GREMLIN Database
DKGA - 2,5-diketo-D-gluconic acid reductase A
UniProt: Q46857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13015
Length: 275 (252)
Sequences: 32509 (20993)
Seq/√Len: 1322.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K239_A3.1341.00
90_L131_L2.9671.00
62_K97_Q2.7761.00
27_N59_K2.7631.00
209_Y253_E2.6691.00
89_L126_L2.5111.00
250_D253_E2.4691.00
31_I63_N2.4341.00
8_K14_V2.3921.00
86_R125_E2.3861.00
86_R129_E2.3431.00
36_K40_V2.2921.00
208_K256_E2.1411.00
203_R207_D2.0181.00
31_I59_K2.0151.00
208_K253_E1.9871.00
124_I128_K1.9711.00
91_D95_K1.9601.00
223_D254_L1.9211.00
7_I17_Q1.9201.00
251_K255_G1.9081.00
100_Y133_K1.9071.00
175_W179_H1.9071.00
125_E129_E1.8761.00
67_N70_E1.8741.00
204_D256_E1.8441.00
235_P239_A1.8301.00
176_N183_T1.8101.00
105_L158_I1.8031.00
19_G44_S1.7971.00
211_K247_F1.7811.00
82_H125_E1.7711.00
73_I98_L1.7541.00
182_Q227_V1.7371.00
146_Q150_D1.7101.00
37_A42_Y1.7081.00
36_K235_P1.7071.00
224_S258_A1.6861.00
40_V239_A1.6831.00
125_E128_K1.6721.00
75_T101_I1.6571.00
82_H86_R1.6571.00
219_R247_F1.6501.00
31_I60_A1.6051.00
55_E95_K1.6021.00
77_L104_Y1.5971.00
40_V242_F1.5921.00
75_T92_S1.5851.00
77_L85_P1.5761.00
212_T240_E1.5671.00
31_I35_Q1.5571.00
89_L104_Y1.5571.00
146_Q175_W1.5541.00
74_T105_L1.5511.00
35_Q63_N1.5381.00
201_V204_D1.5191.00
255_G259_K1.5181.00
36_K39_E1.5141.00
86_R90_L1.5121.00
22_V45_I1.5011.00
243_D246_D1.4961.00
122_G125_E1.4791.00
49_A88_A1.4541.00
27_N31_I1.4311.00
105_L184_E1.4271.00
101_I132_I1.4251.00
87_E91_D1.4201.00
13_N134_S1.4091.00
38_L71_L1.3991.00
34_I60_A1.3971.00
177_A225_G1.3851.00
90_L94_K1.3761.00
211_K215_Q1.3751.00
171_Q174_A1.3751.00
174_A178_T1.3691.00
13_N72_F1.3361.00
239_A243_D1.3331.00
29_E32_T1.3281.00
82_H121_K1.3081.00
141_Q144_H1.3061.00
134_S157_V1.3061.00
161_I183_T1.3061.00
219_R223_D1.2931.00
149_I179_H1.2891.00
35_Q39_E1.2821.00
126_L132_I1.2711.00
232_S237_R1.2671.00
256_E259_K1.2591.00
86_R122_G1.2541.00
91_D94_K1.2511.00
149_I175_W1.2501.00
132_I135_I1.2381.00
82_H122_G1.2331.00
211_K216_I1.2281.00
58_G97_Q1.2151.00
72_F103_L1.2111.00
68_R100_Y1.2091.00
32_T36_K1.2081.00
54_E92_S1.2041.00
232_S238_I1.2001.00
212_T215_Q1.1951.00
142_I175_W1.1921.00
128_K153_G1.1761.00
201_V256_E1.1701.00
68_R98_L1.1591.00
204_D208_K1.1521.00
59_K97_Q1.1481.00
89_L101_I1.1461.00
96_L101_I1.1371.00
45_I57_V1.1321.00
103_L158_I1.1291.00
173_H177_A1.1281.00
163_L224_S1.1251.00
117_V151_E1.1251.00
109_P144_H1.1231.00
236_S239_A1.1171.00
146_Q178_T1.1131.00
83_K87_E1.1071.00
205_L216_I1.0981.00
11_D134_S1.0981.00
44_S184_E1.0931.00
35_Q60_A1.0871.00
127_Q157_V1.0851.00
28_E32_T1.0821.00
165_P257_I1.0811.00
166_L199_Q1.0791.00
55_E59_K1.0791.00
