GREMLIN Database
GHXQ - Guanine/hypoxanthine permease GhxQ
UniProt: Q46817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13067
Length: 455 (386)
Sequences: 10771 (6148)
Seq/√Len: 312.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_F316_G3.4781.00
236_V239_P3.2641.00
35_V345_V3.2381.00
167_V193_S3.2091.00
403_F416_L3.1671.00
399_V420_T3.0681.00
82_G344_T3.0071.00
131_S306_T2.9021.00
31_V341_L2.7071.00
79_L347_G2.5961.00
235_L239_P2.5841.00
246_G251_F2.4891.00
337_G342_T2.4461.00
80_L314_F2.4361.00
84_W310_V2.4311.00
137_T302_G2.3481.00
79_L344_T2.2551.00
122_L267_V2.2501.00
173_N181_A2.2211.00
38_G345_V2.2201.00
235_L240_S2.1711.00
73_V323_A2.1511.00
58_K103_F2.1251.00
129_A133_T2.1231.00
332_G342_T2.0951.00
185_F190_V2.0871.00
125_V129_A2.0861.00
197_L374_Y2.0621.00
191_M195_L2.0131.00
381_S384_S1.9951.00
75_G351_L1.9871.00
348_A352_L1.9671.00
400_C417_G1.9571.00
285_V333_T1.9521.00
214_L220_S1.9491.00
430_E433_K1.9431.00
121_F313_I1.9281.00
285_V329_S1.9231.00
221_I225_I1.9191.00
125_V313_I1.9171.00
315_S320_A1.8971.00
216_I220_S1.8931.00
222_I226_F1.8471.00
77_G311_S1.8441.00
248_S251_F1.8321.00
247_K251_F1.8251.00
409_N412_T1.8221.00
178_L181_A1.8151.00
214_L217_I1.7741.00
37_A337_G1.7591.00
244_E247_K1.7561.00
132_V306_T1.7431.00
237_A240_S1.7411.00
128_T313_I1.7311.00
403_F407_T1.7301.00
196_G219_I1.7101.00
31_V35_V1.6711.00
80_L84_W1.6701.00
75_G347_G1.6561.00
90_A346_V1.6411.00
245_D248_S1.6391.00
246_G249_L1.6291.00
345_V349_L1.6191.00
89_M325_V1.6091.00
197_L370_P1.6091.00
196_G370_P1.6081.00
220_S223_G1.6011.00
30_T338_K1.5911.00
200_I215_V1.5781.00
195_L199_V1.5781.00
207_R210_G1.5661.00
244_E248_S1.5641.00
193_S370_P1.5621.00
78_S347_G1.5601.00
126_I271_V1.5571.00
236_V240_S1.5541.00
219_I223_G1.5431.00
33_Q338_K1.5331.00
220_S224_L1.5291.00
99_A321_A1.5241.00
254_D257_G1.5161.00
80_L307_S1.5101.00
219_I367_A1.4991.00
198_A202_G1.4891.00
402_V406_L1.4781.00
37_A342_T1.4691.00
122_L263_V1.4561.00
214_L218_A1.4531.00
391_F395_M1.4421.00
204_E378_L1.4391.00
39_L349_L1.4241.00
314_F318_V1.4201.00
95_I98_T1.4141.00
251_F254_D1.4141.00
31_V345_V1.4021.00
243_G246_G1.4001.00
128_T306_T1.3961.00
27_R30_T1.3891.00
384_S388_F1.3791.00
124_G313_I1.3691.00
130_I135_V1.3671.00
35_V39_L1.3631.00
425_R433_K1.3401.00
105_L270_L1.3381.00
178_L182_L1.3371.00
212_I216_I1.3261.00
192_M219_I1.3241.00
246_G258_A1.3141.00
167_V369_A1.3121.00
42_F349_L1.3121.00
129_A132_V1.3011.00
