GREMLIN Database
YGBL - Putative aldolase class 2 protein YgbL
UniProt: Q46890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13106
Length: 212 (188)
Sequences: 6371 (3774)
Seq/√Len: 275.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_A69_E4.9331.00
172_E176_E3.2431.00
189_K193_I3.1651.00
103_W193_I3.1221.00
43_N63_K3.0201.00
112_G195_G2.6851.00
11_L37_L2.6261.00
44_L84_L2.5371.00
45_L61_L2.5341.00
14_E175_Q2.4181.00
144_K148_Q2.2911.00
93_C170_C2.2171.00
106_A193_I2.1061.00
102_T189_K2.0951.00
43_N71_L2.0941.00
85_A148_Q2.0891.00
103_W189_K2.0871.00
9_Q13_E2.0761.00
103_W192_F1.9931.00
16_T58_P1.9091.00
37_L174_L1.8821.00
13_E17_R1.8771.00
85_A88_R1.8441.00
57_D60_R1.8291.00
159_A184_L1.8111.00
45_L63_K1.8091.00
97_V177_A1.7971.00
137_P163_A1.7931.00
39_L45_L1.7681.00
94_K173_S1.7111.00
193_I196_D1.7111.00
21_S25_R1.6991.00
95_A174_L1.6731.00
173_S176_E1.6661.00
15_M35_L1.6461.00
90_N93_C1.6381.00
64_V80_V1.6261.00
10_S14_E1.5861.00
18_I178_A1.5771.00
139_Y149_D1.5761.00
111_Q163_A1.5331.00
25_R182_E1.4931.00
13_E58_P1.4911.00
16_T20_S1.4851.00
171_G176_E1.4831.00
134_P157_N1.4721.00
67_D88_R1.4341.00
167_P184_L1.4191.00
102_T106_A1.4031.00
37_L95_A1.3891.00
89_N151_A1.3891.00
15_M61_L1.3651.00
89_N155_A1.3321.00
99_L181_M1.3281.00
100_H165_H1.3181.00
85_A89_N1.2971.00
20_S24_Q1.2731.00
169_V181_M1.2481.00
107_L195_G1.2421.00
40_P43_N1.2321.00
44_L66_A1.2301.00
46_A77_S1.2301.00
84_L88_R1.2251.00
98_H165_H1.2181.00
21_S24_Q1.2141.00
137_P152_E1.2081.00
36_S96_V1.1971.00
36_S87_Y1.1871.00
38_L94_K1.1751.00
102_T186_E1.1621.00
158_Q180_N1.1581.00
111_Q200_R1.1511.00
105_T108_S1.1501.00
16_T61_L1.1441.00
162_L168_V1.1411.00
103_W185_E1.1331.00
149_D152_E1.1311.00
104_S167_P1.1301.00
191_I195_G1.1201.00
185_E189_K1.1111.00
22_F35_L1.1031.00
87_Y96_V1.1001.00
48_P51_S1.0921.00
51_S60_R1.0811.00
23_F54_G1.0791.00
99_L167_P1.0781.00
39_L63_K1.0701.00
148_Q152_E1.0671.00
22_F97_V1.0661.00
197_R200_R1.0631.00
150_L162_L1.0481.00
18_I174_L1.0461.00
192_F196_D1.0451.00
186_E189_K1.0441.00
137_P149_D1.0321.00
104_S184_L1.0321.00
159_A169_V1.0121.00
154_A170_C1.0051.00
70_W73_G0.9971.00
65_A71_L0.9931.00
44_L80_V0.9921.00
19_A35_L0.9771.00
136_V149_D0.9631.00
195_G198_P0.9621.00
25_R178_A0.9391.00
60_R74_D0.9281.00
145_R148_Q0.9271.00
120_R191_I0.9241.00
109_C122_F0.9231.00
56_L60_R0.9091.00
63_K72_S0.9091.00
66_A88_R0.9081.00
102_T193_I0.9071.00
22_F178_A0.9071.00
14_E17_R0.9011.00
16_T56_L0.9001.00
90_N170_C0.8971.00
136_V139_Y0.8931.00
18_I35_L0.8911.00
125_Y130_M0.8891.00
14_E37_L0.8871.00
138_Y142_G0.8851.00
171_G180_N0.8821.00
44_L64_V0.8801.00
62_S75_K0.8711.00
154_A160_F0.8671.00
11_L39_L0.8631.00
39_L43_N0.8561.00
97_V181_M0.8551.00
101_S104_S0.8551.00
86_L93_C0.8401.00
133_V184_L0.8381.00
48_P61_L0.8381.00
47_T56_L0.8351.00
167_P181_M0.8270.99
106_A192_F0.8260.99
139_Y142_G0.8240.99
198_P201_Y0.8230.99
176_E180_N0.8170.99
82_F150_L0.8150.99
55_N175_Q0.8150.99
85_A151_A0.8120.99
38_L66_A0.8090.99
136_V153_L0.8050.99
101_S181_M0.8050.99
136_V162_L0.7990.99
86_L154_A0.7920.99
89_N152_E0.7910.99
