GREMLIN Database
YGBM - Putative hydroxypyruvate isomerase YgbM
UniProt: Q46891 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13107
Length: 258 (219)
Sequences: 14794 (10618)
Seq/√Len: 717.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_F201_A3.1291.00
88_D132_R3.1221.00
22_A52_N2.9711.00
46_Q50_E2.8281.00
220_N223_W2.7101.00
92_E136_H2.5881.00
31_A236_W2.5511.00
194_R227_L2.5051.00
123_I167_E2.4671.00
207_G215_D2.4241.00
47_K51_Q2.3891.00
92_E132_R2.3261.00
139_R174_F2.2121.00
139_R201_A2.1951.00
16_P19_E2.1531.00
141_L201_A2.1511.00
18_I48_Q2.1431.00
162_L195_D2.1351.00
95_L136_H2.1041.00
131_D170_R2.0971.00
119_R163_A1.9491.00
163_A167_E1.9271.00
22_A26_K1.9241.00
194_R230_E1.8421.00
101_Q141_L1.7941.00
227_L230_E1.7821.00
84_H128_Y1.7761.00
49_L56_L1.7521.00
48_Q51_Q1.7511.00
48_Q52_N1.7421.00
43_L96_A1.7121.00
91_L136_H1.7111.00
132_R135_P1.7031.00
81_H85_A1.7031.00
119_R167_E1.6801.00
188_N191_H1.6581.00
130_A173_V1.6401.00
162_L166_E1.5981.00
134_A172_N1.5691.00
79_R82_E1.5661.00
141_L176_Q1.5531.00
203_V228_F1.5531.00
120_A167_E1.5301.00
85_A89_L1.5281.00
132_R136_H1.5211.00
226_R230_E1.5211.00
25_R52_N1.5211.00
191_H195_D1.5031.00
123_I127_R1.5001.00
222_P226_R1.4701.00
117_R120_A1.4651.00
18_I51_Q1.4641.00
120_A124_D1.4641.00
94_A99_C1.4611.00
44_Q47_K1.4541.00
89_L92_E1.4371.00
207_G217_G1.4291.00
21_F52_N1.4221.00
190_T223_W1.4181.00
131_D135_P1.4091.00
91_L133_F1.3981.00
124_D127_R1.3921.00
179_T224_L1.3801.00
88_D128_Y1.3691.00
227_L231_V1.3631.00
80_E125_N1.3511.00
210_D213_E1.3431.00
23_A26_K1.3161.00
41_S44_Q1.3161.00
130_A168_V1.3091.00
85_A88_D1.2861.00
134_A170_R1.2771.00
174_F199_K1.2771.00
19_E22_A1.2751.00
157_S160_Q1.2581.00
101_Q139_R1.2541.00
44_Q48_Q1.2531.00
47_K50_E1.2481.00
123_I168_V1.2411.00
197_A231_V1.2401.00
84_H88_D1.2301.00
22_A48_Q1.2271.00
166_E199_K1.2251.00
137_G172_N1.2131.00
25_R53_H1.1991.00
121_V124_D1.1961.00
162_L196_Y1.1931.00
43_L47_K1.1901.00
161_A175_I1.1881.00
159_Y195_D1.1781.00
190_T194_R1.1741.00
128_Y131_D1.1661.00
91_L132_R1.1541.00
88_D92_E1.1471.00
91_L138_K1.1421.00
88_D135_P1.1271.00
228_F231_V1.1071.00
156_S160_Q1.1051.00
81_H128_Y1.1041.00
46_Q96_A1.0931.00
133_F140_I1.0921.00
223_W227_L1.0901.00
18_I44_Q1.0851.00
31_A57_A1.0801.00
192_L196_Y1.0771.00
162_L199_K1.0691.00
177_L182_A1.0651.00
134_A171_D1.0561.00
163_A166_E1.0431.00
