GREMLIN Database
YQHD - Alcohol dehydrogenase YqhD
UniProt: Q46856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13014
Length: 387 (361)
Sequences: 10233 (6953)
Seq/√Len: 365.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_K376_L3.8581.00
354_P380_R3.8221.00
229_P336_Q3.5821.00
294_N331_R3.2011.00
350_G384_E3.1781.00
79_K83_E3.1241.00
72_E155_K2.8881.00
234_E237_N2.8151.00
77_A104_I2.7171.00
230_K237_N2.6851.00
227_D243_N2.5831.00
375_T378_V2.5471.00
181_Y238_Y2.5251.00
48_D52_D2.5141.00
31_R58_D2.4881.00
16_K178_V2.4351.00
353_I380_R2.3831.00
269_L383_Y2.3631.00
349_D352_S2.3331.00
64_G76_N2.3051.00
219_G222_L2.2671.00
21_G24_E2.2621.00
32_V88_F2.2341.00
380_R384_E2.2251.00
199_T220_I2.2131.00
342_H345_D2.1921.00
18_A21_G2.1381.00
175_L245_M2.0801.00
332_N336_Q2.0351.00
214_D303_K2.0321.00
17_G178_V2.0311.00
195_A224_L1.9321.00
81_V131_I1.9301.00
98_L135_C1.9161.00
196_F221_L1.9151.00
116_P119_I1.8971.00
357_L380_R1.8931.00
376_L380_R1.8721.00
60_L84_Q1.8451.00
89_L101_T1.8301.00
66_E73_T1.8271.00
30_A87_T1.8161.00
190_N283_Q1.7911.00
188_V241_R1.7801.00
81_V108_A1.7531.00
296_K370_E1.7421.00
356_L383_Y1.7381.00
329_A332_N1.7361.00
51_L55_K1.7181.00
308_A326_A1.7071.00
357_L376_L1.6961.00
225_I311_V1.6891.00
229_P233_K1.6821.00
270_G284_T1.6691.00
16_K238_Y1.6601.00
287_I346_Y1.6551.00
354_P376_L1.6341.00
233_K336_Q1.6191.00
48_D51_L1.6161.00
302_A319_D1.6111.00
221_L307_Y1.5861.00
335_E341_T1.5761.00
73_T76_N1.5711.00
60_L86_V1.5351.00
192_V228_G1.5221.00
185_P189_A1.5221.00
91_A133_M1.5121.00
11_R25_Q1.5081.00
309_E322_R1.4981.00
180_T241_R1.4951.00
76_N79_K1.4941.00
80_L84_Q1.4931.00
381_R384_E1.4791.00
60_L80_L1.4781.00
293_W330_T1.4701.00
294_N324_D1.4691.00
23_R53_A1.4621.00
239_D243_N1.4601.00
16_K242_A1.4581.00
276_M355_A1.4571.00
154_R157_T1.4561.00
328_A332_N1.4531.00
32_V90_L1.4531.00
20_A49_Q1.4481.00
26_I88_F1.4421.00
218_E306_Q1.4291.00
74_L152_I1.4191.00
39_G44_T1.4181.00
186_R283_Q1.4181.00
25_Q28_H1.4021.00
55_K59_V1.3971.00
178_V238_Y1.3821.00
78_V107_A1.3721.00
355_A359_K1.3721.00
192_V244_V1.3711.00
35_T104_I1.3691.00
269_L288_V1.3581.00
218_E310_R1.3461.00
279_L284_T1.3421.00
193_V334_F1.3401.00
180_T245_M1.3361.00
80_L83_E1.3291.00
91_A101_T1.3231.00
352_S355_A1.3191.00
75_M115_D1.3181.00
185_P232_L1.3101.00
71_Y75_M1.3101.00
49_Q178_V1.3041.00
31_R60_L1.2971.00
13_L25_Q1.2891.00
51_L59_V1.2891.00
237_N240_V1.2841.00
109_N129_S1.2801.00
81_V86_V1.2711.00
188_V235_P1.2651.00
358_K362_E1.2631.00
227_D230_K1.2571.00
89_L105_A1.2521.00
378_V381_R1.2511.00
230_K234_E1.2481.00
12_I249_T1.2451.00
297_R324_D1.2421.00
105_A130_A1.2411.00
75_M79_K1.2381.00
25_Q172_F1.2341.00
33_L86_V1.2321.00
134_G172_F1.2291.00
66_E70_A1.2281.00
227_D240_V1.2261.00
226_E243_N1.2241.00
295_E378_V1.2231.00
193_V339_V1.2171.00
116_P120_L1.2111.00
35_T65_I1.2081.00
