GREMLIN Database
YGHU - Disulfide-bond oxidoreductase YghU
UniProt: Q46845 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13005
Length: 288 (227)
Sequences: 3722 (2272)
Seq/√Len: 150.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_K245_E4.4101.00
232_D235_S3.8571.00
149_W189_V2.8741.00
241_R245_E2.8421.00
63_E254_R2.5621.00
61_M122_L2.5611.00
153_A186_L2.5111.00
172_I175_A2.4231.00
148_F152_G2.2751.00
195_A238_H2.2641.00
63_E74_E2.2331.00
133_L144_M2.2001.00
173_E177_N2.1461.00
132_F210_M2.0871.00
200_V212_I2.0431.00
156_F179_F2.0151.00
149_W186_L2.0011.00
61_M132_F2.0001.00
89_S93_V1.9561.00
34_H37_T1.9121.00
133_L140_R1.8951.00
51_G257_I1.8931.00
41_G108_T1.8891.00
123_L144_M1.8581.00
78_W82_I1.8011.00
154_A190_L1.8001.00
146_W150_L1.7991.00
146_W193_Q1.7481.00
152_G160_G1.7201.00
191_D237_K1.7181.00
234_G240_Q1.7151.00
88_F92_F1.7121.00
61_M210_M1.7081.00
216_F242_W1.6951.00
33_T36_K1.6901.00
49_S59_T1.6761.00
205_Y249_R1.6541.00
245_E249_R1.6441.00
210_M246_V1.6401.00
190_L239_V1.6261.00
88_F91_G1.6131.00
79_L82_I1.5901.00
90_S94_E1.5761.00
240_Q244_K1.5681.00
31_G37_T1.5621.00
153_A182_E1.5411.00
46_Q78_W1.5361.00
32_P36_K1.5301.00
191_D238_H1.5121.00
45_L62_L1.4721.00
136_D139_K1.4641.00
193_Q197_H1.4581.00
263_G267_E1.4521.00
205_Y246_V1.4481.00
64_E249_R1.4431.00
225_Y266_N1.4351.00
92_F97_P1.4301.00
213_W256_R1.4031.00
91_G95_V1.3811.00
154_A186_L1.3751.00
246_V252_V1.3741.00
89_S92_F1.3691.00
154_A183_A1.3621.00
75_Y82_I1.3411.00
146_W201_A1.3361.00
136_D204_E1.3281.00
78_W84_D1.3251.00
245_E248_E1.3241.00
259_N263_G1.3231.00
205_Y210_M1.3191.00
153_A189_V1.3171.00
82_I85_G1.3141.00
92_F95_V1.3021.00
231_L236_Y1.2931.00
87_Q90_S1.2861.00
193_Q200_V1.2691.00
240_Q243_A1.2671.00
31_G36_K1.2491.00
81_R84_D1.2341.00
127_E140_R1.2291.00
60_I252_V1.2271.00
33_T37_T1.2241.00
123_L207_I1.2201.00
31_G34_H1.2081.00
46_Q76_D1.2001.00
46_Q107_H1.1911.00
149_W153_A1.1891.00
32_P35_E1.1881.00
120_S145_N1.1861.00
88_F95_V1.1851.00
115_V124_Y1.1851.00
65_L126_A1.1841.00
93_V97_P1.1821.00
92_F96_N1.1721.00
114_R142_E1.1691.00
142_E193_Q1.1681.00
38_L110_N1.1671.00
87_Q96_N1.1521.00
141_T145_N1.1491.00
32_P40_V1.1431.00
56_Q214_P1.1411.00
51_G59_T1.1391.00
160_G182_E1.1371.00
198_K203_D1.1261.00
180_T230_F1.1240.99
161_F180_T1.1170.99
91_G94_E1.1150.99
233_A243_A1.0950.99
126_A131_Y1.0930.99
32_P37_T1.0930.99
37_T40_V1.0910.99
80_I84_D1.0900.99
175_A179_F1.0880.99
60_I210_M1.0850.99
