GREMLIN Database
YGBK - Uncharacterized protein YgbK
UniProt: Q46889 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13105
Length: 388 (368)
Sequences: 1795 (1358)
Seq/√Len: 70.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_E205_H4.8701.00
137_A152_S4.5171.00
293_Y296_E3.9001.00
124_V129_L3.5381.00
8_A14_A3.4131.00
198_L209_Q3.2401.00
184_E188_L3.2301.00
271_R276_A3.2161.00
127_G168_V3.1071.00
119_V203_E2.9591.00
100_D164_G2.8471.00
21_L45_A2.8201.00
103_M111_T2.8091.00
69_S105_A2.8071.00
151_D156_R2.6931.00
181_V208_I2.6901.00
99_T220_T2.6671.00
125_Y201_L2.6361.00
185_L196_A2.6201.00
96_G161_Q2.5881.00
170_S173_V2.5701.00
171_A175_E2.5581.00
221_G225_L2.5091.00
295_H299_E2.4101.00
298_A347_R2.3971.00
55_C63_Q2.3651.00
254_V357_I2.3571.00
91_A160_A2.3531.00
153_Y156_R2.3491.00
173_V184_E2.3131.00
169_V198_L2.2421.00
184_E187_R2.1991.00
112_V213_L2.1861.00
302_L351_E2.1661.00
276_A313_F2.1491.00
27_P44_D2.1291.00
280_D283_R2.1141.00
23_E381_T2.0721.00
6_V17_I2.0721.00
80_Y225_L2.0431.00
56_P59_E2.0241.00
155_P168_V2.0231.00
127_G199_D2.0161.00
68_L102_L1.9931.00
103_M108_T1.9331.00
100_D162_S1.9301.00
116_A200_A1.9281.00
188_L196_A1.9221.00
269_H272_Q1.9151.00
346_A370_S1.9051.00
145_P148_P1.8641.00
99_T158_V1.8501.00
210_G228_G1.8361.00
349_A356_F1.8361.00
256_S263_T1.8201.00
164_G194_R1.8041.00
295_H347_R1.7791.00
253_V356_F1.7791.00
269_H273_I1.7741.00
5_G71_L1.7611.00
68_L105_A1.7431.00
65_L105_A1.7271.00
131_V136_L1.7181.00
255_L345_A1.7011.00
109_P189_Q1.6981.00
113_F195_Y1.6861.00
305_E308_L1.6671.00
283_R296_E1.6661.00
62_Q66_A1.6581.00
268_A272_Q1.6350.99
367_V371_L1.6170.99
275_P308_L1.5960.99
81_F98_V1.5770.99
153_Y168_V1.5720.99
81_F86_T1.5720.99
150_T160_A1.5560.99
182_R215_D1.5440.99
173_V180_A1.5380.99
267_V311_L1.5320.99
169_V181_V1.5320.99
128_Y135_L1.5060.99
100_D195_Y1.4880.99
251_R354_T1.4840.99
253_V348_L1.4820.99
301_V312_V1.4780.99
296_E300_W1.4590.99
110_F196_A1.4370.99
167_G192_G1.4330.99
121_G132_M1.4240.98
358_V364_S1.3980.98
135_L152_S1.3970.98
61_T104_D1.3970.98
64_S81_F1.3940.98
16_D221_G1.3730.98
174_F177_G1.3710.98
183_Q187_R1.3620.98
19_S381_T1.3600.98
171_A205_H1.3550.98
16_D260_S1.3470.98
124_V200_A1.3440.98
58_V62_Q1.3430.98
7_I50_L1.3380.98
221_G229_L1.3330.98
181_V209_Q1.3330.98
104_D164_G1.3150.97
363_T385_A1.3090.97
167_G193_Y1.3030.97
61_T101_A1.2910.97
261_Q265_R1.2780.97
167_G188_L1.2760.97
54_S147_N1.2680.97
284_C340_L1.2630.97
113_F197_V1.2590.97
174_F200_A1.2580.97
264_N315_T1.2350.96
18_A47_V1.2330.96
202_T205_H1.2290.96
141_M147_N1.2200.96
141_M144_H1.2180.96
174_F212_A1.2150.96
16_D223_S1.2070.96
96_G162_S1.2020.96
113_F220_T1.1940.95
100_D163_T1.1910.95
174_F209_Q1.1900.95
127_G155_P1.1820.95
226_A230_A1.1770.95
167_G194_R1.1640.95
79_I106_L1.1620.95
169_V209_Q1.1550.95
178_V211_E1.1510.94
21_L226_A1.1430.94
222_G225_L1.1430.94
346_A350_A1.1420.94
27_P377_H1.1400.94
