GREMLIN Database
MQSR - mRNA interferase MqsR
UniProt: Q46865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13023
Length: 98 (97)
Sequences: 177 (135)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_T42_M4.5961.00
38_D41_G4.5801.00
75_L78_G2.5960.93
26_R30_L2.3100.88
90_V93_V2.3060.88
86_V91_L2.1730.85
31_N78_G2.1570.85
5_T65_T1.9560.78
53_D73_P1.9520.78
76_V80_V1.8840.75
60_T68_Q1.8720.75
84_I91_L1.6210.63
5_T64_H1.5720.61
86_V90_V1.5560.60
42_M92_I1.4870.57
58_M70_V1.4790.56
24_T37_L1.4450.54
6_P14_K1.4430.54
23_R92_I1.4310.54
37_L60_T1.4010.52
26_R34_E1.3910.51
11_S18_N1.3810.51
27_S94_S1.3670.50
6_P97_E1.3410.49
54_F82_L1.3260.48
2_E7_H1.3070.47
17_V47_I1.2700.45
84_I90_V1.2650.45
29_L33_D1.2540.44
68_Q80_V1.2320.43
26_R33_D1.1750.40
7_H10_L1.1370.38
59_T64_H1.1090.37
27_S30_L1.1020.36
55_Y90_V1.0950.36
59_T63_D1.0920.36
16_L86_V1.0810.35
33_D48_G1.0600.34
39_F72_R1.0400.33
22_V38_D1.0390.33
35_L51_E1.0260.33
25_T56_K1.0210.32
3_K10_L1.0200.32
37_L63_D1.0170.32
3_K7_H1.0160.32
8_T77_T1.0150.32
26_R40_D1.0050.32
80_V94_S1.0030.32
6_P92_I0.9870.31
1_M10_L0.9850.31
49_L90_V0.9760.30
14_K21_Q0.9680.30
13_V49_L0.9610.30
24_T32_A0.9570.29
43_C75_L0.9540.29
17_V65_T0.9520.29
19_A53_D0.9470.29
40_D44_N0.9420.29
68_Q85_T0.9330.28
6_P35_L0.9320.28
39_F82_L0.9140.28
40_D75_L0.9110.27
28_A56_K0.9050.27
49_L73_P0.8960.27
34_E44_N0.8920.27
94_S97_E0.8900.27
86_V93_V0.8830.26
37_L42_M0.8820.26
4_R12_Q0.8810.26
4_R47_I0.8800.26
29_L36_G0.8790.26
16_L54_F0.8780.26
48_G52_S0.8710.26
38_D46_I0.8670.26
4_R11_S0.8540.25
49_L61_Y0.8420.25
3_K59_T0.8420.25
29_L39_F0.8410.25
22_V45_V0.8380.24
83_K96_K0.8240.24
39_F73_P0.8200.24
48_G51_E0.8200.24
2_E63_D0.8180.24
7_H49_L0.8070.23
41_G45_V0.8020.23
52_S62_S0.7930.23
55_Y87_I0.7910.23
30_L74_R0.7900.23
27_S87_I0.7840.22
18_N27_S0.7790.22
36_G74_R0.7690.22
84_I93_V0.7660.22
42_M60_T0.7620.22
82_L90_V0.7610.21
6_P10_L0.7530.21
24_T43_C0.7420.21
57_S64_H0.7330.20
44_N51_E0.7300.20
15_K97_E0.7260.20
23_R87_I0.7210.20
27_S76_V0.7170.20
37_L80_V0.7120.20
88_H91_L0.7120.20
84_I88_H0.6960.19
2_E25_T0.6930.19
80_V86_V0.6810.19
49_L82_L0.6800.19
57_S67_W0.6730.18
43_C80_V0.6620.18
13_V53_D0.6520.18
34_E40_D0.6510.18
13_V76_V0.6480.18
17_V38_D0.6450.18
28_A71_Y0.6440.18
41_G76_V0.6430.18
31_N37_L0.6370.17
21_Q46_I0.6370.17
14_K53_D0.6340.17
31_N34_E0.6320.17
20_G47_I0.6220.17
8_T88_H0.6160.17
31_N80_V0.6130.17
71_Y95_F0.6120.17
46_I88_H0.6090.16
24_T86_V0.6060.16
32_A79_Q0.6050.16
11_S51_E0.5770.16
20_G46_I0.5710.15
35_L85_T0.5620.15
37_L93_V0.5530.15
31_N36_G0.5500.15
49_L91_L0.5490.15
58_M68_Q0.5420.15
24_T45_V0.5400.15
60_T93_V0.5380.15
22_V47_I0.5320.14
53_D92_I0.5230.14
20_G55_Y0.5210.14
61_Y65_T0.5190.14
43_C92_I0.5190.14
31_N51_E0.5120.14
18_N32_A0.5100.14
22_V35_L0.5090.14
31_N75_L0.5030.14
16_L90_V0.5030.14
12_Q72_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hi2B 1 0.9898 100 0.118 Contact Map
4ui9S 1 0 15.3 0.938 Contact Map
2d0tA 1 0.898 12.8 0.94 Contact Map
2q6tA 1 0.7245 8.7 0.944 Contact Map
2r6aA 5 0.7041 7.9 0.945 Contact Map
2opaA 4 0.6122 7.7 0.946 Contact Map
4fazA 4 0.6224 7.7 0.946 Contact Map
2ivfA 1 0.2857 7.5 0.946 Contact Map
2zj8A 2 0.4898 7.5 0.946 Contact Map
3kuzA 2 0.2857 7.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.