GREMLIN Database
UACT - Uric acid transporter UacT
UniProt: Q46821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13071
Length: 482 (406)
Sequences: 4386 (2233)
Seq/√Len: 110.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_I306_G5.0431.00
194_F217_F5.0351.00
190_A221_L5.0191.00
170_A188_S4.1031.00
157_S431_A3.9571.00
195_I214_G3.8391.00
220_L224_M3.5091.00
131_I261_T3.4811.00
72_F345_G3.4611.00
231_S235_D3.4181.00
238_W349_K3.3011.00
402_V434_S3.0921.00
198_I213_L3.0601.00
187_I222_S3.0581.00
123_G252_F2.7491.00
75_G342_I2.6911.00
230_L233_L2.6711.00
190_A217_F2.6551.00
399_S435_A2.6461.00
187_I227_E2.6281.00
119_L251_I2.6261.00
245_M307_T2.5611.00
236_A349_K2.4651.00
120_G251_I2.4441.00
192_L368_V2.4031.00
275_F294_G2.3591.00
34_G336_S2.3251.00
390_R443_N2.3221.00
38_V340_I2.3181.00
77_V301_G2.2751.00
126_I303_M2.2731.00
92_R288_S2.2721.00
127_A257_I2.2241.00
187_I225_M2.2241.00
216_V220_L2.2091.00
31_I340_I2.1921.00
30_L336_S2.1811.00
117_G120_G2.1551.00
186_G190_A2.1321.00
190_A194_F2.1281.00
220_L223_W2.0871.00
233_L353_L2.0821.00
234_H237_S2.0821.00
133_T303_M2.0741.00
73_C308_F2.0681.00
79_L338_G2.0541.00
130_F134_L2.0251.00
79_L335_I2.0151.00
145_L440_V2.0031.00
194_F221_L1.9981.00
133_T296_R1.9941.00
136_A296_R1.9781.00
194_F198_I1.9691.00
183_V227_E1.9371.00
82_C335_I1.9171.00
437_V441_F1.8901.00
219_F228_V1.8881.00
328_V333_V1.8641.00
52_I107_M1.8641.00
232_G356_S1.8591.00
107_M121_I1.8491.00
130_F303_M1.8211.00
135_L268_F1.8171.00
198_I202_A1.8111.00
129_G303_M1.8071.00
182_P186_G1.8001.00
125_T306_G1.7911.00
219_F356_S1.7831.00
116_I253_D1.7791.00
72_F342_I1.7701.00
231_S234_H1.7681.00
22_D284_R1.7601.00
195_I365_A1.7331.00
279_G286_L1.7121.00
160_L374_L1.7111.00
197_L201_Y1.7091.00
221_L225_M1.7091.00
147_P439_N1.6981.00
169_W359_Q1.6671.00
282_V285_K1.6561.00
339_I343_L1.6531.00
236_A352_V1.6481.00
233_L236_A1.5921.00
53_G58_L1.5851.00
253_D256_S1.5771.00
38_V337_S1.5721.00
287_S290_D1.5711.00
133_T299_G1.5641.00
186_G189_F1.5561.00
205_F209_V1.5471.00
192_L398_I1.5401.00
399_S434_S1.5281.00
108_I111_G1.4931.00
202_A206_M1.4881.00
74_C96_I1.4811.00
24_I332_W1.4661.00
189_F193_I1.4601.00
395_I438_L1.4561.00
244_P309_N1.4511.00
221_L224_M1.4481.00
133_T300_V1.4471.00
183_V225_M1.4281.00
149_L396_V1.4131.00
244_P307_T1.4081.00
218_G361_V1.4071.00
402_V430_L1.3721.00
284_R290_D1.3601.00
79_L82_C1.3581.00
223_W230_L1.3461.00
224_M227_E1.3421.00
245_M248_G1.3421.00
129_G302_T1.3361.00
120_G253_D1.3321.00
290_D293_R1.3321.00
206_M213_L1.3301.00
433_L437_V1.3170.99
232_G235_D1.3160.99
