GREMLIN Database
NORV - Anaerobic nitric oxide reductase flavorubredoxin
UniProt: Q46877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12963
Length: 479 (387)
Sequences: 1748 (1219)
Seq/√Len: 62.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V132_I4.5421.00
4_V7_N4.4501.00
139_I157_T3.7181.00
75_I88_L3.5861.00
160_A219_P3.2731.00
64_R94_Q3.2031.00
99_P122_N3.1871.00
155_Y160_A3.1371.00
143_T153_M3.0951.00
160_A221_D3.0821.00
180_D232_R3.0321.00
78_N154_T2.9911.00
75_I98_T2.8811.00
138_L154_T2.8041.00
131_D137_Q2.8041.00
207_T246_A2.7011.00
279_T390_R2.6981.00
44_K73_D2.6111.00
6_K221_D2.5991.00
311_G343_F2.5931.00
268_M385_C2.5721.00
102_C106_A2.5181.00
103_T106_A2.5011.00
243_L247_A2.4871.00
129_T137_Q2.4851.00
9_I161_V2.4801.00
275_G389_G2.3071.00
45_N72_I2.2881.00
288_F301_N2.2691.00
103_T152_M2.2501.00
255_T305_S2.1711.00
266_R270_D2.1201.00
12_V63_L2.0841.00
309_L392_I2.0411.00
381_A384_L1.9891.00
129_T157_T1.9591.00
136_K159_D1.9411.00
156_L159_D1.9281.00
40_I48_I1.9031.00
290_V298_I1.9021.00
178_F232_R1.9011.00
275_G386_R1.8891.00
101_Y122_N1.8871.00
358_T361_Q1.8761.00
105_N108_D1.8551.00
378_D381_A1.8441.00
40_I138_L1.8381.00
102_C107_I1.8371.00
191_C238_I1.7831.00
214_L243_L1.7741.00
358_T362_D1.7670.99
253_R305_S1.7330.99
46_V76_V1.7100.99
9_I40_I1.7100.99
240_E244_K1.7060.99
48_I78_N1.6900.99
278_E386_R1.6890.99
254_I276_I1.6870.99
383_K386_R1.6710.99
251_E284_A1.6690.99
207_T243_L1.6590.99
101_Y130_L1.6500.99
90_E93_A1.6490.99
310_V323_I1.6350.99
256_I273_A1.6310.99
339_R366_E1.6270.99
153_M209_K1.6210.99
99_P120_N1.6210.99
74_Y101_Y1.6060.99
9_I156_L1.6020.99
134_N158_G1.5930.99
389_G393_A1.5690.99
12_V47_L1.5650.99
371_L388_H1.5650.99
14_Q55_F1.5650.99
391_E394_R1.5630.99
111_N117_P1.5590.99
19_V29_T1.5420.99
39_L47_L1.5360.99
103_T142_E1.5350.99
357_S370_S1.5250.98
161_V222_M1.5190.98
129_T139_I1.5180.98
208_P211_T1.5150.98
92_M98_T1.5120.98
236_T240_E1.5110.98
286_K301_N1.5090.98
290_V323_I1.5070.98
384_L387_E1.4950.98
214_L217_N1.4860.98
42_E134_N1.4860.98
153_M167_A1.4840.98
91_L98_T1.4770.98
165_N226_S1.4760.98
48_I163_F1.4630.98
307_G392_I1.4550.98
42_E131_D1.4520.98
151_S165_N1.4460.98
104_A125_K1.4380.98
47_L91_L1.4330.98
211_T214_L1.4270.98
126_T212_E1.4180.98
269_A343_F1.4160.98
383_K387_E1.3930.97
137_Q158_G1.3750.97
276_I309_L1.3630.97
211_T243_L1.3430.97
125_K128_D1.3400.97
69_L95_I1.3380.96
137_Q157_T1.3370.96
90_E94_Q1.3350.96
