GREMLIN Database
GPR - L-glyceraldehyde 3-phosphate reductase
UniProt: Q46851 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13010
Length: 346 (282)
Sequences: 28165 (17640)
Seq/√Len: 1050.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_K309_E3.2961.00
42_L79_R2.9801.00
121_D161_K2.9611.00
82_R128_G2.9431.00
277_R324_E2.8331.00
17_Y24_R2.5441.00
321_S324_E2.5411.00
117_L159_S2.4301.00
117_L155_H2.4141.00
51_K55_L2.3971.00
120_L156_A2.3901.00
276_Q327_Q2.3591.00
154_A158_Q2.2361.00
46_R83_E2.2251.00
16_R27_A2.1591.00
271_N275_Q2.1051.00
291_K325_L2.0541.00
131_Y163_L2.0451.00
322_T326_A1.9911.00
276_Q324_E1.9631.00
72_S75_E1.9511.00
88_Y91_E1.9191.00
29_S59_H1.8791.00
155_H159_S1.8761.00
46_R79_R1.8691.00
113_R155_H1.8691.00
272_E327_Q1.8561.00
41_A44_S1.8481.00
211_T215_N1.8481.00
55_L309_E1.8341.00
305_A309_E1.8221.00
269_L272_E1.7981.00
51_K305_A1.7911.00
212_L219_C1.7901.00
136_Y191_I1.7841.00
176_Q180_E1.7601.00
122_Q126_R1.7571.00
155_H158_Q1.7461.00
96_T132_V1.7311.00
15_Y24_R1.7271.00
98_A116_L1.6701.00
287_S318_L1.6571.00
55_L312_V1.6551.00
113_R117_L1.6521.00
75_E126_R1.6521.00
52_A57_I1.6401.00
326_A330_Q1.6261.00
279_Q318_L1.6211.00
152_A155_H1.6201.00
280_S310_E1.6151.00
98_A135_F1.6151.00
94_I129_L1.6121.00
95_S136_Y1.6071.00
46_R50_R1.6061.00
313_Q316_N1.6001.00
207_G210_D1.5961.00
46_R80_L1.5911.00
32_L60_F1.5891.00
120_L135_F1.5791.00
117_L121_D1.5621.00
118_A122_Q1.5581.00
136_Y220_I1.5431.00
176_Q211_T1.5281.00
154_A187_I1.5251.00
292_D329_D1.5101.00
42_L46_R1.5031.00
44_S47_A1.5031.00
51_K54_D1.4961.00
14_Q27_A1.4851.00
23_L164_Y1.4791.00
218_G297_S1.4721.00
96_T123_S1.4691.00
158_Q186_K1.4661.00
50_R83_E1.4501.00
64_N119_S1.4491.00
279_Q283_Q1.4461.00
49_L80_L1.4441.00
213_Q293_D1.4131.00
171_S174_R1.4091.00
53_F92_L1.3871.00
122_Q125_K1.3551.00
23_L93_I1.3471.00
117_L152_A1.3411.00
132_V162_A1.3381.00
162_A165_V1.3371.00
327_Q330_Q1.3071.00
179_V215_N1.3041.00
120_L132_V1.2941.00
269_L327_Q1.2881.00
279_Q284_M1.2851.00
121_D125_K1.2841.00
272_E276_Q1.2811.00
113_R151_S1.2771.00
179_V211_T1.2761.00
50_R54_D1.2731.00
210_D214_N1.2721.00
78_G128_G1.2701.00
156_A162_A1.2551.00
309_E313_Q1.2551.00
176_Q214_N1.2401.00
60_F77_F1.2201.00
172_P211_T1.2191.00
280_S283_Q1.2141.00
287_S291_K1.2141.00
79_R128_G1.2011.00
140_V174_R1.1991.00
89_R129_L1.1931.00
164_Y190_L1.1921.00
157_V187_I1.1871.00
75_E79_R1.1861.00
127_M132_V1.1841.00
47_A51_K1.1841.00
93_I134_I1.1801.00
306_E309_E1.1791.00
74_E123_S1.1721.00
273_M284_M1.1721.00
137_S153_L1.1541.00
271_N281_M1.1521.00
113_R152_A1.1511.00
302_A308_L1.1491.00
268_R271_N1.1481.00
48_I308_L1.1451.00
194_P219_C1.1441.00
58_T93_I1.1351.00
195_S200_N1.1301.00
213_Q294_R1.1301.00
198_L328_I1.1271.00
147_E181_L1.1261.00
17_Y22_G1.1231.00
43_E47_A1.1211.00
203_V219_C1.1161.00
114_K118_A1.1101.00
302_A307_Q1.1031.00
134_I191_I1.0991.00
268_R272_E1.0981.00
153_L165_V1.0911.00
59_H95_S1.0801.00
89_R131_Y1.0771.00
47_A305_A1.0731.00
21_S164_Y1.0661.00
59_H220_I1.0641.00
