GREMLIN Database
YGBJ - Uncharacterized oxidoreductase YgbJ
UniProt: Q46888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13104
Length: 302 (279)
Sequences: 11465 (7432)
Seq/√Len: 444.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_A158_E3.6571.00
78_K110_E3.3911.00
147_D151_E3.3781.00
33_W54_S3.0171.00
8_H31_S2.9431.00
46_K53_V2.8631.00
121_E149_A2.8601.00
121_E152_R2.7111.00
23_L48_A2.6851.00
242_D282_K2.3361.00
55_D59_T2.2531.00
43_A47_E2.2371.00
151_E154_A2.2241.00
42_C53_V2.1491.00
115_L120_L2.1451.00
10_G60_F2.0721.00
96_A153_L2.0241.00
219_N224_E2.0081.00
205_P208_V1.9811.00
56_N59_T1.9651.00
19_M44_T1.9391.00
88_A115_L1.8911.00
30_L159_A1.8891.00
147_D166_R1.8671.00
58_A62_E1.8361.00
112_A171_P1.8321.00
106_A257_A1.8151.00
69_V97_V1.8111.00
121_E146_S1.8041.00
8_H33_W1.8001.00
24_S27_R1.8001.00
31_S51_C1.7861.00
26_V50_A1.7771.00
254_T257_A1.7751.00
28_A159_A1.7721.00
38_N41_A1.7321.00
92_K95_T1.7091.00
40_N43_A1.6961.00
146_S149_A1.6941.00
116_A146_S1.6871.00
33_W63_K1.6791.00
113_T117_G1.6791.00
199_A209_M1.6461.00
60_F64_L1.6231.00
70_L100_S1.6211.00
141_V160_V1.6191.00
34_G50_A1.6111.00
81_L97_V1.6031.00
39_S43_A1.6021.00
123_L145_G1.5871.00
96_A149_A1.5851.00
114_A117_G1.5761.00
242_D276_S1.5691.00
280_Y283_E1.5541.00
150_F154_A1.5271.00
112_A116_A1.5261.00
110_E114_A1.5131.00
91_L95_T1.5051.00
24_S137_G1.4781.00
123_L153_L1.4781.00
125_A141_V1.4761.00
141_V161_A1.4661.00
68_L100_S1.4471.00
207_D211_D1.4381.00
270_N273_T1.4271.00
150_F166_R1.4011.00
228_R232_D1.3891.00
167_I177_V1.3821.00
33_W51_C1.3801.00
131_A135_A1.3781.00
73_N76_Q1.3771.00
58_A90_H1.3771.00
241_V275_A1.3751.00
179_I250_L1.3741.00
187_V191_A1.3711.00
43_A46_K1.3701.00
132_V136_N1.3541.00
266_S270_N1.3401.00
74_A107_D1.3361.00
65_D92_K1.3101.00
96_A152_R1.3041.00
108_A122_M1.2951.00
214_T224_E1.2941.00
27_R48_A1.2831.00
70_L127_V1.2781.00
138_E162_G1.2761.00
39_S55_D1.2741.00
115_L122_M1.2741.00
123_L150_F1.2511.00
200_A206_L1.2511.00
269_L273_T1.2501.00
86_G89_Q1.2491.00
98_M153_L1.2441.00
283_E290_K1.2421.00
23_L135_A1.2341.00
27_R135_A1.2331.00
242_D281_G1.2291.00
267_T270_N1.2241.00
20_G135_A1.2221.00
75_A79_Q1.2181.00
10_G64_L1.2131.00
57_A90_H1.2111.00
245_V276_S1.2101.00
45_L50_A1.2091.00
66_A96_A1.1861.00
153_L157_L1.1811.00
256_K266_S1.1791.00
59_T62_E1.1781.00
146_S169_A1.1741.00
202_A258_L1.1641.00
61_A90_H1.1641.00
253_D257_A1.1601.00
186_G248_L1.1551.00
22_A32_T1.1511.00
100_S141_V1.1481.00
186_G244_F1.1481.00
197_A201_R1.1471.00
78_K114_A1.1461.00
44_T47_E1.1451.00
88_A118_F1.1451.00
255_A262_L1.1441.00
66_A156_V1.1411.00
11_I21_A1.1261.00
89_Q118_F1.1221.00
104_A107_D1.1191.00
95_T120_L1.1111.00
91_L120_L1.1081.00
11_I68_L1.1071.00
109_Q176_T1.1051.00
97_V115_L1.1021.00
8_H65_D1.0991.00
71_V80_V1.0951.00
109_Q171_P1.0931.00
23_L27_R1.0861.00
11_I22_A1.0831.00
261_P266_S1.0711.00
33_W64_L1.0571.00
78_K107_D1.0511.00
74_A104_A1.0501.00
239_S243_I1.0421.00
