GREMLIN Database
YQHC - Uncharacterized HTH-type transcriptional regulator YqhC
UniProt: Q46855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13013
Length: 318 (252)
Sequences: 23949 (20183)
Seq/√Len: 1271.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_R301_F3.2091.00
253_T261_N3.1071.00
220_E262_Y3.0341.00
264_L301_F3.0261.00
276_M284_R3.0071.00
230_E240_V2.8571.00
222_K225_E2.7111.00
266_K269_M2.6901.00
218_R222_K2.6851.00
261_N300_Y2.4941.00
267_A293_F2.3571.00
297_F308_D2.3101.00
270_M284_R2.2951.00
215_V243_F2.2391.00
79_I86_V2.1681.00
247_F258_Y2.0991.00
270_M285_V1.9941.00
79_I88_R1.9941.00
219_I259_L1.9881.00
303_V311_R1.9541.00
223_Y262_Y1.9341.00
276_M280_A1.9131.00
228_S231_Q1.8971.00
256_L260_K1.8581.00
81_Y86_V1.8521.00
212_I251_T1.8491.00
216_L251_T1.8101.00
215_V236_A1.8051.00
218_R235_E1.8001.00
232_L255_P1.7521.00
90_D93_E1.7391.00
270_M276_M1.7391.00
264_L300_Y1.7301.00
229_V244_H1.7211.00
77_H88_R1.7171.00
74_F118_L1.7141.00
75_S116_A1.6951.00
271_I278_A1.6791.00
296_E299_R1.6611.00
277_K280_A1.6531.00
220_E258_Y1.6411.00
182_I185_E1.6231.00
290_A294_S1.6141.00
253_T257_Q1.6061.00
242_A246_N1.5871.00
268_R308_D1.5761.00
262_Y266_K1.5761.00
217_K221_N1.5611.00
218_R227_L1.5591.00
77_H90_D1.5581.00
243_F255_P1.5481.00
79_I106_E1.5271.00
306_G310_A1.5191.00
83_N101_L1.5161.00
223_Y266_K1.5151.00
279_S290_A1.5121.00
255_P259_L1.5111.00
81_Y104_E1.5101.00
292_Q296_E1.4951.00
280_A284_R1.4761.00
303_V307_E1.4741.00
269_M273_H1.4641.00
219_I262_Y1.4531.00
241_S245_H1.4451.00
159_L163_E1.4411.00
281_A285_V1.4281.00
224_T284_R1.4271.00
242_A245_H1.4261.00
230_E234_A1.4121.00
266_K270_M1.4041.00
266_K285_V1.3841.00
280_A283_M1.3801.00
209_F250_V1.3751.00
231_Q235_E1.3701.00
267_A285_V1.3621.00
238_M242_A1.3601.00
244_H255_P1.3541.00
287_Y296_E1.3511.00
240_V244_H1.3491.00
279_S283_M1.3371.00
185_E189_Y1.3311.00
254_S257_Q1.3291.00
211_L238_M1.3251.00
181_Q188_Y1.3041.00
68_P99_V1.3011.00
294_S304_T1.2921.00
238_M243_F1.2891.00
75_S91_A1.2811.00
225_E231_Q1.2701.00
215_V232_L1.2551.00
291_S294_S1.2551.00
294_S306_G1.2551.00
148_G151_S1.2511.00
239_S242_A1.2291.00
274_D309_A1.2241.00
261_N265_H1.2201.00
276_M281_A1.2201.00
260_K296_E1.2161.00
262_Y265_H1.2141.00
98_T101_L1.2071.00
74_F116_A1.1891.00
246_N249_S1.1651.00
216_L220_E1.1521.00
307_E310_A1.1521.00
295_R299_R1.1491.00
181_Q184_R1.1451.00
219_I255_P1.1431.00
181_Q185_E1.1421.00
160_C163_E1.1401.00
218_R236_A1.1341.00
265_H268_R1.1271.00
224_T266_K1.1101.00
233_A240_V1.0991.00
306_G309_A1.0871.00
188_Y192_T1.0861.00
178_L185_E1.0851.00
229_V255_P1.0831.00
172_P175_A1.0821.00
211_L236_A1.0801.00
268_R272_I1.0591.00
210_S214_R1.0581.00
65_M103_F1.0421.00
184_R188_Y1.0341.00
69_G103_F1.0291.00
304_T307_E1.0281.00
