GREMLIN Database
BGLA - 6-phospho-beta-glucosidase BglA
UniProt: Q46829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13079
Length: 479 (437)
Sequences: 6776 (4232)
Seq/√Len: 202.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_G109_E4.2341.00
393_N463_K4.0091.00
119_D171_K3.5611.00
408_M419_L3.1481.00
115_D171_K3.1141.00
81_A124_Y3.0951.00
74_K120_E3.0091.00
132_L164_V2.8881.00
115_D167_R2.8771.00
461_R465_F2.8591.00
120_E123_K2.8351.00
108_E112_K2.8171.00
68_D71_G2.8161.00
53_K61_Y2.7591.00
112_K116_D2.7451.00
98_F163_V2.7021.00
108_E167_R2.6971.00
407_E410_K2.6881.00
316_Y404_H2.6241.00
29_K71_G2.6071.00
251_S256_D2.5651.00
162_E166_E2.5521.00
16_G85_F2.4381.00
401_L424_P2.3391.00
359_R415_D2.2891.00
78_K124_Y2.2871.00
399_D403_A2.2451.00
363_C415_D2.2441.00
155_D224_L2.2281.00
229_A238_V2.2031.00
42_G64_H2.1961.00
395_D463_K2.1711.00
446_Y460_S2.1401.00
227_K231_R2.1381.00
74_K116_D2.1231.00
118_F168_Y2.1101.00
69_F113_F2.0851.00
87_C423_T2.0771.00
127_E173_K2.0381.00
77_I117_M1.9871.00
387_E391_S1.9841.00
469_K473_A1.9741.00
92_I130_I1.9711.00
69_F88_F1.9521.00
158_V228_A1.9051.00
109_E112_K1.8871.00
281_S285_N1.8811.00
122_L171_K1.8781.00
39_V139_L1.8771.00
162_E228_A1.8701.00
216_H279_Y1.8641.00
90_T118_F1.8611.00
162_E232_I1.8581.00
35_S95_T1.8241.00
77_I124_Y1.8201.00
27_W34_P1.8021.00
229_A236_M1.7911.00
301_L305_R1.7821.00
115_D119_D1.7721.00
34_P39_V1.7481.00
359_R410_K1.7361.00
248_Y360_Y1.7181.00
120_E124_Y1.6971.00
18_V23_V1.6851.00
299_G302_D1.6711.00
14_W475_N1.6621.00
119_D122_L1.6541.00
127_E174_Y1.6511.00
121_L126_I1.6421.00
140_H144_Q1.6291.00
233_N236_M1.6291.00
90_T117_M1.6271.00
26_G29_K1.6261.00
356_V407_E1.6261.00
362_L417_V1.6201.00
158_V224_L1.5951.00
118_F122_L1.5901.00
115_D168_Y1.5791.00
78_K120_E1.5791.00
145_Y156_F1.5681.00
364_E368_R1.5511.00
316_Y357_G1.5511.00
359_R363_C1.5491.00
276_R370_Q1.5431.00
298_D301_L1.5371.00
73_Y116_D1.5341.00
77_I120_E1.5311.00
470_E473_A1.5291.00
47_V50_E1.5291.00
265_R282_Y1.5281.00
21_H63_N1.5251.00
374_F420_M1.5221.00
13_L87_C1.5221.00
153_V156_F1.5151.00
176_M241_M1.5101.00
300_D303_V1.4931.00
278_Y305_R1.4891.00
87_C129_V1.4771.00
151_R300_D1.4751.00
72_H75_E1.4681.00
149_T210_T1.4621.00
215_L270_F1.4601.00
165_F229_A1.4581.00
448_N456_D1.4571.00
33_G101_G1.4451.00
18_V88_F1.4451.00
271_T312_L1.4421.00
269_V283_V1.4371.00
111_L163_V1.4261.00
348_D383_Y1.4211.00
302_D306_E1.4181.00
176_M311_Y1.4051.00
77_I121_L1.4031.00
80_F85_F1.3991.00
366_Y371_R1.3951.00
170_H233_N1.3941.00
409_K413_T1.3911.00
378_N422_Y1.3791.00
98_F106_P1.3751.00
358_L408_M1.3751.00
146_G150_N1.3721.00
82_E465_F1.3601.00
424_P444_F1.3591.00
228_A231_R1.3491.00
90_T130_I1.3421.00
173_K235_E1.3321.00
26_G71_G1.3291.00
