GREMLIN Database
SSNA - Protein SsnA
UniProt: Q46812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13062
Length: 442 (357)
Sequences: 27373 (21036)
Seq/√Len: 1113.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
404_M409_M5.0061.00
4_L49_M4.6841.00
362_L367_Y4.6451.00
52_R401_H3.9511.00
402_S409_M3.8091.00
26_E31_V3.6651.00
49_M373_I3.6091.00
336_L339_D3.5321.00
7_V49_M3.4151.00
57_G120_T3.2411.00
364_E367_Y3.1951.00
55_M374_C3.1921.00
5_K46_F2.8221.00
32_A365_A2.8031.00
360_F368_K2.7971.00
368_K406_N2.6971.00
28_D368_K2.6511.00
55_M372_T2.6001.00
45_S412_E2.5731.00
3_I24_A2.4841.00
54_V373_I2.4711.00
359_K368_K2.4061.00
29_V359_K2.3371.00
274_T303_D2.3221.00
251_A279_R2.3101.00
356_F360_F2.3061.00
25_I371_L2.2991.00
363_L371_L2.2941.00
23_I54_V2.2911.00
306_N350_E2.2351.00
115_I410_V2.2131.00
339_D342_A2.1861.00
371_L404_M2.1821.00
216_A219_A2.1611.00
403_V411_Y2.1601.00
342_A346_T2.1161.00
29_V368_K2.0901.00
9_A21_V2.0781.00
116_K411_Y2.0351.00
346_T362_L2.0181.00
52_R373_I1.9871.00
7_V54_V1.9681.00
24_A44_A1.9481.00
52_R375_D1.9091.00
6_N48_E1.8761.00
28_D406_N1.8631.00
375_D401_H1.8341.00
54_V371_L1.8211.00
23_I363_L1.8191.00
13_H364_E1.7981.00
99_D102_S1.7861.00
5_K22_D1.7811.00
409_M412_E1.7501.00
41_Y44_A1.7291.00
55_M58_I1.7121.00
34_G37_L1.6961.00
274_T278_Q1.6811.00
33_I365_A1.6641.00
372_T400_V1.6471.00
18_Q21_V1.5961.00
347_N350_E1.5951.00
49_M54_V1.5771.00
9_A23_I1.5541.00
4_L25_I1.5271.00
342_A347_N1.5241.00
23_I371_L1.5181.00
176_F179_L1.5091.00
30_I363_L1.5071.00
24_A32_A1.5061.00
358_A367_Y1.5061.00
215_E219_A1.4831.00
308_A351_L1.4741.00
273_I303_D1.4601.00
401_H413_D1.4461.00
248_A252_Q1.4371.00
22_D36_A1.4241.00
301_L339_D1.4001.00
300_H305_R1.3981.00
346_T350_E1.3971.00
275_L279_R1.3951.00
402_S412_E1.3861.00
6_N51_G1.3621.00
59_V348_G1.3531.00
206_P209_G1.3391.00
211_E215_E1.3371.00
61_S308_A1.3371.00
207_D211_E1.3361.00
211_E252_Q1.3191.00
373_I402_S1.3161.00
64_H264_H1.3101.00
319_F322_M1.3091.00
218_K260_T1.3031.00
4_L371_L1.2951.00
405_V410_V1.2941.00
114_A122_V1.2911.00
373_I404_M1.2911.00
178_R182_E1.2901.00
282_F351_L1.2861.00
24_A31_V1.2861.00
374_C400_V1.2831.00
350_E362_L1.2591.00
208_A211_E1.2591.00
212_M215_E1.2571.00
12_L346_T1.2561.00
61_S348_G1.2541.00
8_T18_Q1.2491.00
53_I376_Y1.2481.00
341_F345_L1.2431.00
178_R219_A1.2371.00
356_F359_K1.2351.00
216_A220_T1.2321.00
308_A347_N1.2301.00
225_H263_A1.2301.00
4_L404_M1.2271.00
217_V224_L1.2231.00
192_L195_A1.2201.00
275_L278_Q1.2081.00
21_V33_I1.1961.00
22_D34_G1.1901.00
138_T141_D1.1861.00
7_V373_I1.1831.00
171_E175_R1.1791.00
24_A41_Y1.1761.00
320_E323_K1.1761.00
282_F306_N1.1741.00
346_T367_Y1.1711.00
55_M341_F1.1691.00
380_T399_S1.1661.00
22_D37_L1.1661.00
21_V34_G1.1651.00
123_I352_M1.1631.00
45_S409_M1.1591.00
25_I404_M1.1551.00
59_V121_S1.1531.00