33_A238_I1.0751.00
27_N56_G1.0731.00
118_E121_K1.0691.00
84_R87_E1.0631.00
203_R213_P1.0581.00
204_D207_D1.0561.00
162_E167_M1.0551.00
221_H228_V1.0501.00
123_M135_I1.0471.00
106_M123_M1.0461.00
44_S74_T1.0431.00
146_Q179_H1.0371.00
90_L129_E1.0321.00
16_P43_R1.0311.00
22_V57_V1.0261.00
168_Q261_D1.0221.00
124_I127_Q1.0201.00
10_Q157_V1.0161.00
215_Q243_D1.0011.00
222_L244_V1.0001.00
165_P217_V0.9991.00
32_T235_P0.9931.00
126_L131_L0.9911.00
238_I242_F0.9831.00
202_I213_P0.9731.00
8_K12_G0.9681.00
59_K63_N0.9661.00
127_Q154_V0.9641.00
49_A84_R0.9641.00
55_E94_K0.9621.00
43_R72_F0.9591.00
54_E95_K0.9581.00
82_H118_E0.9581.00
170_R174_A0.9561.00
16_P42_Y0.9551.00
147_R151_E0.9501.00
137_V156_P0.9461.00
117_V147_R0.9371.00
158_I184_E0.9371.00
142_I146_Q0.9191.00
121_K125_E0.9141.00
102_D133_K0.9141.00
17_Q222_L0.9111.00
86_R89_L0.9081.00
74_T184_E0.9041.00
126_L129_E0.9031.00
49_A81_D0.9021.00
215_Q240_E0.9011.00
240_E243_D0.9001.00
174_A177_A0.8921.00
61_L71_L0.8911.00
124_I153_G0.8801.00
17_Q245_W0.8781.00
137_V145_L0.8691.00
236_S240_E0.8691.00
11_D157_V0.8671.00
34_I45_I0.8651.00
205_L209_Y0.8601.00
122_G126_L0.8551.00
38_L67_N0.8541.00
218_I244_V0.8531.00
200_K204_D0.8501.00
208_K250_D0.8491.00
87_E90_L0.8471.00
200_K203_R0.8461.00
139_N186_W0.8461.00
234_T237_R0.8451.00
159_N176_N0.8421.00
255_G258_A0.8421.00
11_D127_Q0.8391.00
121_K124_I0.8351.00
224_S254_L0.8261.00
32_T35_Q0.8231.00
124_I135_I0.8181.00
86_R126_L0.8121.00
223_D248_R0.8111.00
135_I156_P0.8081.00
252_D256_E0.8051.00
252_D255_G0.8021.00
74_T103_L0.7971.00
49_A95_K0.7961.00
175_W178_T0.7901.00
145_L181_I0.7901.00
219_R244_V0.7881.00
108_W139_N0.7841.00
169_Q174_A0.7791.00
209_Y250_D0.7791.00
93_L131_L0.7771.00
168_Q258_A0.7771.00
188_P230_P0.7731.00
22_V53_N0.7701.00
217_V221_H0.7651.00
163_L173_H0.7641.00
173_H183_T0.7631.00
63_N67_N0.7611.00
147_R150_D0.7531.00
20_L37_A0.7531.00
19_G230_P0.7521.00
223_D251_K0.7451.00
40_V243_D0.7361.00
233_V237_R0.7351.00
47_T57_V0.7351.00
197_F200_K0.7341.00
85_P119_A0.7331.00
7_I182_Q0.7331.00
142_I172_L0.7301.00
75_T104_Y0.7291.00
20_L25_A0.7281.00
36_K238_I0.7261.00
185_S228_V0.7121.00
185_S188_P0.7101.00
211_K246_D0.7091.00
35_Q67_N0.7091.00
28_E31_I0.7081.00
172_L176_N0.7081.00
124_I152_T0.7051.00
137_V159_N0.7051.00
49_A91_D0.7031.00
120_W156_P0.7031.00
33_A235_P0.7021.00
30_V56_G0.6951.00
92_S104_Y0.6901.00
120_W148_L0.6891.00
149_I155_T0.6811.00
201_V260_L0.6741.00
173_H224_S0.6731.00
220_W258_A0.6721.00
93_L98_L0.6711.00
119_A122_G0.6681.00
176_N181_I0.6681.00
42_Y242_F0.6681.00
88_A91_D0.6671.00
209_Y216_I0.6641.00
202_I257_I0.6641.00
120_W135_I0.6641.00
38_L45_I0.6641.00
89_L131_L0.6601.00
18_L222_L0.6571.00
