GREMLIN Database
CSE1 - CRISPR system Cascade subunit CasA
UniProt: Q46901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13119
Length: 502 (470)
Sequences: 620 (537)
Seq/√Len: 24.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_G162_F8.4271.00
22_I27_L5.1011.00
57_I212_I4.9811.00
15_N18_K4.6601.00
5_I88_I4.3831.00
13_P20_Q4.0411.00
178_G183_S3.5801.00
279_H284_C3.5511.00
140_C143_C3.5511.00
460_M464_Q3.4231.00
30_S33_Q3.3311.00
55_G185_V3.3151.00
179_I183_S3.2801.00
463_N483_R3.1351.00
25_Q85_A3.0761.00
151_Q239_I2.9921.00
43_M147_A2.9811.00
22_I26_S2.9161.00
93_L145_A2.8931.00
94_N141_G2.8671.00
26_S30_S2.8070.99
232_L280_P2.6740.99
25_Q81_Q2.6230.99
11_V22_I2.5870.99
3_L100_F2.5840.99
105_G240_E2.5730.99
54_I84_I2.5670.99
428_E432_P2.4600.99
75_L182_R2.4590.99
112_T116_K2.3150.98
344_E364_V2.2900.98
2_N5_I2.2810.98
42_D150_N2.2720.98
38_L43_M2.2700.98
144_T241_L2.2330.97
10_P47_A2.2020.97
9_I36_L2.1550.97
36_L51_L2.1340.96
277_W284_C2.0940.96
178_G184_T2.0790.96
3_L8_W2.0510.95
286_V291_G2.0080.95
83_L212_I1.9930.95
8_W145_A1.9870.95
38_L47_A1.9650.94
427_S454_L1.9590.94
39_P43_M1.9280.94
48_L148_L1.9260.94
442_Q447_I1.9120.93
423_F458_C1.8900.93
237_A450_L1.8790.93
488_K492_E1.8630.92
21_I142_G1.8550.92
32_D182_R1.8500.92
455_H491_R1.8500.92
166_L171_P1.8460.92
474_K478_T1.8330.92
10_P365_L1.8310.92
128_A133_P1.8290.92
75_L80_F1.8270.92
238_H352_N1.8230.92
353_N357_I1.8200.92
48_L175_F1.8050.91
7_N21_I1.8010.91
182_R186_L1.7940.91
85_A88_I1.7930.91
331_V345_L1.7610.90
2_N6_D1.7590.90
223_A230_R1.7360.89
163_K171_P1.7270.89
99_P307_W1.7110.89
346_I362_H1.7000.88
442_Q445_E1.6930.88
128_A132_Q1.6790.88
180_D183_S1.6770.88
351_R358_L1.6750.88
50_L149_F1.6500.87
92_Y95_H1.6400.87
353_N356_S1.6380.86
99_P184_T1.6290.86
281_H285_L1.6280.86
92_Y96_A1.6140.86
49_A154_Q1.6110.85
12_R35_R1.6020.85
207_N227_G1.5890.85
24_L54_I1.5770.84
95_H239_I1.5620.84
115_E131_N1.5470.83
159_G165_G1.5410.83
167_R236_P1.5150.82
155_A352_N1.5100.81
117_L164_S1.4700.80
215_I218_N1.4620.79
260_R263_G1.4560.79
426_Q464_Q1.4410.78
122_S133_P1.4370.78
306_S347_M1.4350.78
158_F170_T1.4300.78
212_I306_S1.4140.77
13_P18_K1.4120.77
94_N243_D1.4090.77
386_L390_T1.4030.76
42_D350_Y1.4030.76
459_E487_Y1.3960.76
187_L237_A1.3950.76
279_H282_S1.3910.76
26_S54_I1.3890.76
424_Y431_I1.3870.76
95_H98_H1.3830.75
227_G230_R1.3570.74
76_T80_F1.3540.74
332_N364_V1.3510.74
84_I470_A1.3480.73
