GPR - ECOLI - GREMLIN Contacts

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GPR - L-glyceraldehyde 3-phosphate reductase

UniProt:	Q46851	Sequences: MVWLANPERYGQMQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRLLREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVTSVLIGASRAEQLEENVQALNNLTFSTKELAQIDQHIADGELNLWQASSDK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13010
Length:	346 (282)
Sequences:	28165 (17640)
Seq/√Len:	1050.4

ECOLI - GPR YAJO YDJG TAS YDHF YEAE YDBC DKGA DKGB
BACSU - GS69 YRPG IOLS YCCK YCSN YQKF YTBE GR
HALSA - Q9HPH9 Q9HQU7 Q9HNN3 Q9HSE6 Q9HS02 Q9HQT1
SULSO - Q97UG6 Q97UJ7 Q97ZZ1 Q97UV9 Q97V56 Q97U17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_K	309_E	3.296	1.00
42_L	79_R	2.980	1.00
121_D	161_K	2.961	1.00
82_R	128_G	2.943	1.00
277_R	324_E	2.833	1.00
17_Y	24_R	2.544	1.00
321_S	324_E	2.541	1.00
117_L	159_S	2.430	1.00
117_L	155_H	2.414	1.00
51_K	55_L	2.397	1.00
120_L	156_A	2.390	1.00
276_Q	327_Q	2.359	1.00
154_A	158_Q	2.236	1.00
46_R	83_E	2.225	1.00
16_R	27_A	2.159	1.00
271_N	275_Q	2.105	1.00
291_K	325_L	2.054	1.00
131_Y	163_L	2.045	1.00
322_T	326_A	1.991	1.00
276_Q	324_E	1.963	1.00
72_S	75_E	1.951	1.00
88_Y	91_E	1.919	1.00
29_S	59_H	1.879	1.00
155_H	159_S	1.876	1.00
46_R	79_R	1.869	1.00
113_R	155_H	1.869	1.00
272_E	327_Q	1.856	1.00
41_A	44_S	1.848	1.00
211_T	215_N	1.848	1.00
55_L	309_E	1.834	1.00
305_A	309_E	1.822	1.00
269_L	272_E	1.798	1.00
51_K	305_A	1.791	1.00
212_L	219_C	1.790	1.00
136_Y	191_I	1.784	1.00
176_Q	180_E	1.760	1.00
122_Q	126_R	1.757	1.00
155_H	158_Q	1.746	1.00
96_T	132_V	1.731	1.00
15_Y	24_R	1.727	1.00
98_A	116_L	1.670	1.00
287_S	318_L	1.657	1.00
55_L	312_V	1.655	1.00
113_R	117_L	1.652	1.00
75_E	126_R	1.652	1.00
52_A	57_I	1.640	1.00
326_A	330_Q	1.626	1.00
279_Q	318_L	1.621	1.00
152_A	155_H	1.620	1.00
280_S	310_E	1.615	1.00
98_A	135_F	1.615	1.00
94_I	129_L	1.612	1.00
95_S	136_Y	1.607	1.00
46_R	50_R	1.606	1.00
313_Q	316_N	1.600	1.00
207_G	210_D	1.596	1.00
46_R	80_L	1.591	1.00
32_L	60_F	1.589	1.00
120_L	135_F	1.579	1.00
117_L	121_D	1.562	1.00
118_A	122_Q	1.558	1.00
136_Y	220_I	1.543	1.00
176_Q	211_T	1.528	1.00
154_A	187_I	1.525	1.00
292_D	329_D	1.510	1.00
42_L	46_R	1.503	1.00
44_S	47_A	1.503	1.00
51_K	54_D	1.496	1.00
14_Q	27_A	1.485	1.00
23_L	164_Y	1.479	1.00
218_G	297_S	1.472	1.00
96_T	123_S	1.469	1.00
158_Q	186_K	1.466	1.00
50_R	83_E	1.450	1.00
64_N	119_S	1.449	1.00
279_Q	283_Q	1.446	1.00
49_L	80_L	1.444	1.00
213_Q	293_D	1.413	1.00
171_S	174_R	1.409	1.00
53_F	92_L	1.387	1.00
122_Q	125_K	1.355	1.00
23_L	93_I	1.347	1.00
117_L	152_A	1.341	1.00
132_V	162_A	1.338	1.00
162_A	165_V	1.337	1.00
327_Q	330_Q	1.307	1.00
179_V	215_N	1.304	1.00
120_L	132_V	1.294	1.00
