GREMLIN Database
YGBN - Inner membrane permease YgbN
UniProt: Q46892 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13108
Length: 454 (420)
Sequences: 5765 (3880)
Seq/√Len: 189.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_S312_P3.8801.00
46_P49_E3.5931.00
299_S302_H3.5311.00
347_I350_P3.3101.00
237_V241_T3.2181.00
277_P280_A3.2091.00
277_P281_L3.0281.00
13_G327_F2.9831.00
16_M38_L2.9771.00
81_H306_I2.8351.00
91_Y95_K2.7821.00
329_K333_E2.7681.00
424_S427_D2.7661.00
13_G39_V2.7201.00
246_I287_L2.6881.00
437_T441_F2.5951.00
353_P444_F2.5831.00
53_V333_E2.5731.00
338_K342_N2.5121.00
81_H302_H2.5031.00
91_Y237_V2.4941.00
199_I203_R2.4381.00
356_F440_G2.4221.00
91_Y94_R2.3781.00
445_L449_C2.3601.00
15_I19_L2.2981.00
238_A242_S2.1881.00
236_G239_L2.1861.00
359_S376_T2.1791.00
46_P50_V2.1341.00
342_N345_Q2.1221.00
113_G117_F2.0441.00
52_K56_A2.0321.00
192_V442_T2.0271.00
195_F199_I2.0001.00
56_A60_G1.9911.00
181_I184_A1.9851.00
412_S417_V1.9831.00
237_V240_V1.9611.00
165_V168_A1.9541.00
441_F445_L1.9531.00
19_L23_K1.9451.00
202_K206_A1.9431.00
271_L275_G1.9351.00
184_A188_P1.8891.00
86_E90_N1.8751.00
272_Q275_G1.8581.00
204_Q208_S1.8081.00
205_Y208_S1.7931.00
47_A50_V1.7861.00
247_P251_I1.7841.00
171_L399_A1.7811.00
413_G417_V1.7661.00
188_P192_V1.7541.00
73_A307_M1.7531.00
16_M35_V1.7471.00
238_A241_T1.7121.00
240_V243_L1.6991.00
103_A194_Y1.6981.00
280_A288_A1.6971.00
196_A200_I1.6801.00
384_V395_V1.6771.00
244_I251_I1.6771.00
430_K434_V1.6751.00
58_M66_T1.6751.00
149_G193_G1.6611.00
68_I321_T1.6561.00
412_S416_I1.6541.00
251_I254_G1.6531.00
200_I204_Q1.6391.00
355_A399_A1.6281.00
144_G421_L1.6271.00
360_L405_G1.6091.00
280_A285_L1.6011.00
364_A406_A1.5981.00
206_A210_E1.5891.00
339_A343_M1.5841.00
167_A373_I1.5691.00
16_M20_L1.5681.00
49_E52_K1.5551.00
243_L247_P1.5501.00
206_A209_V1.5461.00
434_V438_I1.5361.00
77_R81_H1.5321.00
425_V429_L1.5151.00
286_V290_W1.5151.00
208_S211_V1.5011.00
87_S91_Y1.5001.00
305_D309_S1.4921.00
252_M255_T1.4911.00
251_I255_T1.4881.00
254_G258_A1.4831.00
284_A288_A1.4711.00
201_N204_Q1.4691.00
273_L276_S1.4611.00
205_Y209_V1.4421.00
243_L251_I1.4381.00
206_A212_L1.4301.00
391_Q394_L1.4271.00
9_I42_A1.4151.00
98_D135_V1.4081.00
186_S190_G1.3971.00
328_G332_V1.3871.00
207_M210_E1.3821.00
302_H305_D1.3771.00
301_Q305_D1.3731.00
156_V404_L1.3701.00
385_M392_C1.3691.00
250_I283_I1.3651.00
209_V212_L1.3641.00
388_N391_Q1.3611.00
254_G259_T1.3581.00
240_V247_P1.3551.00
236_G240_V1.3521.00
289_F293_A1.3491.00
212_L215_M1.3431.00
237_V244_I1.3381.00
281_L289_F1.3321.00
435_L439_L1.3251.00
448_W451_W1.3101.00
277_P282_M1.3051.00
185_I446_I1.3051.00
