.00
103_S125_P0.6851.00
29_K50_I0.6841.00
105_M217_T0.6821.00
396_N400_V0.6801.00
159_R170_A0.6761.00
177_G218_E0.6751.00
450_S458_W0.6741.00
465_K475_N0.6731.00
472_G475_N0.6701.00
317_K320_E0.6701.00
307_R310_Q0.6701.00
196_R199_G0.6681.00
250_E307_R0.6681.00
180_A190_I0.6661.00
178_L190_I0.6651.00
201_D464_L0.6641.00
397_M403_Y0.6611.00
396_N399_F0.6601.00
442_I450_S0.6591.00
292_R296_V0.6591.00
414_I418_H0.6591.00
408_C411_E0.6581.00
434_G438_H0.6561.00
57_L63_V0.6541.00
380_I388_S0.6531.00
323_F328_W0.6531.00
267_E270_T0.6521.00
407_D410_P0.6521.00
259_S263_L0.6521.00
346_M350_T0.6511.00
25_E50_I0.6491.00
263_L266_A0.6481.00
189_R198_A0.6441.00
147_K150_A0.6431.00
242_K361_E0.6411.00
262_R268_D0.6381.00
294_A298_G0.6381.00
126_L152_M0.6371.00
340_I343_T0.6371.00
213_L464_L0.6371.00
415_D418_H0.6361.00
26_T30_K0.6361.00
348_F351_E0.6361.00
337_R340_I0.6351.00
285_F289_G0.6341.00
257_R262_R0.6341.00
343_T346_M0.6331.00
392_Q395_T0.6321.00
317_K321_T0.6321.00
28_L31_N0.6321.00
338_V345_N0.6311.00
345_N348_F0.6301.00
78_V97_S0.6281.00
396_N403_Y0.6271.00
328_W332_K0.6261.00
85_A90_L0.6261.00
179_E220_T0.6261.00
264_Y268_D0.6251.00
254_E300_G0.6221.00
22_I31_N0.6221.00
351_E355_C0.6211.00
133_L136_K0.6201.00
249_R252_M0.6191.00
438_H444_K0.6191.00
188_T460_L0.6181.00
387_S392_Q0.6171.00
306_A310_Q0.6171.00
108_I121_Q0.6151.00
28_L50_I0.6151.00
323_F327_N0.6141.00
397_M401_Y0.6131.00
384_G387_S0.6121.00
76_N476_T0.6101.00
57_L105_M0.6081.00
64_S67_L0.6081.00
296_V300_G0.6071.00
398_Y402_D0.6071.00
203_R207_I0.6061.00
295_K302_A0.6061.00
400_V403_Y0.6061.00
130_E139_T0.6051.00
27_V30_K0.6021.00
345_N349_T0.6011.00
387_S391_Y0.6011.00
69_F98_V0.6001.00
111_I136_K0.5991.00
111_I223_I0.5981.00
436_M441_G0.5971.00
413_E417_Y0.5971.00
167_L259_S0.5971.00
238_L247_I0.5971.00
426_C430_I0.5971.00
434_G437_V0.5971.00
367_I370_I0.5961.00
204_H207_I0.5951.00
324_N328_W0.5951.00
424_I428_E0.5931.00
232_L295_K0.5921.00
244_G248_L0.5921.00
162_G165_S0.5911.00
33_I48_L0.5911.00
115_N357_S0.5911.00
385_G389_H0.5901.00
140_T221_V0.5901.00
362_I367_I0.5881.00
355_C359_I0.5881.00
108_I120_A0.5871.00
256_Y259_S0.5871.00
319_I324_N0.5871.00
127_E147_K0.5811.00
279_G282_V0.5791.00
240_D244_G0.5771.00
31_N56_K0.5771.00
165_S170_A0.5761.00
195_R203_R0.5761.00
451_K458_W0.5751.00
322_W325_N0.5741.00
29_K32_S0.5731.00
277_A280_K0.5721.00
283_L288_E0.5721.00
344_G350_T0.5691.00
188_T457_A0.5691.00
190_I195_R0.5681.00
254_E304_I0.5681.00
439_H444_K0.5681.00