353_I384_E1.2081.00
218_E222_L1.1981.00
79_K82_R1.1981.00
305_L322_R1.1961.00
74_L100_G1.1931.00
265_A374_I1.1891.00
324_D328_A1.1871.00
88_F134_G1.1851.00
224_L244_V1.1841.00
377_D380_R1.1831.00
18_A174_V1.1791.00
13_L21_G1.1781.00
35_T101_T1.1681.00
81_V104_I1.1661.00
116_P121_Q1.1641.00
101_T133_M1.1621.00
355_A358_K1.1541.00
70_A73_T1.1451.00
178_V181_Y1.1451.00
33_L80_L1.1271.00
140_P188_V1.1251.00
78_V82_R1.1191.00
307_Y326_A1.1151.00
202_Q254_G1.1141.00
177_P242_A1.1061.00
361_E376_L1.0981.00
219_G223_T1.0971.00
34_I59_V1.0931.00
31_R84_Q1.0921.00
188_V231_A1.0911.00
297_R323_I1.0901.00
183_L187_Q1.0801.00
222_L310_R1.0791.00
19_I136_V1.0751.00
269_L379_S1.0731.00
215_R219_G1.0721.00
16_K181_Y1.0701.00
377_D381_R1.0671.00
15_G18_A1.0641.00
298_D372_H1.0631.00
301_R320_D1.0631.00
17_G20_A1.0611.00
305_L319_D1.0601.00
203_Y306_Q1.0591.00
19_I49_Q1.0561.00
33_L81_V1.0531.00
38_G64_G1.0501.00
146_S249_T1.0501.00
299_T372_H1.0431.00
50_V92_V1.0421.00
71_Y155_K1.0371.00
295_E372_H1.0271.00
266_T289_L1.0231.00
306_Q309_E1.0211.00
31_R85_K1.0191.00
196_F224_L1.0161.00
214_D217_A1.0121.00
72_E156_T1.0111.00
185_P233_K1.0101.00
305_L323_I1.0031.00
309_E319_D1.0031.00
193_V286_A1.0001.00
189_A232_L0.9971.00
38_G63_G0.9931.00
199_T251_A0.9921.00
276_M359_K0.9901.00
52_D55_K0.9871.00
36_Y63_G0.9861.00
268_M367_Q0.9851.00
305_L309_E0.9821.00
266_T285_L0.9811.00
135_C170_P0.9751.00
41_V47_L0.9721.00
22_L50_V0.9721.00
225_I329_A0.9711.00
149_G164_H0.9671.00
68_N278_G0.9631.00
186_R190_N0.9611.00
321_E325_A0.9581.00
34_I47_L0.9581.00
230_K239_D0.9521.00
70_A155_K0.9521.00
181_Y236_E0.9501.00
341_T345_D0.9501.00
231_A235_P0.9451.00
146_S173_A0.9441.00
117_W121_Q0.9421.00
91_A135_C0.9401.00
306_Q310_R0.9341.00
117_W120_L0.9331.00
26_I134_G0.9261.00
65_I100_G0.9231.00
78_V104_I0.9221.00
270_G274_T0.9191.00
223_T243_N0.9181.00
325_A328_A0.9131.00
235_P241_R0.9131.00
230_K240_V0.9121.00
47_L51_L0.9081.00
66_E76_N0.9081.00
202_Q214_D0.9071.00
224_L247_A0.9051.00
17_G176_D0.9021.00
32_V87_T0.9021.00
132_P171_V0.8961.00
319_D322_R0.8931.00
220_I251_A0.8901.00
98_L137_L0.8901.00
62_F77_A0.8891.00
34_I51_L0.8861.00
232_L338_G0.8831.00
78_V108_A0.8801.00
265_A292_L0.8781.00
110_Y128_K0.8771.00
223_T247_A0.8751.00
32_V57_M0.8731.00
20_A53_A0.8701.00
232_L337_L0.8701.00
190_N280_D0.8651.00
246_W250_Q0.8611.00
35_T97_V0.8611.00
15_G21_G0.8591.00
108_A131_I0.8541.00
354_P358_K0.8541.00
19_I178_V0.8511.00
197_V289_L0.8491.00
222_L226_E0.8481.00
200_V307_Y0.8471.00
272_E383_Y0.8451.00
45_G48_D0.8441.00
49_Q52_D0.8431.00
55_K58_D0.8431.00
11_R28_H0.8421.00
291_A294_N0.8411.00
91_A98_L0.8411.00
39_G43_K0.8401.00
19_I179_Y0.8371.00
100_G104_I0.8361.00
359_K362_E0.8351.00
49_Q53_A0.8331.00
49_Q179_Y0.8331.00
105_A131_I0.8301.00
112_E118_H0.8281.00
231_A240_V0.8281.00
140_P245_M0.8261.00