319_M355_R1.3350.96
92_M100_I1.3350.96
40_I132_I1.3330.96
107_I121_F1.3320.96
179_N233_D1.3320.96
43_E134_N1.3240.96
377_P381_A1.3200.96
10_H41_R1.3140.96
39_L63_L1.3080.96
71_D97_D1.3010.96
156_L163_F1.2920.96
8_N41_R1.2870.96
234_N237_Q1.2860.96
8_N134_N1.2840.96
353_V370_S1.2800.95
57_R90_E1.2600.95
45_N73_D1.2560.95
252_D306_K1.2520.95
276_I389_G1.2450.95
352_A355_R1.2430.95
299_L330_M1.2390.95
40_I46_V1.2280.94
41_R70_A1.2270.94
207_T247_A1.2260.94
115_H378_D1.2260.94
387_E391_E1.2220.94
20_R292_R1.2100.94
48_I138_L1.2070.94
15_R173_C1.2050.94
273_A277_A1.2020.94
241_L244_K1.1980.94
387_E390_R1.1890.93
293_S298_I1.1860.93
46_V131_D1.1860.93
47_L72_I1.1810.93
327_V356_L1.1810.93
264_N345_S1.1790.93
57_R61_Q1.1790.93
261_M313_S1.1760.93
342_A356_L1.1750.93
60_V94_Q1.1750.93
46_V101_Y1.1720.93
48_I76_V1.1700.93
251_E304_R1.1690.93
107_I111_N1.1570.92
142_E152_M1.1560.92
126_T142_E1.1530.92
243_L246_A1.1470.92
132_I138_L1.1440.92
195_Y203_S1.1420.92
41_R71_D1.1380.92
179_N237_Q1.1340.92
272_I389_G1.1250.91
136_K158_G1.1250.91
156_L161_V1.1220.91
275_G279_T1.1200.91
279_T394_R1.1180.91
136_K156_L1.1170.91
279_T389_G1.1140.91
210_I239_V1.1120.91
380_D384_L1.1080.91
244_K249_Y1.1010.90
107_I123_V1.1000.90
131_D134_N1.0920.90
272_I385_C1.0900.90
5_V222_M1.0880.90
108_D374_K1.0850.90
377_P382_L1.0760.89
256_I309_L1.0680.89
78_N152_M1.0650.89
213_I218_L1.0650.89
195_Y206_V1.0640.89
331_T362_D1.0630.89
41_R45_N1.0620.89
6_K159_D1.0590.88
385_C389_G1.0510.88
141_V213_I1.0460.88
275_G278_E1.0430.88
354_D358_T1.0420.88
271_A274_Q1.0400.88
250_Q338_K1.0370.87
271_A275_G1.0370.87
253_R304_R1.0360.87
31_R190_Q1.0340.87
275_G393_A1.0300.87
340_A360_L1.0290.87
279_T393_A1.0260.87
155_Y219_P1.0240.87
314_T351_G1.0140.86
95_I98_T1.0130.86
231_W238_I1.0070.86
9_I163_F1.0000.85
39_L66_E0.9920.85
106_A142_E0.9910.85
312_T356_L0.9740.84
56_S87_A0.9720.84
351_G372_K0.9670.83
40_I136_K0.9650.83
255_T302_V0.9650.83
69_L72_I0.9640.83
310_V356_L0.9630.83
357_S361_Q0.9620.83
77_I100_I0.9580.83
124_V128_D0.9530.83
279_T397_A0.9450.82
8_N136_K0.9390.82
204_R208_P0.9390.82
254_I307_G0.9390.82
342_A353_V0.9390.82
271_A382_L0.9370.81
257_F290_V0.9370.81
63_L66_E0.9350.81
4_V10_H0.9330.81
8_N159_D0.9300.81
189_E300_T0.9280.81
240_E243_L0.9270.81
76_V130_L0.9230.80
309_L388_H0.9200.80
45_N67_I0.9110.80
76_V154_T0.9080.79
43_E131_D0.9060.79
255_T288_F0.9040.79
10_H66_E0.9020.79
130_L138_L0.9010.79