129_V423_T1.3291.00
151_R217_H1.3241.00
39_V144_Q1.3171.00
240_C274_Q1.3161.00
92_I164_V1.3141.00
68_D72_H1.3081.00
467_W471_V1.3081.00
362_L408_M1.3041.00
174_Y237_K1.3011.00
470_E474_S1.2981.00
461_R466_N1.2781.00
278_Y284_L1.2731.00
278_Y370_Q1.2631.00
155_D158_V1.2521.00
178_F218_Q1.2481.00
204_H210_T1.2311.00
139_L143_Q1.2281.00
152_K155_D1.2281.00
402_R406_E1.2251.00
405_I408_M1.2191.00
178_F221_A1.2061.00
102_D156_F1.2041.00
403_A406_E1.2041.00
78_K82_E1.2021.00
466_N469_K1.1991.00
92_I97_I1.1981.00
302_D305_R1.1961.00
111_L167_R1.1921.00
363_C417_V1.1881.00
184_Q218_Q1.1831.00
80_F445_I1.1741.00
102_D145_Y1.1741.00
100_K140_H1.1701.00
9_P412_V1.1701.00
69_F117_M1.1681.00
67_V428_I1.1591.00
73_Y120_E1.1581.00
165_F225_A1.1551.00
387_E393_N1.1521.00
115_D170_H1.1461.00
391_S463_K1.1411.00
33_G140_H1.1391.00
227_K306_E1.1391.00
137_M153_V1.1351.00
166_E232_I1.1291.00
249_P260_A1.1281.00
249_P257_V1.1251.00
366_Y418_D1.1221.00
132_L157_F1.1221.00
27_W32_K1.1191.00
161_A225_A1.1101.00
139_L144_Q1.1101.00
18_V90_T1.1101.00
148_W153_V1.1061.00
264_M364_E1.1001.00
26_G30_G1.0951.00
272_D276_R1.0941.00
254_P258_M1.0931.00
158_V225_A1.0911.00
272_D368_R1.0911.00
449_K457_M1.0891.00
165_F238_V1.0891.00
409_K412_V1.0891.00
299_G303_V1.0841.00
468_Y472_I1.0751.00
390_G460_S1.0741.00
356_V360_Y1.0711.00
158_V162_E1.0651.00
227_K307_G1.0591.00
254_P257_V1.0561.00
145_Y152_K1.0531.00
247_L263_S1.0521.00
111_L115_D1.0521.00
258_M262_E1.0511.00
82_E461_R1.0491.00
244_M361_A1.0481.00
118_F171_K1.0471.00
226_V230_R1.0451.00
8_L412_V1.0441.00
104_A159_R1.0401.00
106_P163_V1.0401.00
152_K156_F1.0381.00
65_E449_K1.0381.00
72_H458_S1.0321.00
33_G99_P1.0321.00
228_A232_I1.0291.00
229_A234_P1.0291.00
118_F130_I1.0261.00
161_A228_A1.0261.00
115_D122_L1.0231.00
256_D324_A1.0231.00
386_V460_S1.0231.00
255_D356_V1.0231.00
224_L228_A1.0231.00
255_D324_A1.0221.00
217_H220_V1.0191.00
300_D305_R1.0141.00
100_K105_Q1.0101.00
8_L409_K1.0081.00
358_L419_L1.0061.00
65_E457_M1.0051.00
224_L304_L1.0041.00
346_A352_Q1.0041.00
398_I467_W1.0011.00
250_Y323_K1.0011.00
253_N257_V0.9951.00
358_L375_I0.9911.00
347_S380_F0.9881.00
448_N458_S0.9871.00
345_K403_A0.9841.00
349_W381_G0.9831.00
265_R283_V0.9821.00
261_Q265_R0.9811.00
129_V174_Y0.9791.00
97_I163_V0.9771.00
16_G80_F0.9761.00
11_D420_M0.9741.00
399_D402_R0.9721.00
345_K396_Y0.9721.00
278_Y281_S0.9711.00
156_F159_R0.9691.00
206_N210_T0.9680.99
163_V167_R0.9670.99
383_Y439_S0.9660.99
301_L304_L0.9650.99
164_V168_Y0.9640.99
169_K236_M0.9620.99
263_S322_V0.9620.99
257_V260_A0.9540.99
129_V374_F0.9530.99
239_G313_G0.9450.99
146_G149_T0.9440.99
137_M147_S0.9410.99
275_L371_R0.9400.99
154_V224_L0.9390.99
13_L129_V0.9380.99
382_A396_Y0.9380.99
32_K95_T0.9360.99
