GREMLIN Database
XDHD - Probable hypoxanthine oxidase XdhD
UniProt: Q46814 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13064
Length: 956 (737)
Sequences: 4686 (3064)
Seq/√Len: 112.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_L289_L5.0321.00
206_L290_I4.7541.00
380_E492_K4.6271.00
279_S282_I4.2061.00
222_K291_D4.0741.00
201_C230_V4.0331.00
382_T490_T3.8691.00
625_L628_G3.8541.00
210_H213_A3.7581.00
588_E618_S3.6591.00
496_K500_R3.5201.00
376_D496_K3.5101.00
495_A575_L3.4921.00
505_K540_D3.4801.00
376_D497_K3.4431.00
226_L282_I3.4261.00
214_L295_E3.4061.00
370_K374_D3.3881.00
206_L287_L3.3281.00
367_D370_K3.2971.00
581_I589_R3.2971.00
216_T293_E3.2111.00
698_A738_A3.2041.00
501_L572_L3.1651.00
213_A294_Y3.1351.00
677_F704_C3.1001.00
507_D542_Q2.9931.00
276_V460_A2.9921.00
210_H296_V2.9771.00
535_P596_Q2.9331.00
230_V278_E2.9251.00
380_E490_T2.9091.00
701_V743_E2.8641.00
212_H297_L2.8031.00
832_K897_R2.7131.00
492_K505_K2.6681.00
770_G778_E2.6591.00
585_E589_R2.6581.00
217_H293_E2.6181.00
739_R743_E2.5601.00
581_I586_I2.4981.00
278_E466_R2.4891.00
304_D488_K2.4401.00
372_F494_G2.4311.00
409_I423_V2.4111.00
278_E282_I2.3891.00
408_V437_I2.3891.00
500_R589_R2.3821.00
931_I944_F2.3631.00
220_V224_E2.3531.00
507_D544_T2.3201.00
406_R717_D2.3141.00
624_I816_F2.2831.00
216_T295_E2.2681.00
203_I470_F2.2651.00
511_N550_I2.2511.00
941_E948_K2.2241.00
305_E308_A2.1851.00
928_A944_F2.1831.00
435_H715_D2.1741.00
493_L571_A2.1681.00
377_V495_A2.1641.00
780_S783_D2.1541.00
585_E588_E2.0941.00
820_A831_D2.0711.00
588_E621_L2.0701.00
401_R410_H2.0541.00
856_T896_F2.0531.00
375_A494_G2.0441.00
620_A816_F2.0421.00
203_I274_A2.0061.00
491_V571_A1.9941.00
193_E469_L1.9921.00
593_H596_Q1.9911.00
857_L892_I1.9881.00
671_L745_L1.9861.00
619_C899_V1.9781.00
746_R750_L1.9741.00
669_I679_V1.9661.00
676_T708_D1.9641.00
377_V497_K1.9591.00
222_K289_L1.9541.00
209_P272_V1.9511.00
817_A926_A1.9391.00
500_R535_P1.9221.00
364_H540_D1.9101.00
619_C622_E1.9021.00
219_D291_D1.8881.00
214_L264_K1.8841.00
584_L621_L1.8821.00
618_S622_E1.8651.00
221_S224_E1.8571.00
203_I468_V1.8531.00
841_T902_P1.8481.00
397_I471_R1.8391.00
731_T843_V1.8381.00
593_H614_P1.8281.00
210_H294_Y1.8221.00
575_L586_I1.8201.00
274_A460_A1.8151.00
695_T711_V1.8101.00
277_A283_A1.8071.00
229_V277_A1.8001.00
220_V232_V1.7831.00
214_L263_K1.7731.00
677_F702_L1.7521.00
384_N941_E1.7451.00
176_Y706_P1.7411.00
230_V466_R1.7371.00
392_P447_S1.7311.00
226_L286_A1.7301.00
760_P763_D1.7261.00
212_H264_K1.7231.00
493_L575_L1.7151.00
391_C881_L1.7151.00
222_K225_A1.7141.00
302_S305_E1.7101.00
287_L290_I1.6961.00
372_F492_K1.6891.00
828_I949_I1.6891.00
705_P708_D1.6811.00
842_P900_L1.6801.00
375_A502_T1.6771.00
621_L627_Q1.6741.00
848_A915_I1.6561.00
672_E678_I1.6551.00
197_T200_A1.6491.00
701_V910_F1.6321.00
679_V698_A1.6161.00
276_V464_T1.6141.00
496_K502_T1.6141.00
