GREMLIN Database
YGHQ - Inner membrane protein YghQ
UniProt: Q46841 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13001
Length: 355 (277)
Sequences: 24488 (19653)
Seq/√Len: 1180.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_R163_L4.3591.00
89_N92_Q4.2701.00
56_V276_K4.2381.00
118_L121_F4.1491.00
144_P201_L3.3851.00
236_K240_S3.3081.00
120_P124_H2.9311.00
84_A92_Q2.6591.00
77_V100_S2.5061.00
162_D166_V2.4831.00
179_S182_A2.2621.00
121_F124_H2.2291.00
95_N231_S2.2101.00
16_R20_R2.1721.00
231_S234_Y2.1681.00
81_G157_A2.1521.00
133_F136_A2.1431.00
115_G139_Y2.0821.00
232_A236_K2.0591.00
268_G271_A2.0311.00
48_T51_M1.9901.00
167_Q206_M1.9601.00
140_C143_I1.9521.00
92_Q95_N1.9501.00
84_A89_N1.9461.00
97_V154_I1.9351.00
79_Q83_P1.8871.00
83_P87_N1.8781.00
40_L280_T1.8721.00
119_L136_A1.8471.00
137_A190_A1.8081.00
174_L202_V1.7941.00
112_I116_I1.7881.00
80_Y241_F1.7551.00
147_A204_G1.7221.00
42_C180_V1.7191.00
209_W213_R1.7071.00
205_T209_W1.6981.00
133_F190_A1.6511.00
84_A87_N1.6481.00
99_F235_I1.6401.00
167_Q207_Y1.6341.00
92_Q234_Y1.6231.00
121_F125_S1.6021.00
163_L210_F1.5911.00
208_W212_A1.5641.00
188_G191_G1.5551.00
26_G291_L1.5511.00
116_I136_A1.5341.00
154_I158_V1.5311.00
190_A194_I1.5291.00
178_G195_A1.5211.00
259_S275_F1.5171.00
171_K203_G1.5061.00
270_A274_L1.4851.00
104_D150_T1.4751.00
95_N99_F1.4741.00
96_V234_Y1.4731.00
31_V169_A1.4651.00
95_N234_Y1.4641.00
263_V275_F1.4631.00
24_W162_D1.4621.00
160_R214_E1.4611.00
90_P94_R1.4411.00
94_R98_S1.4301.00
261_V265_I1.4241.00
151_P207_Y1.4081.00
91_Q95_N1.3971.00
17_T20_R1.3951.00
181_V185_F1.3881.00
49_P270_A1.3811.00
57_I264_G1.3661.00
100_S238_A1.3661.00
41_S45_K1.3611.00
177_A181_V1.3361.00
159_D299_E1.3331.00
243_W247_I1.3301.00
76_L241_F1.3301.00
137_A194_I1.3231.00
250_S254_A1.3191.00
103_L235_I1.3191.00
132_S136_A1.3071.00
116_I120_P1.3021.00
190_A193_V1.2881.00
166_V170_T1.2841.00
191_G195_A1.2831.00
143_I146_M1.2811.00
23_A27_S1.2781.00
106_V110_V1.2681.00
234_Y237_G1.2601.00
128_L131_Q1.2571.00
233_R236_K1.2531.00
257_S260_T1.2461.00
139_Y143_I1.2421.00
151_P208_W1.2351.00
194_I197_Y1.2201.00
85_L158_V1.2151.00
210_F214_E1.2111.00
187_F191_G1.2081.00
85_L93_F1.1981.00
80_Y83_P1.1971.00
55_L59_Q1.1911.00
152_T156_R1.1761.00
181_V184_Y1.1761.00
175_R199_S1.1751.00
114_G118_L1.1731.00
129_D132_S1.1601.00
197_Y200_N1.1591.00
230_E235_I1.1531.00
83_P237_G1.1531.00
49_P274_L1.1481.00
84_A96_V1.1471.00
50_A131_Q1.1431.00
127_G130_D1.1421.00
30_V34_L1.1401.00
43_A192_F1.1311.00
102_S106_V1.1251.00
80_Y96_V1.1211.00
44_G277_I1.1151.00
140_C144_P1.1051.00
173_F177_A1.0971.00
29_N33_A1.0941.00
37_L41_S1.0941.00
144_P204_G1.0911.00
46_G183_W1.0841.00
141_T197_Y1.0801.00
95_N98_S1.0781.00
34_L38_L1.0721.00
212_A216_R1.0711.00
51_M54_V1.0681.00
22_S26_G1.0671.00
39_A176_A1.0581.00
117_A121_F1.0531.00
55_L189_F1.0521.00
113_V117_A1.0441.00
180_V184_Y1.0391.00
77_V81_G1.0371.00
85_L90_P1.0331.00
194_I198_V1.0301.00
262_L266_V1.0231.00
