GREMLIN Database
CPTA - Toxin CptA
UniProt: Q46824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13074
Length: 135 (129)
Sequences: 103 (71)
Seq/√Len: 6.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_Q19_L3.0980.82
83_S87_A2.8120.74
12_W15_Q2.7780.74
33_P57_Q2.7240.72
5_Q14_A2.3690.61
4_W11_S2.3100.59
6_S96_M2.0270.48
94_G112_A1.9990.47
75_L117_D1.9950.47
91_I111_L1.9480.46
113_A126_R1.9480.46
7_D12_W1.9270.45
33_P45_L1.9100.44
4_W9_R1.9050.44
3_L15_Q1.8520.42
78_Q91_I1.8280.41
37_S95_M1.8200.41
24_L92_K1.7830.40
18_S69_L1.7460.38
4_W8_L1.7340.38
46_L99_L1.7070.37
52_D130_Q1.6510.35
23_G43_M1.6320.35
8_L84_I1.5860.33
42_W57_Q1.5650.32
16_W21_I1.5630.32
8_L11_S1.5450.32
25_V43_M1.5240.31
5_Q8_L1.4680.29
27_A36_L1.4620.29
58_R125_R1.4430.29
9_R48_L1.4320.28
83_S105_K1.4040.28
3_L6_S1.3980.27
39_T91_I1.3750.27
48_L55_R1.3680.27
33_P66_E1.3400.26
56_S89_W1.3320.26
98_R126_R1.3220.25
28_V37_S1.3220.25
63_R113_A1.3160.25
40_P119_A1.3150.25
112_A127_I1.3100.25
46_L91_I1.3010.25
27_A32_M1.2850.24
64_Q71_M1.2780.24
2_V5_Q1.2770.24
42_W112_A1.2760.24
34_W69_L1.2730.24
67_I116_M1.2100.22
13_R16_W1.2080.22
42_W115_S1.2070.22
67_I75_L1.1990.22
59_R74_R1.1750.21
111_L116_M1.1670.21
33_P42_W1.1570.21
33_P50_V1.1420.21
60_I115_S1.1370.21
67_I84_I1.1330.20
12_W19_L1.1210.20
6_S35_P1.1020.20
44_V50_V1.0740.19
58_R116_M1.0690.19
52_D123_D1.0600.19
34_W88_P1.0510.19
3_L16_W1.0480.19
27_A113_A1.0420.18
80_Q118_E1.0410.18
41_L44_V1.0350.18
9_R47_S1.0290.18
69_L84_I0.9930.17
6_S11_S0.9840.17
31_L58_R0.9800.17
23_G42_W0.9790.17
22_H64_Q0.9770.17
63_R96_M0.9740.17
3_L12_W0.9680.17
14_A67_I0.9540.17
62_A91_I0.9530.17
41_L103_G0.9500.16
15_Q18_S0.9450.16
22_H56_S0.9430.16
19_L38_Y0.9370.16
9_R55_R0.9350.16
35_P48_L0.9330.16
45_L128_L0.9250.16
69_L122_R0.9240.16
6_S16_W0.8980.15
32_M105_K0.8950.15
49_V128_L0.8770.15
59_R79_G0.8680.15
60_I112_A0.8430.14
40_P90_M0.8370.14
3_L18_S0.8290.14
70_L103_G0.8250.14
10_V115_S0.8160.14
24_L91_I0.8090.14
23_G55_R0.8050.14
23_G56_S0.8050.14
46_L49_V0.8040.14
38_Y66_E0.7920.14
79_G125_R0.7920.14
58_R93_S0.7880.14
2_V52_D0.7860.13
51_F66_E0.7820.13
4_W15_Q0.7790.13
53_C59_R0.7750.13
6_S108_H0.7740.13
47_S52_D0.7720.13
76_R80_Q0.7660.13
3_L21_I0.7650.13
23_G30_L0.7550.13
40_P64_Q0.7500.13
47_S51_F0.7460.13
38_Y51_F0.7390.13
101_S106_R0.7370.13
21_I48_L0.7340.13
30_L56_S0.7330.13
15_Q23_G0.7310.13
56_S60_I0.7300.13
95_M120_E0.7270.13
43_M112_A0.7270.13
43_M94_G0.7230.12
41_L64_Q0.7210.12
29_I51_F0.7180.12
9_R115_S0.7170.12
22_H47_S0.7120.12
15_Q62_A0.7090.12
14_A93_S0.6970.12
52_D61_N0.6850.12
44_V53_C0.6720.12
103_G116_M0.6660.12
71_M80_Q0.6650.12
61_N67_I0.6640.12
42_W56_S0.6550.11
29_I107_Q0.6540.11
49_V81_E0.6520.11
29_I66_E0.6490.11
41_L61_N0.6450.11
104_G107_Q0.6420.11
29_I54_V0.6420.11
104_G113_A0.6380.11
77_W110_W0.6340.11
77_W114_D0.6340.11
110_W114_D0.6340.11
49_V97_L0.6330.11
32_M79_G0.6320.11
94_G127_I0.6300.11
25_V47_S0.6270.11
70_L101_S0.6270.11
3_L19_L0.6220.11
54_V123_D0.6110.11
2_V81_E0.6020.11
14_A59_R0.5990.11
86_K127_I0.5950.11
46_L95_M0.5930.11
8_L116_M0.5900.10
73_G95_M0.5890.10
10_V13_R0.5890.10
74_R81_E0.5850.10
48_L51_F0.5820.10
18_S22_H0.5800.10
50_V123_D0.5790.10
111_L125_R0.5740.10
112_A115_S0.5700.10
35_P109_L0.5660.10
17_L24_L0.5630.10
79_G111_L0.5630.10
71_M83_S0.5630.10
41_L58_R0.5620.10
2_V13_R0.5600.10
82_W110_W0.5540.10
82_W114_D0.5540.10
77_W82_W0.5540.10
97_L124_L0.5530.10
20_L88_P0.5520.10
3_L86_K0.5510.10
11_S14_A0.5460.10
90_M101_S0.5450.10
63_R79_G0.5430.10
2_V6_S0.5410.10
12_W42_W0.5410.10
43_M103_G0.5400.10
8_L100_R0.5380.10
34_W99_L0.5360.10
59_R125_R0.5350.10
11_S15_Q0.5330.10
2_V130_Q0.5320.10
12_W60_I0.5290.10
25_V59_R0.5250.10
111_L124_L0.5230.10
30_L89_W0.5120.09
42_W50_V0.5110.09
80_Q102_D0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.4963 3.6 0.964 Contact Map
2micA 2 0.2963 1.7 0.969 Contact Map
4gh4D 3 0.2222 1.6 0.97 Contact Map
2l2tA 2 0.3259 1.5 0.971 Contact Map
2m20A 2 0.4444 1.4 0.971 Contact Map
2it9A 2 0.3926 1.4 0.971 Contact Map
2ks1B 1 0.3259 1.2 0.972 Contact Map
2nvnA 2 0.4 1.1 0.973 Contact Map
2rddB 1 0.2593 1.1 0.973 Contact Map
4b2kA 5 0.1111 1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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