355_A358_L1.3440.73
122_S126_N1.3440.73
168_G171_P1.3430.73
363_D428_E1.3400.73
13_P22_I1.3390.73
486_L490_L1.3350.73
20_Q26_S1.3350.73
69_H72_M1.3340.73
80_F84_I1.3240.72
296_K353_N1.3230.72
26_S29_C1.3110.71
56_Q190_L1.3000.71
55_G189_V1.2920.70
173_T300_F1.2880.70
45_L348_G1.2860.70
474_K479_L1.2850.70
119_A150_N1.2780.69
457_L460_M1.2730.69
38_L146_I1.2710.69
151_Q155_A1.2710.69
155_A238_H1.2700.69
49_A56_Q1.2690.69
397_Y420_E1.2640.68
72_M80_F1.2590.68
28_Y33_Q1.2520.68
32_D180_D1.2420.67
152_A237_A1.2410.67
297_F406_K1.2410.67
5_I476_I1.2360.67
80_F154_Q1.2350.67
426_Q460_M1.2260.66
98_H215_I1.2250.66
183_S486_L1.2230.66
155_A353_N1.2210.66
123_G129_F1.2210.66
176_V314_V1.2190.66
155_A355_A1.2150.65
19_V37_S1.2110.65
152_A450_L1.2100.65
441_S446_V1.2050.65
89_D98_H1.2040.65
170_T352_N1.2000.64
7_N69_H1.1960.64
57_I306_S1.1960.64
49_A233_F1.1930.64
174_T283_P1.1910.64
352_N357_I1.1890.64
50_L446_V1.1860.63
28_Y94_N1.1850.63
73_N89_D1.1770.63
399_F486_L1.1720.62
423_F427_S1.1700.62
282_S285_L1.1680.62
483_R487_Y1.1630.62
139_L155_A1.1580.61
160_G167_R1.1440.60
27_L318_I1.1430.60
208_Q213_K1.1420.60
103_T399_F1.1420.60
12_R34_W1.1340.60
54_I374_Y1.1320.60
4_L88_I1.1270.59
24_L28_Y1.1260.59
391_A394_K1.1240.59
27_L34_W1.1160.59
123_G128_A1.1150.58
117_L327_V1.1150.58
2_N89_D1.1140.58
49_A83_L1.1130.58
14_R32_D1.1120.58
48_L54_I1.1100.58
157_G355_A1.1070.58
179_I341_S1.1070.58
78_D86_P1.1030.58
49_A427_S1.0960.57
95_H99_P1.0950.57
474_K477_S1.0880.57
93_L99_P1.0870.56
420_E424_Y1.0820.56
5_I25_Q1.0780.56
148_L239_I1.0750.56
55_G154_Q1.0750.56
69_H391_A1.0730.56
330_V424_Y1.0710.55
287_T296_K1.0690.55
83_L91_F1.0670.55
52_V188_N1.0670.55
9_I338_A1.0650.55
2_N91_F1.0560.54
115_E136_G1.0550.54
40_R360_R1.0550.54
72_M322_E1.0500.54
99_P212_I1.0470.54
23_N83_L1.0470.54
8_W100_F1.0450.53
170_T238_H1.0430.53
155_A237_A1.0430.53
349_G367_F1.0430.53
155_A159_G1.0420.53
112_T435_L1.0370.53
281_H284_C1.0310.52
31_R49_A1.0300.52
392_L454_L1.0270.52
403_F406_K1.0240.52
287_T290_K1.0170.51
65_V72_M1.0150.51
215_I219_E1.0140.51
125_T129_F1.0130.51
26_S377_V1.0100.51
20_Q179_I1.0100.51
49_A149_F1.0080.51
65_V69_H1.0040.51
246_G460_M1.0020.50
83_L207_N0.9990.50
2_N101_M0.9930.50
4_L85_A0.9920.50
71_I264_F0.9840.49
157_G160_G0.9830.49
56_Q232_L0.9830.49
186_L279_H0.9800.49
157_G163_K0.9780.49
27_L51_L0.9750.48
48_L356_S0.9750.48
83_L209_P0.9750.48
316_D375_G0.9740.48
