GREMLIN Database
CASC - CRISPR system Cascade subunit CasC
UniProt: Q46899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13117
Length: 363 (331)
Sequences: 668 (543)
Seq/√Len: 29.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_T308_S10.6741.00
199_W214_L9.3081.00
31_F292_N4.4031.00
15_P29_A4.2781.00
189_T222_G4.1831.00
162_L182_M4.1001.00
259_A279_V4.0281.00
39_I44_L3.5641.00
236_Q247_A3.5591.00
189_T220_S2.9721.00
7_I255_V2.9721.00
7_I281_V2.7931.00
273_F286_M2.6741.00
124_E128_K2.6011.00
228_A258_L2.5520.99
158_V250_I2.5300.99
34_K297_A2.4510.99
37_V220_S2.3810.99
3_N233_A2.3670.99
5_I281_V2.2900.99
193_V220_S2.2720.99
200_F213_H2.2680.99
256_H260_T2.2600.99
85_Q89_D2.2040.98
278_M313_N2.2030.98
300_A307_P2.1770.98
181_A238_N2.1710.98
29_A188_I2.1430.98
13_H18_L2.1250.98
9_V48_M2.0960.98
230_I251_A2.0890.98
296_K311_A2.0730.98
78_K124_E2.0650.98
14_S274_N2.0600.98
267_Q273_F2.0550.97
115_V118_E2.0270.97
183_S268_R1.9350.96
227_Y287_P1.9200.96
74_V77_Q1.8900.96
15_P188_I1.8850.96
296_K306_Q1.8800.96
307_P311_A1.8590.95
73_D77_Q1.8330.95
6_N13_H1.8290.95
15_P270_Y1.8090.95
110_A118_E1.8010.95
74_V120_A1.7900.94
277_D315_Y1.7630.94
267_Q272_A1.7380.93
298_V307_P1.7350.93
191_H303_G1.7220.93
4_F231_N1.7030.93
231_N234_Q1.7000.93
17_C265_A1.6830.92
295_E303_G1.6170.91
288_L323_Y1.5980.90
25_M218_E1.5930.90
43_S47_A1.5830.90
38_R186_H1.5720.89
110_A169_S1.5630.89
96_S99_S1.5370.88
121_W126_V1.5370.88
6_N284_S1.5360.88
13_H262_V1.5290.88
51_S257_M1.4990.87
5_I283_F1.4980.87
141_K147_I1.4950.87
17_C219_F1.4910.87
200_F207_Q1.4820.86
307_P310_Q1.4800.86
252_T256_H1.4770.86
262_V272_A1.4720.86
189_T223_V1.4510.85
10_L305_L1.4470.85
189_T193_V1.4450.85
6_N11_I1.4030.83
318_R335_S1.3940.83
12_S221_S1.3300.79
47_A212_A1.3280.79
129_A133_N1.3260.79
139_L142_V1.3180.79
217_Q266_K1.3100.78
62_S159_D1.3100.78
11_I274_N1.3050.78
168_T177_K1.2770.77
67_H70_Q1.2750.77
110_A121_W1.2730.76
234_Q237_E1.2570.75
232_L251_A1.2550.75
167_A171_M1.2260.74
118_E126_V1.2140.73
125_Q150_I1.2140.73
70_Q73_D1.2080.72
47_A211_S1.2020.72
111_V115_V1.1770.70
110_A115_V1.1750.70
116_V120_A1.1730.70
44_L261_E1.1700.70
299_K302_D1.1700.70
31_F277_D1.1510.69
37_V189_T1.1500.69
28_D35_R1.1270.67
327_G330_A1.1130.66
310_Q317_D1.1100.66
306_Q310_Q1.1070.66
306_Q309_I1.1070.66
19_N45_K1.1010.65
110_A113_P1.0940.65
217_Q269_T1.0900.64
310_Q314_Q1.0840.64
7_I258_L1.0840.64
219_F270_Y1.0820.64
6_N229_N1.0820.64
179_D332_F1.0820.64
132_D135_D1.0780.64
17_C24_N1.0760.63
39_I74_V1.0710.63
11_I284_S1.0680.63
169_S323_Y1.0620.62
304_F308_S1.0580.62
232_L248_L1.0570.62
