GREMLIN Database
YQGA - Uncharacterized protein YqgA
UniProt: Q46831 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12987
Length: 235 (223)
Sequences: 997 (799)
Seq/√Len: 53.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_A216_M5.7081.00
7_I136_I4.9151.00
126_E132_P4.0421.00
74_L77_K3.7741.00
11_A139_S3.4651.00
12_V164_L3.4371.00
9_A165_L3.3251.00
78_G81_T3.0241.00
71_E215_N2.9161.00
44_G196_L2.8891.00
5_P168_Q2.8601.00
49_L195_G2.8541.00
6_F10_S2.8301.00
125_N131_D2.7541.00
69_I222_L2.6381.00
76_E214_V2.5721.00
37_I63_T2.5501.00
125_N129_T2.4151.00
43_L202_G2.2771.00
3_I136_I2.2261.00
16_G158_S2.2041.00
41_A63_T2.1551.00
69_I73_C2.1281.00
33_S67_A2.0981.00
12_V119_G1.9491.00
5_P172_A1.9461.00
204_R209_K1.9171.00
105_N109_I1.8630.99
222_L226_L1.7950.99
203_L208_I1.7920.99
65_L222_L1.7900.99
83_V214_V1.7740.99
123_A127_G1.7520.99
207_G210_M1.7390.99
44_G50_V1.6930.99
63_T196_L1.6880.99
28_E31_R1.6580.99
112_L149_F1.6570.99
113_F146_A1.6290.98
155_I159_V1.6160.98
102_F159_V1.6110.98
58_A226_L1.6020.98
28_E32_V1.5800.98
197_L219_A1.5740.98
30_I72_I1.5300.98
109_I149_F1.5120.97
121_F134_I1.5110.97
101_S104_Q1.5020.97
79_V214_V1.4950.97
5_P126_E1.4880.97
32_V36_S1.4780.97
119_G167_I1.4710.97
27_P30_I1.4620.97
18_L147_M1.4590.97
84_A103_I1.4540.97
106_Y110_I1.4490.97
13_L158_S1.4370.96
132_P136_I1.3780.95
41_A60_V1.3760.95
9_A161_S1.3520.95
211_F216_M1.3450.95
77_K81_T1.2970.94
223_A226_L1.2920.94
62_A222_L1.2830.93
53_C189_D1.2750.93
134_I137_A1.2460.92
76_E80_N1.2410.92
38_F145_T1.2280.92
124_M128_M1.2200.91
40_L200_A1.2190.91
126_E172_A1.2110.91
223_A227_S1.2020.91
124_M171_L1.1690.90
193_V223_A1.1240.88
75_L214_V1.0930.86
105_N153_L1.0920.86
64_L144_F1.0890.86
165_L169_L1.0830.86
146_A149_F1.0700.85
29_R71_E1.0650.85
119_G163_P1.0630.85
212_P224_M1.0600.84
83_V107_V1.0520.84
113_F147_M1.0430.83
60_V137_A1.0390.83
161_S164_L1.0340.83
87_Q102_F1.0300.83
11_A143_F1.0270.82
189_D192_A1.0230.82
83_V110_I1.0160.82
170_T173_W1.0150.82
7_I132_P1.0140.82
37_I67_A1.0120.82
183_T186_M1.0090.81
84_A87_Q1.0050.81
133_S137_A0.9930.80
47_I50_V0.9930.80
162_I166_I0.9900.80
33_S71_E0.9870.80
42_S119_G0.9820.80
168_Q220_L0.9810.79
16_G150_A0.9780.79
136_I165_L0.9780.79
7_I139_S0.9660.78
45_I56_L0.9640.78
42_S145_T0.9570.78
52_K146_A0.9530.77
23_S31_R0.9520.77
13_L17_V0.9520.77
189_D227_S0.9460.77
161_S165_L0.9460.77
7_I11_A0.9440.77