215_V219_I1.3001.00
126_I264_L1.2881.00
201_F374_Y1.2871.00
179_P182_L1.2851.00
223_G228_P1.2781.00
112_S115_V1.2771.00
247_K252_S1.2731.00
214_L224_L1.2731.00
179_P183_G1.2671.00
381_S385_K1.2651.00
382_N385_K1.2621.00
211_G214_L1.2591.00
239_P243_G1.2501.00
156_G376_G1.2471.00
214_L227_D1.2461.00
77_G323_A1.2461.00
300_N303_K1.2331.00
217_I220_S1.2311.00
82_G343_A1.2271.00
202_G206_C1.2241.00
310_V314_F1.2201.00
197_L201_F1.2191.00
200_I374_Y1.2141.00
246_G252_S1.2101.00
256_M259_L1.2081.00
108_G111_I1.2081.00
105_L266_S1.2041.00
189_P366_Y1.2021.00
119_A263_V1.1941.00
221_I224_L1.1811.00
194_L198_A1.1801.00
258_A261_P1.1771.00
341_L345_V1.1761.00
295_D333_T1.1761.00
398_L402_V1.1751.00
83_L344_T1.1721.00
84_W307_S1.1721.00
34_E338_K1.1721.00
75_G79_L1.1711.00
178_L183_G1.1691.00
188_F191_M1.1681.00
187_S191_M1.1671.00
153_I401_A1.1661.00
216_I224_L1.1541.00
235_L238_M1.1491.00
303_K306_T1.1461.00
216_I219_I1.1431.00
93_C97_L1.1391.00
98_T270_L1.1381.00
57_G63_P1.1371.00
306_T310_V1.1361.00
347_G351_L1.1361.00
167_V373_M1.1351.00
186_T189_P1.1291.00
157_L405_V1.1281.00
32_R36_L1.1271.00
204_E374_Y1.1241.00
423_V427_F1.1241.00
187_S190_V1.1141.00
80_L310_V1.1051.00
177_G181_A1.1041.00
212_I371_A1.1031.00
353_I356_L1.1001.00
160_L373_M1.0941.00
94_A98_T1.0931.00
399_V403_F1.0921.00
50_I54_G1.0871.00
149_H385_K1.0861.00
173_N177_G1.0851.00
190_V193_S1.0841.00
137_T141_R1.0771.00
244_E251_F1.0751.00
165_N179_P1.0751.00
190_V194_L1.0651.00
128_T309_S1.0651.00
195_L222_I1.0641.00
332_G337_G1.0611.00
26_A31_V1.0591.00
277_D281_T1.0561.00
130_I271_V1.0501.00
134_G138_W1.0471.00
344_T348_A1.0471.00
227_D230_V1.0411.00
247_K253_L1.0401.00
342_T346_V1.0401.00
226_F230_V1.0361.00
65_A321_A1.0331.00
274_A322_P1.0321.00
249_L252_S1.0301.00
55_M95_I1.0231.00
251_F258_A1.0211.00
123_M271_V1.0161.00
262_T265_P1.0161.00
126_I267_V1.0151.00
211_G216_I1.0141.00
146_G393_D1.0131.00
352_L355_F1.0131.00
193_S373_M1.0101.00
426_V431_W1.0081.00
189_P193_S1.0041.00
217_I221_I1.0011.00
27_R339_T0.9991.00
126_I268_L0.9981.00
196_G367_A0.9971.00
392_I428_A0.9951.00
128_T132_V0.9921.00
257_G260_Q0.9921.00
134_G302_G0.9901.00
184_A187_S0.9891.00
191_M194_L0.9861.00
37_A41_T0.9821.00
245_D249_L0.9811.00
163_A373_M0.9711.00
214_L229_A0.9711.00
200_I204_E0.9641.00
180_V183_G0.9611.00
404_I413_G0.9611.00
282_I304_A0.9581.00
150_G400_C0.9531.00
89_M333_T0.9461.00
30_T33_Q0.9451.00
93_C98_T0.9391.00
161_L406_L0.9381.00