253_A257_S1.2981.00
412_S415_W1.2971.00
81_H309_S1.2951.00
26_V31_A1.2941.00
179_T183_I1.2931.00
167_A171_L1.2911.00
17_L35_V1.2821.00
285_L289_F1.2771.00
196_A199_I1.2721.00
207_M211_V1.2721.00
114_I117_F1.2571.00
280_A291_L1.2571.00
281_L285_L1.2571.00
235_P239_L1.2531.00
246_I284_A1.2481.00
248_I251_I1.2461.00
204_Q209_V1.2441.00
239_L242_S1.2411.00
210_E213_E1.2401.00
255_T258_A1.2321.00
134_K140_P1.2311.00
272_Q276_S1.2281.00
186_S189_V1.2261.00
401_F447_T1.2241.00
237_V251_I1.2231.00
170_L377_G1.2201.00
204_Q211_V1.2181.00
247_P252_M1.2021.00
200_I203_R1.1921.00
405_G440_G1.1911.00
105_L111_F1.1821.00
185_I450_V1.1791.00
279_V285_L1.1751.00
198_K201_N1.1741.00
244_I247_P1.1731.00
53_V329_K1.1711.00
204_Q212_L1.1711.00
137_K207_M1.1701.00
77_R306_I1.1681.00
179_T184_A1.1681.00
321_T412_S1.1671.00
85_A89_A1.1641.00
193_G196_A1.1571.00
353_P448_W1.1531.00
433_T437_T1.1501.00
205_Y210_E1.1461.00
183_I187_I1.1421.00
61_V325_G1.1391.00
108_A111_F1.1351.00
187_I191_V1.1351.00
45_I53_V1.1281.00
387_L390_I1.1271.00
278_M281_L1.1261.00
271_L276_S1.1241.00
231_K234_P1.1231.00
56_A333_E1.1151.00
205_Y212_L1.1151.00
29_F319_L1.1071.00
278_M288_A1.1051.00
105_L109_A1.1051.00
426_A430_K1.1041.00
122_F420_Y1.1021.00
176_G179_T1.1021.00
235_P240_V1.0991.00
75_L284_A1.0981.00
90_N135_V1.0951.00
278_M282_M1.0891.00
248_I252_M1.0881.00
57_G329_K1.0881.00
275_G288_A1.0861.00
247_P250_I1.0841.00
178_L396_T1.0821.00
203_R206_A1.0791.00
38_L42_A1.0771.00
113_G121_G1.0701.00
82_S292_L1.0701.00
237_V242_S1.0661.00
211_V214_Q1.0661.00
208_S212_L1.0611.00
199_I202_K1.0601.00
405_G437_T1.0551.00
279_V283_I1.0551.00
275_G280_A1.0551.00
401_F443_G1.0541.00
179_T182_G1.0441.00
109_A112_L1.0371.00
233_N236_G1.0311.00
407_S411_D1.0301.00
35_V38_L1.0301.00
277_P288_A1.0291.00
112_L186_S1.0291.00
287_L291_L1.0281.00
53_V57_G1.0271.00
446_I450_V1.0271.00
242_S246_I1.0241.00
366_Q375_T1.0221.00
277_P285_L1.0151.00
273_L277_P1.0111.00
192_V195_F1.0091.00
180_I184_A1.0061.00
368_S371_V1.0051.00
173_A178_L1.0031.00
196_A204_Q0.9990.99
202_K205_Y0.9910.99
247_P254_G0.9890.99
285_L291_L0.9860.99
154_V161_H0.9830.99
254_G257_S0.9770.99
196_A434_V0.9760.99
43_A46_P0.9740.99
448_W452_A0.9720.99
250_I254_G0.9700.99
105_L108_A0.9650.99
78_M288_A0.9630.99
280_A292_L0.9630.99
13_G38_L0.9620.99
181_I397_L0.9600.99
359_S372_A0.9600.99
9_I43_A0.9580.99
418_T428_G0.9570.99
406_A433_T0.9570.99
84_G240_V0.9560.99
444_F448_W0.9550.99
166_A170_L0.9550.99
183_I186_S0.9530.99
258_A272_Q0.9500.99
154_V158_V0.9500.99
177_W181_I0.9490.99
356_F444_F0.9470.99
115_P121_G0.9470.99
90_N94_R0.9460.99
196_A438_I0.9430.99
280_A284_A0.9400.99