81_E84_D1.0570.62
78_K127_A1.0490.61
259_A275_P1.0440.61
75_L127_A1.0410.61
13_H44_L1.0410.61
92_L96_S1.0410.61
26_Q265_A1.0330.60
155_Q178_V1.0310.60
95_L108_A1.0310.60
85_Q93_A1.0300.60
6_N14_S1.0260.60
92_L97_G1.0240.60
310_Q331_Q1.0210.59
260_T286_M1.0200.59
178_V238_N1.0190.59
19_N40_S1.0150.59
183_S273_F1.0100.58
6_N282_N1.0060.58
118_E133_N1.0030.58
115_V123_C1.0000.58
71_L299_K1.0000.58
95_L150_I0.9990.58
29_A191_H0.9980.58
16_S29_A0.9920.57
47_A226_R0.9830.56
317_D321_N0.9770.56
10_L309_I0.9770.56
254_V258_L0.9740.56
171_M177_K0.9690.55
157_G211_S0.9680.55
292_N319_V0.9610.55
303_G307_P0.9570.54
13_H224_F0.9550.54
16_S264_G0.9500.54
114_W118_E0.9500.54
74_V181_A0.9500.54
6_N44_L0.9470.54
63_L114_W0.9420.53
265_A270_Y0.9360.53
136_D311_A0.9300.52
57_N246_Q0.9200.51
191_H308_S0.9160.51
11_I223_V0.9150.51
282_N320_A0.9090.51
237_E332_F0.9060.50
61_S180_G0.9050.50
294_F297_A0.9050.50
17_C26_Q0.9020.50
123_C127_A0.9000.50
142_V145_E0.9000.50
200_F334_L0.9000.50
118_E121_W0.8980.50
29_A270_Y0.8950.49
5_I232_L0.8900.49
114_W133_N0.8860.49
66_I177_K0.8860.49
213_H217_Q0.8860.49
197_I265_A0.8850.49
16_S67_H0.8820.48
19_N38_R0.8810.48
286_M290_M0.8810.48
228_A254_V0.8810.48
326_N330_A0.8800.48
112_T133_N0.8790.48
114_W119_I0.8790.48
65_T219_F0.8790.48
13_H274_N0.8760.48
135_D138_K0.8740.48
231_N253_H0.8740.48
96_S100_V0.8730.48
272_A291_A0.8690.47
146_D301_K0.8690.47
28_D193_V0.8680.47
115_V133_N0.8650.47
22_D290_M0.8580.46
115_V126_V0.8560.46
223_V264_G0.8560.46
105_K108_A0.8500.46
123_C126_V0.8500.46
231_N262_V0.8480.46
185_A238_N0.8460.46
112_T119_I0.8450.45
10_L35_R0.8420.45
296_K301_K0.8420.45
273_F287_P0.8400.45
52_G258_L0.8350.45
221_S295_E0.8340.45
223_V276_A0.8320.44
138_K142_V0.8290.44
200_F215_G0.8290.44
119_I126_V0.8280.44
61_S189_T0.8270.44
200_F217_Q0.8260.44
115_V157_G0.8250.44
111_V202_A0.8240.44
186_H227_Y0.8240.44
314_Q318_R0.8230.44
79_L85_Q0.8220.44
336_D339_P0.8200.44
115_V119_I0.8170.43
35_R193_V0.8160.43
40_S45_K0.8150.43
6_N276_A0.8150.43
67_H208_E0.8110.43
141_K146_D0.8110.43
180_G265_A0.8090.43
227_Y273_F0.8030.42
300_A304_F0.8020.42
229_N286_M0.8000.42
234_Q303_G0.7970.42
217_Q270_Y0.7970.42
284_S288_L0.7940.41
12_S295_E0.7890.41
113_P222_G0.7880.41
29_A221_S0.7860.41
77_Q149_A0.7850.41
213_H315_Y0.7830.41
194_D264_G0.7810.40
272_A292_N0.7800.40
18_L264_G0.7800.40
277_D292_N0.7800.40
159_D215_G0.7780.40
311_A314_Q0.7770.40
143_L148_A0.7750.40
220_S289_S0.7740.40
183_S265_A0.7730.40
139_L143_L0.7730.40
84_D96_S0.7720.40
226_R258_L0.7720.40
91_T96_S0.7710.40
230_I255_V0.7700.40
118_E129_A0.7690.40
212_A215_G0.7690.40