209_L213_Q1.0601.00
32_L77_F1.0591.00
115_Y118_A1.0541.00
27_A290_L1.0531.00
289_L298_V1.0521.00
283_Q313_Q1.0471.00
272_E275_Q1.0431.00
148_E151_S1.0391.00
50_R80_L1.0371.00
81_L92_L1.0231.00
176_Q215_N1.0201.00
101_D110_G1.0171.00
198_L285_A1.0091.00
121_D159_S1.0021.00
196_Y292_D0.9911.00
147_E177_K0.9891.00
75_E125_K0.9881.00
167_I189_L0.9851.00
49_L60_F0.9841.00
290_L314_A0.9841.00
270_L281_M0.9811.00
151_S155_H0.9811.00
175_T217_V0.9751.00
283_Q310_E0.9741.00
154_A157_V0.9741.00
111_G137_S0.9721.00
117_L120_L0.9661.00
201_R204_D0.9651.00
112_S115_Y0.9641.00
26_P58_T0.9621.00
26_P57_I0.9591.00
14_Q319_T0.9581.00
196_Y204_D0.9581.00
165_V189_L0.9471.00
113_R148_E0.9431.00
64_N115_Y0.9401.00
323_K326_A0.9381.00
152_A156_A0.9341.00
177_K181_L0.9331.00
21_S190_L0.9321.00
156_A161_K0.9311.00
308_L312_V0.9301.00
133_D163_L0.9261.00
157_V190_L0.9221.00
213_Q295_V0.9211.00
167_I175_T0.9211.00
235_L271_N0.9191.00
42_L76_N0.9111.00
210_D213_Q0.9111.00
172_P176_Q0.9051.00
156_A159_S0.9011.00
310_E313_Q0.8991.00
220_I297_S0.8981.00
261_E265_N0.8971.00
199_L267_L0.8971.00
55_L313_Q0.8961.00
306_E310_E0.8941.00
53_F88_Y0.8921.00
326_A329_D0.8891.00
292_D325_L0.8891.00
117_L156_A0.8881.00
191_I220_I0.8831.00
201_R332_I0.8791.00
47_A50_R0.8791.00
151_S154_A0.8781.00
177_K180_E0.8751.00
27_A315_L0.8721.00
323_K327_Q0.8701.00
95_S134_I0.8571.00
83_E88_Y0.8531.00
118_A121_D0.8451.00
110_G115_Y0.8441.00
192_H212_L0.8431.00
169_S222_F0.8331.00
273_M277_R0.8311.00
30_L52_A0.8271.00
79_R83_E0.8241.00
74_E126_R0.8201.00
304_R307_Q0.8181.00
116_L156_A0.8161.00
265_N268_R0.8111.00
291_K319_T0.8091.00
139_R169_S0.8081.00
209_L219_C0.8051.00
44_S305_A0.8041.00
57_I312_V0.8041.00
291_K322_T0.8021.00
32_L73_A0.8011.00
201_R329_D0.8001.00
286_L314_A0.7991.00
20_K190_L0.7901.00
150_A178_M0.7811.00
277_R321_S0.7801.00
42_L72_S0.7791.00
264_L268_R0.7781.00
64_N126_R0.7771.00
29_S300_I0.7771.00
218_G296_T0.7761.00
320_F325_L0.7731.00
15_Y58_T0.7731.00
211_T214_N0.7721.00
43_E46_R0.7711.00
269_L331_H0.7701.00
37_G40_N0.7591.00
124_L161_K0.7591.00
95_S220_I0.7551.00
119_S122_Q0.7541.00
275_Q278_G0.7491.00
303_S307_Q0.7431.00
276_Q321_S0.7421.00
50_R88_Y0.7391.00
62_L77_F0.7381.00
45_Q76_N0.7381.00
150_A189_L0.7381.00
48_I305_A0.7351.00
21_S157_V0.7321.00
221_A298_V0.7301.00
224_P300_I0.7241.00
235_L268_R0.7191.00
287_S314_A0.7151.00
90_D131_Y0.7141.00
179_V188_P0.7141.00
146_M181_L0.7121.00
282_A310_E0.7121.00
167_I170_Y0.7081.00
64_N122_Q0.7061.00
120_L161_K0.7041.00
208_L212_L0.7031.00
149_T152_A0.7021.00
221_A224_P0.7011.00
49_L53_F0.7001.00
49_L77_F0.7001.00
88_Y92_L0.6981.00
53_F60_F0.6971.00
153_L157_V0.6961.00
154_A165_V0.6951.00
28_L290_L0.6941.00
172_P207_G0.6901.00
236_N268_R0.6891.00
273_M324_E0.6891.00
150_A165_V0.6841.00
111_G149_T0.6801.00
124_L129_L0.6781.00
284_M318_L0.6761.00
29_S297_S0.6751.00
154_A186_K0.6731.00
116_L149_T0.6721.00
212_L217_V0.6711.00
53_F91_E0.6711.00
72_S76_N0.6661.00
285_A289_L0.6621.00
288_W329_D0.6621.00
25_L59_H0.6611.00
20_K216_G0.6611.00