231_H463_V1.6101.00
815_N833_F1.5951.00
848_A900_L1.5911.00
377_V578_Q1.5861.00
623_E897_R1.5781.00
377_V496_K1.5751.00
192_V397_I1.5711.00
378_I492_K1.5681.00
200_A469_L1.5671.00
697_L735_G1.5561.00
223_A290_I1.5521.00
750_L764_V1.5511.00
369_D373_A1.5371.00
676_T710_H1.5361.00
408_V435_H1.5251.00
490_T507_D1.5231.00
205_M470_F1.5211.00
573_A929_T1.5131.00
429_M434_V1.5071.00
264_K316_D1.5021.00
236_L263_K1.4961.00
764_V771_V1.4931.00
382_T488_K1.4931.00
669_I742_A1.4901.00
667_C738_A1.4881.00
833_F856_T1.4871.00
377_V579_L1.4861.00
817_A833_F1.4781.00
423_V434_V1.4751.00
614_P618_S1.4701.00
620_A814_A1.4681.00
498_D589_R1.4641.00
512_T519_S1.4601.00
371_G503_A1.4571.00
368_M372_F1.4551.00
619_C623_E1.4541.00
215_I218_L1.4531.00
197_T401_R1.4481.00
224_E231_H1.4441.00
672_E676_T1.4421.00
569_T587_I1.4321.00
189_P440_R1.4191.00
699_A709_V1.4161.00
945_T948_K1.4111.00
859_A923_A1.4101.00
751_F761_V1.4071.00
377_V575_L1.4061.00
381_R574_E1.4051.00
407_L429_M1.4051.00
285_E289_L1.3971.00
384_N488_K1.3951.00
644_W820_A1.3951.00
486_V511_N1.3951.00
701_V739_R1.3921.00
372_F503_A1.3881.00
694_V738_A1.3881.00
623_E899_V1.3851.00
612_S615_S1.3781.00
212_H298_K1.3771.00
616_A814_A1.3681.00
372_F378_I1.3651.00
740_L744_N1.3601.00
406_R433_K1.3591.00
842_P848_A1.3491.00
579_L586_I1.3421.00
697_L731_T1.3361.00
235_H262_G1.3321.00
371_G538_N1.3251.00
556_Y858_R1.3241.00
233_I460_A1.3211.00
424_A434_V1.3191.00
460_A468_V1.3111.00
577_E933_D1.3040.99
495_A579_L1.3000.99
400_T457_C1.2970.99
753_G784_I1.2960.99
693_V731_T1.2940.99
400_T409_I1.2930.99
830_L860_I1.2910.99
828_I864_M1.2900.99
400_T461_T1.2880.99
391_C886_A1.2850.99
201_C466_R1.2850.99
744_N747_E1.2830.99
369_D540_D1.2830.99
313_V320_V1.2790.99
624_I834_Y1.2760.99
501_L536_C1.2740.99
193_E471_R1.2680.99
577_E932_H1.2620.99
772_V775_K1.2610.99
591_R617_A1.2600.99
215_I292_V1.2580.99
489_V567_A1.2560.99
369_D505_K1.2540.99
493_L501_L1.2510.99
821_V828_I1.2490.99
509_R544_T1.2480.99
303_I509_R1.2470.99
631_M635_S1.2440.99
819_V931_I1.2410.99
204_K287_L1.2400.99
839_C842_P1.2400.99
585_E627_Q1.2360.99
834_Y897_R1.2350.99
573_A583_Q1.2350.99
588_E614_P1.2300.99
566_F928_A1.2200.99
759_E763_D1.2170.99
282_I286_A1.2140.99
482_T554_G1.2120.99
407_L458_A1.2060.99
869_I878_T1.2020.99
307_M546_Y1.1980.99
828_I931_I1.1930.99
214_L297_L1.1920.99
368_M371_G1.1890.99
430_K433_K1.1840.99
233_I464_T1.1840.99
495_A586_I1.1810.99
197_T399_F1.1810.99
217_H291_D1.1780.99
315_H547_Y1.1760.99
204_K280_E1.1750.99
229_V283_A1.1750.99
852_I856_T1.1750.99
750_L766_L1.1740.99
204_K284_L1.1730.99
266_R270_D1.1720.99
574_E940_R1.1720.99
817_A927_I1.1690.99
179_T695_T1.1650.99
370_K373_A1.1640.99
623_E836_L1.1610.99
201_C464_T1.1570.99
836_L899_V1.1520.99
947_E951_T1.1490.99
616_A836_L1.1480.99
736_N739_R1.1450.99
207_R476_E1.1430.99
708_D769_P1.1430.99
264_K297_L1.1400.99
272_V294_Y1.1400.99
