GREMLIN Database
IDI - Isopentenyl-diphosphate Delta-isomerase
UniProt: Q46822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13072
Length: 182 (163)
Sequences: 2563 (1757)
Seq/√Len: 137.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_N14_V6.1371.00
41_N45_Q5.6131.00
53_L60_G4.6801.00
50_R138_D3.9361.00
42_A126_T3.6771.00
85_R91_E3.3781.00
50_R137_M2.8791.00
142_C147_V2.8081.00
37_S80_V2.6811.00
75_S78_D2.3631.00
66_V84_C2.3481.00
53_L137_M2.1711.00
23_A27_A2.1691.00
143_D146_D2.1691.00
150_G158_F2.0831.00
13_G33_L1.9941.00
9_L33_L1.9781.00
5_H18_T1.9571.00
45_Q143_D1.8271.00
76_N119_P1.8191.00
19_L24_A1.8131.00
83_R86_Y1.7891.00
60_G137_M1.7801.00
19_L23_A1.7631.00
47_L139_Y1.7351.00
58_W160_P1.7181.00
74_E82_R1.7161.00
20_E23_A1.6941.00
40_F46_L1.6221.00
129_L139_Y1.6081.00
79_A82_R1.5061.00
42_A124_R1.4801.00
25_H69_H1.4531.00
62_W140_Q1.4351.00
84_C92_I1.4311.00
6_V24_A1.4061.00
50_R60_G1.3991.00
19_L30_R1.3801.00
25_H116_E1.3581.00
140_Q150_G1.3451.00
47_L141_W1.3381.00
131_I136_V1.3241.00
39_L123_A1.2801.00
90_V125_T1.2671.00
88_L139_Y1.2581.00
7_I72_L1.2391.00
63_T159_S1.2301.00
48_V142_C1.2121.00
90_V129_L1.1901.00
27_A30_R1.1851.00
149_H153_A1.1821.00
63_T67_C1.1811.00
3_T20_E1.1740.99
131_I139_Y1.1560.99
81_I91_E1.1460.99
49_T63_T1.1340.99
46_L147_V1.1340.99
25_H32_H1.1300.99
147_V162_M1.1290.99
69_H116_E1.1270.99
39_L90_V1.0980.99
103_R117_V1.0690.99
76_N121_F1.0620.99
46_L65_S1.0530.99
37_S84_C1.0470.99
64_N67_C1.0470.99
4_E82_R1.0450.99
5_H20_E1.0370.99
31_L103_R1.0270.99
62_W138_D1.0220.99
105_R113_V1.0100.98
100_P120_V1.0080.98
45_Q146_D1.0040.98
4_E71_Q1.0030.98
90_V127_S0.9980.98
86_Y132_N0.9970.98
41_N141_W0.9960.98
125_T129_L0.9810.98
151_I166_A0.9810.98
3_T22_Y0.9700.98
18_T72_L0.9600.98
61_V159_S0.9480.98
36_S64_N0.9440.98
105_R115_N0.9230.97
92_I123_A0.9160.97
140_Q146_D0.9110.97
149_H152_D0.9050.97
158_F162_M0.8930.97
40_F122_A0.8890.97
50_R62_W0.8860.96
49_T139_Y0.8760.96
21_K83_R0.8730.96
39_L84_C0.8640.96
6_V32_H0.8630.96
40_F124_R0.8610.96
81_I85_R0.8570.96
56_K112_I0.8540.96
142_C150_G0.8510.96
146_D149_H0.8450.95
154_T157_A0.8400.95
36_S116_E0.8320.95
35_F79_A0.8280.95
11_A103_R0.8280.95
6_V69_H0.8270.95
148_L152_D0.8190.94
8_L30_R0.8190.94
13_G76_N0.8170.94
7_I73_G0.8030.94
136_V139_Y0.8010.94
13_G117_V0.7920.93
36_S63_T0.7880.93
70_P79_A0.7840.93
88_L136_V0.7800.93
4_E68_G0.7770.93
70_P83_R0.7730.93
18_T22_Y0.7720.93
155_P158_F0.7690.92
36_S118_C0.7640.92
104_Y114_E0.7620.92
38_W165_Q0.7620.92
125_T128_A0.7590.92
101_D119_P0.7570.92
32_H69_H0.7560.92
21_K56_K0.7560.92
6_V71_Q0.7510.92
44_G124_R0.7500.91
77_E80_V0.7470.91
154_T158_F0.7450.91
