GREMLIN Database
PPPA - Leader peptidase PppA
UniProt: Q46836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12992
Length: 269 (236)
Sequences: 2617 (2025)
Seq/√Len: 131.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_D92_R4.9491.00
101_R145_D4.4171.00
63_R72_T3.6041.00
157_V214_A2.9751.00
139_A149_L2.8971.00
113_F134_A2.7061.00
32_I141_V2.6001.00
215_L227_V2.5371.00
14_P114_L2.5201.00
18_T110_A2.5091.00
77_D93_D2.4471.00
135_W153_F2.3801.00
71_Q93_D2.3671.00
24_I28_L2.3611.00
151_D210_L2.3211.00
71_Q77_D2.2561.00
206_M209_V2.2531.00
17_A117_S2.2191.00
57_I65_H2.2171.00
133_S260_I2.1791.00
18_T114_L2.1381.00
22_L81_L2.1151.00
37_I57_I2.0591.00
140_S256_S2.0591.00
128_A164_A2.0291.00
195_A199_L2.0061.00
59_L62_P2.0031.00
84_W100_K2.0031.00
236_L239_A1.9971.00
77_D87_L1.9351.00
116_A126_G1.9181.00
58_S62_P1.8671.00
126_G130_M1.8161.00
109_T137_I1.8111.00
109_T113_F1.8081.00
68_H96_A1.7601.00
195_A203_A1.7571.00
74_R77_D1.6721.00
215_L259_G1.6611.00
82_F86_M1.6401.00
174_L178_V1.6371.00
116_A133_S1.6211.00
100_K104_L1.6161.00
184_G224_L1.6141.00
28_L138_A1.6091.00
22_L110_A1.6041.00
112_A133_S1.5961.00
136_L256_S1.5931.00
73_I78_N1.5921.00
234_C261_A1.5601.00
113_F130_M1.5441.00
73_I93_D1.5391.00
17_A114_L1.5321.00
227_V258_G1.5321.00
238_Y254_C1.5311.00
129_V263_L1.5221.00
31_V35_Y1.5081.00
108_L141_V1.4971.00
18_T22_L1.4851.00
161_G218_W1.4421.00
71_Q74_R1.4421.00
88_K95_Q1.4281.00
149_L154_T1.4231.00
81_L107_L1.4211.00
74_R92_R1.4171.00
149_L252_G1.4121.00
258_G262_T1.3971.00
21_G110_A1.3901.00
232_S236_L1.3491.00
223_S227_V1.3431.00
192_R202_E1.3421.00
192_R206_M1.3331.00
150_P210_L1.3101.00
131_I160_T1.3081.00
244_R247_T1.2961.00
101_R141_V1.2961.00
33_W57_I1.2951.00
114_L118_L1.2911.00
32_I105_V1.2601.00
79_I83_S1.2511.00
147_Q248_T1.2421.00
231_A255_L1.2361.00
109_T134_A1.2301.00
69_C94_C1.2071.00
74_R93_D1.1990.99
179_T183_V1.1840.99
65_H70_Q1.1730.99
173_T176_D1.1710.99
112_A137_I1.1680.99
105_V141_V1.1600.99
223_S262_T1.1560.99
26_S64_S1.1520.99
234_C254_C1.1460.99
149_L211_L1.1340.99
190_S194_I1.1200.99
67_P98_I1.1160.99
133_S264_Y1.1100.99
141_V145_D1.1080.99
180_G184_G1.1060.99
67_P102_Y1.1050.99
99_S102_Y1.1050.99
199_L203_A1.1020.99
117_S126_G1.0970.99
150_P153_F1.0930.99
212_F255_L1.0920.99
192_R209_V1.0790.99
21_G113_F1.0750.99
66_C94_C1.0730.99
31_V138_A1.0610.99
14_P118_L1.0590.99
78_N87_L1.0590.99
132_L259_G1.0560.99
212_F227_V1.0550.99
120_W123_S1.0310.98
181_V217_G1.0200.98
29_N32_I1.0140.98
188_F192_R1.0140.98
236_L240_V1.0090.98
66_C69_C1.0040.98
