GREMLIN Database
YGCN - Probable electron transfer flavoprotein-quinone oxidoreductase YgcN
UniProt: Q46904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13121
Length: 423 (347)
Sequences: 27374 (20901)
Seq/√Len: 1122.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_L120_I4.3191.00
35_R124_T3.5761.00
8_I147_A3.5741.00
15_A315_A3.4201.00
6_D29_S3.2141.00
343_H347_E3.1851.00
6_D148_R3.1571.00
127_A139_I2.8851.00
124_T141_G2.8061.00
5_C31_L2.7891.00
123_A142_D2.7721.00
139_I144_I2.7641.00
111_E114_K2.6991.00
33_L145_L2.6421.00
19_C151_V2.6111.00
126_D141_G2.5961.00
129_Y137_G2.5431.00
26_A327_I2.5261.00
137_G144_I2.4981.00
22_R323_A2.4951.00
137_G146_R2.4601.00
127_A163_R2.4561.00
8_I138_V2.3831.00
106_P110_A2.3251.00
65_A110_A2.2781.00
8_I33_L2.2461.00
15_A295_V2.1971.00
123_A140_C2.1101.00
129_Y139_I2.0961.00
18_A316_L2.0821.00
140_C145_L2.0411.00
152_L160_L2.0321.00
120_I123_A1.9961.00
325_T345_N1.9791.00
65_A111_E1.9531.00
33_L140_C1.9501.00
58_L63_L1.9371.00
37_E122_G1.9251.00
7_I23_C1.9201.00
134_R146_R1.9011.00
21_L111_E1.8791.00
111_E115_E1.8791.00
325_T341_L1.8541.00
244_P247_E1.8281.00
7_I28_L1.8091.00
273_H276_P1.7921.00
125_V138_V1.7821.00
288_A340_P1.7641.00
131_E137_G1.7511.00
319_A323_A1.7281.00
29_S118_E1.7251.00
347_E352_W1.7171.00
56_E320_Q1.7161.00
153_A295_V1.7041.00
6_D31_L1.6951.00
152_L294_L1.6831.00
28_L327_I1.6731.00
53_A313_D1.6491.00
109_V121_P1.6471.00
24_A117_V1.6331.00
273_H277_E1.5891.00
321_A345_N1.5851.00
59_P320_Q1.5791.00
130_E289_G1.5571.00
140_C143_D1.5561.00
288_A293_L1.5531.00
275_V278_G1.5511.00
112_A117_V1.5461.00
128_L150_V1.5431.00
247_E250_T1.5241.00
321_A325_T1.5231.00
21_L25_R1.5211.00
19_C319_A1.5201.00
20_A32_L1.5061.00
184_S266_E1.5021.00
65_A68_E1.4961.00
31_L145_L1.4951.00
25_R115_E1.4891.00
154_E158_S1.4811.00
65_A114_K1.4771.00
131_E146_R1.4761.00
8_I145_L1.4601.00
109_V113_E1.4551.00
131_E134_R1.4321.00
149_Y339_F1.4321.00
293_L322_A1.4311.00
159_V163_R1.4201.00
24_A115_E1.4081.00
151_V295_V1.4071.00
164_H292_W1.4031.00
64_T68_E1.3951.00
250_T253_K1.3911.00
246_S250_T1.3801.00
247_E251_R1.3801.00
10_I125_V1.3781.00
53_A316_L1.3651.00
22_R60_Q1.3601.00
14_I312_M1.3531.00
272_A276_P1.3531.00
245_A249_L1.3441.00
324_Q345_N1.3341.00
5_C8_I1.3241.00
318_G346_V1.3101.00
129_Y144_I1.2981.00
260_P263_K1.2981.00
69_R103_R1.2971.00
39_P121_P1.2881.00
274_L277_E1.2871.00
325_T328_S1.2761.00
317_T349_S1.2641.00
120_I145_L1.2541.00
21_L112_A1.2471.00
151_V293_L1.2461.00
256_P259_R1.2431.00
139_I143_D1.2391.00
272_A277_E1.2391.00
125_V128_L1.2321.00
10_I154_E1.2301.00
126_D139_I1.2261.00
184_S226_T1.2161.00
205_L208_G1.2151.00
159_V162_E1.2121.00
325_T338_L1.2121.00
31_L118_E1.2051.00
74_E78_L1.2011.00
100_L103_R1.1981.00