105_I109_A1.0161.00
137_A193_V1.0151.00
112_I143_I1.0081.00
98_S102_S1.0061.00
179_S195_A1.0051.00
99_F230_E1.0021.00
47_M51_M1.0011.00
209_W212_A0.9971.00
19_I23_A0.9941.00
167_Q210_F0.9911.00
239_W242_V0.9891.00
119_L123_S0.9881.00
49_P273_G0.9841.00
81_G93_F0.9781.00
80_Y237_G0.9741.00
109_A113_V0.9721.00
22_S295_S0.9701.00
63_K67_D0.9661.00
195_A199_S0.9661.00
297_Y301_M0.9651.00
276_K280_T0.9641.00
264_G272_A0.9631.00
117_A120_P0.9591.00
163_L166_V0.9551.00
140_C197_Y0.9541.00
239_W243_W0.9531.00
93_F158_V0.9521.00
39_A196_W0.9481.00
199_S203_G0.9371.00
272_A276_K0.9361.00
196_W200_N0.9311.00
263_V272_A0.9271.00
279_M283_D0.9231.00
78_V153_G0.9231.00
55_L192_F0.9181.00
60_S260_T0.9151.00
18_I22_S0.9121.00
92_Q96_V0.9101.00
151_P211_A0.9091.00
257_S261_V0.9081.00
110_V113_V0.9061.00
271_A274_L0.9051.00
70_K74_W0.9041.00
27_S165_A0.9031.00
56_V273_G0.8971.00
182_A187_F0.8941.00
158_V214_E0.8941.00
156_R164_I0.8941.00
136_A140_C0.8921.00
206_M210_F0.8901.00
59_Q63_K0.8831.00
128_L132_S0.8691.00
160_R210_F0.8661.00
115_G119_L0.8631.00
197_Y201_L0.8591.00
215_L218_R0.8521.00
113_V116_I0.8511.00
105_I147_A0.8511.00
41_S44_G0.8461.00
27_S31_V0.8451.00
42_C179_S0.8431.00
178_G182_A0.8401.00
179_S192_F0.8391.00
118_L122_L0.8381.00
241_F245_T0.8371.00
233_R237_G0.8361.00
206_M209_W0.8341.00
275_F279_M0.8341.00
90_P93_F0.8301.00
260_T272_A0.8241.00
178_G198_V0.8231.00
258_C262_L0.8191.00
102_S230_E0.8171.00
112_I115_G0.8151.00
52_F277_I0.8111.00
213_R216_R0.8091.00
76_L238_A0.8081.00
214_E217_R0.8071.00
253_S257_S0.8071.00
82_T157_A0.8051.00
280_T284_A0.8051.00
43_A55_L0.8041.00
243_W246_N0.8041.00
84_A234_Y0.8031.00
28_S165_A0.7931.00
119_L139_Y0.7911.00
101_F151_P0.7911.00
240_S244_S0.7771.00
187_F190_A0.7751.00
76_L242_V0.7711.00
166_V169_A0.7701.00
155_L211_A0.7681.00
103_L107_S0.7671.00
81_G158_V0.7661.00
106_V109_A0.7651.00
207_Y211_A0.7621.00
99_F103_L0.7601.00
290_G294_K0.7581.00
175_R179_S0.7581.00
57_I272_A0.7571.00
289_A293_G0.7541.00
161_F295_S0.7541.00
19_I22_S0.7511.00
104_D146_M0.7491.00
282_F285_A0.7471.00
77_V96_V0.7461.00
72_Q242_V0.7441.00
259_S279_M0.7441.00
286_G289_A0.7341.00
177_A180_V0.7281.00
81_G96_V0.7271.00
237_G241_F0.7241.00
70_K146_M0.7231.00
50_A53_G0.7221.00
28_S168_Q0.7221.00
170_T174_L0.7221.00
130_D134_W0.7201.00
91_Q94_R0.7201.00
32_S172_P0.7201.00
42_C46_G0.7161.00
277_I280_T0.7121.00
124_H130_D0.7081.00
141_T200_N0.7061.00
53_G272_A0.7051.00
291_L294_K0.7021.00
31_V35_L0.6981.00
273_G277_I0.6971.00
99_F231_S0.6961.00
110_V114_G0.6941.00
187_F194_I0.6941.00
102_S105_I0.6931.00
54_V269_P0.6931.00
207_Y210_F0.6871.00
240_S243_W0.6841.00
120_P136_A0.6841.00
127_G132_S0.6821.00
153_G156_R0.6821.00
127_G131_Q0.6771.00
116_I139_Y0.6771.00
58_V138_L0.6771.00
192_F195_A0.6751.00
237_G240_S0.6741.00
130_D133_F0.6691.00
167_Q203_G0.6691.00
25_L295_S0.6661.00
148_S203_G0.6661.00
170_T206_M0.6611.00
108_G112_I0.6601.00
155_L207_Y0.6591.00
278_A282_F0.6561.00
