GREMLIN Database
YQJH - NADPH-dependent ferric-chelate reductase
UniProt: Q46871 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12953
Length: 254 (235)
Sequences: 2720 (2042)
Seq/√Len: 133.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_C154_L4.6001.00
27_R33_Q4.3251.00
36_V100_A3.8551.00
182_Q197_A3.5841.00
24_R98_E3.0741.00
23_L38_G3.0491.00
19_E123_K2.9431.00
171_S192_N2.8681.00
54_S101_I2.7351.00
146_C150_G2.6951.00
93_D96_R2.6941.00
91_L159_E2.5581.00
216_D244_R2.4371.00
141_Y217_Y2.4211.00
148_E198_H2.3661.00
103_F111_A2.3561.00
119_Q122_D2.3381.00
219_I235_F2.2941.00
208_A238_E2.2861.00
234_R239_Q2.2641.00
171_S194_E2.1881.00
21_T123_K2.1851.00
31_G181_C2.0561.00
93_D100_A2.0201.00
25_V33_Q1.9901.00
170_V191_F1.9861.00
105_I116_M1.9791.00
26_E100_A1.9351.00
32_F183_D1.8981.00
175_S198_H1.8931.00
55_K87_D1.8901.00
25_V35_I1.8391.00
36_V98_E1.8381.00
34_R102_D1.8271.00
37_L101_I1.7981.00
33_Q105_I1.7961.00
145_V207_L1.7911.00
24_R36_V1.7671.00
93_D98_E1.7621.00
170_V188_L1.7261.00
39_G42_L1.7141.00
170_V190_G1.7001.00
173_L210_M1.6941.00
187_H190_G1.6891.00
140_A216_D1.6811.00
161_L170_V1.6641.00
225_G249_A1.6461.00
141_Y215_D1.6431.00
154_L174_V1.6361.00
173_L194_E1.5911.00
118_A122_D1.5601.00
207_L231_L1.5561.00
176_V182_Q1.5501.00
221_I228_V1.5331.00
20_L126_V1.5211.00
234_R238_E1.5151.00
20_L37_L1.4831.00
158_L172_A1.4711.00
43_D97_H1.4641.00
56_L101_I1.4591.00
141_Y213_P1.4301.00
53_H87_D1.3781.00
141_Y171_S1.3611.00
155_R185_L1.3481.00
60_Q63_A1.3431.00
221_I231_L1.3191.00
143_L219_I1.3171.00
205_A209_Q1.3171.00
140_A215_D1.3121.00
40_E43_D1.3111.00
91_L155_R1.3041.00
154_L172_A1.2881.00
90_P99_L1.2841.00
107_D113_G1.2721.00
23_L98_E1.2651.00
223_G228_V1.2501.00
208_A234_R1.2411.00
25_V120_P1.2321.00
221_I247_A1.2221.00
167_K190_G1.2161.00
113_G116_M1.2121.00
212_I239_Q1.2061.00
173_L196_L1.1810.99
141_Y212_I1.1520.99
182_Q195_W1.1470.99
223_G227_V1.1250.99
158_L185_L1.1250.99
225_G252_H1.1200.99
36_V93_D1.1180.99
236_E245_V1.1150.99
177_R181_C1.1010.99
37_L103_F1.1000.99
136_P218_F1.0960.99
45_F128_G1.0960.99
22_V25_V1.0900.99
179_N182_Q1.0850.99
56_L124_L1.0840.99
171_S210_M1.0790.99
228_V247_A1.0780.99
35_I114_W1.0660.99
19_E125_T1.0660.99
37_L126_V1.0640.99
241_D244_R1.0600.99
178_D197_A1.0470.99
179_N197_A1.0400.99
187_H191_F1.0360.99
53_H248_A1.0360.99
155_R183_D1.0350.99
161_L168_P1.0340.99
27_R116_M1.0310.98
22_V35_I1.0300.98
236_E247_A1.0210.98
144_Y157_R1.0160.98
151_M174_V1.0150.98
92_Y99_L1.0110.98
176_V197_A1.0050.98
31_G178_D1.0030.98