47_A50_L0.9700.48
482_A486_L0.9690.48
22_I51_L0.9680.48
2_N88_I0.9670.48
89_D95_H0.9650.48
209_P212_I0.9650.48
380_E402_G0.9650.48
118_L166_L0.9560.47
120_G424_Y0.9500.47
24_L95_H0.9490.47
375_G452_D0.9490.47
32_D54_I0.9450.46
147_A393_R0.9440.46
385_G447_I0.9420.46
91_F145_A0.9370.46
127_C166_L0.9360.46
175_F348_G0.9350.46
129_F157_G0.9300.45
67_F187_L0.9240.45
28_Y80_F0.9240.45
14_R180_D0.9200.45
26_S41_D0.9190.44
51_L392_L0.9180.44
45_L173_T0.9150.44
235_Q238_H0.9140.44
35_R44_E0.9130.44
162_F355_A0.9090.44
167_R358_L0.9080.44
42_D147_A0.9080.44
425_R483_R0.9040.43
76_T441_S0.9040.43
49_A212_I0.9010.43
172_V279_H0.8970.43
156_P167_R0.8940.43
96_A208_Q0.8920.43
354_Q357_I0.8920.43
287_T291_G0.8910.42
298_L325_N0.8880.42
297_F482_A0.8880.42
9_I47_A0.8860.42
303_S387_G0.8860.42
229_V281_H0.8850.42
52_V307_W0.8820.42
121_V479_L0.8820.42
303_S358_L0.8810.42
2_N92_Y0.8810.42
210_T235_Q0.8790.42
40_R150_N0.8720.41
35_R347_M0.8700.41
40_R428_E0.8700.41
159_G352_N0.8700.41
282_S297_F0.8680.41
33_Q140_C0.8660.41
477_S486_L0.8660.41
423_F462_F0.8640.41
179_I344_E0.8640.41
122_S158_F0.8630.40
167_R175_F0.8610.40
119_A147_A0.8610.40
489_H492_E0.8600.40
19_V36_L0.8580.40
234_W238_H0.8580.40
50_L394_K0.8570.40
9_I456_Q0.8520.40
239_I357_I0.8500.40
422_H464_Q0.8490.40
288_V292_E0.8480.39
106_V158_F0.8440.39
69_H73_N0.8440.39
67_F186_L0.8380.39
127_C161_G0.8370.39
6_D484_A0.8360.39
97_E464_Q0.8350.39
159_G353_N0.8340.38
73_N223_A0.8330.38
3_L349_G0.8330.38
78_D453_K0.8320.38
212_I431_I0.8290.38
141_G243_D0.8270.38
130_V185_V0.8260.38
56_Q191_T0.8250.38
26_S441_S0.8210.38
169_G356_S0.8200.38
282_S299_A0.8180.37
159_G355_A0.8160.37
82_Q433_D0.8140.37
314_V454_L0.8130.37
153_N352_N0.8120.37
185_V233_F0.8120.37
152_A236_P0.8110.37
68_R72_M0.8100.37
28_Y167_R0.8080.37
60_P190_L0.8080.37
39_P146_I0.8070.37
179_I370_G0.8060.37
392_L396_L0.8060.37
49_A53_C0.8020.36
119_A235_Q0.8020.36
49_A328_A0.7980.36
339_P490_L0.7940.36
116_K123_G0.7930.36
205_T453_K0.7920.36
124_A156_P0.7910.36
165_G282_S0.7900.36
126_N133_P0.7900.36
180_D488_K0.7890.35
387_G433_D0.7890.35
4_L24_L0.7850.35
70_R101_M0.7850.35
392_L442_Q0.7830.35
83_L125_T0.7830.35
77_E80_F0.7790.35
78_D488_K0.7790.35
83_L233_F0.7770.35
88_I359_E0.7760.35
229_V431_I0.7750.35
489_H493_L0.7750.35
113_P257_S0.7740.34
43_M188_N0.7730.34
101_M176_V0.7730.34
388_Y458_C0.7720.34
409_K415_V0.7720.34
9_I328_A0.7710.34