39_G205_I0.9410.77
110_I164_L0.9330.76
50_V199_L0.9280.76
120_I190_F0.9200.75
136_I139_S0.9190.75
85_K89_L0.9170.75
4_G135_L0.9150.74
221_L224_M0.9130.74
4_G126_E0.9090.74
2_V172_A0.9030.74
22_L25_R0.9010.73
85_K88_N0.9010.73
55_N189_D0.8950.73
123_A171_L0.8930.73
129_T134_I0.8900.72
58_A223_A0.8900.72
145_T148_I0.8800.72
20_A158_S0.8780.71
61_L222_L0.8780.71
118_T134_I0.8740.71
2_V132_P0.8730.71
69_I72_I0.8720.71
141_L145_T0.8650.70
180_P183_T0.8620.70
143_F146_A0.8550.69
192_A195_G0.8460.69
29_R74_L0.8450.68
25_R148_I0.8440.68
131_D134_I0.8440.68
11_A141_L0.8330.67
198_L201_T0.8240.66
28_E183_T0.8230.66
53_C196_L0.8220.66
117_G121_F0.8220.66
74_L78_G0.8210.66
33_S37_I0.8190.66
124_M127_G0.8190.66
49_L223_A0.8170.66
113_F195_G0.8140.66
48_L52_K0.8120.65
72_I225_P0.8080.65
47_I199_L0.8070.65
14_L143_F0.8060.65
32_V212_P0.7990.64
42_S205_I0.7950.64
75_L78_G0.7930.64
141_L148_I0.7920.63
87_Q103_I0.7890.63
186_M190_F0.7880.63
13_L161_S0.7880.63
17_V77_K0.7860.63
58_A193_V0.7710.61
33_S36_S0.7650.61
203_L209_K0.7650.61
71_E212_P0.7640.61
112_L167_I0.7640.61
125_N134_I0.7550.60
41_A195_G0.7500.59
219_A223_A0.7490.59
42_S198_L0.7490.59
44_G63_T0.7410.58
111_V198_L0.7290.57
61_L65_L0.7270.57
26_L33_S0.7240.56
203_L211_F0.7230.56
74_L81_T0.7230.56
86_A159_V0.7210.56
114_C183_T0.7130.55
174_A177_L0.7080.55
102_F156_A0.7080.55
59_M196_L0.7070.55
5_P9_A0.7040.54
186_M223_A0.7030.54
168_Q172_A0.6970.54
146_A150_A0.6950.53
104_Q210_M0.6950.53
81_T85_K0.6940.53
49_L134_I0.6930.53
120_I186_M0.6890.53
10_S14_L0.6890.53
41_A198_L0.6880.53
204_R210_M0.6880.53
190_F221_L0.6870.53
123_A172_A0.6850.52
10_S65_L0.6840.52
23_S61_L0.6800.52
87_Q104_Q0.6800.52
33_S216_M0.6750.51
157_V167_I0.6730.51
17_V170_T0.6720.51
113_F143_F0.6720.51
45_I187_M0.6700.51
109_I113_F0.6690.51
46_G202_G0.6660.50
52_K208_I0.6660.50
186_M224_M0.6650.50
145_T196_L0.6630.50
26_L153_L0.6620.50
48_L193_V0.6610.50
16_G155_I0.6600.50
73_C78_G0.6590.50
174_A180_P0.6570.49
9_A13_L0.6560.49
38_F64_L0.6550.49
79_V111_V0.6540.49
61_L140_F0.6530.49
14_L77_K0.6500.49
169_L173_W0.6490.49
199_L202_G0.6480.48
54_A189_D0.6460.48
180_P191_S0.6450.48
40_L196_L0.6440.48
87_Q124_M0.6440.48
105_N149_F0.6430.48
110_I123_A0.6430.48
38_F149_F0.6420.48
108_A215_N0.6410.48
39_G202_G0.6410.48
105_N157_V0.6390.48
16_G146_A0.6390.48
141_L149_F0.6390.48
83_V102_F0.6370.47
34_M144_F0.6370.47
18_L45_I0.6330.47