25_H114_E0.7440.91
148_L166_A0.7430.91
50_R53_L0.7330.91
8_L19_L0.7300.90
102_F165_Q0.7270.90
26_T29_T0.7260.90
23_A26_T0.7130.89
99_Y122_A0.7100.89
37_S123_A0.7050.89
68_G83_R0.7050.89
15_P72_L0.7040.89
10_N16_T0.6980.88
25_H36_S0.6970.88
58_W112_I0.6920.88
31_L115_N0.6910.88
41_N124_R0.6910.88
55_K135_E0.6870.87
24_A30_R0.6850.87
44_G144_L0.6830.87
144_L148_L0.6820.87
8_L17_G0.6780.87
36_S67_C0.6780.87
57_A112_I0.6770.87
38_W162_M0.6680.86
41_N44_G0.6650.86
32_H116_E0.6640.86
76_N80_V0.6620.85
24_A69_H0.6580.85
4_E83_R0.6570.85
40_F99_Y0.6570.85
160_P163_V0.6550.85
54_S134_D0.6530.85
80_V121_F0.6470.84
143_D147_V0.6350.83
93_T96_E0.6340.83
6_V56_K0.6290.82
22_Y26_T0.6270.82
34_A69_H0.6260.82
77_E121_F0.6230.82
36_S114_E0.6230.82
81_I96_E0.6220.82
85_R92_I0.6200.82
65_S88_L0.6190.81
4_E21_K0.6180.81
34_A67_C0.6150.81
118_C165_Q0.6130.81
96_E125_T0.6100.81
7_I47_L0.6090.80
19_L27_A0.6070.80
150_G153_A0.6010.80
70_P114_E0.6000.79
21_K57_A0.6000.79
7_I33_L0.5960.79
7_I18_T0.5960.79
67_C114_E0.5960.79
34_A114_E0.5950.79
150_G154_T0.5920.79
41_N126_T0.5910.78
58_W61_V0.5910.78
64_N114_E0.5900.78
33_L76_N0.5880.78
5_H72_L0.5870.78
35_F69_H0.5820.77
46_L144_L0.5820.77
26_T30_R0.5820.77
45_Q141_W0.5790.77
98_I101_D0.5790.77
5_H130_Q0.5790.77
23_A30_R0.5780.77
144_L162_M0.5760.77
74_E86_Y0.5740.76
36_S69_H0.5730.76
77_E81_I0.5710.76
114_E161_W0.5670.76
8_L24_A0.5670.76
66_V88_L0.5660.75
21_K71_Q0.5660.75
9_L13_G0.5610.75
67_C70_P0.5600.75
49_T88_L0.5590.74
51_R55_K0.5580.74
81_I94_P0.5540.74
164_M167_T0.5520.74
64_N118_C0.5520.74
147_V158_F0.5500.73
96_E149_H0.5480.73
21_K25_H0.5450.73
74_E79_A0.5450.73
13_G16_T0.5410.72
48_V140_Q0.5410.72
13_G103_R0.5400.72
101_D117_V0.5360.71
21_K82_R0.5320.71
7_I13_G0.5310.71
92_I95_P0.5310.71
13_G119_P0.5310.71
36_S161_W0.5300.71
160_P164_M0.5290.70
81_I93_T0.5270.70
57_A64_N0.5260.70
25_H34_A0.5260.70
77_E148_L0.5250.70
74_E78_D0.5250.70
21_K26_T0.5220.69
58_W118_C0.5220.69
65_S69_H0.5210.69
150_G157_A0.5210.69
35_F80_V0.5200.69
4_E59_P0.5180.69
145_A148_L0.5120.68
37_S88_L0.5090.68
13_G101_D0.5080.67
91_E127_S0.5030.67
57_A69_H0.5030.67
95_P123_A0.5000.66
81_I92_I0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pnyA 1 0.989 100 0.333 Contact Map
2dhoA 1 0.989 100 0.334 Contact Map
1hztA 1 0.8352 100 0.4 Contact Map
3dupA 2 0.9835 100 0.449 Contact Map
1q27A 1 0.9176 100 0.51 Contact Map
2fkbA 1 0.8901 100 0.516 Contact Map
2xsqA 2 0.8516 99.9 0.62 Contact Map
3e57A 2 0.8407 99.8 0.643 Contact Map
3q91A 2 0.7253 99.8 0.655 Contact Map
1sjyA 2 0.8242 99.8 0.655 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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