63_P103_F1.0271.00
232_L235_E1.0201.00
231_Q234_A1.0171.00
157_E189_Y1.0021.00
163_E167_D1.0001.00
226_N288_E0.9991.00
178_L182_I0.9981.00
214_R235_E0.9961.00
164_R182_I0.9941.00
246_N250_V0.9921.00
160_C164_R0.9861.00
81_Y106_E0.9851.00
268_R297_F0.9831.00
211_L246_N0.9711.00
256_L292_Q0.9701.00
216_L258_Y0.9661.00
152_A155_S0.9641.00
294_S298_K0.9611.00
157_E160_C0.9571.00
296_E300_Y0.9551.00
257_Q261_N0.9501.00
236_A243_F0.9491.00
241_S244_H0.9441.00
263_R285_V0.9391.00
62_T102_P0.9361.00
278_A281_A0.9251.00
72_I94_Y0.9241.00
289_S295_R0.9241.00
223_Y259_L0.9191.00
307_E311_R0.9151.00
270_M281_A0.9141.00
78_K89_Y0.9101.00
71_I119_R0.9021.00
73_L78_K0.8931.00
227_L232_L0.8921.00
223_Y227_L0.8881.00
260_K299_R0.8881.00
212_I246_N0.8861.00
164_R185_E0.8811.00
218_R232_L0.8811.00
292_Q295_R0.8781.00
65_M69_G0.8751.00
68_P96_L0.8681.00
264_L296_E0.8671.00
256_L259_L0.8671.00
274_D281_A0.8651.00
282_A290_A0.8611.00
75_S114_P0.8601.00
212_I215_V0.8581.00
301_F308_D0.8581.00
271_I309_A0.8551.00
238_M246_N0.8541.00
214_R236_A0.8531.00
208_H249_S0.8511.00
223_Y285_V0.8481.00
271_I281_A0.8471.00
147_S151_S0.8451.00
214_R217_K0.8451.00
226_N231_Q0.8421.00
148_G152_A0.8411.00
124_I128_Q0.8351.00
180_K184_R0.8341.00
213_S217_K0.8311.00
78_K115_L0.8291.00
213_S216_L0.8251.00
232_L243_F0.8251.00
247_F255_P0.8241.00
82_I85_R0.8231.00
67_E121_N0.8221.00
257_Q260_K0.8221.00
219_I258_Y0.8191.00
257_Q300_Y0.8161.00
128_Q132_M0.8161.00
78_K88_R0.8091.00
264_L293_F0.8091.00
229_V240_V0.8061.00
69_G121_N0.8061.00
222_K231_Q0.8061.00
73_L76_G0.8051.00
168_V192_T0.7981.00
258_Y262_Y0.7971.00
166_L170_E0.7961.00
62_T104_E0.7951.00
215_V255_P0.7901.00
71_I117_G0.7891.00
244_H254_S0.7891.00
298_K307_E0.7851.00
298_K304_T0.7831.00
177_I180_K0.7821.00
80_G95_L0.7811.00
212_I250_V0.7781.00
189_Y193_G0.7781.00
247_F251_T0.7761.00
222_K235_E0.7751.00
81_Y84_E0.7731.00
89_Y95_L0.7661.00
151_S155_S0.7651.00
215_V218_R0.7631.00
73_L89_Y0.7621.00
303_V308_D0.7591.00
267_A270_M0.7541.00
283_M288_E0.7531.00
244_H248_K0.7501.00
278_A306_G0.7491.00
260_K300_Y0.7481.00
71_I97_L0.7361.00
289_S292_Q0.7341.00
156_E160_C0.7321.00
245_H249_S0.7311.00
178_L188_Y0.7271.00
223_Y263_R0.7261.00
78_K105_C0.7261.00
97_L103_F0.7251.00
211_L214_R0.7251.00
73_L117_G0.7231.00
72_I162_A0.7231.00
176_R180_K0.7221.00
281_A309_A0.7151.00
215_V247_F0.7131.00
175_A179_G0.7111.00
264_L287_Y0.7091.00
227_L263_R0.7031.00
157_E161_A0.6961.00
150_N154_L0.6951.00
70_I96_L0.6911.00
178_L192_T0.6911.00
297_F303_V0.6861.00
272_I308_D0.6851.00
212_I243_F0.6781.00
215_V235_E0.6781.00
155_S159_L0.6761.00
157_E164_R0.6751.00
229_V256_L0.6731.00
161_A182_I0.6731.00
215_V219_I0.6731.00
71_I80_G0.6721.00
147_S150_N0.6701.00
116_A119_R0.6691.00
288_E292_Q0.6691.00
