YGCN - ECOLI - GREMLIN Contacts

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YGCN - Probable electron transfer flavoprotein-quinone oxidoreductase YgcN

UniProt:	Q46904	Sequences: MEDDCDIIIIGAGIAGTACALRCARAGLSVLLLERAEIPGSKNLSGGRLYTHALAELLPQFHLTAPLERRITHESLSLLTPDGVTTFSSLQPGGESWSVLRARFDPWLVAEAEKEGVECIPGATVDALYEENGRVCGVICGDDILRARYVVLAEGANSVLAERHGLVTRPAGEAMALGIKEVLSLETSAIEERFHLENNEGAALLFSGRICDDLPGGAFLYTNQQTLSLGIVCPLSSLTQSRVPASELLTRFKAHPAVRPLIKNTESLEYGAHLVPEGGLHSMPVQYAGNGWLLVGDALRSCVNTGISVRGMDMALTGAQAAAQTLISACQHREPQNLFPLYHHNVERSLLWDVLQRYQHVPALLQRPGWYRTWPALMQDISRDLWDQGDKPVPPLRQLFWHHLRRHGLWHLAGDVIRSLRCL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13121
Length:	423 (347)
Sequences:	27374 (20901)
Seq/√Len:	1122.0

ECOLI - YGCN YDIS FIXC MHPA UBIF UBII UBIH CBRA
BACSU - YHJG YETM
HALSA - Q9HS01 Q9HS24 Q9HQE5 Q9HMA0
SULSO - Q97V59 Q97V18 Q97ZK8 Q97W83 Q97W89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_L	120_I	4.319	1.00
35_R	124_T	3.576	1.00
8_I	147_A	3.574	1.00
15_A	315_A	3.420	1.00
6_D	29_S	3.214	1.00
343_H	347_E	3.185	1.00
6_D	148_R	3.157	1.00
127_A	139_I	2.885	1.00
124_T	141_G	2.806	1.00
5_C	31_L	2.789	1.00
123_A	142_D	2.772	1.00
139_I	144_I	2.764	1.00
111_E	114_K	2.699	1.00
33_L	145_L	2.642	1.00
19_C	151_V	2.611	1.00
126_D	141_G	2.596	1.00
129_Y	137_G	2.543	1.00
26_A	327_I	2.526	1.00
137_G	144_I	2.498	1.00
22_R	323_A	2.495	1.00
137_G	146_R	2.460	1.00
127_A	163_R	2.456	1.00
8_I	138_V	2.383	1.00
106_P	110_A	2.325	1.00
65_A	110_A	2.278	1.00
8_I	33_L	2.246	1.00
15_A	295_V	2.197	1.00
123_A	140_C	2.110	1.00
129_Y	139_I	2.096	1.00
18_A	316_L	2.082	1.00
140_C	145_L	2.041	1.00
152_L	160_L	2.032	1.00
120_I	123_A	1.996	1.00
325_T	345_N	1.979	1.00
65_A	111_E	1.953	1.00
33_L	140_C	1.950	1.00
58_L	63_L	1.937	1.00
37_E	122_G	1.925	1.00
7_I	23_C	1.920	1.00
134_R	146_R	1.901	1.00
21_L	111_E	1.879	1.00
111_E	115_E	1.879	1.00
325_T	341_L	1.854	1.00
244_P	247_E	1.828	1.00
7_I	28_L	1.809	1.00
273_H	276_P	1.792	1.00
125_V	138_V	1.782	1.00
288_A	340_P	1.764	1.00
131_E	137_G	1.751	1.00
319_A	323_A	1.728	1.00
29_S	118_E	1.725	1.00
347_E	352_W	1.717	1.00
56_E	320_Q	1.716	1.00
153_A	295_V	1.704	1.00
6_D	31_L	1.695	1.00
152_L	294_L	1.683	1.00