247_K258_A0.9371.00
228_P232_Y0.9371.00
253_L257_G0.9361.00
123_M270_L0.9351.00
407_T412_T0.9341.00
246_G253_L0.9331.00
424_G428_A0.9321.00
157_L401_A0.9321.00
253_L256_M0.9311.00
251_F256_M0.9301.00
223_G229_A0.9301.00
50_I331_A0.9241.00
222_I225_I0.9241.00
120_V316_G0.9231.00
93_C328_E0.9221.00
118_G122_L0.9191.00
250_I253_L0.9191.00
313_I316_G0.9171.00
240_S244_E0.9161.00
267_V271_V0.9141.00
225_I229_A0.9101.00
383_V401_A0.9081.00
171_I174_P0.9051.00
205_K209_P0.9031.00
345_V348_A0.8971.00
311_S323_A0.8971.00
76_F314_F0.8971.00
254_D260_Q0.8951.00
81_M92_G0.8951.00
59_A66_V0.8941.00
311_S314_F0.8931.00
341_L344_T0.8931.00
364_P367_A0.8911.00
177_G180_V0.8891.00
225_I228_P0.8871.00
310_V313_I0.8861.00
153_I156_G0.8861.00
215_V220_S0.8851.00
201_F395_M0.8811.00
420_T424_G0.8801.00
174_P177_G0.8781.00
397_G401_A0.8771.00
196_G215_V0.8741.00
199_V215_V0.8731.00
390_D393_D0.8711.00
254_D259_L0.8701.00
224_L227_D0.8691.00
123_M274_A0.8681.00
385_K389_N0.8651.00
118_G255_I0.8641.00
201_F377_L0.8601.00
145_M149_H0.8601.00
387_D394_A0.8581.00
213_L216_I0.8511.00
216_I229_A0.8501.00
359_L362_L0.8471.00
65_A69_A0.8441.00
76_F318_V0.8421.00
330_A334_A0.8391.00
253_L317_L0.8341.00
89_M285_V0.8331.00
255_I259_L0.8261.00
210_G214_L0.8241.00
119_A266_S0.8231.00
160_L376_G0.8231.00
239_P244_E0.8231.00
58_K102_A0.8191.00
256_M261_P0.8171.00
94_A97_L0.8161.00
313_I317_L0.8161.00
200_I212_I0.8131.00
380_L383_V0.8121.00
217_I224_L0.8121.00
156_G380_L0.8111.00
204_E211_G0.8061.00
121_F317_L0.8031.00
246_G250_I0.8031.00
33_Q37_A0.7971.00
249_L254_D0.7931.00
161_L165_N0.7921.00
214_L230_V0.7901.00
92_G308_D0.7901.00
203_L214_L0.7891.00
274_A312_S0.7891.00
165_N172_K0.7871.00
193_S366_Y0.7831.00
94_A324_A0.7811.00
52_V350_F0.7771.00
224_L362_L0.7761.00
38_G42_F0.7761.00
248_S252_S0.7761.00
240_S243_G0.7740.99
412_T415_M0.7740.99
87_L304_A0.7740.99
98_T102_A0.7710.99
232_Y235_L0.7710.99
219_I222_I0.7690.99
240_S246_G0.7670.99
34_E339_T0.7660.99
54_G63_P0.7650.99
415_M419_V0.7640.99
102_A322_P0.7620.99
161_L180_V0.7600.99
185_F188_F0.7600.99
52_V98_T0.7590.99
166_G369_A0.7580.99
35_V341_L0.7540.99
131_S137_T0.7520.99
74_A78_S0.7520.99
203_L211_G0.7510.99
123_M322_P0.7500.99
248_S261_P0.7470.99
100_F103_F0.7440.99
214_L232_Y0.7410.99
220_S227_D0.7400.99
212_I215_V0.7390.99
119_A270_L0.7380.99
116_A120_V0.7380.99
195_L219_I0.7370.99
219_I224_L0.7350.99
213_L220_S0.7340.99
84_W303_K0.7330.99
213_L217_I0.7330.99
