GREMLIN Database
ISPD - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
UniProt: Q46893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13110
Length: 236 (218)
Sequences: 4396 (3419)
Seq/√Len: 231.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Q43_H3.7011.00
143_R153_H2.7901.00
57_A92_G2.7341.00
36_T39_E2.6711.00
120_L168_F2.6381.00
84_E87_D2.5751.00
37_I214_V2.5031.00
134_A204_L2.4291.00
104_V174_L2.4221.00
113_H208_R2.4181.00
60_P80_D2.2631.00
90_L94_K2.1921.00
53_R77_T2.1071.00
144_A204_L2.0871.00
173_L195_L2.0781.00
116_D133_L2.0681.00
48_H118_A2.0581.00
115_D119_R2.0111.00
143_R159_G1.9701.00
103_L168_F1.9531.00
171_R175_H1.9511.00
50_R118_A1.8661.00
156_D159_G1.8111.00
12_V45_L1.8091.00
21_M30_L1.7921.00
195_L200_F1.7911.00
141_M162_H1.7821.00
180_R184_E1.7741.00
9_C53_R1.7701.00
83_D87_D1.7331.00
132_I192_A1.6841.00
94_K179_T1.6721.00
129_T170_P1.6711.00
101_W124_S1.6561.00
128_R203_Q1.6511.00
137_V160_L1.6441.00
13_P57_A1.6101.00
176_D180_R1.6071.00
10_A45_L1.5481.00
142_K196_E1.5161.00
26_P62_D1.5101.00
57_A88_S1.5071.00
63_S80_D1.4981.00
38_L66_A1.4931.00
46_L75_Q1.4291.00
184_E197_Y1.4271.00
45_L117_L1.4191.00
124_S129_T1.4181.00
173_L200_F1.4131.00
132_I163_A1.4121.00
12_V42_V1.3921.00
141_M160_L1.3851.00
103_L121_L1.3701.00
46_L74_P1.3621.00
154_T196_E1.3561.00
113_H116_D1.3421.00
31_S34_N1.3401.00
142_K154_T1.3401.00
143_R155_V1.3271.00
84_E187_T1.3261.00
120_L205_V1.3171.00
9_C96_A1.3071.00
132_I151_I1.3071.00
43_H47_A1.3021.00
140_T154_T1.3011.00
138_R209_A1.2971.00
195_L198_C1.2921.00
9_C99_A1.2911.00
186_A197_Y1.2881.00
111_C223_A1.2841.00
137_V162_H1.2821.00
164_L207_G1.2731.00
21_M220_L1.2711.00
144_A161_W1.2671.00
162_H209_A1.2541.00
23_T30_L1.2531.00
119_R206_E1.2481.00
39_E43_H1.2341.00
134_A161_W1.2311.00
35_Q40_H1.2281.00
35_Q39_E1.2051.00
15_A81_G1.2021.00
120_L133_L1.1951.00
47_A114_Q1.1911.00
178_L194_A1.1831.00
123_L205_V1.1821.00
137_V141_M1.1721.00
58_I78_V1.1701.00
48_H51_V1.1671.00
53_R97_G1.1631.00
116_D208_R1.1581.00
221_A225_F1.1531.00
63_S67_Q1.1511.00
112_L117_L1.1471.00
129_T200_F1.1461.00
124_S131_G1.1461.00
140_T189_T1.1431.00
150_A201_H1.1301.00
172_E176_D1.1291.00
33_G224_E1.1231.00
44_A112_L1.0921.00
48_H114_Q1.0921.00
188_I194_A1.0911.00
93_L102_V1.0881.00
135_A207_G1.0861.00
124_S168_F1.0851.00
176_D200_F1.0701.00
90_L182_L1.0671.00
46_L54_V1.0631.00
91_A94_K1.0611.00
58_I66_A1.0561.00
96_A171_R1.0561.00
212_I222_L1.0511.00
33_G228_T1.0461.00
8_V121_L1.0441.00
99_A171_R1.0401.00
50_R122_A1.0371.00
178_L191_E1.0351.00
79_V95_A1.0341.00
177_C198_C1.0331.00
145_E152_A1.0261.00
11_V92_G1.0251.00
175_H179_T1.0221.00
86_A178_L1.0221.00
13_P89_V1.0171.00
135_A164_L1.0121.00
42_V70_L1.0011.00
133_L161_W0.9891.00
94_K175_H0.9891.00
170_P173_L0.9881.00
58_I63_S0.9741.00
135_A209_A0.9721.00
19_R84_E0.9711.00
63_S78_V0.9551.00
86_A188_I0.9521.00
32_I223_A0.9521.00
169_F195_L0.9481.00
31_S36_T0.9471.00
210_D226_Y0.9471.00
139_D162_H0.9471.00
133_L207_G0.9411.00
64_R67_Q0.9401.00
77_T95_A0.9391.00
181_A188_I0.9391.00
102_V171_R0.9361.00
129_T173_L0.9311.00
112_L116_D0.9271.00
111_C227_L0.9271.00
87_D182_L0.9191.00
188_I197_Y0.9191.00
224_E228_T0.9081.00
214_V223_A0.9030.99
136_P206_E0.9020.99
30_L220_L0.8980.99
101_W125_E0.8960.99
100_Q170_P0.8920.99
41_S44_A0.8880.99
101_W168_F0.8840.99
188_I193_S0.8820.99
17_F59_S0.8810.99
123_L203_Q0.8790.99
10_A51_V0.8760.99
221_A224_E0.8700.99
29_Y62_D0.8570.99
97_G175_H0.8510.99
29_Y66_A0.8480.99
118_A122_A0.8420.99
18_G26_P0.8390.99
138_R216_R0.8320.99
111_C212_I0.8320.99