572_L586_I1.1360.99
870_Y876_P1.1310.99
421_R431_Q1.1290.99
620_A836_L1.1290.99
695_T706_P1.1220.98
622_E627_Q1.1200.98
630_E633_Q1.1180.98
233_I463_V1.1160.98
494_G502_T1.1110.98
493_L504_V1.1060.98
204_K283_A1.1060.98
698_A742_A1.1060.98
182_A186_Q1.1030.98
200_A399_F1.1010.98
797_L803_Y1.0950.98
826_G949_I1.0910.98
196_V200_A1.0880.98
645_H823_T1.0870.98
233_I276_V1.0860.98
452_L455_E1.0820.98
817_A830_L1.0820.98
273_A292_V1.0820.98
213_A292_V1.0810.98
379_I495_A1.0790.98
584_L650_V1.0720.98
230_V282_I1.0710.98
372_F505_K1.0700.98
865_S891_D1.0690.98
410_H437_I1.0690.98
398_C457_C1.0680.98
234_T260_M1.0660.98
864_M927_I1.0630.98
752_H788_G1.0600.98
177_P846_E1.0590.98
238_C459_W1.0570.98
307_M509_R1.0560.98
280_E284_L1.0560.98
441_V686_I1.0530.98
304_D382_T1.0530.98
523_P543_V1.0460.98
171_V700_E1.0450.98
402_M462_C1.0450.98
383_Y571_A1.0440.98
644_W823_T1.0420.98
381_R578_Q1.0420.98
871_D875_H1.0410.98
179_T692_T1.0370.97
379_I578_Q1.0360.97
403_D408_V1.0360.97
487_A526_G1.0300.97
229_V286_A1.0290.97
265_M294_Y1.0280.97
275_V287_L1.0270.97
696_K844_N1.0260.97
763_D773_R1.0250.97
861_G887_P1.0240.97
364_H367_D1.0240.97
213_A297_L1.0230.97
412_S448_K1.0190.97
402_M405_D1.0190.97
286_A289_L1.0190.97
199_D466_R1.0190.97
405_D433_K1.0190.97
218_L292_V1.0170.97
212_H299_P1.0160.97
689_G847_L1.0150.97
652_I814_A1.0140.97
230_V276_V1.0130.97
485_H563_K1.0130.97
374_D502_T1.0120.97
175_H849_L1.0110.97
653_I813_G1.0100.97
629_R818_E1.0070.97
414_Q444_G1.0070.97
509_R546_Y1.0050.97
205_M274_A1.0050.97
444_G686_I1.0020.97
756_M787_K1.0010.97
527_P541_F0.9990.97
749_I781_F0.9940.97
495_A501_L0.9930.97
183_K188_K0.9930.97
226_L285_E0.9930.97
643_D822_N0.9920.97
692_T696_K0.9900.97
752_H784_I0.9900.97
376_D502_T0.9870.97
427_V458_A0.9850.97
701_V742_A0.9840.96
218_L272_V0.9830.96
615_S901_V0.9820.96
944_F948_K0.9820.96
744_N748_K0.9810.96
371_G494_G0.9810.96
619_C836_L0.9780.96
227_P278_E0.9770.96
402_M461_T0.9770.96
203_I460_A0.9760.96
679_V709_V0.9760.96
678_I712_I0.9740.96
429_M462_C0.9730.96
766_L771_V0.9730.96
392_P477_E0.9730.96
749_I784_I0.9710.96
475_E879_R0.9710.96
390_Q447_S0.9650.96
401_R408_V0.9620.96
374_D496_K0.9620.96
892_I896_F0.9610.96
231_H464_T0.9610.96
642_G645_H0.9600.96
683_G730_G0.9570.96
212_H549_N0.9520.96
215_I294_Y0.9510.96
233_I459_W0.9500.96
534_Y569_T0.9500.96
360_S542_Q0.9480.96
798_V801_G0.9470.96
307_M322_V0.9460.96
492_K540_D0.9440.96
487_A510_A0.9410.95
304_D384_N0.9400.95
534_Y587_I0.9390.95
819_V830_L0.9390.95
643_D823_T0.9370.95
205_M271_R0.9330.95
235_H263_K0.9330.95
368_M538_N0.9320.95
615_S618_S0.9320.95
573_A587_I0.9310.95
860_I892_I0.9310.95
744_N799_G0.9280.95
615_S619_C0.9270.95
360_S544_T0.9240.95
175_H846_E0.9230.95
183_K440_R0.9200.95
362_H542_Q0.9190.95
708_D782_G0.9190.95
183_K691_D0.9170.95
697_L843_V0.9170.95
644_W829_R0.9160.95
698_A709_V0.9160.95
747_E751_F0.9160.95