340_P345_D0.8241.00
331_R335_E0.8201.00
202_Q217_A0.8201.00
27_P57_M0.8191.00
38_G43_K0.8171.00
215_R222_L0.8161.00
293_W304_L0.8141.00
227_D244_V0.8141.00
295_E374_I0.8131.00
31_R87_T0.8111.00
204_V293_W0.8081.00
325_A329_A0.8061.00
112_E119_I0.8041.00
200_V221_L0.7911.00
105_A133_M0.7901.00
98_L144_S0.7831.00
272_E359_K0.7831.00
70_A278_G0.7821.00
196_F200_V0.7801.00
216_F250_Q0.7801.00
158_G278_G0.7781.00
148_A166_A0.7781.00
74_L103_F0.7771.00
185_P338_G0.7761.00
239_D242_A0.7761.00
22_L136_V0.7721.00
115_D118_H0.7711.00
185_P235_P0.7711.00
294_N327_I0.7701.00
206_K373_D0.7691.00
72_E76_N0.7631.00
226_E229_P0.7611.00
277_H352_S0.7601.00
307_Y330_T0.7591.00
357_L361_E0.7581.00
19_I176_D0.7571.00
21_G25_Q0.7551.00
135_C173_A0.7551.00
361_E379_S0.7551.00
203_Y218_E0.7531.00
13_L18_A0.7501.00
199_T217_A0.7501.00
353_I383_Y0.7501.00
39_G45_G0.7501.00
273_L284_T0.7501.00
265_A379_S0.7491.00
133_M171_V0.7471.00
298_D320_D0.7471.00
189_A339_V0.7451.00
62_F76_N0.7451.00
183_L191_G0.7401.00
32_V59_V0.7351.00
230_K233_K0.7311.00
260_V264_W0.7301.00
332_N335_E0.7281.00
229_P232_L0.7261.00
194_D281_H0.7241.00
335_E345_D0.7181.00
19_I50_V0.7171.00
293_W326_A0.7160.99
140_P180_T0.7140.99
283_Q340_P0.7130.99
180_T188_V0.7120.99
106_A168_V0.7110.99
225_I229_P0.7110.99
109_N131_I0.7080.99
267_H281_H0.7080.99
74_L104_I0.7080.99
301_R319_D0.7070.99
354_P357_L0.7070.99
36_Y61_E0.7040.99
24_E28_H0.7040.99
340_P346_Y0.7040.99
219_G250_Q0.7030.99
222_L306_Q0.7010.99
33_L62_F0.7000.99
14_F242_A0.6990.99
75_M107_A0.6980.99
290_P334_F0.6950.99
30_A58_D0.6940.99
286_A334_F0.6940.99
288_V382_I0.6930.99
297_R301_R0.6910.99
37_G43_K0.6890.99
308_A312_W0.6880.99
75_M78_V0.6880.99
208_V303_K0.6870.99
227_D239_D0.6850.99
333_F337_L0.6840.99
76_N80_L0.6840.99
175_L249_T0.6830.99
51_L61_E0.6810.99
192_V337_L0.6790.99
203_Y303_K0.6780.99
27_P30_A0.6770.99
91_A97_V0.6770.99
238_Y242_A0.6760.99
44_T47_L0.6750.99
271_H363_H0.6730.99
372_H378_V0.6680.99
270_G285_L0.6680.99
23_R27_P0.6600.99
103_F150_A0.6600.99
295_E375_T0.6580.99
26_I90_L0.6560.99
193_V337_L0.6560.99
31_R86_V0.6550.99
374_I379_S0.6550.99
20_A178_V0.6510.99
200_V289_L0.6500.99
221_L311_V0.6500.99
255_L260_V0.6500.99
81_V89_L0.6480.99
273_L383_Y0.6450.99
194_D267_H0.6440.99
343_L348_L0.6440.99
48_D55_K0.6430.99
68_N96_S0.6420.99
46_V92_V0.6310.99
320_D324_D0.6300.99
226_E230_K0.6290.99
177_P238_Y0.6290.99
134_G174_V0.6270.99
231_A244_V0.6260.99
14_F246_W0.6260.99
197_V285_L0.6240.99
197_V266_T0.6230.99
13_L172_F0.6230.99
19_I53_A0.6210.99
330_T334_F0.6170.99
227_D231_A0.6170.99
146_S253_N0.6170.99
331_R341_T0.6170.99
26_I54_L0.6150.98
23_R57_M0.6150.98
259_G369_G0.6140.98
279_L346_Y0.6140.98
374_I378_V0.6130.98
33_L84_Q0.6130.98
293_W327_I0.6110.98
294_N297_R0.6100.98
322_R325_A0.6090.98
150_A163_F0.6090.98
320_D323_I0.6080.98
348_L356_L0.6070.98