246_S309_N1.3150.99
421_Q425_H1.3030.99
76_I342_I1.2950.99
37_H319_N1.2920.99
20_E23_R1.2850.99
134_L138_L1.2840.99
245_M250_P1.2790.99
110_I256_S1.2720.99
280_E383_R1.2700.99
79_L342_I1.2660.99
398_I434_S1.2630.99
171_A179_Y1.2610.99
418_A421_Q1.2580.99
104_V108_I1.2550.99
83_I335_I1.2510.99
41_M45_A1.2450.99
19_D23_R1.2420.99
82_C334_C1.2370.99
349_K352_V1.2340.99
202_A207_S1.2310.99
209_V213_L1.2280.99
20_E284_R1.2280.99
28_G32_I1.2150.99
217_F221_L1.2120.99
78_T96_I1.2110.99
126_I250_P1.2050.99
384_C392_N1.2040.99
178_Q181_N1.2010.99
278_L323_V1.2010.99
323_V329_H1.1970.99
274_M317_S1.1820.99
213_L217_F1.1820.99
72_F308_F1.1690.99
95_V278_L1.1670.99
252_F257_I1.1620.99
129_G299_G1.1620.99
149_L153_V1.1550.99
100_T267_V1.1400.99
254_P257_I1.1380.99
157_S403_G1.1330.98
167_I405_T1.1300.98
193_I197_L1.1210.98
420_L423_L1.1210.98
386_Y396_V1.1130.98
116_I256_S1.1130.98
400_L404_M1.1080.98
347_V351_A1.0930.98
172_G179_Y1.0890.98
132_T267_V1.0820.98
89_M300_V1.0810.98
116_I120_G1.0790.98
240_A348_P1.0770.98
102_A267_V1.0750.98
183_V186_G1.0750.98
98_S316_F1.0720.98
126_I307_T1.0700.98
190_A225_M1.0600.98
223_W228_V1.0510.98
27_P31_I1.0490.97
60_K67_I1.0470.97
128_A264_L1.0450.97
271_S275_F1.0380.97
186_G225_M1.0310.97
97_M315_S1.0250.97
270_E314_T1.0210.97
25_L330_S1.0210.97
343_L347_V1.0180.97
110_I260_M1.0170.97
106_P263_V1.0140.97
19_D25_L1.0140.97
111_G121_I0.9980.97
275_F298_D0.9970.97
394_Y398_I0.9970.97
31_I35_L0.9910.96
274_M320_V0.9870.96
90_G293_R0.9830.96
305_G313_H0.9830.96
183_V187_I0.9810.96
40_V322_L0.9630.96
420_L424_L0.9600.96
222_S227_E0.9590.96
96_I337_S0.9560.96
95_V315_S0.9560.96
156_T400_L0.9500.95
197_L441_F0.9450.95
76_I80_L0.9390.95
25_L333_V0.9380.95
48_V101_F0.9380.95
76_I304_I0.9350.95
123_G127_A0.9350.95
203_K207_S0.9320.95
181_N184_Y0.9270.95
25_L30_L0.9240.95
136_A292_I0.9240.95
271_S294_G0.9220.95
176_N184_Y0.9220.95
304_I308_F0.9180.95
24_I30_L0.9170.95
222_S226_N0.9170.95
50_L67_I0.9020.94
249_M307_T0.9000.94
332_W335_I0.8940.94
35_L340_I0.8900.94
21_V24_I0.8900.94
26_S29_K0.8870.94
168_D179_Y0.8850.93
243_T246_S0.8820.93
412_F417_P0.8770.93
255_V259_T0.8690.93
100_T314_T0.8660.93
163_I401_G0.8660.93
146_F432_T0.8660.93
176_N181_N0.8620.93
124_A256_S0.8610.92
254_P258_L0.8570.92
335_I338_G0.8560.92
37_H41_M0.8550.92
75_G338_G0.8550.92
172_G180_G0.8550.92
79_L339_I0.8540.92
37_H40_V0.8530.92
184_Y360_F0.8510.92
375_A393_L0.8480.92
166_G191_V0.8470.92
229_N232_G0.8460.92
230_L356_S0.8460.92
156_T378_I0.8440.92
350_M353_L0.8410.92
187_I221_L0.8400.92
282_V329_H0.8350.91