310_P313_F1.1390.94
221_G226_A1.1360.94
97_P101_A1.1350.94
234_A237_N1.1280.94
262_M265_R1.1270.94
29_V43_I1.1250.94
126_Q170_S1.1240.94
61_T97_P1.1230.94
72_Q105_A1.1140.93
58_V92_K1.1100.93
159_E166_C1.1100.93
301_V348_L1.1100.93
210_G232_Q1.1070.93
135_L138_E1.0970.93
91_A157_L1.0960.93
80_Y221_G1.0950.93
221_G385_A1.0770.92
70_W74_Q1.0690.92
61_T65_L1.0610.92
65_L104_D1.0570.91
175_E201_L1.0570.91
120_N223_S1.0570.91
275_P304_Q1.0520.91
113_F158_V1.0490.91
54_S146_V1.0480.91
299_E303_G1.0480.91
378_I387_R1.0410.91
117_L381_T1.0390.91
238_G242_R1.0380.91
181_V212_A1.0360.91
222_G387_R1.0360.91
16_D82_K1.0310.90
279_V340_L1.0280.90
108_T217_P1.0240.90
28_T47_V1.0240.90
278_E313_F1.0200.90
359_A364_S1.0140.90
20_F223_S1.0140.90
134_Q153_Y1.0130.90
116_A224_G1.0120.90
52_T63_Q1.0100.89
9_D13_G1.0090.89
283_R293_Y1.0080.89
99_T195_Y1.0050.89
334_S382_I1.0020.89
155_P166_C0.9980.89
207_E231_R0.9960.89
18_A362_E0.9880.88
125_Y130_F0.9860.88
15_T337_V0.9860.88
171_A174_F0.9860.88
294_A344_L0.9820.88
103_M194_R0.9780.88
169_V185_L0.9710.88
111_T220_T0.9700.88
82_K221_G0.9670.87
271_R274_A0.9660.87
340_L344_L0.9600.87
174_F198_L0.9510.86
69_S73_Q0.9490.86
180_A183_Q0.9480.86
117_L120_N0.9480.86
294_A340_L0.9480.86
347_R351_E0.9450.86
298_A344_L0.9430.86
177_G212_A0.9320.85
176_Q249_A0.9310.85
345_A367_V0.9300.85
52_T64_S0.9300.85
137_A142_R0.9260.85
172_H183_Q0.9180.84
182_R211_E0.9170.84
165_R193_Y0.9130.84
10_D13_G0.9130.84
128_Y152_S0.9100.84
275_P300_W0.9080.84
19_S120_N0.9060.84
188_L193_Y0.9030.83
128_Y153_Y0.9010.83
298_A302_L0.9000.83
204_H207_E0.8980.83
20_F117_L0.8970.83
158_V195_Y0.8940.83
16_D385_A0.8940.83
282_A285_L0.8940.83
183_Q186_A0.8940.83
16_D387_R0.8910.83
174_F181_V0.8890.83
156_R159_E0.8890.83
118_P224_G0.8840.82
49_S365_G0.8820.82
207_E228_G0.8790.82
142_R152_S0.8790.82
180_A184_E0.8770.82
178_V208_I0.8750.82
127_G170_S0.8700.81
68_L218_L0.8680.81
383_S386_C0.8660.81
55_C59_E0.8650.81
128_Y137_A0.8650.81
87_F364_S0.8580.80
76_C79_I0.8540.80
91_A98_V0.8420.79
64_S102_L0.8410.79
125_Y133_N0.8380.79
177_G180_A0.8380.79
342_S366_V0.8370.79
136_L139_S0.8350.78
8_A47_V0.8320.78
225_L229_L0.8310.78
256_S359_A0.8300.78
299_E302_L0.8250.78
114_S209_Q0.8250.78
119_V357_I0.8220.77
57_V61_T0.8220.77
4_I45_A0.8190.77
300_W304_Q0.8170.77
330_A334_S0.8170.77
134_Q138_E0.8160.77
144_H260_S0.8150.77
140_G261_Q0.8130.77
30_Q86_T0.8130.77
253_V301_V0.8100.76
230_A234_A0.8060.76
16_D30_Q0.8060.76
188_L192_G0.8040.76
111_T195_Y0.8000.75
82_K118_P0.7980.75
90_T139_S0.7960.75
259_C314_A0.7950.75
230_A235_Q0.7940.75
343_Q347_R0.7930.75
52_T81_F0.7920.75
358_V367_V0.7890.74
144_H148_P0.7870.74
270_Y274_A0.7860.74
200_A206_L0.7850.74
338_E373_I0.7840.74
121_G131_V0.7830.74
353_V356_F0.7830.74
177_G208_I0.7830.74
220_T279_V0.7800.73
225_L230_A0.7790.73
89_S385_A0.7760.73
292_A303_G0.7730.73
9_D12_T0.7730.73
220_T226_A0.7720.73