747_E750_L0.9130.95
232_V273_A0.9130.95
368_M505_K0.9120.95
505_K542_Q0.9100.95
743_E747_E0.9100.95
434_V458_A0.9090.95
172_I696_K0.9080.95
375_A503_A0.9080.95
220_V290_I0.9070.94
683_G690_L0.9060.94
273_A290_I0.9040.94
591_R614_P0.9020.94
643_D824_R0.9000.94
501_L575_L0.8990.94
270_D515_Y0.8980.94
704_C708_D0.8970.94
740_L743_E0.8950.94
705_P769_P0.8950.94
272_V292_V0.8950.94
849_L900_L0.8940.94
368_M503_A0.8930.94
839_C848_A0.8900.94
303_I488_K0.8900.94
867_E948_K0.8870.94
457_C470_F0.8850.94
202_V469_L0.8850.94
383_Y574_E0.8840.94
833_F896_F0.8830.94
920_V924_A0.8790.94
366_G371_G0.8780.93
574_E938_W0.8740.93
746_R766_L0.8740.93
765_Q773_R0.8720.93
301_M874_G0.8710.93
696_K845_P0.8700.93
217_H221_S0.8700.93
835_A856_T0.8690.93
367_D538_N0.8690.93
372_F375_A0.8690.93
206_L292_V0.8690.93
495_A571_A0.8680.93
701_V746_R0.8650.93
668_M680_H0.8640.93
368_M540_D0.8640.93
630_E933_D0.8640.93
832_K894_R0.8620.93
184_M191_Y0.8610.93
379_I493_L0.8600.93
747_E761_V0.8580.93
494_G503_A0.8570.93
212_H314_V0.8570.93
413_T419_L0.8550.93
644_W822_N0.8540.93
220_V223_A0.8530.92
389_Q868_I0.8520.92
284_L473_T0.8500.92
503_A538_N0.8490.92
491_V567_A0.8490.92
283_A287_L0.8480.92
584_L617_A0.8460.92
302_S488_K0.8460.92
795_G798_V0.8450.92
170_E700_E0.8440.92
871_D877_L0.8430.92
944_F949_I0.8410.92
621_L626_R0.8410.92
571_A575_L0.8400.92
628_G631_M0.8400.92
420_R431_Q0.8400.92
307_M544_T0.8370.92
636_S641_N0.8340.92
396_H477_E0.8340.92
671_L781_F0.8330.92
738_A742_A0.8320.92
876_P879_R0.8310.91
693_V847_L0.8310.91
407_L462_C0.8270.91
798_V804_I0.8260.91
749_I771_V0.8250.91
815_N922_G0.8240.91
859_A920_V0.8230.91
635_S640_Q0.8230.91
192_V471_R0.8230.91
753_G757_L0.8220.91
224_E236_L0.8210.91
688_T725_A0.8200.91
640_Q644_W0.8190.91
376_D500_R0.8170.91
363_G366_G0.8170.91
274_A456_V0.8170.91
266_R515_Y0.8170.91
411_A419_L0.8160.91
668_M800_T0.8150.91
763_D775_K0.8150.91
822_N827_E0.8140.91
380_E505_K0.8140.91
209_P294_Y0.8140.91
207_R480_A0.8130.91
932_H938_W0.8110.90
405_D462_C0.8110.90
667_C737_A0.8100.90
282_I285_E0.8090.90
880_D883_S0.8080.90
228_G286_A0.8080.90
371_G502_T0.8080.90
232_V275_V0.8080.90
403_D406_R0.8070.90
197_T410_H0.8070.90
489_V506_M0.8060.90
779_V784_I0.8060.90
626_R629_R0.8050.90
195_R410_H0.8040.90
757_L779_V0.8040.90
881_L886_A0.8020.90
176_Y695_T0.8020.90
759_E764_V0.8020.90
849_L853_Y0.8020.90
939_L944_F0.8010.90
308_A311_A0.8000.90
300_V312_P0.7990.90
531_L539_V0.7990.90
472_Y477_E0.7980.90
671_L749_I0.7960.90
678_I710_H0.7960.90
300_V306_A0.7950.90
378_I494_G0.7940.90
478_F881_L0.7940.90
770_G780_S0.7900.89
237_N463_V0.7890.89
205_M456_V0.7880.89
819_V930_A0.7870.89
781_F785_A0.7860.89
574_E578_Q0.7860.89
804_I807_D0.7830.89
281_E285_E0.7820.89
215_I272_V0.7820.89
240_D244_T0.7820.89
745_L799_G0.7810.89
839_C915_I0.7810.89
449_Q726_Y0.7790.89
504_V536_C0.7790.89
929_T938_W0.7790.89
202_V280_E0.7780.89