374_L400_L0.8350.91
219_F230_L0.8330.91
179_Y409_S0.8300.91
136_A299_G0.8290.91
140_G292_I0.8270.91
219_F357_I0.8260.91
289_H293_R0.8250.91
96_I334_C0.8230.91
73_C310_S0.8210.91
176_N179_Y0.8200.91
31_I336_S0.8160.90
119_L248_G0.8160.90
171_A412_F0.8130.90
81_Q93_L0.8120.90
139_I295_L0.8120.90
387_T392_N0.8120.90
95_V275_F0.8110.90
161_S428_I0.8060.90
119_L250_P0.8030.90
212_L216_V0.8030.90
110_I124_A0.8010.89
241_I346_M0.8000.89
133_T137_P0.7990.89
247_F250_P0.7980.89
326_T340_I0.7960.89
109_A112_M0.7940.89
368_V394_Y0.7940.89
124_A128_A0.7920.89
220_L343_L0.7910.89
132_T299_G0.7900.89
193_I196_L0.7890.89
267_V314_T0.7880.89
300_V304_I0.7880.89
120_G256_S0.7870.89
31_I234_H0.7850.89
50_L53_G0.7810.88
189_F225_M0.7800.88
344_F350_M0.7770.88
238_W242_V0.7750.88
95_V322_L0.7740.88
238_W347_V0.7740.88
403_G431_A0.7700.88
73_C304_I0.7670.87
192_L196_L0.7660.87
19_D26_S0.7660.87
335_I339_I0.7650.87
82_C331_R0.7650.87
169_W370_F0.7620.87
198_I214_G0.7590.87
233_L349_K0.7590.87
265_I269_I0.7590.87
170_A367_L0.7580.87
237_S240_A0.7570.87
44_G318_Q0.7560.87
102_A369_M0.7560.87
166_G188_S0.7550.87
198_I206_M0.7540.86
48_V99_V0.7530.86
169_W362_L0.7520.86
233_L356_S0.7510.86
320_V323_V0.7500.86
171_A180_G0.7470.86
153_V399_S0.7470.86
155_I274_M0.7440.86
179_Y182_P0.7440.86
395_I443_N0.7420.86
168_D171_A0.7410.86
104_V265_I0.7390.85
271_S298_D0.7390.85
50_L362_L0.7370.85
187_I360_F0.7360.85
233_L352_V0.7360.85
406_P430_L0.7360.85
99_V103_A0.7360.85
145_L436_V0.7360.85
214_G217_F0.7350.85
184_Y227_E0.7340.85
194_F214_G0.7330.85
398_I438_L0.7330.85
44_G370_F0.7260.84
197_L202_A0.7260.84
199_T325_V0.7250.84
45_A74_C0.7230.84
156_T381_L0.7220.84
198_I217_F0.7210.84
250_P253_D0.7210.84
200_R373_V0.7210.84
126_I130_F0.7190.84
94_P334_C0.7180.84
265_I277_A0.7170.84
390_R395_I0.7140.83
27_P340_I0.7140.83
105_T108_I0.7130.83
126_I252_F0.7120.83
302_T313_H0.7040.82
41_M319_N0.7010.82
199_T394_Y0.7010.82
271_S314_T0.6990.82
69_S72_F0.6970.82
427_G431_A0.6960.82
33_L37_H0.6960.82
127_A252_F0.6960.82
120_G124_A0.6950.82
41_M96_I0.6940.82
371_G375_A0.6920.81
119_L122_F0.6920.81
176_N180_G0.6890.81
215_I365_A0.6880.81
34_G337_S0.6880.81
93_L294_G0.6880.81
70_D311_F0.6860.81
278_L320_V0.6860.81
340_I344_F0.6860.81
397_A401_G0.6850.81
241_I345_G0.6830.81
132_T264_L0.6820.80
80_L297_V0.6810.80
38_V344_F0.6810.80
100_T103_A0.6810.80
278_L315_S0.6800.80
395_I399_S0.6800.80
68_S351_A0.6790.80
402_V406_P0.6780.80
70_D74_C0.6770.80
211_V322_L0.6760.80
107_M125_T0.6750.80
194_F213_L0.6750.80
217_F220_L0.6750.80
168_D176_N0.6750.80