105_I115_A0.9960.98
73_E77_W0.9920.98
24_R100_A0.9870.98
64_H68_P0.9830.98
29_S183_D0.9810.98
117_Q122_D0.9780.98
162_S168_P0.9780.98
204_D208_A0.9740.98
204_D230_N0.9740.98
167_K187_H0.9710.98
183_D195_W0.9480.97
45_F90_P0.9470.97
240_Y245_V0.9290.97
38_G41_A0.9230.97
26_E36_V0.9140.97
144_Y154_L0.9110.97
219_I240_Y0.9100.97
142_Q168_P0.9100.97
169_Q190_G0.9010.96
141_Y169_Q0.8980.96
24_R120_P0.8980.96
102_D183_D0.8980.96
156_R160_T0.8940.96
32_F148_E0.8920.96
221_I235_F0.8920.96
62_D65_F0.8900.96
176_V183_D0.8860.96
15_L130_R0.8840.96
93_D97_H0.8760.96
58_F124_L0.8600.95
158_L170_V0.8580.95
35_I120_P0.8570.95
144_Y172_A0.8520.95
32_F104_F0.8500.95
99_L126_V0.8490.95
40_E97_H0.8490.95
68_P71_T0.8480.95
113_G117_Q0.8450.95
53_H157_R0.8440.95
52_D130_R0.8440.95
176_V195_W0.8350.95
149_S223_G0.8310.94
212_I217_Y0.8290.94
222_T248_A0.8270.94
175_S200_E0.8250.94
57_F85_S0.8250.94
187_H193_I0.8210.94
16_R44_G0.8080.94
32_F155_R0.8070.94
20_L124_L0.8030.93
87_D130_R0.8030.93
175_S227_V0.7990.93
72_E76_V0.7980.93
163_K167_K0.7960.93
55_K128_G0.7960.93
173_L206_R0.7890.93
103_F115_A0.7880.93
29_S32_F0.7860.93
150_G154_L0.7810.92
178_D181_C0.7730.92
150_G222_T0.7710.92
110_V113_G0.7670.92
158_L191_F0.7650.92
64_H69_T0.7640.92
249_A252_H0.7560.91
207_L235_F0.7550.91
28_I183_D0.7530.91
29_S181_C0.7520.91
20_L42_L0.7460.91
163_K186_A0.7420.90
53_H130_R0.7390.90
178_D182_Q0.7330.90
188_L191_F0.7240.89
27_R30_A0.7230.89
44_G97_H0.7210.89
70_V74_G0.7210.89
157_R220_W0.7190.89
65_F70_V0.7170.89
163_K188_L0.7160.89
162_S167_K0.7160.89
57_F127_A0.7160.89
18_R44_G0.7150.89
52_D87_D0.7120.88
87_D129_P0.7080.88
54_S126_V0.7070.88
170_V187_H0.7050.88
23_L36_V0.7000.88
142_Q145_V0.6980.87
88_Y104_F0.6980.87
72_E77_W0.6970.87
169_Q192_N0.6960.87
21_T38_G0.6940.87
55_K129_P0.6930.87
16_R41_A0.6910.87
112_S116_M0.6870.87
108_G112_S0.6820.86
53_H129_P0.6790.86
148_E177_R0.6760.86
71_T74_G0.6700.85
58_F84_P0.6690.85
217_Y240_Y0.6630.85
152_P159_E0.6630.85
32_F102_D0.6620.85
104_F112_S0.6600.84
35_I115_A0.6590.84
205_A208_A0.6590.84
19_E41_A0.6570.84
227_V231_L0.6570.84
31_G177_R0.6540.84
55_K228_V0.6520.84
87_D228_V0.6500.83
79_E82_R0.6490.83
153_A220_W0.6490.83
50_F160_T0.6470.83
231_L235_F0.6460.83
236_E239_Q0.6450.83
53_H128_G0.6440.83
167_K189_D0.6430.83
35_I103_F0.6380.82
219_I245_V0.6350.82
143_L207_L0.6340.82
58_F111_A0.6340.82
52_D156_R0.6320.82
71_T76_V0.6300.82
177_R199_D0.6290.81
78_P81_P0.6250.81
25_V115_A0.6240.81
53_H132_S0.6230.81
87_D248_A0.6230.81
25_V119_Q0.6210.81
104_F177_R0.6200.80