69_A113_V0.7310.99
154_G404_I0.7310.99
249_L255_I0.7310.99
245_D251_F0.7310.99
393_D396_A0.7290.99
246_G254_D0.7280.99
71_C75_G0.7260.99
61_F66_V0.7250.99
97_L102_A0.7250.99
353_I360_S0.7230.99
114_P252_S0.7220.99
265_P269_A0.7220.99
84_W306_T0.7200.99
218_A222_I0.7180.99
54_G58_K0.7180.99
211_G215_V0.7170.99
392_I425_R0.7160.99
399_V416_L0.7140.99
248_S256_M0.7120.99
26_A30_T0.7110.99
281_T326_Y0.7100.99
425_R430_E0.7100.99
91_I343_A0.7090.99
117_L120_V0.7070.99
384_S387_D0.7070.99
252_S256_M0.7050.99
79_L83_L0.7040.99
248_S258_A0.7010.99
331_A335_A0.7010.99
27_R300_N0.7010.99
38_G349_L0.6970.99
384_S389_N0.6950.99
355_F358_P0.6930.99
152_G284_A0.6920.99
28_G32_R0.6910.99
253_L258_A0.6910.99
227_D232_Y0.6900.99
120_V322_P0.6880.99
212_I220_S0.6880.99
243_G253_L0.6850.99
119_A123_M0.6800.99
154_G401_A0.6800.99
202_G427_F0.6790.99
68_V354_L0.6790.99
314_F317_L0.6780.99
87_L298_I0.6770.99
130_I305_L0.6760.99
131_S309_S0.6740.99
224_L229_A0.6730.99
394_A398_L0.6730.99
392_I424_G0.6680.99
247_K256_M0.6640.98
257_G261_P0.6630.98
244_E258_A0.6630.98
114_P251_F0.6620.98
248_S257_G0.6620.98
255_I258_A0.6610.98
52_V70_T0.6590.98
73_V77_G0.6580.98
126_I130_I0.6570.98
93_C96_S0.6570.98
227_D231_K0.6570.98
244_E256_M0.6550.98
403_F412_T0.6540.98
243_G248_S0.6540.98
96_S99_A0.6530.98
254_D258_A0.6530.98
109_Q112_S0.6520.98
74_A350_F0.6510.98
216_I227_D0.6510.98
263_V266_S0.6500.98
141_R297_Q0.6490.98
256_M260_Q0.6470.98
200_I370_P0.6460.98
55_M74_A0.6460.98
266_S269_A0.6440.98
422_V426_V0.6420.98
247_K250_I0.6420.98
146_G150_G0.6390.98
220_S363_I0.6390.98
87_L300_N0.6390.98
243_G249_L0.6350.98
205_K208_V0.6350.98
81_M91_I0.6340.98
199_V203_L0.6340.98
96_S101_T0.6310.98
217_I227_D0.6300.98
114_P117_L0.6300.98
98_T123_M0.6290.98
161_L164_A0.6280.98
192_M223_G0.6270.98
81_M307_S0.6270.98
205_K210_G0.6260.98
346_V353_I0.6260.98
228_P231_K0.6240.98
134_G137_T0.6230.98
197_L373_M0.6230.98
51_V346_V0.6220.98
148_A283_R0.6200.98
309_S313_I0.6200.98
91_I323_A0.6190.98
37_A335_A0.6180.98
240_S245_D0.6170.98
292_L298_I0.6160.97
220_S362_L0.6160.97
354_L357_S0.6150.97
101_T270_L0.6150.97
220_S229_A0.6130.97
26_A86_N0.6100.97
290_N299_I0.6090.97
416_L420_T0.6090.97
394_A397_G0.6080.97
95_I325_V0.6060.97
94_A102_A0.6040.97
102_A116_A0.6040.97
186_T190_V0.6040.97
425_R429_R0.6000.97
154_G405_V0.5960.97
352_L356_L0.5950.97
122_L126_I0.5940.97
374_Y378_L0.5940.97
111_I262_T0.5920.97
421_L425_R0.5900.97