88_F97_P1.0850.99
143_T201_A1.0750.99
186_L189_V1.0730.99
31_G35_E1.0650.99
198_K241_R1.0630.99
90_S93_V1.0440.99
49_S55_G1.0390.99
135_Q140_R1.0350.99
75_Y80_I1.0340.99
89_S95_V1.0270.99
147_L211_A1.0100.99
198_K248_E1.0090.99
75_Y84_D1.0060.99
267_E270_H1.0060.99
75_Y79_L1.0040.99
161_F183_A1.0020.99
87_Q93_V0.9910.99
143_T206_T0.9830.99
142_E145_N0.9820.99
89_S94_E0.9810.99
35_E40_V0.9810.99
93_V96_N0.9660.98
192_K196_Q0.9600.98
80_I83_G0.9480.98
193_Q201_A0.9460.98
133_L143_T0.9450.98
201_A208_A0.9340.98
37_T110_N0.9280.98
79_L84_D0.9250.98
238_H241_R0.9210.98
60_I214_P0.9170.98
200_V208_A0.9140.98
192_K195_A0.9140.98
59_T77_A0.9120.98
95_V105_R0.9080.98
264_P269_L0.9010.98
56_Q60_I0.8950.97
197_H201_A0.8900.97
56_Q256_R0.8900.97
181_M185_R0.8860.97
39_P110_N0.8850.97
188_D236_Y0.8790.97
76_D82_I0.8740.97
75_Y78_W0.8710.97
241_R248_E0.8690.97
88_F96_N0.8640.97
244_K248_E0.8620.97
264_P268_Q0.8570.97
89_S96_N0.8490.97
88_F99_S0.8410.96
87_Q91_G0.8410.96
217_G256_R0.8370.96
87_Q94_E0.8360.96
153_A185_R0.8340.96
160_G179_F0.8320.96
180_T231_L0.8270.96
77_A82_I0.8170.96
213_W252_V0.8170.96
178_R182_E0.8080.95
65_L130_G0.8070.95
233_A240_Q0.8070.95
262_N266_N0.8060.95
185_R189_V0.8030.95
55_G101_I0.7990.95
87_Q92_F0.7970.95
78_W83_G0.7910.95
250_P254_R0.7910.95
47_L104_L0.7900.95
222_G264_P0.7870.95
32_P128_K0.7870.95
152_G182_E0.7860.95
56_Q255_G0.7850.95
226_D264_P0.7770.94
90_S97_P0.7750.94
188_D231_L0.7720.94
45_L104_L0.7710.94
32_P39_P0.7710.94
33_T39_P0.7700.94
222_G226_D0.7670.94
91_G96_N0.7670.94
191_D241_R0.7660.94
95_V103_A0.7660.94
146_W189_V0.7650.94
81_R85_G0.7620.94
199_F246_V0.7580.94
88_F93_V0.7450.93
78_W81_R0.7450.93
213_W217_G0.7440.93
201_A206_T0.7430.93
174_Y178_R0.7260.92
143_T147_L0.7260.92
90_S95_V0.7190.92
35_E110_N0.7170.92
146_W190_L0.7170.92
119_G147_L0.7160.91
148_F151_Q0.7150.91
190_L193_Q0.7150.91
145_N149_W0.7150.91
34_H40_V0.7130.91
217_G258_V0.7100.91
248_E253_K0.7090.91
223_G247_G0.7060.91
76_D84_D0.7050.91
126_A130_G0.7010.91
257_I260_R0.6980.90
190_L212_I0.6950.90
251_A254_R0.6940.90
246_V249_R0.6910.90
177_N180_T0.6910.90
210_M249_R0.6880.90
140_R144_M0.6880.90
105_R112_P0.6850.90
94_E97_P0.6820.89
123_L148_F0.6820.89
157_L183_A0.6810.89
91_G97_P0.6740.89
198_K201_A0.6710.89
177_N181_M0.6700.89
88_F94_E0.6690.89
217_G243_A0.6680.88
146_W149_W0.6650.88
171_K176_I0.6650.88
90_S96_N0.6640.88
80_I86_D0.6590.88
59_T255_G0.6580.88
191_D195_A0.6580.88