215_I269_I0.6750.80
155_I158_I0.6730.80
272_M291_I0.6730.80
47_A169_W0.6710.79
222_S225_M0.6690.79
73_C305_G0.6650.79
43_A49_P0.6620.78
52_I215_I0.6620.78
94_P124_A0.6610.78
102_A158_I0.6580.78
70_D99_V0.6570.78
149_L392_N0.6550.78
375_A396_V0.6550.78
141_R288_S0.6530.78
171_A185_L0.6530.78
69_S73_C0.6520.77
225_M350_M0.6510.77
41_M379_R0.6510.77
187_I361_V0.6500.77
396_V400_L0.6490.77
405_T412_F0.6490.77
111_G116_I0.6480.77
97_M271_S0.6470.77
386_Y392_N0.6460.77
126_I249_M0.6440.77
261_T264_L0.6420.76
352_V356_S0.6410.76
204_G214_G0.6410.76
45_A70_D0.6410.76
161_S426_S0.6400.76
216_V441_F0.6370.76
215_I362_L0.6350.76
186_G221_L0.6330.75
72_F346_M0.6320.75
141_R145_L0.6320.75
45_A48_V0.6320.75
317_S376_T0.6300.75
200_R375_A0.6290.75
193_I216_V0.6280.75
102_A314_T0.6260.75
108_I112_M0.6260.75
267_V270_E0.6240.74
105_T109_A0.6230.74
185_L189_F0.6220.74
73_C301_G0.6200.74
270_E298_D0.6200.74
208_N443_N0.6190.74
352_V355_A0.6190.74
324_S379_R0.6180.74
21_V25_L0.6170.73
144_P440_V0.6170.73
339_I383_R0.6150.73
109_A115_D0.6150.73
76_I308_F0.6140.73
195_I368_V0.6140.73
34_G155_I0.6130.73
195_I378_I0.6130.73
165_V169_W0.6120.73
401_G404_M0.6110.73
130_F133_T0.6110.73
132_T268_F0.6100.73
135_L138_L0.6080.72
141_R146_F0.6070.72
381_L384_C0.6070.72
163_I404_M0.6040.72
442_F445_Y0.6010.72
37_H322_L0.6010.72
23_R330_S0.6000.71
140_G144_P0.5970.71
386_Y393_L0.5960.71
416_L421_Q0.5950.71
302_T305_G0.5950.71
149_L395_I0.5940.71
213_L216_V0.5930.70
107_M260_M0.5910.70
281_I324_S0.5910.70
286_L290_D0.5910.70
195_I198_I0.5910.70
111_G117_G0.5910.70
431_A435_A0.5910.70
78_T338_G0.5900.70
239_F347_V0.5860.70
403_G427_G0.5860.70
303_M307_T0.5860.70
45_A341_L0.5860.70
283_G329_H0.5850.69
260_M360_F0.5850.69
419_V422_P0.5850.69
124_A257_I0.5840.69
345_G351_A0.5840.69
202_A205_F0.5830.69
198_I210_A0.5830.69
223_W226_N0.5820.69
228_V356_S0.5820.69
97_M302_T0.5800.69
317_S429_M0.5800.69
91_I290_D0.5790.69
118_L122_F0.5780.69
112_M115_D0.5780.69
271_S315_S0.5780.69
35_L171_A0.5770.68
374_L378_I0.5770.68
324_S367_L0.5760.68
298_D397_A0.5740.68
156_T374_L0.5740.68
153_V435_A0.5740.68
274_M315_S0.5740.68
388_T446_Q0.5740.68
216_V353_L0.5730.68
94_P282_V0.5730.68
187_I215_I0.5720.68
206_M210_A0.5720.68
74_C95_V0.5700.67
274_M376_T0.5700.67
152_G377_G0.5700.67
379_R386_Y0.5680.67
218_G226_N0.5680.67
110_I123_G0.5660.67
99_V166_G0.5660.67
110_I121_I0.5650.67
241_I265_I0.5650.67
318_Q370_F0.5650.67
379_R383_R0.5640.67
147_P321_G0.5640.67
277_A376_T0.5630.67
156_T195_I0.5630.67
169_W366_G0.5610.66
147_P152_G0.5600.66