130_V146_I0.7700.34
45_L56_Q0.7690.34
175_F345_L0.7690.34
147_A231_G0.7690.34
382_V425_R0.7640.34
26_S428_E0.7630.34
50_L100_F0.7600.34
119_A357_I0.7580.33
151_Q162_F0.7560.33
8_W91_F0.7550.33
38_L147_A0.7520.33
36_L47_A0.7500.33
207_N233_F0.7500.33
318_I452_D0.7490.33
363_D432_P0.7470.33
291_G295_E0.7460.33
132_Q478_T0.7460.33
131_N269_F0.7430.32
36_L457_L0.7420.32
476_I482_A0.7370.32
208_Q230_R0.7360.32
62_K66_E0.7350.32
427_S450_L0.7350.32
26_S82_Q0.7350.32
159_G170_T0.7300.32
352_N355_A0.7300.32
122_S131_N0.7300.32
69_H448_A0.7300.32
28_Y84_I0.7290.32
277_W281_H0.7280.32
8_W11_V0.7280.32
26_S376_N0.7280.32
48_L184_T0.7280.32
71_I186_L0.7260.31
235_Q355_A0.7240.31
93_L142_G0.7230.31
410_G417_E0.7230.31
83_L99_P0.7220.31
93_L148_L0.7220.31
41_D158_F0.7210.31
152_A162_F0.7210.31
118_L147_A0.7170.31
12_R19_V0.7170.31
214_P426_Q0.7170.31
81_Q85_A0.7170.31
106_V170_T0.7160.31
477_S485_T0.7160.31
122_S419_A0.7160.31
164_S353_N0.7150.31
78_D459_E0.7150.31
309_Q423_F0.7140.31
103_T350_Y0.7120.31
155_A166_L0.7120.31
160_G353_N0.7110.30
42_D119_A0.7110.30
157_G354_Q0.7100.30
169_G355_A0.7090.30
102_Q184_T0.7080.30
8_W450_L0.7060.30
217_S220_S0.7060.30
142_G244_P0.7040.30
18_K33_Q0.7040.30
3_L9_I0.7030.30
73_N471_H0.7020.30
122_S130_V0.7020.30
89_D92_Y0.7010.30
91_F211_W0.7000.30
480_A490_L0.6990.30
222_P364_V0.6980.30
96_A178_G0.6970.30
296_K299_A0.6960.30
244_P318_I0.6960.30
402_G485_T0.6960.30
341_S486_L0.6950.30
272_T279_H0.6940.29
177_R346_I0.6910.29
131_N268_K0.6870.29
10_P492_E0.6860.29
131_N363_D0.6860.29
161_G355_A0.6850.29
464_Q468_P0.6840.29
435_L443_A0.6840.29
133_P238_H0.6830.29
351_R359_E0.6830.29
32_D35_R0.6830.29
11_V20_Q0.6800.29
59_A365_L0.6800.29
179_I488_K0.6800.29
57_I207_N0.6790.29
17_G158_F0.6760.28
150_N357_I0.6760.28
156_P356_S0.6760.28
57_I229_V0.6760.28
390_T394_K0.6750.28
144_T227_G0.6750.28
106_V314_V0.6710.28
65_V332_N0.6680.28
279_H428_E0.6680.28
205_T458_C0.6680.28
360_R431_I0.6680.28
426_Q458_C0.6670.28
49_A143_C0.6660.28
147_A166_L0.6630.28
300_F352_N0.6620.28
24_L99_P0.6620.28
26_S485_T0.6620.28
227_G363_D0.6620.28
332_N411_A0.6600.27
488_K491_R0.6600.27
239_I458_C0.6590.27
133_P159_G0.6580.27
340_Q440_F0.6580.27
49_A450_L0.6580.27
236_P240_E0.6580.27
336_N476_I0.6560.27
387_G492_E0.6560.27
301_T304_A0.6560.27
42_D427_S0.6560.27
33_Q214_P0.6530.27
99_P227_G0.6520.27
109_N116_K0.6510.27
21_I486_L0.6500.27
166_L172_V0.6490.27
186_L462_F0.6480.27
