GREMLIN Database
MQSA - Antitoxin MqsA
UniProt: Q46864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13022
Length: 131 (125)
Sequences: 217 (167)
Seq/√Len: 14.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_H113_T4.0231.00
123_H129_E3.0840.98
88_A99_F2.6450.95
37_C40_C2.5810.95
83_L127_L2.5770.95
22_F64_V2.4750.93
58_K61_R2.2570.89
109_P114_I2.1650.87
91_I115_K2.1200.86
101_R110_H2.1060.86
60_F64_V2.0060.83
15_I29_L1.9390.81
22_F65_N1.8690.78
67_E114_I1.8330.77
73_F77_V1.7830.75
49_E57_V1.6770.70
6_C37_C1.6650.69
83_L87_E1.6590.69
40_C100_S1.6010.66
20_Y60_F1.5890.65
43_S54_M1.5850.65
92_F115_K1.5710.65
107_A118_R1.5600.64
123_H126_L1.5500.63
3_C7_H1.5000.61
119_V122_K1.4910.60
5_V44_I1.4750.59
6_C40_C1.4480.58
98_A102_Y1.4390.58
21_T43_S1.4210.57
88_A94_G1.4170.56
47_K76_K1.4170.56
84_T87_E1.3940.55
3_C6_C1.3760.54
11_M112_S1.3370.52
36_Y43_S1.3080.50
87_E118_R1.2830.49
13_S49_E1.2490.47
46_N49_E1.2450.47
94_G98_A1.2440.47
95_G98_A1.2430.47
5_V43_S1.2410.47
13_S33_H1.2360.46
18_I26_K1.2190.45
99_F102_Y1.1970.44
17_D28_V1.1920.44
96_V130_I1.1840.43
76_K121_D1.1730.43
3_C40_C1.1680.42
42_E101_R1.1230.40
92_F113_T1.1160.40
27_T63_S1.1130.39
94_G112_S1.1100.39
19_P28_V1.0930.38
43_S53_F1.0890.38
14_G36_Y1.0810.38
53_F57_V1.0640.37
29_L56_Q1.0620.37
80_K121_D1.0610.37
15_I33_H1.0480.36
45_M53_F1.0300.35
44_I107_A1.0280.35
49_E56_Q1.0280.35
61_R67_E1.0180.35
75_V82_S1.0070.34
80_K87_E1.0040.34
105_G113_T0.9890.33
4_P24_G0.9750.32
88_A98_A0.9730.32
43_S127_L0.9560.31
95_G102_Y0.9500.31
37_C100_S0.9450.31
16_K83_L0.9390.31
87_E90_E0.9350.30
31_G77_V0.9290.30
9_G38_V0.9280.30
105_G123_H0.9240.30
72_E89_S0.9240.30
66_A77_V0.9210.30
34_G123_H0.9120.29
51_D55_A0.9040.29
34_G109_P0.9040.29
66_A114_I0.9040.29
62_A113_T0.9000.29
5_V119_V0.8990.29
41_E71_P0.8980.29
81_L127_L0.8980.29
74_I113_T0.8830.28
97_N105_G0.8800.28
66_A75_V0.8760.28
94_G102_Y0.8720.28
7_H113_T0.8690.27
7_H10_E0.8680.27
34_G42_E0.8540.27
50_S58_K0.8470.26
86_K97_N0.8460.26
114_I118_R0.8450.26
84_T107_A0.8340.26
90_E121_D0.8240.25
125_E128_N0.8150.25
3_C37_C0.8130.25
17_D32_I0.8130.25
76_K80_K0.8110.25
88_A102_Y0.8010.24
84_T104_K0.7950.24
68_T114_I0.7910.24
34_G98_A0.7800.24
33_H104_K0.7780.24
86_K130_I0.7740.23
25_R64_V0.7640.23
19_P24_G0.7620.23
35_L120_L0.7600.23
74_I96_V0.7550.23
80_K86_K0.7500.22
4_P44_I0.7450.22
10_E38_V0.7280.22
101_R113_T0.7240.21
62_A79_K0.7220.21
46_N112_S0.7220.21
49_E53_F0.7210.21
9_G27_T0.7190.21
34_G126_L0.7180.21
17_D49_E0.7170.21
29_L64_V0.7150.21
97_N129_E0.7110.21
86_K91_I0.7100.21
111_P115_K0.7040.21
113_T117_L0.7030.21
34_G120_L0.7020.21
29_L60_F0.6990.21
31_G89_S0.6980.20
77_V121_D0.6930.20
80_K91_I0.6900.20
21_T26_K0.6820.20
61_R96_V0.6800.20
31_G119_V0.6730.20
93_G96_V0.6700.19
10_E80_K0.6690.19
75_V91_I0.6640.19
74_I117_L0.6570.19
60_F63_S0.6520.19
65_N71_P0.6500.19
107_A122_K0.6340.18
91_I117_L0.6320.18
55_A61_R0.6320.18
50_S57_V0.6310.18
83_L123_H0.6310.18
51_D68_T0.6290.18
73_F114_I0.6270.18
89_S125_E0.6140.18
88_A97_N0.6080.17
72_E86_K0.6040.17
27_T60_F0.5930.17
62_A130_I0.5930.17
25_R74_I0.5920.17
107_A125_E0.5910.17
32_I57_V0.5870.17
52_A100_S0.5840.17
75_V84_T0.5800.17
11_M88_A0.5750.16
45_M84_T0.5730.16
16_K23_R0.5690.16
17_D31_G0.5680.16
43_S104_K0.5680.16
14_G76_K0.5650.16
22_F111_P0.5640.16
98_A109_P0.5570.16
21_T68_T0.5490.16
50_S55_A0.5490.16
41_E95_G0.5460.15
10_E64_V0.5440.15
48_E82_S0.5400.15
62_A111_P0.5400.15
88_A112_S0.5390.15
100_S104_K0.5340.15
93_G100_S0.5340.15
25_R82_S0.5330.15
37_C42_E0.5320.15
92_F110_H0.5310.15
76_K91_I0.5240.15
79_K90_E0.5240.15
45_M87_E0.5210.15
47_K128_N0.5150.15
23_R75_V0.5140.15
76_K119_V0.5130.15
91_I116_L0.5130.15
54_M58_K0.5090.14
19_P130_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 0.9924 100 0.505 Contact Map
3ga8A 1 0.5038 99.7 0.674 Contact Map
1s4kA 2 0.4962 98.8 0.788 Contact Map
3fmyA 2 0.4962 98.7 0.794 Contact Map
2ppxA 4 0.4656 98.3 0.821 Contact Map
2auwA 2 0.916 97.9 0.839 Contact Map
2p5tA 2 0.0153 97.6 0.848 Contact Map
4y42A 6 0.5496 97.6 0.849 Contact Map
4yv9A 3 0.4733 97.6 0.849 Contact Map
1y9qA 1 0.5344 97.6 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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