47_K404_M1.1511.00
61_S284_V1.1501.00
121_S360_F1.1381.00
276_L280_D1.1361.00
24_A43_D1.1291.00
104_Y141_D1.1291.00
21_V35_D1.1291.00
172_E176_F1.1271.00
31_V365_A1.1211.00
264_H268_L1.1211.00
323_K327_F1.1181.00
262_V265_G1.1171.00
8_T19_E1.1161.00
155_E158_D1.1061.00
173_N176_F1.1001.00
4_L54_V1.0981.00
3_I22_D1.0961.00
284_V308_A1.0891.00
138_T142_A1.0851.00
265_G268_L1.0811.00
276_L283_L1.0621.00
223_G355_N1.0621.00
137_S141_D1.0611.00
271_D274_T1.0541.00
221_G259_K1.0531.00
281_A284_V1.0521.00
177_A180_I1.0521.00
59_V360_F1.0451.00
308_A348_G1.0421.00
47_K402_S1.0411.00
115_I405_V1.0331.00
6_N20_G1.0271.00
13_H16_K1.0241.00
265_G283_L1.0151.00
175_R178_R1.0141.00
6_N50_H1.0081.00
286_N289_S1.0071.00
194_E199_A1.0041.00
61_S352_M0.9981.00
326_F330_R0.9941.00
108_L112_L0.9931.00
30_I371_L0.9931.00
143_F147_G0.9871.00
217_V222_R0.9841.00
322_M344_A0.9831.00
111_S115_I0.9821.00
190_P194_E0.9801.00
179_L182_E0.9771.00
179_L183_A0.9761.00
43_D46_F0.9751.00
108_L145_K0.9721.00
115_I403_V0.9721.00
141_D145_K0.9711.00
293_N296_G0.9681.00
245_D272_D0.9671.00
11_Q14_P0.9631.00
64_H227_H0.9621.00
172_E175_R0.9551.00
194_E198_G0.9431.00
198_G201_A0.9421.00
318_M324_F0.9371.00
277_N305_R0.9321.00
289_S292_N0.9311.00
154_F158_D0.9311.00
319_F324_F0.9311.00
250_L254_D0.9301.00
377_N380_T0.9291.00
59_V349_N0.9221.00
324_F327_F0.9221.00
285_H289_S0.9211.00
7_V371_L0.9201.00
64_H312_D0.9201.00
59_V352_M0.9151.00
335_P343_K0.9051.00
227_H312_D0.9051.00
156_T159_R0.9021.00
8_T53_I0.8991.00
372_T403_V0.8991.00
322_M326_F0.8971.00
264_H267_Y0.8971.00
49_M52_R0.8951.00
24_A34_G0.8951.00
65_F110_C0.8921.00
264_H269_S0.8831.00
4_L47_K0.8821.00
8_T20_G0.8761.00
326_F329_H0.8761.00
115_I411_Y0.8751.00
268_L300_H0.8741.00
359_K367_Y0.8731.00
317_D324_F0.8731.00
343_K347_N0.8661.00
344_A348_G0.8641.00
169_G172_E0.8621.00
10_V341_F0.8541.00
317_D320_E0.8541.00
65_F122_V0.8521.00
248_A271_D0.8521.00
8_T377_N0.8501.00
62_H264_H0.8491.00
321_E324_F0.8491.00
189_E195_A0.8461.00
261_L351_L0.8401.00
192_L196_H0.8381.00
175_R179_L0.8381.00
264_H312_D0.8331.00
318_M321_E0.8321.00
190_P195_A0.8321.00
227_H264_H0.8311.00
286_N310_G0.8281.00
270_K299_H0.8271.00
37_L41_Y0.8261.00
188_S191_Y0.8161.00
151_M155_E0.8151.00
3_I43_D0.8101.00
104_Y145_K0.8101.00
400_V403_V0.8091.00
270_K274_T0.8071.00
285_H290_N0.8041.00
62_H227_H0.8001.00
146_V149_R0.8001.00
13_H362_L0.7971.00
326_F340_S0.7971.00
155_E159_R0.7961.00
58_I344_A0.7931.00
121_S370_D0.7881.00
62_H312_D0.7871.00
269_S272_D0.7861.00
9_A19_E0.7841.00
289_S293_N0.7801.00
375_D378_S0.7791.00
286_N290_N0.7771.00
375_D399_S0.7711.00
65_F111_S0.7701.00
228_A262_V0.7701.00
249_R253_F0.7681.00
194_E197_I0.7651.00
319_F323_K0.7641.00
149_R153_C0.7621.00
5_K48_E0.7591.00
290_N294_H0.7571.00
277_N303_D0.7561.00
189_E192_L0.7541.00