272_I309_L0.8980.79
132_I156_L0.8980.79
45_N70_A0.8940.78
368_S391_E0.8920.78
170_Q229_V0.8900.78
80_A109_S0.8860.78
256_I272_I0.8850.78
235_P238_I0.8770.77
324_A328_E0.8750.77
252_D307_G0.8750.77
41_R66_E0.8730.77
309_L341_S0.8720.77
87_A90_E0.8670.76
188_F237_Q0.8670.76
72_I98_T0.8670.76
48_I156_L0.8660.76
310_V327_V0.8650.76
64_R69_L0.8620.76
112_G375_W0.8590.75
295_K325_G0.8590.75
38_Y230_V0.8580.75
278_E390_R0.8580.75
271_A386_R0.8570.75
290_V326_L0.8550.75
339_R368_S0.8530.75
16_D35_Y0.8520.75
379_Q383_K0.8520.75
128_D131_D0.8490.75
237_Q241_L0.8490.75
325_G329_E0.8450.74
80_A106_A0.8430.74
143_T209_K0.8430.74
192_Q245_W0.8420.74
271_A377_P0.8420.74
193_R297_E0.8380.74
269_A311_G0.8320.73
76_V138_L0.8310.73
85_A114_H0.8300.73
146_L199_L0.8290.73
390_R393_A0.8230.72
3_I177_L0.8220.72
37_S47_L0.8190.72
9_I48_I0.8170.72
223_I239_V0.8160.72
67_I72_I0.8150.72
75_I100_I0.8140.71
17_W173_C0.8130.71
308_V340_A0.8120.71
167_A199_L0.8110.71
272_I311_G0.8040.71
42_E136_K0.8030.70
343_F385_C0.8020.70
350_G372_K0.8010.70
37_S59_F0.8010.70
102_C121_F0.8000.70
273_A285_V0.7970.70
302_V326_L0.7970.70
205_L208_P0.7970.70
210_I235_P0.7940.70
321_P325_G0.7860.69
252_D397_A0.7840.69
122_N128_D0.7840.69
113_H376_R0.7730.68
359_R362_D0.7720.67
56_S90_E0.7710.67
44_K74_Y0.7680.67
258_Y287_I0.7670.67
275_G382_L0.7670.67
199_L206_V0.7660.67
275_G385_C0.7660.67
112_G374_K0.7630.66
301_N305_S0.7610.66
98_T120_N0.7610.66
342_A360_L0.7610.66
103_T123_V0.7610.66
155_Y220_V0.7560.66
56_S60_V0.7530.65
60_V64_R0.7530.65
60_V91_L0.7510.65
341_S371_L0.7500.65
9_I159_D0.7490.65
308_V330_M0.7490.65
81_E147_H0.7480.65
314_T319_M0.7470.65
164_S220_V0.7470.65
184_Q237_Q0.7470.65
340_A365_F0.7390.64
214_L236_T0.7380.64
132_I154_T0.7380.64
34_S173_C0.7370.64
188_F241_L0.7350.64
5_V161_V0.7310.63
111_N121_F0.7310.63
234_N240_E0.7310.63
18_E289_N0.7290.63
207_T211_T0.7250.63
122_N224_A0.7240.62
255_T301_N0.7230.62
210_I243_L0.7220.62
27_Y315_M0.7220.62
256_I269_A0.7190.62
355_R359_R0.7150.61
302_V330_M0.7140.61
46_V73_D0.7140.61
270_D287_I0.7120.61
184_Q234_N0.7110.61
180_D233_D0.7070.61
132_I136_K0.7060.60
252_D283_V0.7050.60
6_K9_I0.7020.60
261_M320_M0.7010.60
143_T165_N0.6990.60
113_H375_W0.6940.59
237_Q240_E0.6910.59
371_L385_C0.6910.59
210_I214_L0.6880.58
236_T239_V0.6880.58
58_E62_N0.6860.58
179_N232_R0.6850.58
195_Y246_A0.6850.58
41_R63_L0.6840.58
388_H392_I0.6830.58
341_S392_I0.6820.58