236_G241_T0.9400.99
203_R212_L0.9390.99
234_P238_A0.9380.99
54_M326_V0.9350.99
198_K202_K0.9350.99
249_A253_A0.9340.99
363_R372_A0.9340.99
270_T274_I0.9320.99
279_V292_L0.9280.99
414_F417_V0.9280.99
369_A407_S0.9230.99
233_N237_V0.9220.99
234_P237_V0.9200.99
49_E53_V0.9190.99
67_I71_L0.9180.99
436_T439_L0.9130.99
211_V215_M0.9120.99
253_A259_T0.9100.99
413_G416_I0.9100.99
105_L112_L0.9060.99
229_S233_N0.9060.99
432_W436_T0.9050.99
206_A211_V0.9040.99
10_A14_V0.9040.99
209_V213_E0.9020.99
191_V195_F0.8970.99
166_A169_G0.8950.99
280_A283_I0.8940.99
180_I183_I0.8900.99
363_R369_A0.8880.99
252_M256_V0.8880.99
117_F121_G0.8870.99
352_L390_I0.8840.99
117_F120_V0.8810.99
86_E232_I0.8800.99
385_M388_N0.8790.99
194_Y198_K0.8760.99
52_K55_I0.8730.99
204_Q210_E0.8720.99
443_G447_T0.8710.99
427_D430_K0.8670.99
145_L149_G0.8660.99
201_N205_Y0.8660.99
237_V247_P0.8580.98
39_V327_F0.8560.98
314_A318_I0.8540.98
20_L34_L0.8540.98
164_P168_A0.8530.98
246_I250_I0.8470.98
286_V292_L0.8470.98
364_A405_G0.8460.98
205_Y215_M0.8440.98
255_T259_T0.8430.98
235_P249_A0.8430.98
289_F292_L0.8400.98
238_A245_V0.8390.98
12_A16_M0.8380.98
253_A258_A0.8380.98
107_L111_F0.8370.98
254_G260_L0.8350.98
11_L15_I0.8350.98
174_D177_W0.8320.98
397_L447_T0.8310.98
31_A35_V0.8300.98
369_A403_G0.8270.98
103_A110_F0.8220.98
277_P286_V0.8220.98
120_V163_G0.8220.98
242_S245_V0.8220.98
203_R207_M0.8200.98
288_A292_L0.8180.98
166_A171_L0.8160.98
241_T259_T0.8150.98
204_Q207_M0.8130.98
177_W393_V0.8120.98
277_P292_L0.8110.98
177_W180_I0.8100.98
274_I278_M0.8070.98
153_T187_I0.8070.98
242_S291_L0.8060.98
347_I352_L0.8050.98
279_V282_M0.8030.98
197_A201_N0.8020.98
193_G197_A0.8010.98
145_L431_T0.7990.98
360_L440_G0.7940.97
407_S432_W0.7930.97
381_S385_M0.7920.97
388_N392_C0.7910.97
363_R411_D0.7910.97
204_Q213_E0.7900.97
206_A213_E0.7860.97
77_R309_S0.7840.97
335_G338_K0.7820.97
177_W183_I0.7800.97
233_N241_T0.7800.97
256_V260_L0.7790.97
243_L250_I0.7730.97
247_P255_T0.7710.97
104_A110_F0.7710.97
138_I142_K0.7690.97
209_V214_Q0.7660.97
200_I207_M0.7660.97
148_A415_W0.7640.97
394_L447_T0.7620.97
152_L436_T0.7610.97
256_V259_T0.7590.97
414_F418_T0.7580.97
442_T446_I0.7550.97
239_L243_L0.7530.96
413_G418_T0.7520.96
113_G116_V0.7510.96
271_L274_I0.7500.96
72_G310_A0.7480.96
278_M290_W0.7470.96
329_K332_V0.7460.96
27_Q30_V0.7420.96
276_S280_A0.7420.96
231_K235_P0.7400.96
205_Y211_V0.7370.96
231_K249_A0.7370.96
351_L395_V0.7360.96
133_A143_F0.7320.96
363_R403_G0.7310.96
103_A191_V0.7300.96
88_L240_V0.7290.96
129_I133_A0.7290.96
203_R208_S0.7280.96
373_I403_G0.7280.96
178_L182_G0.7280.96
241_T245_V0.7280.96
241_T244_I0.7270.96
372_A411_D0.7270.96