125_H263_A0.7541.00
150_A154_F0.7521.00
10_V53_I0.7501.00
309_L343_K0.7481.00
60_C311_T0.7461.00
276_L281_A0.7441.00
157_T160_N0.7441.00
146_V151_M0.7441.00
22_D32_A0.7401.00
276_L279_R0.7371.00
273_I277_N0.7341.00
6_N49_M0.7321.00
143_F150_A0.7301.00
210_L226_I0.7301.00
284_V289_S0.7291.00
23_I33_I0.7281.00
155_E160_N0.7271.00
306_N347_N0.7261.00
214_R224_L0.7261.00
52_R402_S0.7231.00
271_D275_L0.7231.00
21_V363_L0.7231.00
12_L341_F0.7201.00
144_L147_G0.7201.00
32_A37_L0.7201.00
248_A251_A0.7181.00
18_Q338_P0.7181.00
181_D222_R0.7171.00
125_H225_H0.7161.00
189_E194_E0.7151.00
324_F328_K0.7151.00
309_L325_A0.7141.00
154_F160_N0.7131.00
66_Y127_A0.7131.00
323_K329_H0.7121.00
362_L365_A0.7111.00
21_V36_A0.7101.00
290_N293_N0.7091.00
150_A153_C0.7041.00
284_V290_N0.7041.00
113_E116_K0.7001.00
324_F329_H0.7001.00
349_N361_G0.6991.00
196_H199_A0.6991.00
4_L373_I0.6951.00
195_A199_A0.6951.00
120_T403_V0.6951.00
283_L300_H0.6901.00
273_I300_H0.6901.00
123_I261_L0.6891.00
63_N114_A0.6861.00
176_F180_I0.6861.00
188_S194_E0.6841.00
140_R146_V0.6831.00
153_C158_D0.6831.00
20_G50_H0.6821.00
352_M356_F0.6811.00
17_V338_P0.6791.00
60_C63_N0.6741.00
262_V276_L0.6721.00
10_V18_Q0.6711.00
12_L362_L0.6711.00
122_V150_A0.6701.00
173_N177_A0.6701.00
142_A145_K0.6691.00
274_T277_N0.6691.00
338_P342_A0.6681.00
154_F157_T0.6671.00
299_H302_S0.6661.00
112_L116_K0.6651.00
207_D252_Q0.6641.00
153_C157_T0.6631.00
245_D248_A0.6621.00
178_R216_A0.6601.00
277_N280_D0.6601.00
259_K350_E0.6591.00
5_K36_A0.6581.00
141_D144_L0.6571.00
209_G212_M0.6571.00
58_I119_C0.6561.00
213_L216_A0.6561.00
153_C156_T0.6551.00
323_K326_F0.6541.00
321_E325_A0.6531.00
120_T370_D0.6531.00
140_R147_G0.6521.00
225_H261_L0.6521.00
151_M157_T0.6501.00
10_V17_V0.6491.00
251_A275_L0.6491.00
323_K328_K0.6451.00
250_L255_L0.6441.00
359_K362_L0.6431.00
121_S352_M0.6431.00
191_Y195_A0.6411.00
288_R292_N0.6391.00
177_A181_D0.6391.00
280_D284_V0.6381.00
325_A328_K0.6371.00
191_Y194_E0.6371.00
318_M325_A0.6361.00
121_S356_F0.6361.00
54_V404_M0.6351.00
273_I276_L0.6351.00
233_Y237_Y0.6351.00
337_W379_P0.6331.00
290_N296_G0.6331.00
170_V173_N0.6301.00
170_V181_D0.6301.00
24_A37_L0.6271.00
302_S339_D0.6271.00
139_L143_F0.6261.00
324_F330_R0.6251.00
172_E177_A0.6251.00
104_Y108_L0.6241.00
319_F374_C0.6231.00
229_A266_L0.6231.00
322_M329_H0.6221.00
283_L305_R0.6221.00
321_E327_F0.6191.00
402_S411_Y0.6181.00
317_D322_M0.6161.00
320_E324_F0.6161.00
188_S193_V0.6151.00
142_A146_V0.6131.00
349_N367_Y0.6131.00
230_E233_Y0.6111.00
145_K148_L0.6111.00
285_H288_R0.6101.00
22_D38_T0.6101.00
156_T160_N0.6091.00
33_I363_L0.6071.00
272_D275_L0.6071.00
20_G33_I0.6051.00
139_L142_A0.6041.00
182_E220_T0.6041.00
317_D321_E0.6001.00
263_A266_L0.5971.00
292_N296_G0.5951.00
131_Y134_G0.5941.00
140_R144_L0.5931.00
20_G36_A0.5931.00