206_L273_A0.7770.88
797_L805_T0.7770.88
499_G581_I0.7750.88
398_C453_L0.7750.88
821_V949_I0.7720.88
606_E610_P0.7720.88
236_L262_G0.7720.88
570_M928_A0.7720.88
494_G505_K0.7700.88
314_V549_N0.7690.88
210_H265_M0.7670.88
798_V803_Y0.7670.88
591_R652_I0.7650.88
586_I589_R0.7630.88
228_G278_E0.7630.88
372_F502_T0.7620.88
417_W716_T0.7610.87
192_V195_R0.7600.87
640_Q643_D0.7590.87
401_R461_T0.7590.87
679_V738_A0.7580.87
304_D509_R0.7580.87
371_G374_D0.7560.87
626_R650_V0.7560.87
380_E578_Q0.7540.87
226_L229_V0.7540.87
612_S901_V0.7520.87
402_M407_L0.7520.87
213_A265_M0.7520.87
818_E832_K0.7510.87
617_A652_I0.7510.87
301_M305_E0.7500.87
857_L860_I0.7500.87
383_Y570_M0.7500.87
384_N486_V0.7490.87
206_L209_P0.7470.86
598_L604_I0.7470.86
568_I571_A0.7460.86
645_H820_A0.7450.86
566_F570_M0.7440.86
388_A862_H0.7440.86
510_A523_P0.7430.86
581_I585_E0.7430.86
261_F270_D0.7420.86
218_L290_I0.7410.86
935_C952_A0.7410.86
171_V174_K0.7410.86
763_D774_G0.7400.86
277_A286_A0.7400.86
224_E286_A0.7390.86
383_Y940_R0.7370.86
280_E473_T0.7370.86
571_A574_E0.7370.86
949_I952_A0.7370.86
582_D626_R0.7350.86
665_A734_S0.7350.86
526_G564_G0.7350.86
415_V726_Y0.7340.85
632_I818_E0.7320.85
819_V828_I0.7320.85
416_P716_T0.7310.85
501_L586_I0.7310.85
803_Y807_D0.7310.85
386_T486_V0.7310.85
215_I265_M0.7290.85
276_V468_V0.7280.85
435_H717_D0.7280.85
700_E841_T0.7270.85
460_A464_T0.7260.85
313_V319_V0.7250.85
512_T545_T0.7250.85
677_F745_L0.7240.85
208_S268_V0.7240.85
429_M433_K0.7240.85
698_A701_V0.7230.85
566_F942_W0.7230.85
750_L761_V0.7220.85
504_V571_A0.7220.85
175_H696_K0.7210.84
868_I876_P0.7210.84
565_N925_P0.7210.84
412_S441_V0.7210.84
419_L423_V0.7210.84
640_Q645_H0.7200.84
939_L952_A0.7180.84
626_R816_F0.7160.84
621_L816_F0.7160.84
601_L605_G0.7160.84
322_V544_T0.7150.84
264_K314_V0.7150.84
841_T904_D0.7140.84
834_Y899_V0.7140.84
172_I700_E0.7130.84
694_V698_A0.7130.84
635_S641_N0.7130.84
371_G375_A0.7130.84
797_L807_D0.7110.84
370_K538_N0.7110.84
750_L771_V0.7100.84
650_V816_F0.7100.84
784_I788_G0.7090.83
731_T912_A0.7090.83
301_M550_I0.7080.83
686_I725_A0.7080.83
464_T468_V0.7050.83
313_V317_E0.7050.83
740_L801_G0.7040.83
680_H712_I0.7010.83
315_H515_Y0.7010.83
211_A268_V0.7010.83
171_V706_P0.7010.83
849_L898_A0.7010.83
427_V459_W0.7000.83
195_R399_F0.7000.83
251_P255_P0.7000.83
642_G647_G0.6990.83
669_I745_L0.6990.83
628_G632_I0.6980.83
519_S545_T0.6980.83
268_V875_H0.6980.83
627_Q631_M0.6960.82
210_H272_V0.6950.82
228_G282_I0.6940.82
179_T706_P0.6940.82
286_A290_I0.6910.82
196_V469_L0.6900.82
837_L852_I0.6890.82
669_I741_A0.6890.82
670_K680_H0.6880.82
838_D903_S0.6880.82
176_Y696_K0.6850.81
285_E288_K0.6830.81
783_D787_K0.6830.81
309_E312_P0.6830.81
282_I289_L0.6830.81
669_I698_A0.6820.81
798_V802_S0.6820.81
756_M779_V0.6820.81
266_R514_P0.6820.81
580_Q583_Q0.6820.81
758_G764_V0.6800.81
200_A467_P0.6790.81
603_A606_E0.6780.81