307_G339_R0.6810.58
8_N156_L0.6780.57
171_H315_M0.6780.57
302_V308_V0.6750.57
23_H259_D0.6740.57
34_S225_T0.6730.57
199_L248_D0.6680.56
351_G354_D0.6640.56
331_T359_R0.6630.56
28_K294_D0.6620.56
6_K222_M0.6600.55
316_N333_L0.6600.55
353_V356_L0.6590.55
386_R390_R0.6590.55
209_K212_E0.6580.55
15_R174_D0.6580.55
274_Q277_A0.6580.55
369_L391_E0.6570.55
273_A287_I0.6560.55
81_E166_D0.6540.55
171_H201_P0.6530.55
104_A123_V0.6500.54
366_E395_Q0.6460.54
277_A285_V0.6430.53
33_S171_H0.6410.53
191_C245_W0.6410.53
386_R389_G0.6400.53
101_Y128_D0.6390.53
341_S388_H0.6380.53
179_N234_N0.6370.53
151_S199_L0.6360.53
27_Y320_M0.6360.53
22_F194_Y0.6350.53
64_R68_D0.6350.53
41_R46_V0.6330.52
282_R285_V0.6320.52
5_V11_W0.6310.52
83_D166_D0.6310.52
344_G350_G0.6300.52
72_I91_L0.6300.52
61_Q64_R0.6290.52
77_I110_I0.6270.52
69_L94_Q0.6270.52
26_E29_T0.6260.52
314_T352_A0.6240.51
46_V138_L0.6230.51
147_H166_D0.6230.51
377_P385_C0.6200.51
288_F293_S0.6180.51
197_N333_L0.6170.50
346_H372_K0.6170.50
89_T110_I0.6150.50
83_D147_H0.6150.50
5_V178_F0.6140.50
168_F223_I0.6140.50
352_A356_L0.6130.50
206_V246_A0.6130.50
355_R358_T0.6110.50
48_I161_V0.6100.50
380_D383_K0.6100.50
155_Y221_D0.6090.50
50_T77_I0.6080.49
298_I326_L0.6070.49
100_I110_I0.6040.49
323_I356_L0.6010.49
35_Y83_D0.5990.48
262_S316_N0.5990.48
276_I279_T0.5990.48
263_N266_R0.5970.48
17_W175_E0.5960.48
80_A113_H0.5950.48
251_E306_K0.5940.48
257_F326_L0.5940.48
23_H27_Y0.5940.48
233_D294_D0.5940.48
308_V378_D0.5940.48
7_N57_R0.5930.48
12_V51_V0.5920.48
27_Y245_W0.5910.48
6_K10_H0.5910.48
93_A116_H0.5910.48
312_T327_V0.5910.48
346_H350_G0.5900.47
244_K247_A0.5890.47
49_D224_A0.5890.47
324_A359_R0.5890.47
58_E61_Q0.5880.47
153_M162_L0.5870.47
177_L230_V0.5860.47
272_I343_F0.5850.47
40_I161_V0.5820.46
145_M151_S0.5820.46
62_N65_N0.5810.46
192_Q304_R0.5790.46
190_Q193_R0.5760.46
357_S367_M0.5750.46
196_A300_T0.5750.46
220_V239_V0.5750.46
39_L72_I0.5740.46
349_S372_K0.5740.46
68_D76_V0.5740.46
28_K193_R0.5720.45
13_G62_N0.5720.45
157_T219_P0.5720.45
302_V340_A0.5710.45
393_A396_W0.5690.45
390_R394_R0.5680.45
139_I218_L0.5680.45
109_S150_D0.5680.45
104_A108_D0.5660.45
293_S297_E0.5650.45
351_G355_R0.5640.44
47_L98_T0.5640.44
314_T392_I0.5640.44
50_T85_A0.5640.44
178_F222_M0.5630.44
82_E113_H0.5630.44
8_N40_I0.5620.44
267_M377_P0.5610.44
67_I95_I0.5610.44
59_F88_L0.5610.44
84_H147_H0.5600.44
184_Q233_D0.5600.44
317_N347_G0.5600.44