292_A295_H0.7710.73
138_E151_D0.7710.73
297_L344_L0.7690.72
219_V225_L0.7690.72
17_I338_E0.7680.72
317_S320_A0.7660.72
129_L136_L0.7650.72
339_T370_S0.7640.72
265_R295_H0.7600.72
149_M362_E0.7600.72
17_I226_A0.7570.71
19_S117_L0.7560.71
257_G363_T0.7550.71
230_A285_L0.7540.71
294_A298_A0.7530.71
218_L224_G0.7510.71
11_F141_M0.7490.70
277_R300_W0.7480.70
144_H149_M0.7450.70
173_V176_Q0.7450.70
222_G364_S0.7440.70
171_A201_L0.7440.70
321_L333_A0.7370.69
231_R234_A0.7360.69
175_E202_T0.7350.69
112_V198_L0.7330.69
252_G355_R0.7310.69
219_V222_G0.7260.68
87_F359_A0.7260.68
5_G382_I0.7250.68
63_Q66_A0.7180.67
11_F376_F0.7170.67
343_Q351_E0.7140.67
12_T145_P0.7120.67
78_Q232_Q0.7120.67
337_V341_F0.7100.66
15_T144_H0.7080.66
259_C315_T0.7060.66
182_R186_A0.7030.66
115_P223_S0.7020.65
141_M149_M0.7010.65
162_S195_Y0.6990.65
26_L44_D0.6990.65
114_S226_A0.6960.65
68_L106_L0.6940.65
207_E211_E0.6920.64
64_S98_V0.6920.64
293_Y297_L0.6900.64
173_V272_Q0.6870.64
139_S142_R0.6870.64
104_D163_T0.6870.64
11_F368_T0.6820.63
86_T221_G0.6810.63
98_V144_H0.6800.63
100_D167_G0.6790.63
11_F378_I0.6790.63
68_L107_D0.6790.63
91_A256_S0.6790.63
111_T216_A0.6790.63
100_D202_T0.6740.62
331_Q335_Q0.6740.62
68_L79_I0.6710.62
276_A311_L0.6710.62
322_A326_Q0.6710.62
61_T100_D0.6690.62
221_G224_G0.6680.62
107_D111_T0.6670.61
255_L341_F0.6670.61
95_I145_P0.6660.61
119_V227_I0.6640.61
138_E156_R0.6640.61
16_D224_G0.6640.61
120_N222_G0.6600.61
51_K365_G0.6600.61
20_F222_G0.6590.61
169_V196_A0.6590.61
264_N267_V0.6580.60
357_I363_T0.6580.60
334_S387_R0.6570.60
80_Y226_A0.6530.60
229_L233_W0.6490.59
243_K295_H0.6480.59
362_E365_G0.6470.59
110_F189_Q0.6460.59
241_A302_L0.6430.59
114_S210_G0.6420.59
15_T359_A0.6410.58
87_F141_M0.6390.58
16_D20_F0.6380.58
344_L347_R0.6370.58
222_G385_A0.6370.58
8_A157_L0.6360.58
8_A11_F0.6340.58
52_T98_V0.6340.58
383_S387_R0.6330.57
345_A356_F0.6330.57
145_P149_M0.6330.57
50_L144_H0.6320.57
126_Q133_N0.6320.57
284_C337_V0.6320.57
90_T115_P0.6300.57
259_C338_E0.6300.57
278_E320_A0.6290.57
364_S376_F0.6280.57
101_A105_A0.6270.57
54_S362_E0.6260.57
218_L267_V0.6240.56
271_R278_E0.6240.56
87_F338_E0.6240.56
6_V47_V0.6230.56
277_R312_V0.6220.56
60_A90_T0.6200.56
92_K98_V0.6190.56
17_I20_F0.6190.56
86_T144_H0.6180.56
222_G226_A0.6180.56
50_L362_E0.6170.56
176_Q339_T0.6150.55
75_G78_Q0.6140.55
142_R362_E0.6120.55
128_Y155_P0.6120.55
51_K362_E0.6120.55
58_V183_Q0.6110.55
23_E281_V0.6100.55
225_L385_A0.6100.55
62_Q183_Q0.6090.55
281_V337_V0.6060.54
158_V166_C0.6050.54
168_V199_D0.6050.54
164_G265_R0.6040.54
251_R307_V0.6020.54
221_G260_S0.6020.54
60_A101_A0.6010.54
16_D386_C0.6010.54
120_N385_A0.6010.54
78_Q81_F0.5990.53
314_A337_V0.5980.53
91_A154_L0.5980.53
201_L205_H0.5970.53
275_P372_G0.5970.53
139_S362_E0.5950.53
52_T251_R0.5950.53
51_K54_S0.5940.53
50_L67_A0.5930.53
332_K336_A0.5920.53
100_D165_R0.5910.52
359_A363_T0.5900.52