29_F239_C1.0421.00
119_R123_I1.0371.00
194_R231_V1.0301.00
23_A27_A1.0281.00
21_F49_L1.0261.00
127_R168_V1.0201.00
87_I129_A1.0101.00
191_H194_R1.0051.00
39_N96_A1.0041.00
193_I231_V1.0021.00
130_A170_R1.0021.00
49_L54_L0.9981.00
33_E58_L0.9961.00
21_F48_Q0.9891.00
100_E139_R0.9811.00
76_L79_R0.9771.00
31_A55_T0.9711.00
180_F206_A0.9701.00
127_R131_D0.9691.00
144_A182_A0.9671.00
33_E202_H0.9581.00
101_Q201_A0.9541.00
34_F56_L0.9521.00
178_D240_E0.9471.00
24_A32_V0.9471.00
82_E85_A0.9471.00
219_I224_L0.9451.00
131_D134_A0.9391.00
206_A242_K0.9301.00
205_I221_Y0.9251.00
181_H206_A0.9221.00
190_T227_L0.9211.00
92_E96_A0.9191.00
59_F94_A0.9131.00
25_R30_D0.9101.00
92_E95_L0.9061.00
15_V23_A0.8971.00
127_R169_A0.8971.00
88_D136_H0.8961.00
175_I196_Y0.8931.00
116_E120_A0.8751.00
115_A160_Q0.8731.00
18_I22_A0.8711.00
221_Y225_F0.8681.00
130_A172_N0.8681.00
124_D128_Y0.8661.00
77_P81_H0.8611.00
94_A102_V0.8581.00
84_H125_N0.8571.00
119_R160_Q0.8571.00
158_Q195_D0.8551.00
114_D117_R0.8371.00
209_P218_E0.8311.00
22_A51_Q0.8311.00
57_A236_W0.8311.00
86_D89_L0.8301.00
159_Y163_A0.8301.00
115_A118_Y0.8281.00
49_L52_N0.8241.00
43_L46_Q0.8181.00
139_R172_N0.8111.00
225_F229_D0.8031.00
126_I173_V0.7981.00
223_W226_R0.7971.00
30_D55_T0.7971.00
103_H176_Q0.7931.00
193_I227_L0.7921.00
168_V173_V0.7921.00
116_E163_A0.7921.00
55_T100_E0.7881.00
165_V175_I0.7861.00
180_F208_L0.7861.00
165_V199_K0.7841.00
122_F164_I0.7701.00
158_Q187_G0.7701.00
183_Q218_E0.7681.00
56_L99_C0.7671.00
42_T96_A0.7661.00
95_L138_K0.7611.00
93_Y97_L0.7571.00
160_Q163_A0.7571.00
24_A29_F0.7511.00
129_A140_I0.7461.00
127_R170_R0.7451.00
155_F161_A0.7451.00
179_T221_Y0.7351.00
169_A172_N0.7331.00
42_T93_Y0.7331.00
128_Y132_R0.7231.00
155_F164_I0.7201.00
55_T236_W0.7201.00
205_I237_I0.7191.00
193_I200_Y0.7181.00
143_E240_E0.7111.00
121_V125_N0.7081.00
80_E124_D0.7061.00
150_K153_Y0.6991.00
176_Q202_H0.6981.00
78_G82_E0.6971.00
15_V19_E0.6961.00
62_A90_A0.6921.00
74_S79_R0.6911.00
117_R121_V0.6901.00
202_H238_G0.6901.00
84_H129_A0.6891.00
95_L137_G0.6861.00
225_F237_I0.6841.00
125_N128_Y0.6811.00
89_L93_Y0.6801.00
22_A25_R0.6771.00
18_I52_N0.6751.00
33_E238_G0.6741.00
76_L80_E0.6691.00
183_Q219_I0.6691.00
177_L193_I0.6661.00
127_R167_E0.6651.00
203_V237_I0.6641.00
60_N105_M0.6621.00
39_N43_L0.6571.00
19_E23_A0.6551.00
183_Q189_L0.6521.00
21_F32_V0.6521.00
40_Y44_Q0.6511.00