87_Q97_P0.6530.87
80_I85_G0.6510.87
134_P143_T0.6490.87
63_E75_Y0.6470.87
64_E205_Y0.6420.86
54_N57_K0.6330.86
45_L73_A0.6320.86
189_V193_Q0.6310.85
124_Y128_K0.6290.85
147_L207_I0.6280.85
82_I86_D0.6280.85
193_Q196_Q0.6270.85
142_E197_H0.6270.85
159_G163_H0.6260.85
186_L190_L0.6250.85
120_S123_L0.6230.85
64_E251_A0.6220.85
207_I211_A0.6220.85
197_H203_D0.6210.85
119_G211_A0.6190.84
182_E185_R0.6150.84
150_L208_A0.6140.84
82_I263_G0.6130.84
231_L234_G0.6120.84
85_G88_F0.6100.83
58_V121_I0.6070.83
79_L83_G0.6070.83
230_F236_Y0.6050.83
37_T124_Y0.6040.83
54_N155_P0.6040.83
56_Q218_N0.6020.83
222_G269_L0.6010.83
225_Y262_N0.6010.83
188_D192_K0.5990.82
139_K204_E0.5980.82
146_W200_V0.5920.82
113_I138_A0.5900.81
76_D85_G0.5880.81
143_T208_A0.5880.81
78_W85_G0.5820.81
175_A182_E0.5780.80
78_W86_D0.5740.80
149_W190_L0.5740.80
87_Q95_V0.5730.80
127_E144_M0.5700.79
122_L207_I0.5670.79
54_N156_F0.5650.79
62_L75_Y0.5610.78
35_E38_L0.5610.78
213_W246_V0.5600.78
115_V141_T0.5580.78
220_V233_A0.5560.77
54_N151_Q0.5540.77
181_M230_F0.5530.77
106_D113_I0.5530.77
141_T144_M0.5520.77
81_R263_G0.5520.77
65_L129_F0.5490.77
226_D269_L0.5470.76
38_L124_Y0.5450.76
55_G58_V0.5450.76
81_R86_D0.5440.76
199_F245_E0.5430.76
44_P107_H0.5430.76
93_V99_S0.5430.76
252_V256_R0.5380.75
199_F205_Y0.5360.75
76_D80_I0.5360.75
264_P267_E0.5350.75
88_F112_P0.5330.74
120_S144_M0.5310.74
105_R114_R0.5290.74
89_S97_P0.5280.74
58_V125_L0.5270.74
103_A113_I0.5260.74
33_T40_V0.5250.73
249_R254_R0.5250.73
221_L224_V0.5230.73
86_D89_S0.5230.73
153_A190_L0.5220.73
63_E125_L0.5220.73
33_T120_S0.5210.73
31_G128_K0.5200.73
229_E262_N0.5200.73
154_A212_I0.5190.73
39_P108_T0.5190.73
221_L244_K0.5180.72
35_E39_P0.5160.72
60_I246_V0.5150.72
77_A80_I0.5130.72
139_K142_E0.5130.72
50_L264_P0.5100.71
184_K235_S0.5090.71
218_N223_G0.5080.71
94_E111_P0.5070.71
40_V105_R0.5060.71
220_V223_G0.5040.70
155_P215_W0.5040.70
76_D83_G0.5030.70
150_L212_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8eA 2 0.9826 100 0.299 Contact Map
4puaA 2 0.9028 100 0.375 Contact Map
3gx0A 2 0.6979 100 0.383 Contact Map
1k0dA 2 0.7569 100 0.385 Contact Map
4mf5A 2 0.8125 100 0.391 Contact Map
4ecjA 2 0.7118 100 0.393 Contact Map
4ri6A 2 0.7188 100 0.394 Contact Map
1pn9A 2 0.7083 100 0.395 Contact Map
4pngA 2 0.7569 100 0.395 Contact Map
2imiA 2 0.7535 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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