85_P126_L0.6561.00
211_K219_R0.6471.00
69_E100_Y0.6451.00
127_Q134_S0.6441.00
207_D210_G0.6431.00
23_W187_S0.6411.00
13_N133_K0.6411.00
188_P221_H0.6401.00
137_V140_F0.6401.00
214_A240_E0.6401.00
43_R70_E0.6381.00
105_L136_G0.6381.00
101_I104_Y0.6331.00
216_I249_L0.6321.00
40_V238_I0.6321.00
184_E227_V0.6301.00
150_D154_V0.6291.00
237_R240_E0.6291.00
221_H226_L0.6281.00
124_I154_V0.6271.00
206_A216_I0.6271.00
249_L254_L0.6261.00
24_Q191_Q0.6251.00
142_I171_Q0.6231.00
205_L253_E0.6221.00
34_I38_L0.6221.00
89_L93_L0.6201.00
211_K243_D0.6201.00
216_I247_F0.6131.00
26_S53_N0.6101.00
127_Q132_I0.6101.00
85_P122_G0.6091.00
123_M127_Q0.6081.00
163_L221_H0.6041.00
67_N71_L0.6021.00
202_I217_V0.5991.00
114_D118_E0.5961.00
46_D160_Q0.5931.00
249_L253_E0.5921.00
29_E235_P0.5921.00
25_A33_A0.5901.00
116_Y151_E0.5861.00
116_Y119_A0.5841.00
163_L183_T0.5841.00
25_A30_V0.5821.00
50_A78_W0.5811.00
81_D84_R0.5801.00
82_H85_P0.5761.00
38_L43_R0.5731.00
146_Q149_I0.5731.00
206_A213_P0.5701.00
196_V199_Q0.5691.00
216_I253_E0.5691.00
205_L256_E0.5671.00
93_L101_I0.5641.00
39_E235_P0.5631.00
9_L182_Q0.5611.00
33_A232_S0.5601.00
10_Q155_T0.5601.00
93_L100_Y0.5591.00
45_I61_L0.5581.00
66_V71_L0.5581.00
47_T53_N0.5541.00
15_M44_S0.5541.00
115_H118_E0.5531.00
86_R131_L0.5521.00
93_L99_D0.5521.00
163_L168_Q0.5481.00
104_Y123_M0.5471.00
165_P220_W0.5441.00
110_V114_D0.5421.00
104_Y132_I0.5421.00
34_I57_V0.5411.00
195_G198_D0.5401.00
232_S241_N0.5381.00
144_H147_R0.5371.00
206_A209_Y0.5371.00
115_H119_A0.5351.00
253_E256_E0.5311.00
187_S191_Q0.5301.00
10_Q180_K0.5301.00
79_N108_W0.5291.00
57_V60_A0.5291.00
117_V121_K0.5291.00
68_R102_D0.5281.00
18_L245_W0.5281.00
19_G229_I0.5271.00
163_L226_L0.5261.00
137_V148_L0.5251.00
7_I227_V0.5241.00
202_I206_A0.5221.00
38_L70_E0.5201.00
20_L33_A0.5201.00
222_L228_V0.5191.00
235_P238_I0.5191.00
216_I257_I0.5171.00
77_L88_A0.5161.00
49_A78_W0.5151.00
209_Y247_F0.5151.00
105_L138_C0.5151.00
215_Q247_F0.5131.00
109_P139_N0.5121.00
37_A45_I0.5121.00
219_R248_R0.5121.00
15_M227_V0.5111.00
184_E229_I0.5111.00
7_I15_M0.5081.00
205_L260_L0.5061.00
143_H146_Q0.5051.00
33_A233_V0.5021.00
54_E75_T0.5011.00
152_T156_P0.5011.00
116_Y144_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4otkA 1 0.9927 100 0.088 Contact Map
1mzrA 1 1 100 0.092 Contact Map
2wzmA 1 0.9855 100 0.096 Contact Map
1hw6A 1 0.9345 100 0.098 Contact Map
1mi3A 3 0.9891 100 0.103 Contact Map
4q3mA 2 0.9818 100 0.107 Contact Map
1vbjA 1 0.9855 100 0.109 Contact Map
3f7jA 1 0.9855 100 0.112 Contact Map
4f40A 1 0.9745 100 0.113 Contact Map
3o0kA 1 0.9418 100 0.115 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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