165_F236_M0.9340.99
285_N288_E0.9340.99
23_V69_F0.9330.99
340_P346_A0.9320.99
86_K475_N0.9300.99
258_M261_Q0.9290.99
226_V238_V0.9110.99
116_D119_D0.9110.99
112_K115_D0.9060.99
75_E78_K0.9010.99
161_A165_F0.8950.99
380_F396_Y0.8930.99
441_R449_K0.8890.99
194_Y198_G0.8870.99
366_Y370_Q0.8870.99
31_G107_N0.8850.99
85_F427_C0.8850.99
151_R301_L0.8840.99
428_I447_V0.8840.99
185_R214_V0.8830.99
345_K399_D0.8830.99
143_Q204_H0.8770.99
247_L260_A0.8760.99
264_M268_Y0.8730.99
252_C257_V0.8730.99
261_Q282_Y0.8720.99
111_L164_V0.8720.99
115_D118_F0.8710.99
386_V390_G0.8710.99
61_Y439_S0.8700.99
471_V475_N0.8690.99
225_A228_A0.8690.99
242_L271_T0.8690.99
145_Y153_V0.8680.99
412_V419_L0.8630.99
78_K81_A0.8600.99
208_E290_R0.8560.99
349_W440_K0.8560.99
101_G140_H0.8550.99
381_G440_K0.8540.99
133_S137_M0.8530.99
176_M313_G0.8530.99
239_G311_Y0.8520.99
113_F117_M0.8500.99
170_H236_M0.8490.99
291_G294_I0.8470.99
298_D305_R0.8460.99
122_L128_P0.8450.99
406_E410_K0.8400.99
167_R171_K0.8370.99
229_A233_N0.8370.99
178_F184_Q0.8360.99
160_F164_V0.8350.99
169_K233_N0.8320.98
358_L407_E0.8280.98
386_V391_S0.8270.98
272_D369_Y0.8260.98
395_D399_D0.8260.98
466_N470_E0.8260.98
303_V306_E0.8250.98
102_D144_Q0.8240.98
392_I460_S0.8230.98
286_E290_R0.8210.98
363_C367_E0.8210.98
356_V410_K0.8200.98
354_D357_G0.8190.98
224_L227_K0.8190.98
154_V220_V0.8170.98
133_S136_E0.8160.98
285_N289_R0.8140.98
80_F126_I0.8130.98
149_T204_H0.8110.98
222_S226_V0.8100.98
82_E469_K0.8070.98
7_T10_K0.8050.98
183_N243_A0.8000.98
36_I137_M0.8000.98
314_F373_L0.7980.98
387_E390_G0.7950.98
318_M352_Q0.7940.98
177_T240_C0.7930.98
13_L127_E0.7920.98
23_V67_V0.7910.98
32_K35_S0.7890.98
340_P344_V0.7880.98
14_W405_I0.7870.98
9_P418_D0.7830.98
244_M314_F0.7810.98
463_K466_N0.7790.98
157_F161_A0.7790.98
359_R407_E0.7780.98
85_F468_Y0.7750.98
177_T222_S0.7740.98
250_Y256_D0.7740.98
341_N344_V0.7730.98
319_T352_Q0.7720.98
163_V166_E0.7720.98
319_T354_D0.7680.97
73_Y77_I0.7670.97
20_A93_A0.7670.97
253_N256_D0.7660.97
209_E213_Q0.7650.97
97_I164_V0.7620.97
281_S284_L0.7620.97
202_T205_E0.7610.97
28_N34_P0.7580.97
319_T357_G0.7560.97
366_Y417_V0.7550.97
106_P111_L0.7550.97
81_A125_N0.7540.97
215_L269_V0.7530.97
177_T238_V0.7520.97
362_L419_L0.7510.97
65_E68_D0.7490.97
7_T409_K0.7490.97
194_Y202_T0.7480.97
102_D140_H0.7460.97
150_N156_F0.7450.97
275_L309_C0.7440.97
275_L312_L0.7430.97
227_K304_L0.7420.97
51_I61_Y0.7410.97
247_L322_V0.7400.97
261_Q364_E0.7390.97
83_M461_R0.7370.97
108_E115_D0.7350.97
258_M356_V0.7310.97
128_P173_K0.7310.97
76_D459_R0.7300.97
93_A136_E0.7270.96
27_W64_H0.7270.96
363_C366_Y0.7260.96
11_D475_N0.7250.96
237_K372_P0.7240.96
371_R418_D0.7220.96
445_I461_R0.7210.96
373_L417_V0.7210.96
353_I382_A0.7180.96
63_N66_A0.7180.96