28_L	327_I	1.673	1.00
53_A	313_D	1.649	1.00
109_V	121_P	1.647	1.00
24_A	117_V	1.633	1.00
273_H	277_E	1.589	1.00
321_A	345_N	1.585	1.00
59_P	320_Q	1.579	1.00
130_E	289_G	1.557	1.00
140_C	143_D	1.556	1.00
288_A	293_L	1.553	1.00
275_V	278_G	1.551	1.00
112_A	117_V	1.546	1.00
128_L	150_V	1.543	1.00
247_E	250_T	1.524	1.00
321_A	325_T	1.523	1.00
21_L	25_R	1.521	1.00
19_C	319_A	1.520	1.00
20_A	32_L	1.506	1.00
184_S	266_E	1.502	1.00
65_A	68_E	1.496	1.00
31_L	145_L	1.495	1.00
25_R	115_E	1.489	1.00
154_E	158_S	1.481	1.00
65_A	114_K	1.477	1.00
131_E	146_R	1.476	1.00
8_I	145_L	1.460	1.00
109_V	113_E	1.455	1.00
131_E	134_R	1.432	1.00
149_Y	339_F	1.432	1.00
293_L	322_A	1.431	1.00
159_V	163_R	1.420	1.00
24_A	115_E	1.408	1.00
151_V	295_V	1.407	1.00
164_H	292_W	1.403	1.00
64_T	68_E	1.395	1.00
250_T	253_K	1.391	1.00
246_S	250_T	1.380	1.00
247_E	251_R	1.380	1.00
10_I	125_V	1.378	1.00
53_A	316_L	1.365	1.00
22_R	60_Q	1.360	1.00
14_I	312_M	1.353	1.00
272_A	276_P	1.353	1.00
245_A	249_L	1.344	1.00
324_Q	345_N	1.334	1.00
5_C	8_I	1.324	1.00
318_G	346_V	1.310	1.00
129_Y	144_I	1.298	1.00
260_P	263_K	1.298	1.00
69_R	103_R	1.297	1.00
39_P	121_P	1.288	1.00
274_L	277_E	1.287	1.00
325_T	328_S	1.276	1.00
317_T	349_S	1.264	1.00
120_I	145_L	1.254	1.00
21_L	112_A	1.247	1.00
151_V	293_L	1.246	1.00
256_P	259_R	1.243	1.00
139_I	143_D	1.239	1.00
272_A	277_E	1.239	1.00
125_V	128_L	1.232	1.00
10_I	154_E	1.230	1.00
126_D	139_I	1.226	1.00
184_S	226_T	1.216	1.00
205_L	208_G	1.215	1.00
159_V	162_E	1.212	1.00
325_T	338_L	1.212	1.00
31_L	118_E	1.205	1.00
74_E	78_L	1.201	1.00
100_L	103_R	1.198	1.00
125_V	160_L	1.193	1.00
352_W	356_Q	1.187	1.00
134_R	137_G	1.186	1.00
208_G	213_D	1.176	1.00
288_A	343_H	1.174	1.00
138_V	147_A	1.172	1.00
63_L	67_L	1.168	1.00
65_A	107_W	1.168	1.00
21_L	115_E	1.164	1.00
103_R	106_P	1.163	1.00
9_I	19_C	1.147	1.00
110_A	113_E	1.142	1.00
18_A	60_Q	1.140	1.00
301_S	318_G	1.134	1.00
19_C	23_C	1.130	1.00
32_L	119_C	1.129	1.00
274_L	278_G	1.123	1.00
287_Y	343_H	1.116	1.00
204_L	207_S	1.110	1.00
156_A	302_C	1.108	1.00
8_I	31_L	1.107	1.00
12_A	17_T	1.103	1.00
246_S	249_L	1.101	1.00
10_I	160_L	1.086	1.00
19_C	295_V	1.077	1.00
340_P	344_H	1.067	1.00
249_L	252_F	1.061	1.00