188_I212_A0.7670.39
29_A219_F0.7650.39
186_H290_M0.7640.39
53_Y231_N0.7620.39
163_S196_D0.7610.39
6_N37_V0.7550.39
118_E123_C0.7540.38
34_K248_L0.7540.38
258_L274_N0.7540.38
30_I35_R0.7510.38
4_F287_P0.7510.38
43_S304_F0.7490.38
5_I338_D0.7490.38
63_L91_T0.7490.38
84_D88_I0.7460.38
52_G261_E0.7450.38
315_Y319_V0.7420.38
267_Q270_Y0.7420.38
156_Q212_A0.7420.38
74_V78_K0.7400.37
125_Q129_A0.7390.37
78_K86_K0.7380.37
52_G276_A0.7370.37
123_C132_D0.7350.37
226_R295_E0.7320.37
69_A177_K0.7320.37
16_S221_S0.7300.37
113_P118_E0.7300.37
7_I230_I0.7240.36
11_I226_R0.7240.36
26_Q168_T0.7210.36
3_N285_D0.7190.36
20_R27_K0.7190.36
19_N27_K0.7180.36
44_L284_S0.7150.36
248_L285_D0.7140.35
10_L169_S0.7130.35
37_V193_V0.7110.35
7_I158_V0.7100.35
46_R297_A0.7100.35
250_I255_V0.7090.35
116_V126_V0.7080.35
242_A251_A0.7080.35
66_I207_Q0.7070.35
285_D325_L0.7030.35
6_N274_N0.7020.35
253_H323_Y0.7000.34
75_L80_G0.6990.34
197_I272_A0.6980.34
170_G195_S0.6880.34
185_A227_Y0.6870.34
334_L337_V0.6860.33
126_V133_N0.6850.33
73_D128_K0.6850.33
334_L338_D0.6800.33
144_K148_A0.6780.33
48_M254_V0.6770.33
171_M209_Q0.6760.33
262_V274_N0.6750.33
8_H225_Y0.6750.33
71_L119_I0.6690.32
100_V271_A0.6690.32
14_S44_L0.6660.32
102_E106_I0.6660.32
86_K90_K0.6620.32
191_H304_F0.6620.32
157_G160_I0.6620.32
105_K109_D0.6610.32
95_L101_D0.6590.32
296_K322_G0.6580.32
33_G41_S0.6570.31
8_H289_S0.6570.31
88_I91_T0.6550.31
65_T178_V0.6520.31
230_I320_A0.6510.31
128_K301_K0.6500.31
226_R284_S0.6490.31
12_S191_H0.6490.31
120_A127_A0.6480.31
132_D136_D0.6480.31
162_L226_R0.6470.31
276_A284_S0.6460.31
168_T171_M0.6440.31
62_S158_V0.6410.30
60_E249_E0.6400.30
193_V219_F0.6400.30
266_K291_A0.6390.30
113_P126_V0.6380.30
116_V119_I0.6370.30
247_A318_R0.6360.30
74_V95_L0.6350.30
44_L224_F0.6340.30
185_A291_A0.6330.30
198_D271_A0.6310.30
95_L98_K0.6310.30
287_P293_A0.6300.30
228_A274_N0.6290.30
51_S54_Y0.6290.30
182_M222_G0.6280.30
34_K300_A0.6270.29
258_L262_V0.6270.29
221_S304_F0.6220.29
279_V316_W0.6210.29
38_R41_S0.6210.29
14_S286_M0.6210.29
111_V126_V0.6200.29
21_D38_R0.6200.29
27_K42_Q0.6180.29
19_N41_S0.6170.29
202_A213_H0.6170.29
68_L88_I0.6160.29
42_Q45_K0.6150.29
18_L44_L0.6140.29
28_D272_A0.6140.29
113_P121_W0.6140.29
274_N284_S0.6120.28
31_F303_G0.6090.28
141_K145_E0.6080.28
203_V293_A0.6080.28
177_K187_A0.6070.28
5_I273_F0.6060.28
195_S218_E0.6040.28
114_W123_C0.6030.28
69_A167_A0.6000.28
167_A224_F0.5980.28
6_N286_M0.5960.27
16_S237_E0.5960.27
94_L98_K0.5950.27
186_H287_P0.5940.27
13_H272_A0.5930.27
303_G308_S0.5920.27
13_H226_R0.5910.27
212_A301_K0.5900.27
44_L254_V0.5880.27