100_S160_V1.0421.00
68_L156_V1.0421.00
16_S131_A1.0351.00
109_Q113_T1.0301.00
143_A150_F1.0291.00
169_A173_L1.0271.00
252_A266_S1.0251.00
166_R169_A1.0221.00
113_T116_A1.0171.00
59_T63_K0.9931.00
245_V273_T0.9901.00
112_A146_S0.9871.00
253_D256_K0.9851.00
114_A118_F0.9841.00
36_D41_A0.9841.00
249_G269_L0.9811.00
158_E164_V0.9751.00
184_L195_A0.9721.00
26_V49_G0.9671.00
85_T89_Q0.9651.00
241_V276_S0.9641.00
123_L143_A0.9611.00
214_T223_F0.9581.00
134_A139_M0.9531.00
124_D172_G0.9491.00
54_S59_T0.9481.00
180_I199_A0.9441.00
63_K92_K0.9421.00
85_T114_A0.9401.00
58_A86_G0.9381.00
128_S181_H0.9361.00
167_I173_L0.9281.00
227_M231_V0.9281.00
54_S60_F0.9271.00
91_L97_V0.9261.00
208_V211_D0.9241.00
14_L45_L0.9231.00
196_M210_Y0.9211.00
77_V103_I0.9171.00
68_L98_M0.9171.00
187_V264_L0.9161.00
76_Q79_Q0.9131.00
180_I195_A0.9111.00
273_T276_S0.9101.00
44_T48_A0.9071.00
37_L76_Q0.9061.00
145_G150_F0.9061.00
93_P119_D0.9001.00
151_E166_R0.8971.00
39_S53_V0.8931.00
81_L115_L0.8921.00
249_G273_T0.8841.00
128_S142_M0.8841.00
249_G253_D0.8821.00
142_M212_V0.8771.00
104_A253_D0.8771.00
276_S281_G0.8761.00
24_S160_V0.8731.00
66_A152_R0.8731.00
283_E287_A0.8721.00
273_T277_N0.8701.00
167_I212_V0.8691.00
78_K111_I0.8671.00
107_D110_E0.8641.00
40_N44_T0.8561.00
108_A175_S0.8531.00
11_I32_T0.8511.00
14_L34_G0.8491.00
96_A121_E0.8461.00
103_I107_D0.8451.00
19_M23_L0.8451.00
240_A243_I0.8441.00
227_M230_V0.8381.00
176_T254_T0.8371.00
176_T202_A0.8341.00
221_W225_N0.8341.00
81_L87_V0.8331.00
110_E113_T0.8311.00
124_D174_G0.8281.00
226_R229_H0.8211.00
201_R260_F0.8211.00
21_A160_V0.8161.00
9_V30_L0.8141.00
188_H220_S0.8101.00
155_P158_E0.8061.00
280_Y290_K0.8061.00
67_L87_V0.8041.00
98_M125_A0.7991.00
210_Y227_M0.7951.00
275_A287_A0.7931.00
41_A44_T0.7931.00
190_A264_L0.7921.00
25_Y68_L0.7911.00
177_V204_I0.7871.00
149_A152_R0.7831.00
26_V48_A0.7811.00
226_R230_V0.7811.00
214_T219_N0.7791.00
236_T283_E0.7771.00
207_D232_D0.7731.00
188_H192_G0.7701.00
264_L268_A0.7691.00
69_V77_V0.7691.00
21_A139_M0.7661.00
106_A109_Q0.7601.00
150_F164_V0.7591.00
147_D169_A0.7591.00
144_S174_G0.7561.00
102_T250_L0.7551.00
109_Q172_G0.7551.00
72_V76_Q0.7551.00
201_R258_L0.7481.00
34_G42_C0.7471.00
245_V269_L0.7461.00
130_G133_K0.7451.00
60_F63_K0.7441.00
21_A100_S0.7431.00
99_V122_M0.7401.00
157_L164_V0.7321.00
66_A98_M0.7321.00
123_L149_A0.7311.00
149_A153_L0.7301.00
183_L265_A0.7271.00
88_A120_L0.7251.00
210_Y214_T0.7251.00
199_A204_I0.7221.00
207_D231_V0.7211.00
184_L192_G0.7211.00
33_W60_F0.7201.00
192_G223_F0.7181.00
37_L41_A0.7171.00
183_L251_V0.7141.00
69_V81_L0.7121.00
252_A269_L0.7071.00
274_S278_A0.7061.00
193_A288_V0.7051.00
240_A282_K0.7041.00
71_V76_Q0.7021.00
121_E148_I0.7021.00
21_A70_L0.6991.00
254_T258_L0.6991.00
39_S42_C0.6991.00
242_D246_K0.6981.00
274_S291_I0.6981.00
9_V25_Y0.6981.00
111_I122_M0.6981.00
25_Y32_T0.6961.00
11_I70_L0.6951.00
8_H63_K0.6941.00
278_A291_I0.6881.00
19_M48_A0.6881.00
51_C63_K0.6861.00