133_L142_Q0.6200.80
217_Y244_R0.6190.80
15_L127_A0.6180.80
69_T74_G0.6180.80
32_F181_C0.6180.80
213_P217_Y0.6160.80
167_K170_V0.6150.80
135_V139_Y0.6140.80
155_R159_E0.6090.79
37_L124_L0.6090.79
130_R246_R0.6080.79
138_D244_R0.6080.79
194_E206_R0.6040.79
58_F85_S0.6020.79
38_G98_E0.6020.79
143_L235_F0.5980.78
139_Y244_R0.5980.78
102_D152_P0.5930.77
223_G249_A0.5920.77
174_V185_L0.5920.77
103_F118_A0.5910.77
53_H90_P0.5900.77
53_H131_G0.5890.77
224_E227_V0.5870.77
199_D202_A0.5820.76
112_S115_A0.5810.76
42_L92_Y0.5810.76
52_D132_S0.5810.76
53_H156_R0.5800.76
105_I108_G0.5780.76
31_G110_V0.5780.76
28_I102_D0.5760.75
159_E186_A0.5750.75
55_K85_S0.5700.75
134_V137_E0.5700.75
115_A118_A0.5690.75
67_P125_T0.5660.74
246_R249_A0.5630.74
225_G229_K0.5630.74
235_F239_Q0.5630.74
20_L23_L0.5580.73
167_K188_L0.5540.73
111_A114_W0.5540.73
37_L59_P0.5510.72
145_V203_V0.5500.72
107_D167_K0.5490.72
172_A176_V0.5490.72
18_R128_G0.5480.72
65_F68_P0.5480.72
64_H123_K0.5470.72
163_K189_D0.5450.71
204_D207_L0.5440.71
146_C174_V0.5430.71
104_F116_M0.5410.71
56_L126_V0.5380.70
23_L120_P0.5350.70
54_S129_P0.5350.70
162_S170_V0.5350.70
104_F111_A0.5340.70
220_W223_G0.5340.70
38_G97_H0.5330.70
89_T219_I0.5310.69
25_V118_A0.5310.69
161_L169_Q0.5310.69
152_P220_W0.5300.69
172_A195_W0.5290.69
33_Q116_M0.5280.69
52_D157_R0.5280.69
53_H225_G0.5280.69
67_P70_V0.5270.69
150_G153_A0.5250.69
51_D87_D0.5240.68
28_I75_I0.5220.68
212_I215_D0.5220.68
142_Q218_F0.5220.68
65_F74_G0.5210.68
176_V179_N0.5200.68
92_Y97_H0.5190.68
65_F69_T0.5180.68
107_D116_M0.5180.68
60_Q83_P0.5170.67
28_I32_F0.5170.67
53_H222_T0.5170.67
52_D55_K0.5150.67
113_G220_W0.5130.67
133_L137_E0.5120.67
87_D156_R0.5110.67
69_T75_I0.5110.67
140_A217_Y0.5100.66
30_A181_C0.5090.66
194_E209_Q0.5090.66
51_D133_L0.5080.66
179_N199_D0.5080.66
74_G77_W0.5080.66
41_A44_G0.5060.66
153_A250_Y0.5060.66
133_L157_R0.5050.66
106_H152_P0.5040.65
129_P153_A0.5030.65
222_T232_S0.5030.65
156_R218_F0.5020.65
68_P125_T0.5000.65
236_E242_P0.5000.65
189_D192_N0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gpjA 1 0.8583 100 0.58 Contact Map
4yhbA 1 0.9606 100 0.59 Contact Map
2qdxA 1 0.8583 99.9 0.637 Contact Map
2bgiA 1 0.8543 99.9 0.639 Contact Map
4b4dA 2 0.8543 99.9 0.641 Contact Map
1tvcA 1 0.878 99.9 0.656 Contact Map
1fdrA 1 0.8307 99.9 0.657 Contact Map
4u9uA 1 0.9291 99.9 0.659 Contact Map
2eixA 2 0.878 99.9 0.66 Contact Map
1krhA 1 0.9134 99.9 0.662 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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