385_S487_A0.6770.81
702_L709_V0.6770.81
570_M938_W0.6770.81
435_H716_T0.6770.81
758_G763_D0.6770.81
577_E938_W0.6750.80
402_M406_R0.6750.80
225_A291_D0.6750.80
217_H222_K0.6740.80
400_T468_V0.6740.80
624_I814_A0.6740.80
316_D319_V0.6740.80
596_Q599_K0.6730.80
583_Q630_E0.6730.80
304_D308_A0.6720.80
636_S640_Q0.6720.80
853_Y898_A0.6720.80
220_V226_L0.6710.80
600_I604_I0.6710.80
302_S509_R0.6710.80
451_I455_E0.6690.80
756_M784_I0.6690.80
385_S862_H0.6670.80
381_R940_R0.6670.80
865_S885_G0.6670.80
203_I457_C0.6670.80
258_R262_G0.6660.79
839_C900_L0.6650.79
702_L742_A0.6650.79
223_A229_V0.6640.79
508_F526_G0.6640.79
260_M456_V0.6640.79
594_E614_P0.6640.79
218_L232_V0.6630.79
376_D498_D0.6620.79
265_M268_V0.6620.79
409_I458_A0.6610.79
196_V399_F0.6610.79
504_V568_I0.6600.79
296_V873_E0.6600.79
383_Y567_A0.6600.79
932_H935_C0.6600.79
173_G696_K0.6590.79
703_H746_R0.6590.79
407_L434_V0.6580.79
948_K951_T0.6570.79
852_I898_A0.6560.78
683_G734_S0.6560.78
616_A901_V0.6560.78
690_L730_G0.6560.78
493_L586_I0.6540.78
511_N548_S0.6520.78
275_V290_I0.6520.78
192_V399_F0.6510.78
514_P549_N0.6500.78
223_A228_G0.6500.78
693_V843_V0.6490.78
617_A650_V0.6490.78
220_V234_T0.6490.78
869_I877_L0.6470.78
296_V299_P0.6460.77
251_P254_S0.6450.77
712_I718_H0.6450.77
178_K184_M0.6450.77
365_I539_V0.6440.77
570_M932_H0.6440.77
492_K507_D0.6440.77
647_G655_Q0.6440.77
362_H540_D0.6430.77
860_I927_I0.6430.77
674_D710_H0.6430.77
950_L954_E0.6430.77
215_I261_F0.6420.77
736_N908_G0.6410.77
181_A185_V0.6410.77
502_T538_N0.6410.77
620_A834_Y0.6410.77
169_L700_E0.6410.77
218_L234_T0.6400.77
221_S225_A0.6380.77
423_V436_V0.6370.76
937_I952_A0.6370.76
268_V876_P0.6360.76
385_S566_F0.6360.76
830_L833_F0.6350.76
570_M929_T0.6350.76
842_P845_P0.6320.76
618_S621_L0.6320.76
184_M440_R0.6310.76
426_L455_E0.6310.76
488_K509_R0.6300.76
767_A772_V0.6300.76
625_L832_K0.6290.76
223_A286_A0.6290.76
204_K476_E0.6280.75
205_M276_V0.6270.75
195_R439_E0.6270.75
530_S541_F0.6270.75
742_A745_L0.6260.75
765_Q774_G0.6260.75
783_D786_H0.6250.75
908_G912_A0.6240.75
229_V232_V0.6230.75
260_M271_R0.6220.75
779_V787_K0.6220.75
801_G804_I0.6220.75
771_V784_I0.6220.75
833_F923_A0.6200.74
703_H766_L0.6190.74
186_Q189_P0.6190.74
758_G774_G0.6190.74
371_G537_D0.6190.74
498_D502_T0.6180.74
181_A184_M0.6170.74
364_H368_M0.6150.74
300_V549_N0.6140.74
575_L578_Q0.6130.74
828_I946_P0.6130.74
774_G777_G0.6130.74
228_G277_A0.6120.74
231_H276_V0.6120.74
723_K726_Y0.6110.73
298_K305_E0.6080.73
651_A926_A0.6070.73
307_M488_K0.6070.73
486_V550_I0.6070.73
830_L927_I0.6070.73
197_T467_P0.6070.73
750_L754_A0.6060.73
565_N921_N0.6060.73
322_V546_Y0.6060.73
657_S809_A0.6040.73
799_G803_Y0.6030.72
395_T471_R0.6030.72
227_P282_I0.6030.72
477_E481_N0.6020.72
796_S799_G0.6020.72
550_I870_Y0.6020.72
815_N923_A0.6020.72
535_P593_H0.6010.72
745_L797_L0.6010.72
531_L536_C0.6010.72
561_A655_Q0.6010.72