87_S237_V0.7260.96
240_V251_I0.7250.96
288_A291_L0.7240.96
9_I13_G0.7240.96
289_F307_M0.7220.96
238_A252_M0.7210.95
205_Y213_E0.7180.95
9_I12_A0.7180.95
394_L450_V0.7170.95
178_L393_V0.7140.95
206_A215_M0.7120.95
431_T434_V0.7120.95
360_L406_A0.7060.95
257_S260_L0.7050.95
38_L41_L0.7030.95
175_I178_L0.7020.95
236_G242_S0.7010.95
168_A175_I0.7010.95
347_I351_L0.7000.95
43_A334_S0.6960.95
188_P191_V0.6940.94
39_V330_V0.6920.94
439_L443_G0.6910.94
14_V17_L0.6900.94
121_G151_M0.6900.94
107_L110_F0.6900.94
166_A374_L0.6890.94
245_V252_M0.6860.94
235_P238_A0.6820.94
56_A59_G0.6820.94
201_N208_S0.6800.94
41_L47_A0.6800.94
236_G244_I0.6750.94
84_G87_S0.6730.93
201_N209_V0.6710.93
194_Y197_A0.6690.93
281_L288_A0.6690.93
199_I207_M0.6680.93
369_A412_S0.6680.93
236_G247_P0.6670.93
199_I205_Y0.6670.93
355_A380_L0.6660.93
152_L404_L0.6650.93
20_L31_A0.6640.93
372_A376_T0.6640.93
428_G432_W0.6640.93
243_L291_L0.6620.93
281_L293_A0.6620.93
238_A260_L0.6610.93
209_V215_M0.6570.93
9_I35_V0.6560.93
197_A200_I0.6550.93
188_P446_I0.6540.93
241_T247_P0.6530.92
48_G52_K0.6510.92
186_S192_V0.6510.92
203_R209_V0.6500.92
98_D136_A0.6490.92
147_V150_I0.6490.92
106_T190_G0.6480.92
108_A112_L0.6480.92
366_Q371_V0.6470.92
298_W303_T0.6460.92
446_I449_C0.6450.92
34_L38_L0.6440.92
105_L110_F0.6430.92
397_L401_F0.6410.92
176_G180_I0.6400.92
396_T439_L0.6390.92
157_A401_F0.6390.92
234_P240_V0.6370.92
173_A396_T0.6360.91
164_P369_A0.6340.91
252_M258_A0.6320.91
20_L26_V0.6310.91
300_L303_T0.6300.91
323_A327_F0.6270.91
16_M19_L0.6240.91
39_V336_V0.6230.91
349_L353_P0.6210.90
201_N207_M0.6210.90
355_A359_S0.6190.90
167_A170_L0.6180.90
244_I248_I0.6180.90
37_L279_V0.6170.90
116_V161_H0.6160.90
190_G194_Y0.6150.90
423_L427_D0.6140.90
292_L303_T0.6110.90
288_A293_A0.6090.90
49_E172_H0.6090.90
137_K205_Y0.6090.90
232_I235_P0.6060.89
189_V442_T0.6050.89
363_R407_S0.6050.89
207_M215_M0.6040.89
75_L285_L0.6020.89
279_V288_A0.6010.89
341_A375_T0.6010.89
232_I239_L0.6000.89
274_I277_P0.6000.89
57_G322_G0.6000.89
342_N346_M0.6000.89
236_G243_L0.5990.89
250_I253_A0.5980.89
115_P162_P0.5970.89
289_F303_T0.5970.89
45_I49_E0.5970.89
299_S303_T0.5960.89
234_P249_A0.5960.89
286_V291_L0.5950.89
45_I50_V0.5930.88
231_K236_G0.5910.88
238_A243_L0.5880.88
157_A443_G0.5880.88
348_D352_L0.5880.88
199_I206_A0.5880.88
177_W182_G0.5860.88
149_G432_W0.5860.88
281_L284_A0.5860.88
240_V250_I0.5840.88
77_R80_E0.5830.88
282_M286_V0.5820.87
337_G341_A0.5820.87
113_G120_V0.5820.87
447_T451_W0.5810.87
153_T439_L0.5810.87
293_A297_G0.5810.87
241_T254_G0.5800.87
362_L376_T0.5780.87
44_G47_A0.5780.87
408_H436_T0.5740.87
185_I188_P0.5740.87
126_A421_L0.5730.87