40_L44_G0.6551.00
211_A215_L0.6531.00
80_Y84_A0.6491.00
171_K175_R0.6481.00
131_Q134_W0.6471.00
142_L146_M0.6441.00
99_F234_Y0.6431.00
137_A197_Y0.6411.00
285_A288_P0.6411.00
52_F56_V0.6391.00
148_S204_G0.6381.00
97_V151_P0.6361.00
137_A140_C0.6361.00
260_T276_K0.6361.00
280_T283_D0.6351.00
163_L167_Q0.6351.00
108_G143_I0.6331.00
50_A269_P0.6321.00
167_Q171_K0.6311.00
22_S292_L0.6291.00
25_L294_K0.6291.00
279_M282_F0.6291.00
247_I250_S0.6281.00
191_G194_I0.6271.00
273_G276_K0.6271.00
254_A258_C0.6261.00
98_S101_F0.6261.00
139_Y142_L0.6241.00
58_V135_L0.6211.00
80_Y238_A0.6211.00
141_T145_S0.6191.00
201_L205_T0.6191.00
259_S262_L0.6191.00
268_G272_A0.6191.00
21_N161_F0.6181.00
109_A143_I0.6171.00
24_W28_S0.6171.00
204_G208_W0.6161.00
47_M189_F0.6161.00
198_V202_V0.6151.00
16_R19_I0.6111.00
170_T173_F0.6111.00
35_L38_L0.6101.00
292_L296_F0.6071.00
39_A179_S0.6051.00
153_G157_A0.6041.00
147_A151_P0.6021.00
186_D190_A0.6021.00
112_I139_Y0.5981.00
100_S150_T0.5921.00
99_F232_A0.5901.00
99_F102_S0.5901.00
93_F97_V0.5891.00
75_Q78_V0.5891.00
270_A273_G0.5891.00
39_A175_R0.5881.00
151_P204_G0.5871.00
47_M53_G0.5871.00
57_I128_L0.5861.00
252_W256_N0.5841.00
180_V183_W0.5831.00
251_I255_R0.5811.00
94_R218_R0.5801.00
296_F300_V0.5791.00
180_V185_F0.5781.00
17_T159_D0.5781.00
79_Q241_F0.5771.00
59_Q62_A0.5761.00
38_L41_S0.5761.00
152_T164_I0.5761.00
176_A180_V0.5741.00
78_V157_A0.5741.00
174_L199_S0.5651.00
155_L163_L0.5651.00
182_A195_A0.5651.00
40_L52_F0.5641.00
20_R162_D0.5601.00
152_T168_Q0.5601.00
248_A252_W0.5581.00
212_A215_L0.5551.00
44_G52_F0.5541.00
200_N203_G0.5471.00
175_R178_G0.5421.00
198_V201_L0.5421.00
96_V238_A0.5401.00
264_G269_P0.5371.00
262_L265_I0.5371.00
81_G97_V0.5361.00
28_S31_V0.5361.00
246_N251_I0.5361.00
232_A235_I0.5361.00
108_G139_Y0.5361.00
174_L177_A0.5341.00
182_A185_F0.5311.00
295_S298_P0.5301.00
175_R195_A0.5291.00
150_T153_G0.5281.00
108_G146_M0.5271.00
135_L139_Y0.5271.00
101_F104_D0.5271.00
212_A217_R0.5261.00
34_L37_L0.5241.00
76_L80_Y0.5231.00
116_I140_C0.5221.00
161_F165_A0.5201.00
131_Q136_A0.5191.00
25_L161_F0.5191.00
101_F150_T0.5181.00
179_S183_W0.5151.00
109_A112_I0.5141.00
77_V154_I0.5131.00
21_N295_S0.5131.00
169_A173_F0.5111.00
26_G30_V0.5101.00
111_A115_G0.5071.00
78_V82_T0.5061.00
35_L39_A0.5061.00
241_F244_S0.5061.00
260_T264_G0.5031.00
202_V206_M0.5021.00
175_R196_W0.5021.00
256_N279_M0.5021.00
21_N159_D0.5011.00
260_T279_M0.5011.00
51_M188_G0.5001.00
112_I140_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9859 100 0.271 Contact Map
3w4tA 1 0.9662 100 0.296 Contact Map
4humA 1 0.9831 100 0.3 Contact Map
3mktA 1 0.9746 100 0.302 Contact Map
3wdoA 1 0.8592 49.7 0.925 Contact Map
4ikvA 1 0.9183 40.8 0.929 Contact Map
4xnjA 1 0.9014 36.7 0.931 Contact Map
3o7qA 1 0.8535 33 0.933 Contact Map
4tphA 2 0.8479 29.4 0.934 Contact Map
1pw4A 1 0.8789 28.8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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