178_I181_L0.6310.47
43_L184_P0.6280.46
201_T214_V0.6260.46
170_T174_A0.6250.46
4_G132_P0.6220.46
113_F157_V0.6180.45
35_T153_L0.6170.45
20_A124_M0.6140.45
196_L199_L0.6120.45
44_G195_G0.6100.44
160_I164_L0.6090.44
117_G145_T0.6060.44
11_A166_I0.6040.44
16_G20_A0.6030.44
160_I163_P0.6000.43
76_E215_N0.5990.43
54_A185_S0.5990.43
59_M189_D0.5970.43
151_C155_I0.5970.43
125_N172_A0.5970.43
203_L212_P0.5960.43
64_L175_A0.5940.43
54_A117_G0.5940.43
47_I51_V0.5920.43
69_I77_K0.5920.43
73_C77_K0.5870.42
150_A158_S0.5870.42
14_L101_S0.5870.42
106_Y156_A0.5860.42
6_F9_A0.5860.42
139_S143_F0.5840.42
6_F191_S0.5790.41
209_K212_P0.5750.41
114_C137_A0.5750.41
184_P188_A0.5730.41
127_G134_I0.5730.41
41_A141_L0.5730.41
201_T213_V0.5720.41
177_L181_L0.5720.41
62_A137_A0.5700.40
52_K76_E0.5640.40
14_L208_I0.5630.40
180_P219_A0.5620.40
78_G151_C0.5620.40
26_L37_I0.5610.39
31_R76_E0.5600.39
11_A81_T0.5600.39
56_L139_S0.5580.39
49_L118_T0.5560.39
214_V217_L0.5540.39
175_A217_L0.5510.38
119_G145_T0.5500.38
88_N98_A0.5490.38
47_I222_L0.5490.38
44_G48_L0.5480.38
173_W219_A0.5470.38
20_A155_I0.5470.38
57_P213_V0.5460.38
115_A198_L0.5460.38
36_S206_C0.5460.38
173_W177_L0.5430.38
146_A157_V0.5430.38
123_A163_P0.5380.37
113_F140_F0.5370.37
114_C177_L0.5360.37
182_T187_M0.5360.37
63_T174_A0.5350.37
33_S153_L0.5310.36
31_R39_G0.5310.36
34_M167_I0.5300.36
39_G163_P0.5270.36
149_F186_M0.5250.36
6_F98_A0.5240.36
206_C220_L0.5220.36
145_T149_F0.5210.35
14_L65_L0.5210.35
26_L148_I0.5210.35
99_H102_F0.5210.35
16_G161_S0.5200.35
17_V65_L0.5200.35
102_F120_I0.5170.35
156_A160_I0.5170.35
62_A91_R0.5160.35
144_F223_A0.5160.35
112_L157_V0.5150.35
2_V205_I0.5140.35
105_N193_V0.5110.34
16_G113_F0.5100.34
32_V207_G0.5090.34
127_G138_K0.5080.34
27_P78_G0.5080.34
60_V117_G0.5060.34
35_T152_S0.5050.34
22_L84_A0.5040.34
209_K216_M0.5030.34
78_G140_F0.5030.34
34_M115_A0.5000.33
76_E212_P0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t5jA 1 0.2255 33.2 0.958 Contact Map
3hfwA 1 0.2553 21.2 0.961 Contact Map
2nwlA 3 0.634 9.7 0.967 Contact Map
4eneA 2 0.3745 8.7 0.968 Contact Map
2xq2A 2 0.3234 7.9 0.968 Contact Map
3nd0A 2 0.366 6 0.97 Contact Map
4n7wA 2 0.366 4.2 0.972 Contact Map
3w9iA 3 0.3617 3.6 0.973 Contact Map
3zuxA 1 0.3106 3.5 0.973 Contact Map
4f35D 2 0.8213 3.4 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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