277_P290_W0.5730.87
240_V244_I0.5720.87
298_W302_H0.5710.86
175_I181_I0.5700.86
178_L184_A0.5680.86
250_I257_S0.5680.86
72_G123_I0.5670.86
208_S213_E0.5670.86
302_H306_I0.5660.86
227_K230_D0.5660.86
155_H159_P0.5650.86
255_T260_L0.5650.86
240_V255_T0.5640.86
274_I281_L0.5630.86
253_A260_L0.5630.86
207_M212_L0.5630.86
362_L366_Q0.5620.86
371_V375_T0.5600.85
373_I376_T0.5590.85
311_L315_A0.5570.85
115_P120_V0.5570.85
208_S215_M0.5560.85
178_L181_I0.5560.85
344_L358_I0.5560.85
339_A342_N0.5550.85
418_T421_L0.5550.85
9_I336_V0.5540.85
251_I257_S0.5530.85
139_S204_Q0.5510.84
103_A106_T0.5500.84
398_A402_G0.5490.84
191_V194_Y0.5470.84
433_T440_G0.5470.84
192_V438_I0.5460.84
226_T232_I0.5450.84
348_D351_L0.5440.84
233_N239_L0.5440.84
149_G197_A0.5430.84
200_I205_Y0.5430.84
412_S418_T0.5420.83
280_A293_A0.5410.83
230_D234_P0.5410.83
144_G423_L0.5400.83
195_F198_K0.5400.83
198_K204_Q0.5350.83
44_G49_E0.5350.83
376_T399_A0.5330.82
13_G43_A0.5330.82
145_L197_A0.5330.82
62_L322_G0.5330.82
174_D178_L0.5310.82
156_V369_A0.5310.82
53_V59_G0.5290.82
246_I249_A0.5290.82
145_L435_L0.5280.82
278_M292_L0.5280.82
161_H373_I0.5270.82
99_K228_L0.5270.82
354_A384_V0.5270.82
252_M259_T0.5260.82
155_H369_A0.5260.82
109_A154_V0.5250.82
9_I38_L0.5250.82
272_Q277_P0.5240.81
196_A201_N0.5230.81
153_T189_V0.5220.81
16_M23_K0.5200.81
210_E214_Q0.5190.81
238_A259_T0.5190.81
442_T445_L0.5190.81
305_D308_G0.5190.81
104_A111_F0.5180.81
121_G163_G0.5180.81
416_I421_L0.5180.81
90_N234_P0.5180.81
149_G435_L0.5180.81
243_L248_I0.5180.81
320_V374_L0.5180.81
287_L290_W0.5160.80
356_F360_L0.5160.80
203_R210_E0.5160.80
403_G407_S0.5160.80
185_I189_V0.5160.80
53_V56_A0.5150.80
75_L288_A0.5150.80
242_S247_P0.5150.80
390_I394_L0.5150.80
407_S436_T0.5150.80
181_I393_V0.5150.80
351_L387_L0.5140.80
40_A50_V0.5130.80
393_V397_L0.5110.80
414_F420_Y0.5110.80
380_L395_V0.5090.80
238_A244_I0.5080.79
12_A15_I0.5070.79
364_A433_T0.5070.79
185_I397_L0.5060.79
428_G431_T0.5060.79
129_I147_V0.5050.79
405_G436_T0.5050.79
195_F203_R0.5040.79
279_V284_A0.5020.79
198_K205_Y0.5020.79
142_K146_P0.5020.79
195_F202_K0.5020.79
133_A138_I0.5020.79
56_A329_K0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9692 100 0.58 Contact Map
4r0cA 3 0.9493 100 0.601 Contact Map
4f35D 2 0.8767 100 0.658 Contact Map
2cfqA 1 0.8172 82.1 0.945 Contact Map
2gfpA 2 0.7775 36.3 0.96 Contact Map
4pypA 1 0.4075 32.9 0.96 Contact Map
4zw9A 1 0.4317 25 0.963 Contact Map
4dx5A 3 0.3546 21.9 0.964 Contact Map
3vouA 4 0.2885 21.3 0.964 Contact Map
3aqpA 1 0.3282 21.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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