126_D	143_D	1.052	1.00
20_A	30_V	1.041	1.00
135_V	291_G	1.038	1.00
259_R	263_K	1.037	1.00
44_L	47_G	1.035	1.00
9_I	20_A	1.034	1.00
147_A	150_V	1.032	1.00
273_H	278_G	1.031	1.00
303_V	314_M	1.027	1.00
85_T	89_S	1.026	1.00
272_A	275_V	1.025	1.00
33_L	120_I	1.024	1.00
181_E	184_S	1.023	1.00
25_R	111_E	1.010	1.00
250_T	254_A	1.009	1.00
6_D	28_L	1.007	1.00
30_V	117_V	1.006	1.00
304_N	307_I	1.002	1.00
295_V	342_Y	1.001	1.00
86_T	89_S	1.001	1.00
109_V	119_C	0.999	1.00
59_P	324_Q	0.999	1.00
185_L	188_S	0.998	1.00
287_Y	351_L	0.994	1.00
288_A	336_Q	0.985	1.00
5_C	118_E	0.985	1.00
9_I	30_V	0.984	1.00
128_L	163_R	0.981	1.00
341_L	344_H	0.980	1.00
249_L	253_K	0.974	1.00
368_P	371_Y	0.972	1.00
18_A	22_R	0.972	1.00
294_L	298_A	0.970	1.00
70_R	97_W	0.969	1.00
38_I	121_P	0.969	1.00
201_G	205_L	0.968	1.00
54_L	63_L	0.966	1.00
243_V	247_E	0.964	1.00
5_C	29_S	0.964	1.00
289_G	292_W	0.961	1.00
33_L	123_A	0.959	1.00
17_T	112_A	0.955	1.00
39_P	109_V	0.953	1.00
130_E	135_V	0.952	1.00
55_A	58_L	0.950	1.00
262_I	265_T	0.944	1.00
47_G	312_M	0.944	1.00
266_E	269_E	0.942	1.00
107_W	110_A	0.938	1.00
265_T	268_L	0.934	1.00
257_A	260_P	0.933	1.00
83_G	86_T	0.930	1.00
125_V	159_V	0.928	1.00
169_R	285_V	0.925	1.00
184_S	225_Q	0.918	1.00
64_T	67_L	0.918	1.00
10_I	150_V	0.915	1.00
321_A	324_Q	0.914	1.00
14_I	316_L	0.910	1.00
110_A	114_K	0.909	1.00
24_A	116_G	0.906	1.00
219_F	230_G	0.902	1.00
248_L	252_F	0.902	1.00
31_L	147_A	0.898	1.00
328_S	341_L	0.895	1.00
24_A	30_V	0.892	1.00
369_G	372_R	0.890	1.00
28_L	330_C	0.890	1.00
62_H	111_E	0.889	1.00
293_L	342_Y	0.889	1.00
85_T	88_S	0.883	1.00
138_V	150_V	0.881	1.00
107_W	111_E	0.878	1.00
271_G	277_E	0.875	1.00
203_A	206_F	0.871	1.00
256_P	260_P	0.870	1.00
185_L	189_A	0.868	1.00
80_T	84_V	0.863	1.00
135_V	150_V	0.862	1.00
265_T	269_E	0.856	1.00
336_Q	340_P	0.856	1.00
166_L	284_P	0.856	1.00
128_L	292_W	0.854	1.00
84_V	88_S	0.852	1.00
52_H	310_R	0.851	1.00
264_N	267_S	0.850	1.00
152_L	292_W	0.850	1.00
128_L	164_H	0.849	1.00
22_R	26_A	0.848	1.00
65_A	69_R	0.840	1.00
52_H	317_T	0.839	1.00
57_L	62_H	0.837	1.00
272_A	278_G	0.836	1.00
271_G	275_V	0.835	1.00
17_T	109_V	0.828	1.00
99_V	104_F	0.824	1.00
359_Q	363_A	0.822	1.00
12_A	34_E	0.818	1.00