145_P148_E0.6591.00
58_T91_E0.6591.00
167_I192_H0.6591.00
136_Y166_G0.6571.00
267_L271_N0.6571.00
36_F40_N0.6571.00
196_Y209_L0.6551.00
196_Y289_L0.6521.00
172_P208_L0.6521.00
229_L267_L0.6511.00
265_N269_L0.6481.00
236_N261_E0.6471.00
25_L297_S0.6451.00
203_V209_L0.6451.00
23_L163_L0.6411.00
270_L285_A0.6401.00
96_T135_F0.6401.00
16_R218_G0.6391.00
270_L328_I0.6371.00
176_Q179_V0.6331.00
36_F48_I0.6331.00
33_W223_T0.6321.00
279_Q287_S0.6321.00
264_L267_L0.6311.00
279_Q313_Q0.6301.00
277_R284_M0.6291.00
284_M328_I0.6271.00
98_A111_G0.6261.00
324_E327_Q0.6231.00
150_A182_L0.6221.00
274_A284_M0.6211.00
284_M320_F0.6181.00
157_V162_A0.6171.00
273_M327_Q0.6161.00
273_M331_H0.6141.00
30_L36_F0.6111.00
48_I302_A0.6101.00
198_L332_I0.6101.00
209_L292_D0.6071.00
307_Q310_E0.6061.00
140_V170_Y0.6061.00
199_L229_L0.6051.00
320_F324_E0.6051.00
53_F58_T0.6041.00
146_M149_T0.6041.00
224_P289_L0.6041.00
117_L161_K0.6031.00
41_A45_Q0.6031.00
116_L152_A0.6021.00
18_C218_G0.6001.00
60_F81_L0.5991.00
157_V164_Y0.5961.00
35_N38_H0.5941.00
289_L296_T0.5921.00
87_A92_L0.5921.00
61_D193_Q0.5921.00
55_L308_L0.5911.00
179_V217_V0.5881.00
14_Q316_N0.5811.00
20_K188_P0.5781.00
123_S135_F0.5771.00
279_Q316_N0.5771.00
284_M324_E0.5751.00
81_L88_Y0.5741.00
132_V135_F0.5741.00
51_K308_L0.5721.00
67_G72_S0.5721.00
137_S149_T0.5721.00
262_A265_N0.5681.00
120_L152_A0.5651.00
157_V165_V0.5651.00
62_L73_A0.5641.00
98_A119_S0.5641.00
221_A295_V0.5611.00
135_F162_A0.5591.00
290_L298_V0.5581.00
74_E96_T0.5561.00
46_R76_N0.5561.00
182_L189_L0.5551.00
274_A281_M0.5541.00
154_A182_L0.5531.00
64_N110_G0.5521.00
120_L124_L0.5491.00
194_P208_L0.5491.00
157_V188_P0.5481.00
196_Y201_R0.5481.00
173_E176_Q0.5481.00
166_G191_I0.5471.00
71_G126_R0.5471.00
53_F80_L0.5441.00
174_R177_K0.5441.00
203_V210_D0.5411.00
18_C21_S0.5401.00
29_S299_L0.5401.00
79_R82_R0.5391.00
231_T234_Y0.5381.00
30_L48_I0.5371.00
286_L311_N0.5371.00
229_L263_N0.5351.00
75_E128_G0.5331.00
77_F80_L0.5331.00
124_L131_Y0.5311.00
15_Y26_P0.5301.00
221_A289_L0.5291.00
33_W227_Q0.5281.00
167_I178_M0.5281.00
52_A60_F0.5281.00
236_N264_L0.5271.00
223_T227_Q0.5261.00
124_L132_V0.5261.00
100_Y139_R0.5261.00
28_L314_A0.5221.00
273_M276_Q0.5211.00
26_P59_H0.5181.00
50_R87_A0.5171.00
113_R116_L0.5131.00
134_I166_G0.5121.00
224_P286_L0.5121.00
59_H93_I0.5101.00
49_L81_L0.5091.00
147_E151_S0.5071.00
89_R133_D0.5051.00
101_D109_S0.5041.00
274_A277_R0.5041.00
65_N100_Y0.5031.00
170_Y175_T0.5021.00
146_M174_R0.5011.00
18_C191_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6qA 5 0.9104 100 0.132 Contact Map
3erpA 6 0.896 100 0.158 Contact Map
4xk2A 5 0.8815 100 0.166 Contact Map
1pyfA 1 0.8844 100 0.168 Contact Map
3eauA 3 0.9277 100 0.17 Contact Map
3lutA 3 0.9249 100 0.177 Contact Map
1pz1A 1 0.922 100 0.178 Contact Map
3v0sA 1 0.7803 100 0.184 Contact Map
3n2tA 1 0.9133 100 0.188 Contact Map
1lqaA 2 0.922 100 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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