228_P231_N0.5661.00
120_A124_V0.5661.00
450_S453_E0.5661.00
458_W461_L0.5641.00
342_K346_M0.5641.00
396_N402_D0.5641.00
263_L268_D0.5631.00
247_I305_V0.5621.00
60_T218_E0.5611.00
112_D116_M0.5611.00
281_C285_F0.5611.00
447_V450_S0.5601.00
113_I116_M0.5581.00
305_V310_Q0.5581.00
178_L207_I0.5581.00
347_G352_V0.5571.00
27_V31_N0.5541.00
64_S182_L0.5541.00
363_Y367_I0.5541.00
120_A219_V0.5541.00
116_M222_K0.5521.00
82_G125_P0.5521.00
359_I363_Y0.5521.00
107_Q110_N0.5521.00
388_S392_Q0.5511.00
234_Y285_F0.5511.00
57_L100_L0.5501.00
251_I301_I0.5491.00
395_T403_Y0.5481.00
87_E90_L0.5481.00
342_K345_N0.5471.00
438_H442_I0.5461.00
337_R341_L0.5451.00
110_N113_I0.5441.00
349_T400_V0.5441.00
389_H392_Q0.5441.00
366_V370_I0.5441.00
344_G351_E0.5431.00
202_I468_F0.5411.00
304_I308_Y0.5411.00
316_S327_N0.5401.00
395_T399_F0.5401.00
327_N330_P0.5401.00
303_E307_R0.5391.00
309_P312_Q0.5391.00
125_P151_Q0.5391.00
339_Q347_G0.5391.00
167_L288_E0.5391.00
385_G391_Y0.5381.00
365_S370_I0.5371.00
130_E133_L0.5371.00
145_Q155_L0.5371.00
294_A302_A0.5371.00
363_Y370_I0.5361.00
129_L140_T0.5361.00
325_N328_W0.5361.00
251_I254_E0.5361.00
364_E371_R0.5351.00
246_N360_H0.5341.00
342_K347_G0.5331.00
287_A294_A0.5321.00
283_L286_M0.5311.00
417_Y422_N0.5301.00
241_M245_F0.5301.00
281_C284_I0.5301.00
51_P54_V0.5290.99
460_L467_Q0.5290.99
465_K469_D0.5290.99
318_L322_W0.5270.99
421_L424_I0.5270.99
338_V342_K0.5240.99
199_G467_Q0.5240.99
292_R295_K0.5200.99
183_A471_N0.5200.99
186_T457_A0.5200.99
287_A301_I0.5200.99
230_N291_P0.5190.99
472_G479_I0.5180.99
340_I347_G0.5170.99
317_K323_F0.5160.99
346_M351_E0.5150.99
366_V369_R0.5150.99
126_L145_Q0.5150.99
399_F403_Y0.5130.99
440_H446_R0.5110.99
449_W452_L0.5110.99
76_N473_I0.5110.99
45_I48_L0.5100.99
110_N117_Q0.5090.99
340_I344_G0.5080.99
53_A75_I0.5060.99
81_T153_G0.5050.99
372_T380_I0.5040.99
257_R267_E0.5030.99
141_G221_V0.5020.99
228_P232_L0.5020.99
212_A465_K0.5020.99
351_E356_W0.5020.99
130_E134_R0.5020.99
380_I386_H0.5010.99
300_G304_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uuuA 2 0.9174 100 0.281 Contact Map
3pm9A 5 0.936 100 0.282 Contact Map
4bbyA 2 0.9669 100 0.328 Contact Map
1f0xA 1 0.8884 100 0.331 Contact Map
1wvfA 2 0.9421 100 0.34 Contact Map
1w1oA 1 0.876 100 0.344 Contact Map
4o95A 1 0.8698 100 0.346 Contact Map
2exrA 1 0.8678 100 0.35 Contact Map
4xloA 2 0.9153 100 0.362 Contact Map
4mlaA 1 0.9029 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0133 seconds.