163_K215_N0.6851.00
275_A291_I0.6831.00
235_Y290_K0.6811.00
30_L156_V0.6771.00
9_V156_V0.6761.00
241_V287_A0.6751.00
88_A114_A0.6731.00
12_V35_A0.6711.00
144_S166_R0.6701.00
148_I151_E0.6661.00
210_Y213_V0.6661.00
154_A164_V0.6601.00
122_M171_P0.6591.00
256_K269_L0.6551.00
12_V57_A0.6541.00
71_V77_V0.6541.00
165_Y212_V0.6491.00
180_I198_L0.6470.99
243_I246_K0.6470.99
43_A53_V0.6440.99
274_S277_N0.6420.99
221_W224_E0.6390.99
64_L67_L0.6390.99
184_L188_H0.6390.99
26_V32_T0.6370.99
270_N277_N0.6370.99
204_I209_M0.6340.99
184_L191_A0.6340.99
57_A61_A0.6330.99
107_D111_I0.6320.99
176_T204_I0.6310.99
42_C46_K0.6300.99
103_I175_S0.6280.99
275_A280_Y0.6270.99
197_A200_A0.6260.99
77_V101_S0.6250.99
241_V246_K0.6250.99
177_V209_M0.6240.99
143_A157_L0.6220.99
62_E90_H0.6200.99
184_L213_V0.6200.99
189_I285_D0.6190.99
125_A143_A0.6180.99
19_M45_L0.6160.99
188_H222_M0.6150.99
79_Q85_T0.6120.99
87_V91_L0.6120.99
229_H234_D0.6100.99
271_M274_S0.6100.99
163_K211_D0.6100.99
67_L91_L0.6100.99
104_A250_L0.6090.99
179_I251_V0.6080.99
77_V107_D0.6060.99
157_L161_A0.6060.99
75_A78_K0.6060.99
22_A34_G0.6030.99
61_A64_L0.6000.99
270_N274_S0.5990.99
36_D39_S0.5980.99
103_I108_A0.5970.99
154_A166_R0.5970.99
54_S63_K0.5960.99
198_L262_L0.5960.99
287_A290_K0.5900.99
240_A246_K0.5900.99
17_M21_A0.5890.99
15_G72_V0.5870.99
20_G131_A0.5830.99
93_P118_F0.5830.99
193_A230_V0.5820.99
133_K138_E0.5810.99
58_A89_Q0.5810.99
35_A57_A0.5790.99
58_A85_T0.5790.99
79_Q86_G0.5770.99
237_P240_A0.5760.99
12_V60_F0.5740.99
125_A157_L0.5730.99
210_Y231_V0.5720.99
225_N229_H0.5720.99
36_D76_Q0.5690.99
66_A153_L0.5660.99
77_V99_V0.5660.99
187_V268_A0.5620.99
143_A164_V0.5610.99
92_K120_L0.5580.99
249_G256_K0.5550.98
252_A256_K0.5550.98
20_G137_G0.5520.98
23_L26_V0.5520.98
108_A171_P0.5490.98
77_V111_I0.5490.98
133_K136_N0.5430.98
80_V86_G0.5430.98
147_D150_F0.5430.98
14_L22_A0.5400.98
8_H64_L0.5380.98
234_D237_P0.5340.98
69_V99_V0.5340.98
197_A260_F0.5330.98
261_P274_S0.5300.98
242_D245_V0.5260.98
156_V159_A0.5260.98
181_H216_A0.5240.98
105_S176_T0.5230.98
183_L198_L0.5220.98
106_A110_E0.5220.98
51_C54_S0.5210.98
206_L231_V0.5210.98
213_V218_G0.5210.98
276_S279_G0.5170.98
222_M226_R0.5170.98
57_A60_F0.5170.98
81_L111_I0.5160.98
62_E92_K0.5160.98
36_D42_C0.5100.97
67_L95_T0.5100.97
264_L267_T0.5090.97
245_V249_G0.5070.97
50_A53_V0.5070.97
173_L176_T0.5020.97
81_L88_A0.5010.97
10_G33_W0.5010.97
99_V108_A0.5000.97
98_M157_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dojA 3 0.9669 100 0.368 Contact Map
1vpdA 1 0.9735 100 0.372 Contact Map
3pefA 5 0.9503 100 0.374 Contact Map
3obbA 4 0.9536 100 0.375 Contact Map
3pduA 4 0.9503 100 0.375 Contact Map
3ckyA 4 0.9768 100 0.377 Contact Map
3g0oA 3 0.9404 100 0.379 Contact Map
3zgyA 2 0.957 100 0.382 Contact Map
3ws7A 2 0.947 100 0.383 Contact Map
2uyyA 3 0.9603 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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