125_V160_L1.1931.00
352_W356_Q1.1871.00
134_R137_G1.1861.00
208_G213_D1.1761.00
288_A343_H1.1741.00
138_V147_A1.1721.00
63_L67_L1.1681.00
65_A107_W1.1681.00
21_L115_E1.1641.00
103_R106_P1.1631.00
9_I19_C1.1471.00
110_A113_E1.1421.00
18_A60_Q1.1401.00
301_S318_G1.1341.00
19_C23_C1.1301.00
32_L119_C1.1291.00
274_L278_G1.1231.00
287_Y343_H1.1161.00
204_L207_S1.1101.00
156_A302_C1.1081.00
8_I31_L1.1071.00
12_A17_T1.1031.00
246_S249_L1.1011.00
10_I160_L1.0861.00
19_C295_V1.0771.00
340_P344_H1.0671.00
249_L252_F1.0611.00
126_D143_D1.0521.00
20_A30_V1.0411.00
135_V291_G1.0381.00
259_R263_K1.0371.00
44_L47_G1.0351.00
9_I20_A1.0341.00
147_A150_V1.0321.00
273_H278_G1.0311.00
303_V314_M1.0271.00
85_T89_S1.0261.00
272_A275_V1.0251.00
33_L120_I1.0241.00
181_E184_S1.0231.00
25_R111_E1.0101.00
250_T254_A1.0091.00
6_D28_L1.0071.00
30_V117_V1.0061.00
304_N307_I1.0021.00
295_V342_Y1.0011.00
86_T89_S1.0011.00
109_V119_C0.9991.00
59_P324_Q0.9991.00
185_L188_S0.9981.00
287_Y351_L0.9941.00
288_A336_Q0.9851.00
5_C118_E0.9851.00
9_I30_V0.9841.00
128_L163_R0.9811.00
341_L344_H0.9801.00
249_L253_K0.9741.00
368_P371_Y0.9721.00
18_A22_R0.9721.00
294_L298_A0.9701.00
70_R97_W0.9691.00
38_I121_P0.9691.00
201_G205_L0.9681.00
54_L63_L0.9661.00
243_V247_E0.9641.00
5_C29_S0.9641.00
289_G292_W0.9611.00
33_L123_A0.9591.00
17_T112_A0.9551.00
39_P109_V0.9531.00
130_E135_V0.9521.00
55_A58_L0.9501.00
262_I265_T0.9441.00
47_G312_M0.9441.00
266_E269_E0.9421.00
107_W110_A0.9381.00
265_T268_L0.9341.00
257_A260_P0.9331.00
83_G86_T0.9301.00
125_V159_V0.9281.00
169_R285_V0.9251.00
184_S225_Q0.9181.00
64_T67_L0.9181.00
10_I150_V0.9151.00
321_A324_Q0.9141.00
14_I316_L0.9101.00
110_A114_K0.9091.00
24_A116_G0.9061.00
219_F230_G0.9021.00
248_L252_F0.9021.00
31_L147_A0.8981.00
328_S341_L0.8951.00
24_A30_V0.8921.00
369_G372_R0.8901.00
28_L330_C0.8901.00
62_H111_E0.8891.00
293_L342_Y0.8891.00
85_T88_S0.8831.00
138_V150_V0.8811.00
107_W111_E0.8781.00
271_G277_E0.8751.00
203_A206_F0.8711.00
256_P260_P0.8701.00
185_L189_A0.8681.00
80_T84_V0.8631.00
135_V150_V0.8621.00
265_T269_E0.8561.00
336_Q340_P0.8561.00
166_L284_P0.8561.00
128_L292_W0.8541.00
84_V88_S0.8521.00
52_H310_R0.8511.00
264_N267_S0.8501.00
152_L292_W0.8501.00
128_L164_H0.8491.00
22_R26_A0.8481.00
65_A69_R0.8401.00
52_H317_T0.8391.00
57_L62_H0.8371.00
272_A278_G0.8361.00
271_G275_V0.8351.00
17_T109_V0.8281.00
99_V104_F0.8241.00
359_Q363_A0.8221.00
12_A34_E0.8181.00
54_L97_W0.8151.00
22_R25_R0.8151.00
105_D109_V0.8151.00
184_S187_T0.8141.00
130_E291_G0.8121.00
167_V285_V0.8111.00
62_H107_W0.8081.00
21_L60_Q0.8061.00
287_Y299_L0.8061.00
113_E118_E0.8041.00
182_V185_L0.8041.00
200_E203_A0.8011.00
294_L299_L0.7991.00
341_L345_N0.7981.00
201_G204_L0.7961.00