269_L	327_Q	1.288	1.00
279_Q	284_M	1.285	1.00
121_D	125_K	1.284	1.00
272_E	276_Q	1.281	1.00
113_R	151_S	1.277	1.00
179_V	211_T	1.276	1.00
50_R	54_D	1.273	1.00
210_D	214_N	1.272	1.00
78_G	128_G	1.270	1.00
156_A	162_A	1.255	1.00
309_E	313_Q	1.255	1.00
176_Q	214_N	1.240	1.00
60_F	77_F	1.220	1.00
172_P	211_T	1.219	1.00
280_S	283_Q	1.214	1.00
287_S	291_K	1.214	1.00
79_R	128_G	1.201	1.00
140_V	174_R	1.199	1.00
89_R	129_L	1.193	1.00
164_Y	190_L	1.192	1.00
157_V	187_I	1.187	1.00
75_E	79_R	1.186	1.00
127_M	132_V	1.184	1.00
47_A	51_K	1.184	1.00
93_I	134_I	1.180	1.00
306_E	309_E	1.179	1.00
74_E	123_S	1.172	1.00
273_M	284_M	1.172	1.00
137_S	153_L	1.154	1.00
271_N	281_M	1.152	1.00
113_R	152_A	1.151	1.00
302_A	308_L	1.149	1.00
268_R	271_N	1.148	1.00
48_I	308_L	1.145	1.00
194_P	219_C	1.144	1.00
58_T	93_I	1.135	1.00
195_S	200_N	1.130	1.00
213_Q	294_R	1.130	1.00
198_L	328_I	1.127	1.00
147_E	181_L	1.126	1.00
17_Y	22_G	1.123	1.00
43_E	47_A	1.121	1.00
203_V	219_C	1.116	1.00
114_K	118_A	1.110	1.00
302_A	307_Q	1.103	1.00
134_I	191_I	1.099	1.00
268_R	272_E	1.098	1.00
153_L	165_V	1.091	1.00
59_H	95_S	1.080	1.00
89_R	131_Y	1.077	1.00
47_A	305_A	1.073	1.00
21_S	164_Y	1.066	1.00
59_H	220_I	1.064	1.00
209_L	213_Q	1.060	1.00
32_L	77_F	1.059	1.00
115_Y	118_A	1.054	1.00
27_A	290_L	1.053	1.00
289_L	298_V	1.052	1.00
283_Q	313_Q	1.047	1.00
272_E	275_Q	1.043	1.00
148_E	151_S	1.039	1.00
50_R	80_L	1.037	1.00
81_L	92_L	1.023	1.00
176_Q	215_N	1.020	1.00
101_D	110_G	1.017	1.00
198_L	285_A	1.009	1.00
121_D	159_S	1.002	1.00
196_Y	292_D	0.991	1.00
147_E	177_K	0.989	1.00
75_E	125_K	0.988	1.00
167_I	189_L	0.985	1.00
49_L	60_F	0.984	1.00
290_L	314_A	0.984	1.00
270_L	281_M	0.981	1.00
151_S	155_H	0.981	1.00
175_T	217_V	0.975	1.00
283_Q	310_E	0.974	1.00
154_A	157_V	0.974	1.00
111_G	137_S	0.972	1.00
117_L	120_L	0.966	1.00
201_R	204_D	0.965	1.00
112_S	115_Y	0.964	1.00
26_P	58_T	0.962	1.00
26_P	57_I	0.959	1.00
14_Q	319_T	0.958	1.00
196_Y	204_D	0.958	1.00
165_V	189_L	0.947	1.00
113_R	148_E	0.943	1.00
64_N	115_Y	0.940	1.00
323_K	326_A	0.938	1.00
152_A	156_A	0.934	1.00
177_K	181_L	0.933	1.00
21_S	190_L	0.932	1.00
156_A	161_K	0.931	1.00
308_L	312_V	0.930	1.00
133_D	163_L	0.926	1.00
157_V	190_L	0.922	1.00
213_Q	295_V	0.921	1.00
167_I	175_T	0.921	1.00
235_L	271_N	0.919	1.00
42_L	76_N	0.911	1.00
210_D	213_Q	0.911	1.00
172_P	176_Q	0.905	1.00
156_A	159_S	0.901	1.00
310_E	313_Q	0.899	1.00
220_I	297_S	0.898	1.00
261_E	265_N	0.897	1.00
199_L	267_L	0.897	1.00
55_L	313_Q	0.896	1.00
306_E	310_E	0.894	1.00
53_F	88_Y	0.892	1.00
326_A	329_D	0.889	1.00
292_D	325_L	0.889	1.00
117_L	156_A	0.888	1.00
191_I	220_I	0.883	1.00
201_R	332_I	0.879	1.00
47_A	50_R	0.879	1.00
151_S	154_A	0.878	1.00
177_K	180_E	0.875	1.00