302_L350_A0.5900.52
162_S166_C0.5890.52
12_T142_R0.5880.52
312_V348_L0.5880.52
129_L147_N0.5870.52
8_A16_D0.5860.52
330_A339_T0.5850.52
99_T203_E0.5850.52
33_G372_G0.5840.52
267_V315_T0.5840.52
203_E228_G0.5830.51
49_S87_F0.5830.51
357_I385_A0.5830.51
101_A356_F0.5820.51
30_Q363_T0.5820.51
14_A47_V0.5790.51
117_L223_S0.5750.50
80_Y124_V0.5740.50
355_R364_S0.5740.50
5_G76_C0.5730.50
342_S348_L0.5730.50
179_D182_R0.5730.50
123_T126_Q0.5730.50
137_A151_D0.5710.50
81_F359_A0.5710.50
80_Y123_T0.5710.50
50_L379_G0.5700.50
359_A362_E0.5680.50
152_S184_E0.5670.50
173_V294_A0.5660.49
26_L233_W0.5660.49
30_Q114_S0.5660.49
38_K66_A0.5650.49
7_I60_A0.5650.49
15_T376_F0.5630.49
270_Y380_P0.5620.49
59_E62_Q0.5620.49
67_A71_L0.5620.49
346_A372_G0.5590.49
136_L144_H0.5590.49
214_R249_A0.5580.48
95_I157_L0.5560.48
170_S174_F0.5560.48
329_G332_K0.5540.48
16_D86_T0.5540.48
139_S144_H0.5530.48
228_G233_W0.5530.48
88_D115_P0.5530.48
87_F149_M0.5520.48
12_T144_H0.5520.48
265_R269_H0.5510.48
11_F63_Q0.5510.48
281_V301_V0.5510.48
270_Y309_A0.5500.47
226_A385_A0.5490.47
114_S387_R0.5480.47
208_I287_I0.5480.47
130_F213_L0.5460.47
94_N260_S0.5460.47
90_T131_V0.5450.47
47_V378_I0.5440.47
223_S262_M0.5440.47
104_D108_T0.5430.47
317_S375_G0.5430.47
65_L69_S0.5420.46
219_V383_S0.5420.46
282_A286_S0.5420.46
126_Q134_Q0.5410.46
31_I375_G0.5410.46
258_S361_G0.5400.46
107_D303_G0.5400.46
51_K86_T0.5390.46
279_V297_L0.5390.46
65_L101_A0.5390.46
263_T359_A0.5380.46
49_S144_H0.5380.46
103_M110_F0.5370.46
295_H305_E0.5370.46
11_F147_N0.5370.46
187_R306_S0.5370.46
76_C275_P0.5370.46
87_F95_I0.5360.46
158_V162_S0.5350.46
151_D338_E0.5350.46
134_Q139_S0.5330.45
295_H303_G0.5300.45
49_S364_S0.5290.45
32_N298_A0.5290.45
11_F17_I0.5280.45
94_N257_G0.5280.45
282_A328_Y0.5280.45
6_V50_L0.5280.45
265_R343_Q0.5270.45
110_F216_A0.5240.44
18_A136_L0.5240.44
15_T259_C0.5230.44
197_V225_L0.5220.44
64_S101_A0.5200.44
278_E316_A0.5180.44
69_S72_Q0.5180.44
127_G153_Y0.5180.44
246_R249_A0.5170.43
38_K160_A0.5170.43
8_A18_A0.5170.43
11_F381_T0.5160.43
47_V136_L0.5150.43
355_R359_A0.5150.43
16_D359_A0.5100.43
287_I356_F0.5090.42
241_A244_A0.5090.42
176_Q295_H0.5060.42
178_V181_V0.5060.42
12_T258_S0.5060.42
256_S317_S0.5050.42
16_D222_G0.5050.42
54_S334_S0.5050.42
15_T120_N0.5050.42
30_Q49_S0.5030.42
67_A301_V0.5030.42
20_F227_I0.5020.42
15_T87_F0.5020.42
356_F367_V0.5010.42
51_K359_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dqqA 2 0.9948 100 0.103 Contact Map
1yzyA 1 0.9794 100 0.119 Contact Map
4xfmA 2 0.9149 100 0.186 Contact Map
4xg0A 2 0.8814 100 0.235 Contact Map
2gnpA 1 0.2294 71.1 0.96 Contact Map
4r9nA 1 0.2113 69.1 0.961 Contact Map
4oqpA 2 0.2216 63.3 0.962 Contact Map
2okgA 2 0.232 61.3 0.963 Contact Map
3kv1A 2 0.2088 58.6 0.964 Contact Map
3nzeA 2 0.2294 56 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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