54_L	97_W	0.815	1.00
22_R	25_R	0.815	1.00
105_D	109_V	0.815	1.00
184_S	187_T	0.814	1.00
130_E	291_G	0.812	1.00
167_V	285_V	0.811	1.00
62_H	107_W	0.808	1.00
21_L	60_Q	0.806	1.00
287_Y	299_L	0.806	1.00
113_E	118_E	0.804	1.00
182_V	185_L	0.804	1.00
200_E	203_A	0.801	1.00
294_L	299_L	0.799	1.00
341_L	345_N	0.798	1.00
201_G	204_L	0.796	1.00
77_S	80_T	0.796	1.00
303_V	355_L	0.795	1.00
328_S	333_R	0.795	1.00
27_G	30_V	0.794	1.00
78_L	81_P	0.793	1.00
160_L	292_W	0.787	1.00
320_Q	324_Q	0.786	1.00
125_V	163_R	0.785	1.00
24_A	112_A	0.785	1.00
178_G	181_E	0.784	1.00
34_E	121_P	0.784	1.00
69_R	107_W	0.778	1.00
69_R	106_P	0.778	1.00
128_L	160_L	0.777	1.00
48_R	96_S	0.776	1.00
130_E	290_N	0.772	1.00
66_P	104_F	0.772	1.00
327_I	331_Q	0.767	1.00
66_P	107_W	0.765	1.00
237_S	240_Q	0.764	1.00
202_A	205_L	0.763	1.00
24_A	113_E	0.762	1.00
6_D	147_A	0.760	1.00
33_L	138_V	0.758	1.00
47_G	101_R	0.758	1.00
173_E	177_L	0.757	1.00
369_G	373_T	0.756	1.00
52_H	55_A	0.755	1.00
54_L	58_L	0.754	1.00
33_L	147_A	0.751	1.00
174_A	177_L	0.747	1.00
277_E	280_L	0.747	1.00
158_S	161_A	0.746	1.00
42_K	45_S	0.746	1.00
259_R	265_T	0.745	1.00
251_R	254_A	0.744	1.00
371_Y	374_W	0.743	1.00
53_A	56_E	0.741	1.00
23_C	326_L	0.740	1.00
271_G	276_P	0.734	1.00
281_H	284_P	0.731	1.00
149_Y	293_L	0.731	1.00
261_L	264_N	0.729	1.00
48_R	98_S	0.728	1.00
323_A	327_I	0.727	1.00
166_L	289_G	0.726	1.00
203_A	207_S	0.725	1.00
23_C	28_L	0.722	1.00
18_A	108_L	0.721	1.00
175_M	178_G	0.716	1.00
75_S	88_S	0.715	1.00
6_D	145_L	0.715	1.00
308_S	358_Y	0.714	1.00
348_R	353_D	0.713	1.00
345_N	348_R	0.712	1.00
20_A	117_V	0.710	1.00
20_A	112_A	0.710	1.00
17_T	105_D	0.709	1.00
183_L	186_E	0.706	1.00
7_I	149_Y	0.703	1.00
202_A	206_F	0.701	1.00
282_S	285_V	0.700	1.00
271_G	274_L	0.700	1.00
123_A	141_G	0.700	1.00
370_W	373_T	0.699	1.00
181_E	229_L	0.699	1.00
57_L	316_L	0.697	1.00
181_E	186_E	0.697	1.00
73_H	78_L	0.696	1.00
260_P	264_N	0.694	1.00
370_W	374_W	0.692	1.00
275_V	280_L	0.692	1.00
334_E	338_L	0.686	1.00
261_L	265_T	0.684	1.00
73_H	76_L	0.681	1.00
312_M	316_L	0.680	1.00
22_R	56_E	0.679	1.00
26_A	323_A	0.675	1.00
67_L	70_R	0.672	1.00
101_R	105_D	0.670	1.00
228_S	232_V	0.668	1.00
184_S	188_S	0.667	1.00
79_L	82_D	0.667	1.00