259_T423_L0.5600.66
168_D216_V0.5600.66
151_T348_P0.5590.66
272_M276_L0.5590.66
273_G403_G0.5590.66
75_G326_T0.5570.66
158_I316_F0.5550.65
267_V275_F0.5540.65
241_I244_P0.5540.65
122_F126_I0.5540.65
146_F204_G0.5540.65
33_L317_S0.5530.65
264_L302_T0.5530.65
33_L146_F0.5510.65
303_M306_G0.5510.65
80_L133_T0.5500.65
46_V67_I0.5490.65
77_V297_V0.5490.65
317_S320_V0.5460.64
224_M241_I0.5460.64
220_L234_H0.5450.64
163_I397_A0.5450.64
49_P53_G0.5450.64
111_G348_P0.5430.64
236_A348_P0.5430.64
232_G308_F0.5420.64
127_A261_T0.5410.63
362_L365_A0.5400.63
103_A302_T0.5400.63
161_S427_G0.5400.63
154_V192_L0.5380.63
75_G79_L0.5380.63
89_M293_R0.5380.63
191_V375_A0.5370.63
69_S309_N0.5360.63
230_L353_L0.5360.63
436_V440_V0.5350.63
47_A50_L0.5350.63
72_F425_H0.5350.63
371_G393_L0.5340.63
19_D22_D0.5330.62
148_P393_L0.5320.62
328_V362_L0.5320.62
331_R335_I0.5320.62
132_T431_A0.5300.62
381_L386_Y0.5290.62
169_W363_G0.5280.62
99_V314_T0.5280.62
124_A261_T0.5280.62
38_V260_M0.5280.62
24_I27_P0.5270.61
79_L330_S0.5270.61
97_M274_M0.5270.61
298_D314_T0.5270.61
58_L311_F0.5260.61
27_P30_L0.5260.61
385_N392_N0.5230.61
185_L412_F0.5230.61
74_C263_V0.5230.61
318_Q372_M0.5230.61
97_M275_F0.5210.61
197_L437_V0.5200.60
276_L327_R0.5200.60
159_G166_G0.5200.60
33_L372_M0.5200.60
99_V274_M0.5190.60
135_L389_N0.5190.60
21_V330_S0.5170.60
184_Y187_I0.5170.60
130_F181_N0.5170.60
39_L395_I0.5170.60
275_F286_L0.5160.60
375_A397_A0.5160.60
58_L111_G0.5160.60
47_A51_M0.5140.60
199_T207_S0.5140.60
169_W188_S0.5140.60
81_Q331_R0.5130.59
123_G250_P0.5130.59
78_T314_T0.5120.59
217_F224_M0.5120.59
223_W408_L0.5110.59
163_I367_L0.5110.59
376_T379_R0.5100.59
231_S236_A0.5100.59
319_N322_L0.5100.59
191_V309_N0.5100.59
193_I418_A0.5090.59
25_L332_W0.5090.59
30_L332_W0.5080.59
185_L407_T0.5080.59
402_V407_T0.5080.59
45_A99_V0.5080.59
159_G374_L0.5070.59
46_V354_V0.5060.58
146_F151_T0.5050.58
294_G298_D0.5050.58
429_M433_L0.5030.58
300_V303_M0.5030.58
27_P339_I0.5030.58
82_C338_G0.5030.58
43_A318_Q0.5020.58
340_I433_L0.5010.58
278_L354_V0.5000.58
219_F223_W0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8257 100 0.444 Contact Map
3wdoA 1 0.8506 97.5 0.937 Contact Map
4pypA 1 0.8257 97 0.942 Contact Map
4m64A 1 0.8008 96.5 0.946 Contact Map
4zw9A 1 0.8568 96.4 0.947 Contact Map
2jlnA 1 0.8071 95.9 0.949 Contact Map
1pw4A 1 0.8465 95.9 0.949 Contact Map
4j05A 3 0.7884 94 0.954 Contact Map
4tphA 2 0.7884 93.8 0.955 Contact Map
4ikvA 1 0.8589 93.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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