116_A129_V0.9980.98
166_W179_T0.9970.98
65_H73_I0.9940.98
63_R74_R0.9790.98
16_L20_G0.9760.98
81_L103_P0.9760.98
28_L134_A0.9750.98
184_G216_G0.9680.98
104_L108_L0.9630.98
185_F209_V0.9580.97
185_F189_Y0.9570.97
139_A153_F0.9470.97
58_S61_L0.9470.97
76_R86_M0.9440.97
132_L215_L0.9310.97
19_V23_I0.9250.97
32_I142_I0.9210.97
110_A114_L0.9060.96
195_A201_K0.9060.96
13_M117_S0.9040.96
211_L252_G0.8930.96
138_A153_F0.8920.96
235_G239_A0.8910.96
120_W126_G0.8910.96
260_I264_Y0.8860.96
230_I258_G0.8830.96
190_S193_W0.8810.96
36_P142_I0.8750.96
147_Q250_P0.8750.96
112_A260_I0.8740.96
22_L103_P0.8740.96
69_C91_C0.8730.96
228_A232_S0.8720.96
91_C94_C0.8670.95
206_M210_L0.8650.95
75_I78_N0.8640.95
66_C91_C0.8630.95
25_G109_T0.8620.95
33_W37_I0.8580.95
12_A16_L0.8460.95
229_L232_S0.8430.95
135_W157_V0.8400.95
261_A265_L0.8270.94
139_A154_T0.8270.94
231_A251_F0.8240.94
76_R92_R0.8220.94
123_S126_G0.8170.94
99_S103_P0.8160.94
234_C257_L0.8090.93
77_D83_S0.8050.93
227_V231_A0.8010.93
165_A177_A0.8010.93
30_V36_P0.7970.93
151_D154_T0.7970.93
120_W129_V0.7950.93
180_G216_G0.7840.92
73_I77_D0.7830.92
17_A130_M0.7800.92
189_Y193_W0.7800.92
226_N262_T0.7770.92
219_V262_T0.7750.92
161_G214_A0.7730.92
29_N105_V0.7720.92
148_W210_L0.7690.92
235_G254_C0.7670.91
227_V259_G0.7660.91
26_S106_E0.7650.91
176_D222_L0.7590.91
227_V262_T0.7590.91
182_L185_F0.7590.91
172_L176_D0.7590.91
101_R105_V0.7580.91
219_V223_S0.7570.91
205_G208_D0.7560.91
137_I141_V0.7510.91
204_L232_S0.7460.90
132_L218_W0.7420.90
32_I138_A0.7380.90
36_P146_H0.7380.90
132_L161_G0.7380.90
185_F206_M0.7350.90
103_P107_L0.7310.89
163_I182_L0.7230.89
188_F228_A0.7220.89
151_D155_Q0.7210.89
179_T221_A0.7190.89
136_L211_L0.7120.88
29_N102_Y0.7100.88
163_I167_A0.7080.88
71_Q92_R0.7070.88
108_L137_I0.7060.88
115_L264_Y0.7040.88
24_I134_A0.7040.88
165_A171_P0.6970.87
165_A217_G0.6970.87
113_F116_A0.6930.87
133_S263_L0.6840.86
231_A258_G0.6830.86
79_I86_M0.6810.86
195_A202_E0.6770.85
64_S106_E0.6700.85
158_L213_A0.6680.85
147_Q249_L0.6670.85
116_A264_Y0.6650.84
73_I82_F0.6640.84
72_T77_D0.6620.84
152_V156_G0.6610.84
111_L115_L0.6600.84
219_V227_V0.6560.84
148_W151_D0.6530.83
155_Q159_W0.6520.83
128_A218_W0.6520.83
119_V122_E0.6490.83
130_M134_A0.6470.83
27_F64_S0.6470.83
28_L137_I0.6470.83
28_L109_T0.6450.83
34_R62_P0.6440.83
112_A116_A0.6430.82
180_G220_G0.6400.82
180_G183_V0.6400.82
236_L254_C0.6390.82
192_R195_A0.6380.82
154_T214_A0.6370.82
227_V255_L0.6370.82
129_V171_P0.6330.81
115_L265_L0.6320.81
187_T191_L0.6300.81
193_W206_M0.6280.81
167_A171_P0.6280.81