27_A	315_L	0.872	1.00
323_K	327_Q	0.870	1.00
95_S	134_I	0.857	1.00
83_E	88_Y	0.853	1.00
118_A	121_D	0.845	1.00
110_G	115_Y	0.844	1.00
192_H	212_L	0.843	1.00
169_S	222_F	0.833	1.00
273_M	277_R	0.831	1.00
30_L	52_A	0.827	1.00
79_R	83_E	0.824	1.00
74_E	126_R	0.820	1.00
304_R	307_Q	0.818	1.00
116_L	156_A	0.816	1.00
265_N	268_R	0.811	1.00
291_K	319_T	0.809	1.00
139_R	169_S	0.808	1.00
209_L	219_C	0.805	1.00
44_S	305_A	0.804	1.00
57_I	312_V	0.804	1.00
291_K	322_T	0.802	1.00
32_L	73_A	0.801	1.00
201_R	329_D	0.800	1.00
286_L	314_A	0.799	1.00
20_K	190_L	0.790	1.00
150_A	178_M	0.781	1.00
277_R	321_S	0.780	1.00
42_L	72_S	0.779	1.00
264_L	268_R	0.778	1.00
64_N	126_R	0.777	1.00
29_S	300_I	0.777	1.00
218_G	296_T	0.776	1.00
320_F	325_L	0.773	1.00
15_Y	58_T	0.773	1.00
211_T	214_N	0.772	1.00
43_E	46_R	0.771	1.00
269_L	331_H	0.770	1.00
37_G	40_N	0.759	1.00
124_L	161_K	0.759	1.00
95_S	220_I	0.755	1.00
119_S	122_Q	0.754	1.00
275_Q	278_G	0.749	1.00
303_S	307_Q	0.743	1.00
276_Q	321_S	0.742	1.00
50_R	88_Y	0.739	1.00
62_L	77_F	0.738	1.00
45_Q	76_N	0.738	1.00
150_A	189_L	0.738	1.00
48_I	305_A	0.735	1.00
21_S	157_V	0.732	1.00
221_A	298_V	0.730	1.00
224_P	300_I	0.724	1.00
235_L	268_R	0.719	1.00
287_S	314_A	0.715	1.00
90_D	131_Y	0.714	1.00
179_V	188_P	0.714	1.00
146_M	181_L	0.712	1.00
282_A	310_E	0.712	1.00
167_I	170_Y	0.708	1.00
64_N	122_Q	0.706	1.00
120_L	161_K	0.704	1.00
208_L	212_L	0.703	1.00
149_T	152_A	0.702	1.00
221_A	224_P	0.701	1.00
49_L	53_F	0.700	1.00
49_L	77_F	0.700	1.00
88_Y	92_L	0.698	1.00
53_F	60_F	0.697	1.00
153_L	157_V	0.696	1.00
154_A	165_V	0.695	1.00
28_L	290_L	0.694	1.00
172_P	207_G	0.690	1.00
236_N	268_R	0.689	1.00
273_M	324_E	0.689	1.00
150_A	165_V	0.684	1.00
111_G	149_T	0.680	1.00
124_L	129_L	0.678	1.00
284_M	318_L	0.676	1.00
29_S	297_S	0.675	1.00
154_A	186_K	0.673	1.00
116_L	149_T	0.672	1.00
212_L	217_V	0.671	1.00
53_F	91_E	0.671	1.00
72_S	76_N	0.666	1.00
285_A	289_L	0.662	1.00
288_W	329_D	0.662	1.00
25_L	59_H	0.661	1.00
20_K	216_G	0.661	1.00
145_P	148_E	0.659	1.00
58_T	91_E	0.659	1.00
167_I	192_H	0.659	1.00
136_Y	166_G	0.657	1.00
267_L	271_N	0.657	1.00
36_F	40_N	0.657	1.00
196_Y	209_L	0.655	1.00
196_Y	289_L	0.652	1.00
172_P	208_L	0.652	1.00
229_L	267_L	0.651	1.00
265_N	269_L	0.648	1.00
236_N	261_E	0.647	1.00
25_L	297_S	0.645	1.00
203_V	209_L	0.645	1.00
23_L	163_L	0.641	1.00
270_L	285_A	0.640	1.00
96_T	135_F	0.640	1.00
16_R	218_G	0.639	1.00
270_L	328_I	0.637	1.00
176_Q	179_V	0.633	1.00
36_F	48_I	0.633	1.00
33_W	223_T	0.632	1.00
279_Q	287_S	0.632	1.00
264_L	267_L	0.631	1.00
279_Q	313_Q	0.630	1.00
277_R	284_M	0.629	1.00
284_M	328_I	0.627	1.00
98_A	111_G	0.626	1.00
324_E	327_Q	0.623	1.00
150_A	182_L	0.622	1.00
274_A	284_M	0.621	1.00