100_E104_Y0.5931.00
171_E177_A0.5921.00
214_R218_K0.5921.00
318_M323_K0.5901.00
317_D323_K0.5901.00
139_L144_L0.5901.00
166_L169_G0.5891.00
17_V20_G0.5891.00
109_I113_E0.5851.00
140_R143_F0.5851.00
318_M328_K0.5841.00
319_F326_F0.5841.00
58_I400_V0.5841.00
147_G153_C0.5841.00
263_A284_V0.5841.00
171_E174_I0.5831.00
12_L342_A0.5821.00
294_H297_Y0.5821.00
261_L284_V0.5811.00
290_N295_V0.5801.00
322_M330_R0.5791.00
148_L151_M0.5791.00
208_A212_M0.5791.00
325_A330_R0.5781.00
30_I367_Y0.5781.00
247_L251_A0.5751.00
174_I177_A0.5751.00
137_S140_R0.5751.00
109_I112_L0.5731.00
143_F146_V0.5701.00
23_I30_I0.5691.00
282_F308_A0.5681.00
34_G41_Y0.5671.00
251_A278_Q0.5661.00
319_F325_A0.5661.00
190_P193_V0.5651.00
360_F370_D0.5651.00
154_F159_R0.5651.00
58_I319_F0.5651.00
406_N409_M0.5631.00
180_I184_K0.5631.00
319_F328_K0.5631.00
211_E253_F0.5621.00
335_P339_D0.5611.00
284_V288_R0.5611.00
138_T143_F0.5601.00
214_R255_L0.5591.00
149_R360_F0.5581.00
173_N178_R0.5571.00
49_M402_S0.5561.00
150_A158_D0.5551.00
181_D184_K0.5551.00
270_K303_D0.5541.00
263_A268_L0.5521.00
339_D343_K0.5521.00
322_M325_A0.5521.00
193_V196_H0.5511.00
151_M154_F0.5501.00
111_S122_V0.5461.00
286_N292_N0.5461.00
102_S105_Y0.5441.00
229_A286_N0.5431.00
403_V409_M0.5431.00
370_D406_N0.5431.00
12_L338_P0.5411.00
318_M327_F0.5401.00
360_F367_Y0.5381.00
246_L250_L0.5351.00
3_I41_Y0.5331.00
181_D220_T0.5331.00
180_I183_A0.5331.00
247_L272_D0.5331.00
53_I374_C0.5311.00
47_K409_M0.5291.00
209_G213_L0.5291.00
11_Q18_Q0.5281.00
39_Q44_A0.5261.00
20_G35_D0.5261.00
248_A275_L0.5261.00
119_C318_M0.5261.00
348_G351_L0.5261.00
193_V197_I0.5211.00
53_I337_W0.5211.00
320_E327_F0.5211.00
121_S151_M0.5211.00
293_N297_Y0.5201.00
7_V51_G0.5181.00
207_D249_R0.5181.00
318_M322_M0.5181.00
168_E172_E0.5151.00
371_L409_M0.5151.00
193_V198_G0.5141.00
173_N180_I0.5131.00
270_K273_I0.5131.00
25_I31_V0.5131.00
170_V177_A0.5121.00
378_S395_M0.5121.00
173_N181_D0.5121.00
283_L290_N0.5111.00
27_N31_V0.5111.00
236_S272_D0.5091.00
150_A157_T0.5091.00
190_P196_H0.5091.00
139_L146_V0.5091.00
212_M216_A0.5091.00
100_E141_D0.5081.00
192_L200_H0.5081.00
32_A38_T0.5071.00
171_E212_M0.5071.00
232_L236_S0.5061.00
265_G273_I0.5051.00
318_M326_F0.5021.00
259_K355_N0.5011.00
190_P199_A0.5011.00
58_I341_F0.5001.00
365_A368_K0.5001.00
248_A269_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dzhA 2 0.9457 100 0.266 Contact Map
3lnpA 2 0.948 100 0.268 Contact Map
3ls9A 2 0.9615 100 0.27 Contact Map
2pajA 2 0.8982 100 0.276 Contact Map
4v1xA 5 0.9729 100 0.288 Contact Map
3hpaA 2 0.9344 100 0.291 Contact Map
4gbdA 2 0.9434 100 0.293 Contact Map
4f0rA 2 0.948 100 0.305 Contact Map
2i9uA 2 0.8959 100 0.313 Contact Map
4f0lA 2 0.9412 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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