396_L466_V0.6450.27
265_L406_K0.6450.27
159_G168_G0.6440.27
445_E449_D0.6430.26
327_V331_V0.6420.26
298_L338_A0.6410.26
149_F239_I0.6410.26
385_G409_K0.6390.26
323_N441_S0.6380.26
69_H191_T0.6380.26
139_L166_L0.6360.26
131_N134_G0.6350.26
151_Q240_E0.6350.26
186_L284_C0.6350.26
2_N95_H0.6330.26
305_P418_T0.6330.26
65_V452_D0.6310.26
22_I94_N0.6310.26
69_H480_A0.6310.26
378_I382_V0.6300.26
7_N26_S0.6300.26
456_Q488_K0.6290.26
89_D486_L0.6280.26
122_S482_A0.6270.26
155_A160_G0.6250.25
167_R355_A0.6240.25
205_T387_G0.6230.25
38_L44_E0.6230.25
4_L34_W0.6230.25
239_I450_L0.6220.25
162_F353_N0.6200.25
151_Q238_H0.6180.25
165_G443_A0.6180.25
28_Y38_L0.6160.25
147_A160_G0.6160.25
204_H378_I0.6160.25
425_R471_H0.6150.25
42_D156_P0.6140.25
305_P363_D0.6140.25
22_I143_C0.6130.25
111_V149_F0.6120.25
226_I230_R0.6100.25
39_P173_T0.6100.25
476_I486_L0.6100.25
157_G353_N0.6100.25
448_A460_M0.6090.25
8_W188_N0.6090.25
380_E490_L0.6090.25
422_H439_N0.6090.25
41_D47_A0.6050.24
27_L338_A0.6040.24
298_L345_L0.6040.24
238_H450_L0.6020.24
380_E459_E0.6020.24
437_N449_D0.6020.24
45_L153_N0.6010.24
476_I481_L0.6010.24
341_S392_L0.6000.24
49_A186_L0.5990.24
9_I318_I0.5980.24
115_E305_P0.5980.24
122_S157_G0.5980.24
385_G420_E0.5970.24
154_Q364_V0.5960.24
122_S128_A0.5960.24
32_D75_L0.5960.24
176_V329_A0.5960.24
123_G156_P0.5950.24
130_V184_T0.5940.24
37_S44_E0.5930.24
165_G168_G0.5920.24
6_D380_E0.5920.24
43_M146_I0.5920.24
115_E479_L0.5910.24
194_R459_E0.5910.24
352_N399_F0.5880.24
73_N456_Q0.5880.24
111_V252_C0.5850.23
288_V336_N0.5850.23
158_F162_F0.5840.23
80_F300_F0.5830.23
309_Q462_F0.5830.23
67_F238_H0.5820.23
284_C363_D0.5820.23
9_I465_S0.5820.23
386_L477_S0.5810.23
99_P178_G0.5810.23
72_M378_I0.5790.23
179_I339_P0.5780.23
91_F100_F0.5780.23
5_I337_I0.5780.23
208_Q312_R0.5780.23
66_E468_P0.5780.23
155_A300_F0.5780.23
36_L459_E0.5760.23
99_P232_L0.5760.23
246_G442_Q0.5710.23
122_S136_G0.5710.23
144_T170_T0.5690.23
26_S384_V0.5690.23
66_E461_L0.5680.23
116_K122_S0.5680.23
454_L461_L0.5680.23
143_C251_S0.5680.23
152_A427_S0.5670.22
83_L87_W0.5670.22
49_A281_H0.5670.22
118_L334_F0.5650.22
27_L347_M0.5650.22
31_R34_W0.5640.22
334_F361_R0.5630.22
221_I226_I0.5630.22
74_P455_H0.5600.22
30_S458_C0.5590.22
127_C395_A0.5590.22
164_S171_P0.5580.22
165_G277_W0.5580.22
456_Q484_A0.5580.22
157_G241_L0.5570.22
444_D490_L0.5570.22
160_G352_N0.5560.22
163_K243_D0.5560.22