647_G933_D0.6000.72
287_L291_D0.6000.72
759_E772_V0.6000.72
234_T237_N0.6000.72
306_A311_A0.5990.72
681_S694_V0.5990.72
835_A852_I0.5990.72
218_L294_Y0.5980.72
591_R613_V0.5980.72
784_I787_K0.5970.72
647_G657_S0.5950.71
766_L781_F0.5950.71
751_F755_Q0.5950.71
396_H447_S0.5940.71
202_V279_S0.5940.71
372_F376_D0.5930.71
928_A942_W0.5930.71
629_R632_I0.5920.71
772_V776_K0.5920.71
199_D467_P0.5910.71
725_A730_G0.5900.71
696_K700_E0.5900.71
420_R716_T0.5900.71
441_V684_A0.5900.71
266_R547_Y0.5890.71
704_C709_V0.5890.71
219_D223_A0.5890.71
362_H366_G0.5880.71
602_G605_G0.5880.71
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727_A855_A0.5850.70
592_V611_T0.5850.70
583_Q587_I0.5840.70
217_H497_K0.5840.70
594_E612_S0.5840.70
797_L800_T0.5840.70
753_G764_V0.5830.70
231_H460_A0.5820.70
223_A273_A0.5820.70
767_A770_G0.5820.70
311_A314_V0.5820.70
313_V316_D0.5820.70
241_I428_G0.5820.70
669_I677_F0.5820.70
224_E237_N0.5810.70
816_F834_Y0.5810.70
821_V826_G0.5810.70
504_V539_V0.5810.70
647_G821_V0.5810.70
377_V586_I0.5810.70
797_L801_G0.5810.70
201_C468_V0.5800.70
172_I843_V0.5780.69
496_K589_R0.5780.69
220_V236_L0.5780.69
752_H756_M0.5780.69
183_K189_P0.5770.69
647_G656_K0.5750.69
207_R271_R0.5750.69
821_V931_I0.5750.69
626_R648_R0.5750.69
799_G802_S0.5740.69
183_K404_G0.5740.69
491_V575_L0.5740.69
620_A624_I0.5740.69
265_M292_V0.5740.69
722_D734_S0.5740.69
582_D586_I0.5740.69
381_R571_A0.5720.68
486_V553_N0.5720.68
794_F797_L0.5720.68
612_S903_S0.5720.68
434_V873_E0.5720.68
522_V555_A0.5710.68
753_G756_M0.5710.68
492_K503_A0.5710.68
367_D371_G0.5700.68
669_I709_V0.5700.68
575_L581_I0.5700.68
495_A578_Q0.5700.68
686_I690_L0.5690.68
211_A299_P0.5690.68
371_G378_I0.5680.68
385_S489_V0.5680.68
510_A545_T0.5680.68
423_V428_G0.5680.68
258_R263_K0.5670.68
752_H755_Q0.5670.68
260_M272_V0.5660.68
702_L749_I0.5660.68
685_D691_D0.5650.68
629_R633_Q0.5650.68
212_H265_M0.5650.68
811_P837_L0.5640.67
379_I575_L0.5620.67
215_I235_H0.5620.67
522_V560_G0.5610.67
757_L764_V0.5610.67
376_D495_A0.5600.67
379_I586_I0.5590.67
261_F265_M0.5590.67
366_G538_N0.5590.67
266_R314_V0.5580.67
787_K791_G0.5580.67
452_L456_V0.5570.66
624_I627_Q0.5570.66
730_G734_S0.5570.66
754_A764_V0.5570.66
203_I276_V0.5570.66
826_G950_L0.5560.66
304_D307_M0.5560.66
516_G547_Y0.5560.66
578_Q938_W0.5560.66
420_R424_A0.5550.66
402_M434_V0.5550.66
512_T553_N0.5550.66
632_I636_S0.5550.66
371_G376_D0.5540.66
648_R820_A0.5530.66
641_N820_A0.5530.66
623_E834_Y0.5520.66
629_R648_R0.5520.66
190_C195_R0.5510.66
694_V734_S0.5510.66
502_T537_D0.5490.65
591_R611_T0.5490.65
758_G775_K0.5490.65
416_P684_A0.5490.65
235_H239_P0.5480.65
268_V479_I0.5480.65
202_V471_R0.5480.65
370_K497_K0.5470.65
201_C231_H0.5470.65
473_T476_E0.5470.65
227_P230_V0.5470.65
667_C681_S0.5460.65
617_A621_L0.5450.65
739_R910_F0.5450.65
641_N644_W0.5450.65
374_D497_K0.5440.65
536_C568_I0.5430.65