284_M	320_F	0.618	1.00
157_V	162_A	0.617	1.00
273_M	327_Q	0.616	1.00
273_M	331_H	0.614	1.00
30_L	36_F	0.611	1.00
48_I	302_A	0.610	1.00
198_L	332_I	0.610	1.00
209_L	292_D	0.607	1.00
307_Q	310_E	0.606	1.00
140_V	170_Y	0.606	1.00
199_L	229_L	0.605	1.00
320_F	324_E	0.605	1.00
53_F	58_T	0.604	1.00
146_M	149_T	0.604	1.00
224_P	289_L	0.604	1.00
117_L	161_K	0.603	1.00
41_A	45_Q	0.603	1.00
116_L	152_A	0.602	1.00
18_C	218_G	0.600	1.00
60_F	81_L	0.599	1.00
157_V	164_Y	0.596	1.00
35_N	38_H	0.594	1.00
289_L	296_T	0.592	1.00
87_A	92_L	0.592	1.00
61_D	193_Q	0.592	1.00
55_L	308_L	0.591	1.00
179_V	217_V	0.588	1.00
14_Q	316_N	0.581	1.00
20_K	188_P	0.578	1.00
123_S	135_F	0.577	1.00
279_Q	316_N	0.577	1.00
284_M	324_E	0.575	1.00
81_L	88_Y	0.574	1.00
132_V	135_F	0.574	1.00
51_K	308_L	0.572	1.00
67_G	72_S	0.572	1.00
137_S	149_T	0.572	1.00
262_A	265_N	0.568	1.00
120_L	152_A	0.565	1.00
157_V	165_V	0.565	1.00
62_L	73_A	0.564	1.00
98_A	119_S	0.564	1.00
221_A	295_V	0.561	1.00
135_F	162_A	0.559	1.00
290_L	298_V	0.558	1.00
74_E	96_T	0.556	1.00
46_R	76_N	0.556	1.00
182_L	189_L	0.555	1.00
274_A	281_M	0.554	1.00
154_A	182_L	0.553	1.00
64_N	110_G	0.552	1.00
120_L	124_L	0.549	1.00
194_P	208_L	0.549	1.00
157_V	188_P	0.548	1.00
196_Y	201_R	0.548	1.00
173_E	176_Q	0.548	1.00
166_G	191_I	0.547	1.00
71_G	126_R	0.547	1.00
53_F	80_L	0.544	1.00
174_R	177_K	0.544	1.00
203_V	210_D	0.541	1.00
18_C	21_S	0.540	1.00
29_S	299_L	0.540	1.00
79_R	82_R	0.539	1.00
231_T	234_Y	0.538	1.00
30_L	48_I	0.537	1.00
286_L	311_N	0.537	1.00
229_L	263_N	0.535	1.00
75_E	128_G	0.533	1.00
77_F	80_L	0.533	1.00
124_L	131_Y	0.531	1.00
15_Y	26_P	0.530	1.00
221_A	289_L	0.529	1.00
33_W	227_Q	0.528	1.00
167_I	178_M	0.528	1.00
52_A	60_F	0.528	1.00
236_N	264_L	0.527	1.00
223_T	227_Q	0.526	1.00
124_L	132_V	0.526	1.00
100_Y	139_R	0.526	1.00
28_L	314_A	0.522	1.00
273_M	276_Q	0.521	1.00
26_P	59_H	0.518	1.00
50_R	87_A	0.517	1.00
113_R	116_L	0.513	1.00
134_I	166_G	0.512	1.00
224_P	286_L	0.512	1.00
59_H	93_I	0.510	1.00
49_L	81_L	0.509	1.00
147_E	151_S	0.507	1.00
89_R	133_D	0.505	1.00
101_D	109_S	0.504	1.00
274_A	277_R	0.504	1.00
65_N	100_Y	0.503	1.00
170_Y	175_T	0.502	1.00
146_M	174_R	0.501	1.00
18_C	191_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n6qA	5	0.9104	100	0.132	Contact Map
3erpA	6	0.896	100	0.158	Contact Map
4xk2A	5	0.8815	100	0.166	Contact Map
1pyfA	1	0.8844	100	0.168	Contact Map
3eauA	3	0.9277	100	0.17	Contact Map
3lutA	3	0.9249	100	0.177	Contact Map
1pz1A	1	0.922	100	0.178	Contact Map
3v0sA	1	0.7803	100	0.184	Contact Map
3n2tA	1	0.9133	100	0.188	Contact Map
1lqaA	2	0.922	100	0.191	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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