189_Y206_M0.6270.81
207_G252_G0.6260.81
83_S87_L0.6250.81
180_G221_A0.6240.81
142_I146_H0.6220.80
143_D208_D0.6150.80
64_S98_I0.6140.79
256_S259_G0.6130.79
80_P106_E0.6120.79
212_F232_S0.6100.79
139_A252_G0.6100.79
216_G220_G0.6090.79
63_R75_I0.6060.79
29_N33_W0.6060.79
191_L195_A0.6030.78
181_V213_A0.5980.78
14_P117_S0.5970.78
64_S69_C0.5940.77
21_G25_G0.5930.77
176_D221_A0.5920.77
132_L255_L0.5900.77
211_L256_S0.5900.77
14_P17_A0.5880.76
180_G195_A0.5870.76
57_I60_A0.5850.76
188_F209_V0.5850.76
149_L207_G0.5840.76
84_W89_G0.5830.76
26_S30_V0.5820.76
105_V137_I0.5800.76
123_S127_L0.5800.76
142_I253_P0.5790.75
22_L107_L0.5780.75
33_W101_R0.5780.75
219_V263_L0.5780.75
116_A130_M0.5760.75
156_G217_G0.5750.75
234_C258_G0.5740.75
136_L215_L0.5740.75
33_W67_P0.5730.75
79_I82_F0.5700.74
187_T228_A0.5670.74
97_K100_K0.5630.73
154_T217_G0.5620.73
204_L251_F0.5620.73
37_I145_D0.5610.73
210_L253_P0.5600.73
26_S34_R0.5590.73
65_H81_L0.5580.73
128_A132_L0.5570.73
26_S98_I0.5570.73
15_V18_T0.5560.72
69_C106_E0.5550.72
191_L231_A0.5520.72
29_N87_L0.5490.72
157_V161_G0.5480.71
18_T107_L0.5470.71
64_S80_P0.5460.71
140_S146_H0.5460.71
180_G188_F0.5460.71
58_S63_R0.5450.71
189_Y209_V0.5430.71
242_T247_T0.5400.70
139_A150_P0.5390.70
178_V182_L0.5380.70
143_D207_G0.5360.70
87_L92_R0.5360.70
26_S69_C0.5350.70
121_P126_G0.5350.70
156_G160_T0.5350.70
175_Q179_T0.5350.70
115_L260_I0.5340.69
100_K103_P0.5330.69
192_R204_L0.5320.69
239_A254_C0.5290.69
56_K61_L0.5290.69
61_L65_H0.5260.68
230_I234_C0.5230.68
27_F78_N0.5230.68
234_C238_Y0.5220.68
208_D253_P0.5210.68
73_I76_R0.5210.68
17_A113_F0.5190.67
142_I153_F0.5160.67
142_I150_P0.5160.67
98_I106_E0.5150.67
165_A173_T0.5130.66
26_S94_C0.5130.66
62_P65_H0.5120.66
30_V78_N0.5120.66
142_I145_D0.5110.66
188_F203_A0.5100.66
131_I241_I0.5090.66
168_Q172_L0.5080.66
159_W185_F0.5080.66
37_I146_H0.5080.66
153_F214_A0.5070.65
188_F224_L0.5060.65
12_A15_V0.5050.65
215_L219_V0.5050.65
245_G249_L0.5040.65
143_D205_G0.5030.65
161_G217_G0.5020.65
230_I261_A0.5000.64
94_C106_E0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s0xA 1 0.5316 99.3 0.787 Contact Map
3py7A 1 0.3494 71.1 0.937 Contact Map
2m3lA 1 0.2491 43.4 0.947 Contact Map
3h0gL 1 0.1487 34.1 0.95 Contact Map
2ct0A 1 0.2677 28.2 0.952 Contact Map
2ep4A 1 0.2305 27.5 0.952 Contact Map
3j20Y 1 0.1859 24.6 0.953 Contact Map
1vq8Z 1 0.2714 21.3 0.954 Contact Map
2kizA 1 0.2119 21 0.955 Contact Map
1iymA 1 0.2045 20.9 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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