110_G113_F0.7160.96
169_K232_I0.7110.96
23_V430_C0.7060.96
26_G70_Y0.7010.96
182_N243_A0.7000.96
246_P360_Y0.7000.96
194_Y204_H0.6980.96
130_I172_V0.6980.96
244_M268_Y0.6960.95
149_T214_V0.6960.95
405_I471_V0.6950.95
30_G70_Y0.6940.95
340_P343_Y0.6930.95
219_F274_Q0.6930.95
165_F232_I0.6920.95
221_A225_A0.6910.95
98_F105_Q0.6910.95
18_V428_I0.6870.95
411_A417_V0.6870.95
471_V474_S0.6850.95
151_R220_V0.6850.95
283_V287_W0.6840.95
72_H457_M0.6840.95
34_P42_G0.6840.95
100_K144_Q0.6830.95
257_V261_Q0.6810.95
430_C442_Y0.6800.95
444_F468_Y0.6790.95
206_N209_E0.6790.95
348_D382_A0.6790.95
102_D159_R0.6790.95
63_N436_G0.6760.95
122_L173_K0.6760.95
121_L124_Y0.6740.95
405_I424_P0.6740.95
356_V359_R0.6740.95
298_D303_V0.6670.94
14_W86_K0.6670.94
387_E392_I0.6640.94
143_Q194_Y0.6630.94
155_D159_R0.6620.94
387_E460_S0.6600.94
118_F172_V0.6600.94
314_F365_L0.6590.94
83_M444_F0.6590.94
241_M315_S0.6580.94
164_V175_W0.6560.94
390_G458_S0.6550.94
122_L127_E0.6550.94
316_Y358_L0.6550.94
300_D304_L0.6540.94
242_L270_F0.6540.94
244_M271_T0.6540.94
398_I463_K0.6530.94
198_G205_E0.6530.94
391_S460_S0.6530.94
86_K127_E0.6520.94
42_G47_V0.6520.94
162_E231_R0.6480.93
77_I126_I0.6480.93
34_P139_L0.6470.93
121_L125_N0.6470.93
432_S442_Y0.6460.93
253_N324_A0.6420.93
315_S376_V0.6420.93
17_A423_T0.6400.93
386_V389_D0.6390.93
305_R308_T0.6390.93
122_L125_N0.6390.93
27_W93_A0.6370.93
166_E228_A0.6370.93
209_E294_I0.6370.93
248_Y319_T0.6360.93
80_F427_C0.6360.93
13_L86_K0.6350.93
154_V221_A0.6330.93
259_F263_S0.6330.93
133_S184_Q0.6320.93
212_Y287_W0.6290.92
100_K104_A0.6290.92
161_A164_V0.6260.92
159_R163_V0.6260.92
90_T121_L0.6250.92
391_S466_N0.6250.92
288_E293_N0.6250.92
374_F421_G0.6250.92
325_E328_T0.6240.92
129_V176_M0.6230.92
395_D398_I0.6230.92
74_K78_K0.6220.92
11_D412_V0.6210.92
101_G141_L0.6210.92
362_L411_A0.6200.92
457_M461_R0.6190.92
194_Y200_V0.6190.92
237_K420_M0.6180.92
15_G423_T0.6160.92
97_I111_L0.6160.92
141_L156_F0.6160.92
92_I118_F0.6150.91
431_V449_K0.6140.91
149_T213_Q0.6130.91
172_V175_W0.6130.91
52_T435_T0.6120.91
410_K415_D0.6110.91
408_M412_V0.6110.91
89_R179_N0.6090.91
299_G305_R0.6090.91
251_S323_K0.6070.91
333_S336_E0.6040.91
285_N410_K0.6030.91
349_W435_T0.6030.91
226_V309_C0.6030.91
98_F159_R0.6020.91
312_L371_R0.6020.91
132_L165_F0.6020.91
250_Y321_A0.6000.90
47_V51_I0.5990.90
348_D440_K0.5990.90
224_L303_V0.5980.90
446_Y462_K0.5980.90
244_M365_L0.5970.90
157_F178_F0.5950.90
86_K472_I0.5940.90
41_T431_V0.5940.90
198_G203_E0.5930.90
79_L428_I0.5920.90
227_K308_T0.5900.90
111_L168_Y0.5900.90
446_Y458_S0.5880.90
246_P264_M0.5870.90
81_A123_K0.5870.90
201_Y204_H0.5870.90
8_L475_N0.5850.89
18_V427_C0.5850.89
88_F121_L0.5840.89
284_L301_L0.5840.89
283_V286_E0.5840.89