77_S80_T0.7961.00
303_V355_L0.7951.00
328_S333_R0.7951.00
27_G30_V0.7941.00
78_L81_P0.7931.00
160_L292_W0.7871.00
320_Q324_Q0.7861.00
125_V163_R0.7851.00
24_A112_A0.7851.00
178_G181_E0.7841.00
34_E121_P0.7841.00
69_R107_W0.7781.00
69_R106_P0.7781.00
128_L160_L0.7771.00
48_R96_S0.7761.00
130_E290_N0.7721.00
66_P104_F0.7721.00
327_I331_Q0.7671.00
66_P107_W0.7651.00
237_S240_Q0.7641.00
202_A205_L0.7631.00
24_A113_E0.7621.00
6_D147_A0.7601.00
33_L138_V0.7581.00
47_G101_R0.7581.00
173_E177_L0.7571.00
369_G373_T0.7561.00
52_H55_A0.7551.00
54_L58_L0.7541.00
33_L147_A0.7511.00
174_A177_L0.7471.00
277_E280_L0.7471.00
158_S161_A0.7461.00
42_K45_S0.7461.00
259_R265_T0.7451.00
251_R254_A0.7441.00
371_Y374_W0.7431.00
53_A56_E0.7411.00
23_C326_L0.7401.00
271_G276_P0.7341.00
281_H284_P0.7311.00
149_Y293_L0.7311.00
261_L264_N0.7291.00
48_R98_S0.7281.00
323_A327_I0.7271.00
166_L289_G0.7261.00
203_A207_S0.7251.00
23_C28_L0.7221.00
18_A108_L0.7211.00
175_M178_G0.7161.00
75_S88_S0.7151.00
6_D145_L0.7151.00
308_S358_Y0.7141.00
348_R353_D0.7131.00
345_N348_R0.7121.00
20_A117_V0.7101.00
20_A112_A0.7101.00
17_T105_D0.7091.00
183_L186_E0.7061.00
7_I149_Y0.7031.00
202_A206_F0.7011.00
282_S285_V0.7001.00
271_G274_L0.7001.00
123_A141_G0.7001.00
370_W373_T0.6991.00
181_E229_L0.6991.00
57_L316_L0.6971.00
181_E186_E0.6971.00
73_H78_L0.6961.00
260_P264_N0.6941.00
370_W374_W0.6921.00
275_V280_L0.6921.00
334_E338_L0.6861.00
261_L265_T0.6841.00
73_H76_L0.6811.00
312_M316_L0.6801.00
22_R56_E0.6791.00
26_A323_A0.6751.00
67_L70_R0.6721.00
101_R105_D0.6701.00
228_S232_V0.6681.00
184_S188_S0.6671.00
79_L82_D0.6671.00
361_V364_L0.6651.00
337_N341_L0.6651.00
23_C323_A0.6651.00
151_V322_A0.6651.00
113_E116_G0.6641.00
203_A208_G0.6641.00
201_G206_F0.6621.00
30_V112_A0.6611.00
288_A339_F0.6601.00
124_T159_V0.6591.00
303_V308_S0.6591.00
22_R320_Q0.6591.00
353_D356_Q0.6581.00
368_P372_R0.6551.00
166_L170_P0.6551.00
50_Y313_D0.6521.00
259_R264_N0.6471.00
252_F255_H0.6461.00
112_A116_G0.6421.00
332_H335_P0.6371.00
24_A118_E0.6361.00
312_M315_A0.6361.00
112_A119_C0.6351.00
329_A341_L0.6351.00
21_L24_A0.6341.00
335_P338_L0.6331.00
12_A32_L0.6311.00
112_A115_E0.6291.00
245_A252_F0.6261.00
185_L227_L0.6251.00
234_P237_S0.6231.00
254_A259_R0.6221.00
149_Y326_L0.6181.00
130_E134_R0.6181.00
290_N336_Q0.6161.00
314_M354_V0.6161.00
19_C323_A0.6161.00
213_D216_G0.6121.00
310_R314_M0.6101.00
324_Q328_S0.6081.00
368_P373_T0.6071.00
161_A294_L0.6071.00
80_T83_G0.6041.00
223_N226_T0.6031.00
218_A222_T0.6031.00
287_Y347_E0.6031.00
58_L67_L0.6011.00
84_V87_F0.6001.00
74_E79_L0.5981.00
21_L117_V0.5981.00
200_E204_L0.5971.00
165_G168_T0.5971.00
329_A337_N0.5961.00
52_H349_S0.5941.00
17_T119_C0.5931.00
368_P374_W0.5921.00
362_P366_Q0.5921.00