361_V	364_L	0.665	1.00
337_N	341_L	0.665	1.00
23_C	323_A	0.665	1.00
151_V	322_A	0.665	1.00
113_E	116_G	0.664	1.00
203_A	208_G	0.664	1.00
201_G	206_F	0.662	1.00
30_V	112_A	0.661	1.00
288_A	339_F	0.660	1.00
124_T	159_V	0.659	1.00
303_V	308_S	0.659	1.00
22_R	320_Q	0.659	1.00
353_D	356_Q	0.658	1.00
368_P	372_R	0.655	1.00
166_L	170_P	0.655	1.00
50_Y	313_D	0.652	1.00
259_R	264_N	0.647	1.00
252_F	255_H	0.646	1.00
112_A	116_G	0.642	1.00
332_H	335_P	0.637	1.00
24_A	118_E	0.636	1.00
312_M	315_A	0.636	1.00
112_A	119_C	0.635	1.00
329_A	341_L	0.635	1.00
21_L	24_A	0.634	1.00
335_P	338_L	0.633	1.00
12_A	32_L	0.631	1.00
112_A	115_E	0.629	1.00
245_A	252_F	0.626	1.00
185_L	227_L	0.625	1.00
234_P	237_S	0.623	1.00
254_A	259_R	0.622	1.00
149_Y	326_L	0.618	1.00
130_E	134_R	0.618	1.00
290_N	336_Q	0.616	1.00
314_M	354_V	0.616	1.00
19_C	323_A	0.616	1.00
213_D	216_G	0.612	1.00
310_R	314_M	0.610	1.00
324_Q	328_S	0.608	1.00
368_P	373_T	0.607	1.00
161_A	294_L	0.607	1.00
80_T	83_G	0.604	1.00
223_N	226_T	0.603	1.00
218_A	222_T	0.603	1.00
287_Y	347_E	0.603	1.00
58_L	67_L	0.601	1.00
84_V	87_F	0.600	1.00
74_E	79_L	0.598	1.00
21_L	117_V	0.598	1.00
200_E	204_L	0.597	1.00
165_G	168_T	0.597	1.00
329_A	337_N	0.596	1.00
52_H	349_S	0.594	1.00
17_T	119_C	0.593	1.00
368_P	374_W	0.592	1.00
362_P	366_Q	0.592	1.00
253_K	259_R	0.590	1.00
152_L	164_H	0.589	1.00
358_Y	361_V	0.588	1.00
263_K	266_E	0.586	1.00
74_E	77_S	0.585	1.00
181_E	188_S	0.583	1.00
334_E	337_N	0.581	1.00
340_P	343_H	0.581	1.00
357_R	361_V	0.577	1.00
303_V	358_Y	0.577	1.00
76_L	79_L	0.576	1.00
39_P	105_D	0.574	1.00
49_L	53_A	0.574	1.00
77_S	86_T	0.574	1.00
84_V	89_S	0.573	1.00
228_S	233_C	0.567	1.00
175_M	179_I	0.567	1.00
7_I	19_C	0.566	1.00
258_V	262_I	0.565	1.00
258_V	261_L	0.564	1.00
295_V	319_A	0.562	1.00
77_S	81_P	0.560	1.00
73_H	77_S	0.559	1.00
329_A	332_H	0.559	1.00
353_D	357_R	0.559	1.00
174_A	178_G	0.558	1.00
37_E	121_P	0.558	1.00
302_C	318_G	0.558	1.00
100_L	223_N	0.558	1.00
83_G	87_F	0.557	1.00
321_A	342_Y	0.557	1.00
229_L	232_V	0.557	1.00
257_A	261_L	0.556	1.00
202_A	207_S	0.556	1.00
149_Y	330_C	0.556	1.00
244_P	248_L	0.555	1.00
50_Y	53_A	0.555	1.00
186_E	189_A	0.555	1.00
17_T	32_L	0.554	1.00