613_V616_A0.5430.65
619_C901_V0.5430.65
391_C868_I0.5430.65
935_C953_L0.5430.65
579_L589_R0.5420.64
513_G552_P0.5420.64
399_F469_L0.5420.64
389_Q392_P0.5410.64
822_N825_T0.5400.64
879_R883_S0.5400.64
255_P547_Y0.5400.64
373_A751_F0.5400.64
741_A801_G0.5400.64
173_G845_P0.5400.64
226_L277_A0.5390.64
506_M567_A0.5390.64
779_V783_D0.5380.64
300_V305_E0.5370.64
704_C781_F0.5370.64
257_D270_D0.5370.64
518_H559_Y0.5360.64
885_G888_K0.5350.63
858_R861_G0.5350.63
665_A682_G0.5340.63
299_P549_N0.5340.63
666_N720_L0.5340.63
576_A581_I0.5340.63
682_G719_A0.5340.63
858_R887_P0.5330.63
416_P722_D0.5330.63
559_Y727_A0.5330.63
748_K751_F0.5330.63
279_S285_E0.5320.63
388_A556_Y0.5320.63
671_L677_F0.5310.63
412_S444_G0.5310.63
219_D222_K0.5310.63
275_V292_V0.5300.63
592_V598_L0.5300.63
658_G727_A0.5300.63
518_H521_T0.5300.63
583_Q929_T0.5300.63
390_Q483_S0.5290.63
398_C411_A0.5280.62
214_L217_H0.5280.62
573_A938_W0.5260.62
472_Y481_N0.5260.62
750_L765_Q0.5260.62
450_D517_N0.5250.62
842_P849_L0.5250.62
300_V546_Y0.5240.62
257_D261_F0.5240.62
948_K952_A0.5230.62
588_E617_A0.5230.62
621_L650_V0.5230.62
635_S933_D0.5230.62
437_I715_D0.5220.61
672_E710_H0.5220.61
225_A282_I0.5220.61
411_A454_E0.5210.61
655_Q921_N0.5210.61
939_L949_I0.5200.61
181_A690_L0.5190.61
796_S802_S0.5190.61
690_L725_A0.5190.61
499_G589_R0.5180.61
258_R261_F0.5170.61
389_Q483_S0.5160.61
656_K810_F0.5150.60
388_A484_R0.5140.60
293_E296_V0.5140.60
510_A526_G0.5140.60
809_A905_D0.5140.60
219_D293_E0.5130.60
232_V286_A0.5130.60
260_M274_A0.5130.60
712_I719_A0.5130.60
399_F410_H0.5120.60
597_E603_A0.5120.60
629_R832_K0.5110.60
853_Y896_F0.5100.60
459_W463_V0.5100.60
746_R771_V0.5090.60
389_Q478_F0.5090.60
525_N529_L0.5090.60
476_E480_A0.5090.60
781_F790_T0.5080.59
204_K290_I0.5080.59
559_Y726_Y0.5070.59
478_F876_P0.5070.59
694_V711_V0.5070.59
838_D904_D0.5060.59
604_I610_P0.5060.59
562_P920_V0.5060.59
405_D465_G0.5060.59
256_L516_G0.5050.59
925_P928_A0.5050.59
754_A760_P0.5050.59
259_R426_L0.5050.59
176_Y692_T0.5040.59
493_L568_I0.5040.59
848_A852_I0.5040.59
493_L572_L0.5040.59
556_Y920_V0.5040.59
940_R952_A0.5040.59
218_L226_L0.5030.59
424_A431_Q0.5030.59
211_A871_D0.5030.59
815_N835_A0.5030.59
641_N823_T0.5030.59
230_V464_T0.5020.59
305_E309_E0.5020.59
670_K678_I0.5020.59
627_Q630_E0.5020.59
490_T509_R0.5010.58
622_E625_L0.5010.58
449_Q518_H0.5000.58
644_W831_D0.5000.58
305_E310_D0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.9236 100 0.171 Contact Map
3zyvA 3 0.9163 100 0.176 Contact Map
1dgjA 1 0.9215 100 0.192 Contact Map
4usaA 2 0.9236 100 0.193 Contact Map
1rm6A 2 0.7626 100 0.351 Contact Map
1t3qB 2 0.7908 100 0.352 Contact Map
1ffvB 2 0.7981 100 0.357 Contact Map
1n62B 2 0.8065 100 0.358 Contact Map
2w3sB 2 0.7605 100 0.362 Contact Map
3nvzC 2 0.7531 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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