139_L147_I0.5870.27
180_G230_I0.5870.27
89_D106_I0.5870.27
105_K269_T0.5850.27
159_D202_A0.5840.27
21_D27_K0.5840.27
262_V273_F0.5840.27
189_T291_A0.5830.27
38_R45_K0.5830.27
190_T303_G0.5820.27
12_S223_V0.5820.27
189_T224_F0.5790.26
12_S178_V0.5790.26
12_S292_N0.5790.26
181_A324_G0.5780.26
33_G297_A0.5780.26
184_I271_A0.5780.26
48_M261_E0.5770.26
179_D185_A0.5730.26
33_G311_A0.5720.26
84_D87_I0.5720.26
168_T226_R0.5710.26
231_N238_N0.5700.26
223_V274_N0.5690.26
46_R50_K0.5680.26
20_R36_R0.5660.26
180_G251_A0.5660.26
333_S337_V0.5650.26
11_I14_S0.5650.26
23_M28_D0.5630.25
247_A251_A0.5620.25
112_T123_C0.5620.25
75_L79_L0.5620.25
288_L320_A0.5610.25
9_V258_L0.5600.25
26_Q171_M0.5600.25
261_E276_A0.5590.25
296_K302_D0.5580.25
149_A299_K0.5580.25
76_R306_Q0.5560.25
333_S338_D0.5560.25
68_L323_Y0.5550.25
133_N136_D0.5540.25
20_R32_G0.5540.25
5_I116_V0.5530.25
18_L208_E0.5520.25
96_S103_A0.5520.25
192_Q252_T0.5500.25
71_L312_F0.5470.24
108_A119_I0.5460.24
79_L118_E0.5440.24
48_M110_A0.5440.24
18_L39_I0.5440.24
191_H199_W0.5430.24
150_I160_I0.5420.24
44_L48_M0.5410.24
242_A339_P0.5410.24
292_N315_Y0.5400.24
89_D95_L0.5390.24
62_S269_T0.5380.24
182_M230_I0.5380.24
44_L262_V0.5380.24
239_L324_G0.5370.24
105_K125_Q0.5370.24
67_H207_Q0.5360.24
12_S23_M0.5350.24
63_L87_I0.5320.24
257_M310_Q0.5310.24
71_L178_V0.5310.24
313_N317_D0.5290.23
178_V181_A0.5270.23
121_W124_E0.5260.23
38_R290_M0.5250.23
322_G332_F0.5250.23
162_L189_T0.5240.23
19_N166_M0.5230.23
61_S159_D0.5230.23
38_R196_D0.5210.23
203_V210_G0.5200.23
111_V118_E0.5200.23
11_I44_L0.5190.23
149_A200_F0.5180.23
15_P219_F0.5170.23
119_I294_F0.5170.23
112_T148_A0.5160.23
110_A123_C0.5140.23
18_L61_S0.5140.23
14_S199_W0.5130.23
5_I239_L0.5120.22
119_I257_M0.5110.22
163_S199_W0.5100.22
47_A272_A0.5100.22
13_H229_N0.5090.22
188_I270_Y0.5090.22
267_Q286_M0.5090.22
32_G36_R0.5090.22
162_L220_S0.5070.22
156_Q178_V0.5060.22
62_S157_G0.5050.22
18_L333_S0.5050.22
142_V314_Q0.5050.22
204_D218_E0.5040.22
94_L148_A0.5040.22
101_D137_K0.5040.22
39_I279_V0.5030.22
66_I227_Y0.5020.22
182_M189_T0.5010.22
220_S284_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7uE 3 0.9807 100 0.093 Contact Map
3ps0A 1 0.7548 99.1 0.903 Contact Map
3u5rE 1 0.2672 7.3 0.981 Contact Map
3hryA 2 0.1791 6.3 0.981 Contact Map
3iynN 3 0.3085 5.8 0.982 Contact Map
1vkuA 1 0.2231 5.8 0.982 Contact Map
2lwjA 1 0.3058 5.5 0.982 Contact Map
1o1zA 1 0.2534 5.1 0.982 Contact Map
2qvtA 1 0.1901 4.9 0.982 Contact Map
3myfA 3 0.303 4.9 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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