294_N328_A0.6030.98
137_L248_A0.6020.98
273_L343_L0.5970.98
221_L225_I0.5970.98
23_R26_I0.5970.98
200_V326_A0.5970.98
37_G44_T0.5950.98
328_A331_R0.5940.98
103_F152_I0.5930.98
204_V304_L0.5930.98
280_D283_Q0.5900.98
206_K369_G0.5870.98
115_D119_I0.5860.98
110_Y130_A0.5850.98
129_S167_H0.5850.98
29_D87_T0.5830.98
155_K158_G0.5800.98
22_L53_A0.5790.98
136_V174_V0.5780.98
287_I343_L0.5780.98
147_N252_L0.5780.98
130_A171_V0.5780.98
109_N130_A0.5770.98
276_M356_L0.5770.98
41_V44_T0.5760.98
290_P331_R0.5750.98
90_L134_G0.5730.98
221_L224_L0.5700.98
211_K226_E0.5690.97
35_T77_A0.5680.97
16_K239_D0.5680.97
357_L379_S0.5670.97
177_P245_M0.5660.97
285_L288_V0.5660.97
181_Y241_R0.5660.97
283_Q339_V0.5650.97
12_I173_A0.5630.97
374_I382_I0.5630.97
88_F132_P0.5600.97
46_V49_Q0.5580.97
301_R305_L0.5580.97
110_Y127_I0.5580.97
225_I312_W0.5570.97
265_A268_M0.5560.97
203_Y214_D0.5560.97
137_L175_L0.5550.97
360_L383_Y0.5550.97
54_L59_V0.5540.97
46_V179_Y0.5530.97
50_V53_A0.5530.97
229_P333_F0.5510.97
211_K243_N0.5510.97
198_H251_A0.5510.97
160_K281_H0.5510.97
205_T369_G0.5510.97
225_I333_F0.5490.97
307_Y311_V0.5470.97
66_E278_G0.5470.97
210_A213_Q0.5450.97
334_F339_V0.5450.97
229_P329_A0.5450.97
200_V293_W0.5430.97
26_I57_M0.5420.97
273_L356_L0.5420.97
107_A111_P0.5400.97
264_W369_G0.5380.96
207_P259_G0.5380.96
300_K304_L0.5370.96
106_A126_E0.5360.96
157_T161_Q0.5360.96
223_T250_Q0.5350.96
323_I326_A0.5340.96
112_E115_D0.5330.96
274_T284_T0.5330.96
327_I331_R0.5320.96
197_V264_W0.5320.96
350_G353_I0.5320.96
192_V224_L0.5310.96
291_A382_I0.5310.96
304_L326_A0.5310.96
62_F73_T0.5300.96
33_L60_L0.5290.96
6_L250_Q0.5280.96
301_R323_I0.5270.96
80_L86_V0.5270.96
36_Y97_V0.5270.96
334_F337_L0.5260.96
348_L353_I0.5250.96
13_L174_V0.5240.96
271_H365_M0.5240.96
307_Y312_W0.5230.96
68_N274_T0.5220.96
99_D281_H0.5210.96
24_E27_P0.5200.96
89_L104_I0.5170.96
182_T236_E0.5160.96
227_D247_A0.5160.96
189_A333_F0.5150.96
286_A339_V0.5150.96
297_R304_L0.5120.95
111_P119_I0.5120.95
148_A256_I0.5110.95
47_L92_V0.5110.95
295_E382_I0.5100.95
73_T100_G0.5090.95
220_I250_Q0.5090.95
56_G59_V0.5080.95
82_R111_P0.5080.95
34_I92_V0.5070.95
268_M365_M0.5060.95
304_L308_A0.5040.95
223_T227_D0.5040.95
30_A57_M0.5030.95
242_A246_W0.5020.95
192_V232_L0.5020.95
297_R320_D0.5010.95
81_V84_Q0.5000.95
126_E167_H0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qgsA 2 0.9819 100 0.108 Contact Map
1vljA 2 0.9845 100 0.113 Contact Map
3bfjA 5 0.9742 100 0.114 Contact Map
3ox4A 2 0.9742 100 0.116 Contact Map
1rrmA 2 0.9742 100 0.138 Contact Map
4fr2A 2 0.9716 100 0.143 Contact Map
3zdrA 2 0.9716 100 0.145 Contact Map
1o2dA 1 0.9199 100 0.18 Contact Map
3w5sA 2 0.8811 100 0.204 Contact Map
3iv7A 2 0.8786 100 0.206 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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