144_A161_A0.6451.00
78_G81_H0.6441.00
102_V133_F0.6431.00
90_A102_V0.6411.00
46_Q98_N0.6351.00
21_F25_R0.6321.00
126_I164_I0.6301.00
45_I48_Q0.6291.00
42_T97_L0.6271.00
193_I196_Y0.6261.00
133_F138_K0.6241.00
130_A140_I0.6241.00
232_G235_G0.6241.00
80_E121_V0.6221.00
39_N42_T0.6211.00
143_E204_Q0.6191.00
182_A192_L0.6191.00
21_F54_L0.6191.00
198_G231_V0.6191.00
84_H87_I0.6171.00
197_A200_Y0.6161.00
193_I197_A0.6141.00
20_R24_A0.6131.00
203_V233_Y0.6121.00
130_A134_A0.5991.00
177_L192_L0.5981.00
21_F45_I0.5951.00
101_Q202_H0.5921.00
104_V140_I0.5891.00
165_V169_A0.5871.00
197_A227_L0.5841.00
123_I164_I0.5841.00
131_D172_N0.5781.00
193_I224_L0.5761.00
144_A155_F0.5761.00
202_H233_Y0.5761.00
228_F233_Y0.5761.00
162_L165_V0.5751.00
206_A241_Y0.5721.00
59_F99_C0.5691.00
77_P121_V0.5671.00
77_P80_E0.5621.00
158_Q191_H0.5611.00
164_I168_V0.5601.00
205_I225_F0.5591.00
94_A138_K0.5581.00
80_E84_H0.5541.00
25_R54_L0.5541.00
193_I228_F0.5531.00
74_S83_A0.5511.00
169_A199_K0.5501.00
57_A238_G0.5491.00
39_N97_L0.5481.00
49_L53_H0.5471.00
177_L200_Y0.5461.00
158_Q196_Y0.5451.00
100_E137_G0.5441.00
178_D206_A0.5431.00
119_R164_I0.5421.00
161_A165_V0.5421.00
175_I200_Y0.5381.00
229_D232_G0.5381.00
72_G125_N0.5381.00
72_G75_A0.5381.00
82_E86_D0.5371.00
158_Q162_L0.5371.00
143_E181_H0.5351.00
202_H236_W0.5321.00
122_F126_I0.5321.00
84_H132_R0.5301.00
58_L103_H0.5291.00
42_T46_Q0.5281.00
179_T205_I0.5281.00
214_P217_G0.5261.00
120_A123_I0.5251.00
204_Q238_G0.5241.00
107_G110_P0.5221.00
196_Y200_Y0.5201.00
60_N103_H0.5191.00
203_V224_L0.5181.00
95_L100_E0.5171.00
17_F45_I0.5161.00
105_M181_H0.5141.00
133_F136_H0.5131.00
50_E96_A0.5131.00
165_V173_V0.5131.00
130_A133_F0.5111.00
184_K208_L0.5101.00
229_D237_I0.5091.00
183_Q208_L0.5080.99
168_V171_D0.5080.99
92_E135_P0.5070.99
61_T90_A0.5030.99
180_F242_K0.5030.99
141_L174_F0.5000.99
33_E204_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k77A 1 1 100 0.16 Contact Map
3ngfA 1 0.9961 100 0.196 Contact Map
3kwsA 2 0.969 100 0.238 Contact Map
1i60A 1 0.9574 100 0.238 Contact Map
2qulA 2 0.9651 100 0.243 Contact Map
2hk0A 3 0.9612 100 0.245 Contact Map
3qc0A 2 0.9612 100 0.245 Contact Map
2zvrA 2 0.9729 100 0.246 Contact Map
3wqoA 2 0.9651 100 0.249 Contact Map
3vylA 4 0.9651 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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