307_W352_N0.5550.22
188_N237_A0.5550.22
116_K242_C0.5550.22
297_F300_F0.5550.22
478_T481_L0.5550.22
18_K196_Q0.5530.22
150_N165_G0.5510.22
10_P474_K0.5510.22
246_G336_N0.5500.22
64_D332_N0.5490.22
336_N439_N0.5490.22
380_E384_V0.5490.22
93_L241_L0.5490.22
45_L84_I0.5480.22
103_T235_Q0.5480.22
71_I333_Q0.5460.21
6_D92_Y0.5460.21
118_L347_M0.5450.21
65_V68_R0.5440.21
87_W174_T0.5430.21
132_Q399_F0.5430.21
2_N107_K0.5430.21
325_N448_A0.5420.21
141_G245_I0.5420.21
39_P147_A0.5420.21
5_I491_R0.5420.21
56_Q189_V0.5420.21
482_A489_H0.5420.21
313_V345_L0.5410.21
7_N97_E0.5400.21
159_G163_K0.5400.21
43_M150_N0.5400.21
63_D88_I0.5390.21
397_Y400_A0.5390.21
388_Y449_D0.5390.21
378_I381_I0.5380.21
227_G233_F0.5370.21
163_K353_N0.5370.21
478_T486_L0.5370.21
302_T417_E0.5350.21
427_S457_L0.5340.21
194_R316_D0.5340.21
118_L374_Y0.5320.21
49_A99_P0.5310.21
227_G234_W0.5310.21
397_Y403_F0.5310.21
98_H252_C0.5300.21
261_Y264_F0.5300.21
181_L444_D0.5300.21
448_A491_R0.5290.21
150_N352_N0.5290.21
14_R33_Q0.5270.21
64_D441_S0.5270.21
63_D339_P0.5250.20
307_W310_I0.5240.20
423_F478_T0.5240.20
351_R356_S0.5230.20
9_I196_Q0.5220.20
360_R424_Y0.5220.20
292_E362_H0.5210.20
435_L487_Y0.5210.20
73_N76_T0.5200.20
206_E442_Q0.5190.20
2_N449_D0.5180.20
285_L292_E0.5170.20
159_G234_W0.5170.20
32_D433_D0.5160.20
257_S476_I0.5160.20
152_A167_R0.5160.20
80_F399_F0.5150.20
100_F367_F0.5150.20
80_F483_R0.5140.20
116_K156_P0.5140.20
189_V231_G0.5140.20
272_T283_P0.5130.20
170_T282_S0.5130.20
55_G333_Q0.5120.20
69_H88_I0.5120.20
47_A175_F0.5110.20
41_D106_V0.5100.20
192_L195_L0.5100.20
99_P233_F0.5100.20
160_G237_A0.5100.20
288_V480_A0.5090.20
456_Q460_M0.5080.20
164_S356_S0.5080.20
120_G380_E0.5070.20
45_L59_A0.5070.20
122_S361_R0.5070.20
66_E268_K0.5060.20
291_G435_L0.5060.20
13_P30_S0.5060.20
440_F444_D0.5040.19
122_S190_L0.5040.19
117_L395_A0.5020.19
249_K455_H0.5010.19
82_Q456_Q0.5000.19
196_Q380_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7uA 1 0.9721 100 0.167 Contact Map
4an8A 1 0.8765 100 0.233 Contact Map
4h3tA 1 0.9303 100 0.233 Contact Map
3wvoA 2 0.9562 100 0.25 Contact Map
2f4zA 2 0.1235 8.8 0.98 Contact Map
4p40A 1 0.1414 8.5 0.98 Contact Map
2pwqA 1 0.1215 7.7 0.98 Contact Map
2bepA 1 0.1255 6.9 0.981 Contact Map
4r8pL 1 0.1235 6.4 0.981 Contact Map
3bzhA 2 0.1235 6.3 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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