59_S62_D0.8280.99
48_H121_L0.8260.99
181_A194_A0.8220.99
123_L128_R0.8170.99
55_V96_A0.8080.99
142_K151_I0.8020.99
39_E73_H0.8020.99
87_D91_A0.8010.99
8_V51_V0.7980.99
100_Q171_R0.7980.99
123_L131_G0.7960.99
141_M155_V0.7960.99
13_P41_S0.7930.99
98_D172_E0.7910.99
212_I226_Y0.7890.99
14_A38_L0.7870.99
179_T183_N0.7850.99
151_I163_A0.7820.99
55_V79_V0.7790.99
209_A218_E0.7770.98
176_D179_T0.7760.98
36_T40_H0.7750.98
177_C195_L0.7740.98
82_G87_D0.7710.98
44_A114_Q0.7670.98
79_V91_A0.7640.98
150_A203_Q0.7620.98
136_P161_W0.7600.98
68_L72_N0.7580.98
116_D119_R0.7570.98
31_S224_E0.7510.98
18_G28_Q0.7510.98
96_A99_A0.7410.98
222_L225_F0.7410.98
50_R125_E0.7370.98
178_L182_L0.7360.98
29_Y65_F0.7320.98
25_C65_F0.7300.98
114_Q118_A0.7290.98
180_R183_N0.7210.98
99_A172_E0.7190.97
143_R160_L0.7190.97
69_P73_H0.7170.97
101_W121_L0.7140.97
26_P59_S0.7100.97
101_W170_P0.7020.97
90_L175_H0.7010.97
9_C55_V0.7000.97
189_T193_S0.6980.97
124_S170_P0.6820.97
212_I223_A0.6800.96
142_K163_A0.6770.96
174_L191_E0.6740.96
90_L179_T0.6690.96
222_L226_Y0.6690.96
143_R152_A0.6690.96
181_A186_A0.6670.96
161_W204_L0.6670.96
8_V101_W0.6660.96
49_P118_A0.6570.96
122_A125_E0.6570.96
167_Q190_D0.6550.96
140_T157_R0.6540.96
137_V155_V0.6530.96
15_A59_S0.6510.96
48_H117_L0.6500.95
87_D187_T0.6490.95
111_C226_Y0.6480.95
21_M217_P0.6470.95
46_L76_I0.6420.95
42_V56_I0.6350.95
116_D164_L0.6310.95
130_G195_L0.6290.95
65_F68_L0.6290.95
144_A151_I0.6240.94
11_V55_V0.6240.94
174_L178_L0.6240.94
89_V104_V0.6170.94
155_V160_L0.6170.94
165_T190_D0.6160.94
92_G95_A0.6150.94
39_E69_P0.6120.94
74_P77_T0.6120.94
55_V95_A0.6110.94
64_R68_L0.6100.94
86_A181_A0.6090.94
155_V159_G0.6080.94
130_G169_F0.6070.94
26_P29_Y0.6070.94
145_E150_A0.6070.94
132_I142_K0.6030.93
101_W129_T0.6020.93
51_V103_L0.5970.93
131_G168_F0.5950.93
89_V178_L0.5950.93
138_R162_H0.5910.93
66_A78_V0.5910.93
29_Y58_I0.5900.93
89_V191_E0.5890.92
40_H227_L0.5870.92
218_E222_L0.5850.92
123_L126_T0.5850.92
50_R121_L0.5830.92
41_S108_A0.5830.92
12_V107_A0.5810.92
145_E159_G0.5800.92
51_V121_L0.5780.92
130_G200_F0.5770.92
36_T69_P0.5760.92
13_P108_A0.5730.91
128_R150_A0.5730.91
131_G205_V0.5720.91
88_S92_G0.5700.91
130_G170_P0.5690.91
9_C171_R0.5690.91
173_L176_D0.5630.91
138_R218_E0.5610.91
67_Q71_A0.5600.90
97_G171_R0.5600.90
103_L120_L0.5580.90
113_H210_D0.5570.90
144_A152_A0.5560.90
68_L71_A0.5530.90
79_V92_G0.5520.90
103_L124_S0.5500.90
15_A58_I0.5460.89
103_L117_L0.5430.89
126_T129_T0.5430.89
180_R198_C0.5410.89
106_D165_T0.5390.89
133_L205_V0.5390.89
9_C100_Q0.5360.89
146_P149_N0.5360.89
11_V93_L0.5330.88
54_V76_I0.5310.88
10_A54_V0.5300.88
122_A126_T0.5300.88
39_E70_L0.5280.88
8_V52_K0.5260.88
176_D198_C0.5250.87
86_A194_A0.5230.87
195_L199_G0.5210.87
13_P107_A0.5160.87
56_I78_V0.5160.87
17_F61_G0.5160.87
174_L195_L0.5150.86
28_Q108_A0.5150.86
66_A70_L0.5090.86
113_H211_N0.5090.86
134_A163_A0.5080.86
79_V88_S0.5060.86
146_P150_A0.5060.86
121_L168_F0.5050.85
142_K152_A0.5050.85
112_L133_L0.5040.85
181_A185_G0.5000.85
39_E72_N0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cvhA 2 0.9534 100 0.436 Contact Map
1i52A 2 0.9407 100 0.46 Contact Map
1w55A 4 0.8856 100 0.475 Contact Map
4zdqA 2 0.9534 100 0.479 Contact Map
2yc3A 2 0.9195 100 0.487 Contact Map
1vgwA 2 0.8856 100 0.489 Contact Map
4mybA 2 0.8856 100 0.489 Contact Map
3q80A 2 0.9322 100 0.491 Contact Map
2xwlA 2 0.9407 100 0.505 Contact Map
1vpaA 2 0.9237 100 0.51 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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