92_M120_N0.5590.44
383_K394_R0.5590.44
44_K131_D0.5580.44
23_H201_P0.5570.44
65_N380_D0.5570.44
169_G194_Y0.5570.44
308_V360_L0.5570.44
45_N132_I0.5570.44
283_V389_G0.5550.43
310_V360_L0.5550.43
213_I220_V0.5540.43
307_G389_G0.5530.43
23_H172_Y0.5530.43
81_E84_H0.5500.43
46_V74_Y0.5490.43
151_S226_S0.5490.43
141_V217_N0.5490.43
367_M370_S0.5470.43
60_V93_A0.5470.43
74_Y99_P0.5450.42
161_V310_V0.5450.42
203_S338_K0.5450.42
46_V136_K0.5430.42
44_K133_G0.5430.42
171_H245_W0.5430.42
259_D313_S0.5420.42
57_R236_T0.5410.42
213_I217_N0.5410.42
318_V332_G0.5400.42
119_W150_D0.5400.42
97_D120_N0.5400.42
295_K330_M0.5390.42
258_Y291_A0.5380.42
262_S331_T0.5380.42
48_I226_S0.5380.42
344_G372_K0.5370.41
77_I80_A0.5370.41
76_V161_V0.5360.41
122_N130_L0.5360.41
200_T335_F0.5360.41
13_G16_D0.5360.41
210_I213_I0.5340.41
254_I392_I0.5340.41
62_N221_D0.5340.41
145_M205_L0.5320.41
219_P222_M0.5320.41
5_V78_N0.5320.41
191_C225_T0.5310.41
241_L245_W0.5300.41
47_L76_V0.5280.40
254_I396_W0.5270.40
291_A322_K0.5270.40
78_N151_S0.5260.40
4_V8_N0.5260.40
200_T303_F0.5250.40
99_P119_W0.5240.40
295_K321_P0.5230.40
109_S347_G0.5230.40
134_N137_Q0.5230.40
108_D111_N0.5230.40
302_V310_V0.5230.40
250_Q306_K0.5230.40
261_M333_L0.5220.40
68_D95_I0.5220.40
268_M371_L0.5220.40
141_V157_T0.5220.40
14_Q51_V0.5210.40
314_T348_W0.5200.40
50_T152_M0.5200.40
80_A102_C0.5190.39
212_E263_N0.5180.39
89_T93_A0.5180.39
283_V393_A0.5150.39
125_K330_M0.5150.39
290_V322_K0.5140.39
314_T355_R0.5140.39
143_T151_S0.5130.39
81_E169_G0.5130.39
260_T289_N0.5130.39
27_Y171_H0.5110.39
55_F58_E0.5090.38
61_Q125_K0.5080.38
200_T262_S0.5080.38
109_S113_H0.5070.38
268_M373_A0.5060.38
245_W309_L0.5050.38
193_R303_F0.5050.38
23_H171_H0.5050.38
268_M344_G0.5040.38
35_Y81_E0.5040.38
269_A272_I0.5030.38
42_E46_V0.5030.38
357_S369_L0.5010.38
360_L365_F0.5010.38
16_D223_I0.5010.38
268_M272_I0.5010.38
330_M333_L0.5000.37
13_G51_V0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d02A 2 0.833 100 0.482 Contact Map
1ycgA 5 0.8225 100 0.574 Contact Map
1e5dA 2 0.8309 100 0.598 Contact Map
2q9uA 3 0.8309 100 0.602 Contact Map
2ohhA 3 0.8142 100 0.614 Contact Map
4dikA 2 0.8017 100 0.63 Contact Map
4fekA 1 0.5219 100 0.767 Contact Map
2vw8A 2 0.5491 100 0.772 Contact Map
4pdxA 2 0.8622 100 0.8 Contact Map
2cfuA 2 0.8727 100 0.808 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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