342_P345_K0.5840.89
427_C445_I0.5830.89
265_R364_E0.5810.89
119_D170_H0.5810.89
79_L445_I0.5800.89
132_L161_A0.5790.89
266_E283_V0.5790.89
245_V320_N0.5770.89
34_P95_T0.5760.89
192_F199_V0.5760.89
36_I133_S0.5740.88
98_F102_D0.5730.88
74_K77_I0.5730.88
294_I301_L0.5720.88
83_M465_F0.5710.88
36_I143_Q0.5690.88
376_V420_M0.5680.88
269_V287_W0.5680.88
334_G338_S0.5660.88
119_D123_K0.5650.88
223_A308_T0.5650.88
8_L14_W0.5640.88
41_T47_V0.5630.87
248_Y354_D0.5630.87
365_L373_L0.5630.87
195_C202_T0.5610.87
194_Y201_Y0.5610.87
154_V158_V0.5610.87
372_P418_D0.5610.87
298_D306_E0.5610.87
227_K230_R0.5600.87
26_G32_K0.5590.87
84_G469_K0.5590.87
213_Q217_H0.5570.87
232_I236_M0.5570.87
239_G374_F0.5570.87
431_V438_Y0.5570.87
277_G306_E0.5570.87
100_K156_F0.5570.87
209_E293_N0.5560.87
430_C433_F0.5560.87
271_T365_L0.5550.87
52_T61_Y0.5550.87
140_H156_F0.5550.87
410_K413_T0.5530.87
249_P256_D0.5530.87
374_F423_T0.5510.86
69_F80_F0.5510.86
33_G98_F0.5500.86
222_S274_Q0.5500.86
116_D120_E0.5490.86
41_T63_N0.5470.86
223_A307_G0.5470.86
66_A457_M0.5460.86
27_W42_G0.5460.86
256_D259_F0.5450.86
339_V343_Y0.5450.86
129_V420_M0.5410.85
23_V88_F0.5410.85
140_H143_Q0.5410.85
398_I402_R0.5400.85
373_L419_L0.5390.85
259_F262_E0.5390.85
317_Y377_E0.5370.85
174_Y374_F0.5360.85
347_S382_A0.5360.85
85_F126_I0.5350.85
193_G202_T0.5350.85
245_V267_R0.5320.84
441_R446_Y0.5320.84
18_V69_F0.5310.84
272_D278_Y0.5290.84
69_F77_I0.5290.84
72_H456_D0.5290.84
426_G430_C0.5290.84
360_Y363_C0.5280.84
148_W178_F0.5270.84
11_D86_K0.5270.84
389_D393_N0.5260.84
262_E324_A0.5260.84
80_F88_F0.5250.84
69_F73_Y0.5230.83
49_R52_T0.5230.83
28_N64_H0.5190.83
347_S381_G0.5190.83
212_Y290_R0.5180.83
65_E71_G0.5180.83
401_L405_I0.5180.83
32_K136_E0.5170.83
450_H458_S0.5160.83
193_G197_S0.5160.83
271_T275_L0.5150.82
21_H41_T0.5150.82
177_T225_A0.5140.82
141_L153_V0.5140.82
18_V430_C0.5120.82
332_I335_F0.5110.82
145_Y150_N0.5100.82
425_W430_C0.5100.82
445_I465_F0.5080.82
372_P420_M0.5080.82
301_L306_E0.5070.82
37_C40_L0.5070.82
191_L194_Y0.5060.81
407_E415_D0.5050.81
344_V352_Q0.5040.81
241_M311_Y0.5030.81
194_Y205_E0.5030.81
82_E466_N0.5030.81
323_K339_V0.5020.81
251_S257_V0.5010.81
200_V203_E0.5010.81
131_T241_M0.5000.81
401_L468_Y0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9374 100 0.124 Contact Map
3ptmA 1 0.9374 100 0.125 Contact Map
2jf7A 5 0.9248 100 0.126 Contact Map
2dgaA 5 0.9436 100 0.129 Contact Map
3wq5A 1 0.9374 100 0.129 Contact Map
1v08A 2 0.9395 100 0.131 Contact Map
1cbgA 2 0.9395 100 0.132 Contact Map
3f5lA 2 0.9332 100 0.134 Contact Map
4f66A 2 0.9833 100 0.139 Contact Map
4iplA 2 0.9436 100 0.143 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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