217_G	221_Y	0.554	1.00
344_H	348_R	0.554	1.00
152_L	158_S	0.554	1.00
125_V	140_C	0.552	1.00
133_G	291_G	0.552	1.00
329_A	333_R	0.551	1.00
249_L	263_K	0.551	1.00
57_L	104_F	0.551	1.00
284_P	294_L	0.548	1.00
360_H	363_A	0.548	1.00
363_A	367_R	0.547	1.00
113_E	121_P	0.546	1.00
317_T	321_A	0.546	1.00
55_A	59_P	0.544	1.00
359_Q	362_P	0.543	1.00
58_L	64_T	0.543	1.00
15_A	151_V	0.542	1.00
162_E	167_V	0.542	1.00
307_I	362_P	0.541	1.00
229_L	233_C	0.541	1.00
152_L	159_V	0.540	1.00
243_V	246_S	0.539	1.00
351_L	355_L	0.538	1.00
63_L	66_P	0.538	1.00
173_E	176_A	0.538	1.00
128_L	135_V	0.538	1.00
12_A	39_P	0.537	1.00
258_V	265_T	0.536	1.00
56_E	59_P	0.535	1.00
329_A	338_L	0.534	1.00
134_R	148_R	0.533	1.00
293_L	339_F	0.533	1.00
75_S	202_A	0.533	1.00
283_M	287_Y	0.531	1.00
56_E	60_Q	0.531	1.00
100_L	226_T	0.530	1.00
58_L	94_G	0.530	1.00
337_N	340_P	0.530	1.00
28_L	331_Q	0.530	1.00
28_L	326_L	0.529	1.00
260_P	265_T	0.527	1.00
75_S	78_L	0.527	1.00
181_E	185_L	0.526	1.00
179_I	182_V	0.524	1.00
45_S	101_R	0.523	1.00
297_D	315_A	0.523	1.00
57_L	66_P	0.523	1.00
218_A	221_Y	0.521	1.00
326_L	330_C	0.521	1.00
77_S	88_S	0.519	1.00
310_R	313_D	0.518	1.00
314_M	351_L	0.517	1.00
148_R	330_C	0.516	1.00
201_G	207_S	0.515	1.00
182_V	186_E	0.514	1.00
98_S	222_T	0.514	1.00
263_K	267_S	0.513	1.00
276_P	280_L	0.512	1.00
49_L	312_M	0.512	1.00
293_L	343_H	0.509	1.00
310_R	354_V	0.509	1.00
357_R	360_H	0.508	1.00
356_Q	359_Q	0.507	1.00
261_L	267_S	0.507	1.00
56_E	317_T	0.507	1.00
150_V	292_W	0.506	1.00
149_Y	329_A	0.506	1.00
356_Q	360_H	0.506	1.00
242_R	245_A	0.506	1.00
19_C	153_A	0.505	1.00
264_N	268_L	0.505	1.00
181_E	189_A	0.503	1.00
217_G	222_T	0.501	1.00
66_P	97_W	0.501	1.00
21_L	62_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qa1A	2	0.9031	100	0.389	Contact Map
4bjzA	2	0.8794	100	0.39	Contact Map
2qa2A	2	0.9078	100	0.392	Contact Map
1pn0A	3	0.9267	100	0.394	Contact Map
3c96A	1	0.818	100	0.394	Contact Map
2dkhA	2	0.8747	100	0.399	Contact Map
2gmhA	1	0.9716	100	0.399	Contact Map
4k22A	4	0.8014	100	0.404	Contact Map
4k5sA	2	0.9078	100	0.408	Contact Map
2x3nA	1	0.818	100	0.411	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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