168_V178_L0.6691.00
126_Q129_E0.6661.00
59_F106_E0.6641.00
291_S304_T0.6641.00
82_I97_L0.6631.00
64_V102_P0.6621.00
293_F305_P0.6621.00
77_H113_V0.6591.00
156_E159_L0.6581.00
150_N153_T0.6561.00
267_A281_A0.6541.00
227_L231_Q0.6541.00
160_C167_D0.6511.00
129_E132_M0.6501.00
167_D171_R0.6501.00
179_G182_I0.6471.00
178_L181_Q0.6451.00
71_I95_L0.6391.00
164_R168_V0.6361.00
216_L247_F0.6351.00
177_I184_R0.6351.00
253_T258_Y0.6341.00
129_E133_D0.6301.00
291_S295_R0.6301.00
212_I216_L0.6291.00
115_L119_R0.6221.00
74_F163_E0.6211.00
220_E266_K0.6201.00
151_S154_L0.6181.00
80_G105_C0.6181.00
260_K264_L0.6141.00
208_H211_L0.6091.00
218_R231_Q0.6091.00
244_H256_L0.6061.00
177_I181_Q0.6041.00
209_F213_S0.6021.00
209_F246_N0.5991.00
77_H110_T0.5981.00
164_R167_D0.5981.00
275_G281_A0.5971.00
161_A164_R0.5951.00
219_I227_L0.5941.00
154_L157_E0.5941.00
161_A165_L0.5921.00
161_A189_Y0.5921.00
248_K254_S0.5901.00
229_V241_S0.5901.00
265_H300_Y0.5901.00
222_K227_L0.5871.00
166_L169_M0.5851.00
93_E151_S0.5841.00
290_A293_F0.5841.00
260_K292_Q0.5841.00
232_L236_A0.5831.00
259_L262_Y0.5781.00
206_Q209_F0.5741.00
243_F246_N0.5741.00
251_T258_Y0.5731.00
289_S299_R0.5721.00
138_E141_Q0.5721.00
212_I236_A0.5711.00
218_R223_Y0.5711.00
157_E167_D0.5681.00
86_V106_E0.5681.00
243_F251_T0.5631.00
259_L263_R0.5611.00
69_G97_L0.5591.00
73_L77_H0.5521.00
234_A237_N0.5521.00
236_A240_V0.5501.00
72_I155_S0.5491.00
80_G97_L0.5481.00
245_H248_K0.5481.00
168_V172_P0.5471.00
248_K251_T0.5451.00
277_K281_A0.5441.00
283_M290_A0.5411.00
161_A186_I0.5381.00
189_Y192_T0.5381.00
215_V238_M0.5341.00
185_E188_Y0.5331.00
73_L115_L0.5321.00
118_L166_L0.5301.00
145_A148_G0.5301.00
265_H301_F0.5271.00
263_R286_G0.5271.00
273_H276_M0.5261.00
208_H250_V0.5241.00
174_D192_T0.5241.00
226_N263_R0.5241.00
70_I94_Y0.5221.00
167_D170_E0.5201.00
125_L128_Q0.5191.00
66_Y123_D0.5181.00
169_M179_G0.5181.00
105_C119_R0.5181.00
68_P124_I0.5181.00
178_L189_Y0.5171.00
68_P71_I0.5171.00
211_L215_V0.5161.00
158_I161_A0.5151.00
271_I308_D0.5151.00
68_P98_T0.5141.00
227_L259_L0.5131.00
66_Y100_P0.5121.00
293_F297_F0.5121.00
163_E166_L0.5121.00
61_R104_E0.5091.00
156_E163_E0.5081.00
77_H91_A0.5071.00
260_K287_Y0.5041.00
73_L95_L0.5041.00
229_V233_A0.5021.00
287_Y292_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8019 100 0.289 Contact Map
1bl0A 1 0.3491 100 0.515 Contact Map
3w6vA 1 0.3459 100 0.517 Contact Map
3oouA 1 0.3302 100 0.518 Contact Map
3oioA 1 0.3522 100 0.519 Contact Map
3mklA 1 0.3491 100 0.523 Contact Map
3mn2A 1 0.3333 100 0.524 Contact Map
2k9sA 1 0.3333 100 0.529 Contact Map
3lsgA 2 0.3208 100 0.537 Contact Map
1d5yA 1 0.3491 99.9 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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