253_K259_R0.5901.00
152_L164_H0.5891.00
358_Y361_V0.5881.00
263_K266_E0.5861.00
74_E77_S0.5851.00
181_E188_S0.5831.00
334_E337_N0.5811.00
340_P343_H0.5811.00
357_R361_V0.5771.00
303_V358_Y0.5771.00
76_L79_L0.5761.00
39_P105_D0.5741.00
49_L53_A0.5741.00
77_S86_T0.5741.00
84_V89_S0.5731.00
228_S233_C0.5671.00
175_M179_I0.5671.00
7_I19_C0.5661.00
258_V262_I0.5651.00
258_V261_L0.5641.00
295_V319_A0.5621.00
77_S81_P0.5601.00
73_H77_S0.5591.00
329_A332_H0.5591.00
353_D357_R0.5591.00
174_A178_G0.5581.00
37_E121_P0.5581.00
302_C318_G0.5581.00
100_L223_N0.5581.00
83_G87_F0.5571.00
321_A342_Y0.5571.00
229_L232_V0.5571.00
257_A261_L0.5561.00
202_A207_S0.5561.00
149_Y330_C0.5561.00
244_P248_L0.5551.00
50_Y53_A0.5551.00
186_E189_A0.5551.00
17_T32_L0.5541.00
217_G221_Y0.5541.00
344_H348_R0.5541.00
152_L158_S0.5541.00
125_V140_C0.5521.00
133_G291_G0.5521.00
329_A333_R0.5511.00
249_L263_K0.5511.00
57_L104_F0.5511.00
284_P294_L0.5481.00
360_H363_A0.5481.00
363_A367_R0.5471.00
113_E121_P0.5461.00
317_T321_A0.5461.00
55_A59_P0.5441.00
359_Q362_P0.5431.00
58_L64_T0.5431.00
15_A151_V0.5421.00
162_E167_V0.5421.00
307_I362_P0.5411.00
229_L233_C0.5411.00
152_L159_V0.5401.00
243_V246_S0.5391.00
351_L355_L0.5381.00
63_L66_P0.5381.00
173_E176_A0.5381.00
128_L135_V0.5381.00
12_A39_P0.5371.00
258_V265_T0.5361.00
56_E59_P0.5351.00
329_A338_L0.5341.00
134_R148_R0.5331.00
293_L339_F0.5331.00
75_S202_A0.5331.00
283_M287_Y0.5311.00
56_E60_Q0.5311.00
100_L226_T0.5301.00
58_L94_G0.5301.00
337_N340_P0.5301.00
28_L331_Q0.5301.00
28_L326_L0.5291.00
260_P265_T0.5271.00
75_S78_L0.5271.00
181_E185_L0.5261.00
179_I182_V0.5241.00
45_S101_R0.5231.00
297_D315_A0.5231.00
57_L66_P0.5231.00
218_A221_Y0.5211.00
326_L330_C0.5211.00
77_S88_S0.5191.00
310_R313_D0.5181.00
314_M351_L0.5171.00
148_R330_C0.5161.00
201_G207_S0.5151.00
182_V186_E0.5141.00
98_S222_T0.5141.00
263_K267_S0.5131.00
276_P280_L0.5121.00
49_L312_M0.5121.00
293_L343_H0.5091.00
310_R354_V0.5091.00
357_R360_H0.5081.00
356_Q359_Q0.5071.00
261_L267_S0.5071.00
56_E317_T0.5071.00
150_V292_W0.5061.00
149_Y329_A0.5061.00
356_Q360_H0.5061.00
242_R245_A0.5061.00
19_C153_A0.5051.00
264_N268_L0.5051.00
181_E189_A0.5031.00
217_G222_T0.5011.00
66_P97_W0.5011.00
21_L62_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qa1A 2 0.9031 100 0.389 Contact Map
4bjzA 2 0.8794 100 0.39 Contact Map
2qa2A 2 0.9078 100 0.392 Contact Map
1pn0A 3 0.9267 100 0.394 Contact Map
3c96A 1 0.818 100 0.394 Contact Map
2dkhA 2 0.8747 100 0.399 Contact Map
2gmhA 1 0.9716 100 0.399 Contact Map
4k22A 4 0.8014 100 0.404 Contact Map
4k5sA 2 0.9078 100 0.408 Contact Map
2x3nA 1 0.818 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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