12_R72_S0.7870.99
82_F168_V0.7810.99
112_G198_P0.7800.99
46_A79_E0.7730.99
152_E155_A0.7660.99
21_S178_A0.7640.99
17_R55_N0.7620.99
94_K172_E0.7460.99
118_V188_A0.7430.99
145_R149_D0.7430.99
88_R151_A0.7390.99
10_S13_E0.7300.99
101_S185_E0.7250.99
11_L14_E0.7240.99
134_P160_F0.7230.99
36_S46_A0.7190.99
49_T75_K0.7160.99
79_E146_I0.7150.99
127_V131_G0.7120.98
47_T87_Y0.7100.98
119_I191_I0.7050.98
108_S161_L0.7040.98
26_G189_K0.7030.98
30_G179_N0.7020.98
197_R201_Y0.7020.98
85_A144_K0.7010.98
107_L191_I0.7000.98
132_N157_N0.6920.98
42_G66_A0.6920.98
38_L42_G0.6860.98
19_A53_L0.6830.98
22_F27_Y0.6810.98
176_E179_N0.6790.98
12_R45_L0.6790.98
68_G84_L0.6740.98
120_R201_Y0.6720.98
81_L144_K0.6700.98
80_V84_L0.6640.98
163_A200_R0.6640.98
105_T190_L0.6630.98
31_S49_T0.6590.98
140_R145_R0.6580.97
49_T77_S0.6540.97
153_L160_F0.6530.97
34_N79_E0.6520.97
34_N77_S0.6510.97
110_L194_L0.6450.97
124_P127_V0.6440.97
125_Y128_M0.6440.97
184_L188_A0.6430.97
90_N158_Q0.6400.97
151_A154_A0.6360.97
127_V130_M0.6350.97
63_K71_L0.6350.97
33_G53_L0.6340.97
95_A177_A0.6340.97
51_S56_L0.6320.97
29_T186_E0.6260.97
90_N154_A0.6240.97
86_L168_V0.6170.96
43_N66_A0.6150.96
15_M45_L0.6130.96
128_M131_G0.6100.96
38_L44_L0.6090.96
55_N60_R0.6070.96
169_V180_N0.6060.96
107_L188_A0.6030.96
105_T166_G0.6030.96
12_R58_P0.5990.96
23_F29_T0.5980.96
133_V159_A0.5960.96
97_V169_V0.5950.95
28_A35_L0.5930.95
101_S167_P0.5920.95
160_F168_V0.5880.95
24_Q54_G0.5860.95
21_S30_G0.5860.95
23_F28_A0.5850.95
118_V132_N0.5840.95
110_L192_F0.5800.95
121_P195_G0.5780.95
11_L45_L0.5750.95
62_S70_W0.5730.94
194_L197_R0.5700.94
110_L198_P0.5680.94
17_R20_S0.5640.94
23_F53_L0.5610.94
118_V135_L0.5600.94
52_C55_N0.5580.94
15_M19_A0.5580.94
122_F191_I0.5570.94
128_M179_N0.5560.94
104_S188_A0.5560.94
158_Q176_E0.5550.93
29_T32_A0.5550.93
66_A84_L0.5530.93
12_R61_L0.5510.93
158_Q172_E0.5470.93
103_W106_A0.5450.93
149_D153_L0.5440.93
92_R172_E0.5440.93
123_T126_V0.5440.93
161_L167_P0.5440.93
106_A190_L0.5430.93
25_R30_G0.5430.93
107_L192_F0.5420.93
32_A186_E0.5410.93
9_Q12_R0.5390.92
151_A155_A0.5380.92
14_E174_L0.5360.92
104_S161_L0.5340.92
81_L85_A0.5320.92
87_Y95_A0.5300.92
49_T78_K0.5300.92
89_N160_F0.5280.92
104_S181_M0.5260.92
12_R48_P0.5230.91
144_K147_A0.5180.91
19_A56_L0.5150.91
64_V84_L0.5150.91
65_A68_G0.5140.91
179_N186_E0.5130.91
9_Q58_P0.5120.90
164_N200_R0.5110.90
153_L156_D0.5090.90
86_L96_V0.5090.90
15_M37_L0.5080.90
12_R63_K0.5060.90
138_Y162_L0.5050.90
126_V130_M0.5050.90
35_L174_L0.5050.90
34_N49_T0.5020.90
128_M180_N0.5000.89
119_I122_F0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ocrA 4 0.9764 100 0.149 Contact Map
4c24A 3 0.9623 100 0.163 Contact Map
1e4cP 3 0.9434 100 0.165 Contact Map
2opiA 3 0.9528 100 0.173 Contact Map
4xxfA 3 0.9434 100 0.192 Contact Map
2z7bA 3 0.9481 100 0.197 Contact Map
2v9lA 3 0.967 100 0.205 Contact Map
1k0wA 3 0.9481 100 0.212 Contact Map
2fk5A 4 0.8821 100 0.217 Contact Map
2irpA 4 0.9057 100 0.22 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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