174_P179_P0.5890.97
127_F274_A0.5860.97
216_I230_V0.5850.97
144_P421_L0.5840.97
103_F106_V0.5840.97
252_S258_A0.5830.96
275_V305_L0.5830.96
209_P335_A0.5830.96
95_I326_Y0.5800.96
32_R35_V0.5800.96
216_I223_G0.5780.96
198_A201_F0.5770.96
251_F257_G0.5770.96
138_W141_R0.5770.96
65_A106_V0.5760.96
206_C210_G0.5760.96
97_L105_L0.5760.96
76_F315_S0.5750.96
124_G312_S0.5740.96
309_S312_S0.5740.96
150_G397_G0.5720.96
102_A106_V0.5710.96
223_G227_D0.5700.96
153_I380_L0.5680.96
278_A325_V0.5680.96
117_L316_G0.5670.96
79_L82_G0.5670.96
392_I396_A0.5650.96
306_T313_I0.5650.96
77_G315_S0.5640.96
65_A113_V0.5640.96
138_W302_G0.5630.96
28_G31_V0.5620.96
255_I260_Q0.5610.96
263_V267_V0.5610.96
89_M337_G0.5600.96
105_L119_A0.5600.96
106_V116_A0.5580.96
69_A319_G0.5570.95
215_V371_A0.5560.95
140_L143_L0.5560.95
171_I184_A0.5550.95
274_A278_A0.5530.95
245_D250_I0.5530.95
160_L398_L0.5520.95
311_S315_S0.5500.95
312_S322_P0.5480.95
153_I383_V0.5480.95
52_V55_M0.5460.95
118_G263_V0.5450.95
199_V219_I0.5450.95
271_V275_V0.5450.95
86_N307_S0.5420.95
281_T325_V0.5420.95
99_A102_A0.5420.95
149_H382_N0.5410.95
243_G247_K0.5380.95
245_D258_A0.5380.95
195_L218_A0.5360.94
36_L40_T0.5350.94
334_A378_L0.5350.94
195_L198_A0.5310.94
81_M323_A0.5300.94
81_M308_D0.5280.94
224_L228_P0.5270.94
108_G112_S0.5270.94
206_C209_P0.5260.94
93_C102_A0.5260.94
387_D391_F0.5240.94
211_G220_S0.5240.94
383_V388_F0.5240.94
250_I256_M0.5230.94
52_V95_I0.5220.94
120_V270_L0.5210.94
211_G217_I0.5200.94
219_I228_P0.5200.94
264_L267_V0.5180.93
71_C350_F0.5180.93
221_I228_P0.5180.93
386_L394_A0.5150.93
218_A221_I0.5150.93
383_V397_G0.5140.93
33_Q36_L0.5140.93
119_A267_V0.5130.93
412_T416_L0.5110.93
214_L219_I0.5110.93
194_L197_L0.5080.93
42_F350_F0.5060.93
396_A420_T0.5050.93
29_S32_R0.5050.93
380_L401_A0.5040.92
104_S110_Q0.5040.92
39_L345_V0.5030.92
250_I260_Q0.5030.92
94_A328_E0.5020.92
275_V279_T0.5010.92
132_V135_V0.5010.92
278_A324_A0.5000.92
217_I230_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8286 100 0.553 Contact Map
3o7qA 1 0.422 17.7 0.969 Contact Map
2zy9A 2 0.2571 16.5 0.969 Contact Map
4u9nA 2 0.2527 15.1 0.97 Contact Map
4us3A 1 0.8154 10.8 0.972 Contact Map
2gfpA 2 0.4308 4.1 0.977 Contact Map
4a82A 2 0.167 4 0.977 Contact Map
4j05A 3 0.433 3.9 0.977 Contact Map
1pw4A 1 0.4396 3.2 0.978 Contact Map
1btsA 1 0.0462 3 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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