GREMLIN Database
MOCA - Molybdenum cofactor cytidylyltransferase
UniProt: Q46810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13060
Length: 192 (181)
Sequences: 8509 (6559)
Seq/√Len: 487.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_G37_K4.9971.00
45_R68_T3.0631.00
30_T33_D2.7331.00
22_M100_G2.7011.00
17_M24_L2.6391.00
6_C43_C2.6011.00
6_C39_A2.5571.00
7_I86_A2.5171.00
106_T172_I2.4391.00
109_I172_I2.4311.00
178_T181_D2.2641.00
5_D45_R2.2371.00
39_A98_T2.1731.00
24_L182_F1.9891.00
29_G34_T1.9501.00
176_I185_A1.9221.00
104_T185_A1.8861.00
47_I70_I1.8641.00
143_Q159_M1.8261.00
53_R56_E1.8251.00
5_D90_V1.8031.00
77_Q81_T1.7901.00
7_I95_C1.7861.00
98_T110_F1.7851.00
33_D37_K1.6971.00
54_G71_H1.6921.00
99_H102_M1.6881.00
41_Q107_I1.6851.00
29_G33_D1.6761.00
72_N81_T1.6411.00
40_L66_N1.6241.00
88_P145_I1.6191.00
152_N155_Q1.6181.00
96_F110_F1.5701.00
33_D60_R1.5441.00
143_Q160_G1.5431.00
90_V95_C1.5401.00
54_G58_H1.5311.00
106_T109_I1.4981.00
121_A160_G1.4841.00
87_V145_I1.4571.00
123_L130_P1.4521.00
146_Q163_Y1.4481.00
174_L184_T1.4301.00
8_I36_I1.4051.00
58_H71_H1.4051.00
107_I111_R1.3791.00
83_V97_L1.3591.00
38_N107_I1.3411.00
42_F111_R1.3331.00
95_C137_S1.3311.00
19_Q24_L1.3311.00
19_Q25_P1.3121.00
5_D92_T1.3061.00
98_T105_L1.2971.00
125_L166_E1.2741.00
47_I89_A1.2711.00
49_V86_A1.2711.00
81_T84_K1.2701.00
181_D184_T1.2671.00
13_L76_A1.2541.00
19_Q179_P1.2511.00
87_V95_C1.2471.00
31_I176_I1.2461.00
174_L185_A1.2461.00
50_T69_I1.2441.00
156_A160_G1.2371.00
77_Q151_T1.2351.00
30_T60_R1.2291.00
48_L67_I1.2151.00
5_D47_I1.2101.00
4_I94_H1.2091.00
87_V141_L1.2051.00
94_H135_L1.1861.00
36_I46_I1.1781.00
138_K141_L1.1721.00
94_H137_S1.1671.00
83_V153_M1.1451.00
125_L128_G1.1391.00
26_W31_I1.1381.00
143_Q156_A1.1311.00
154_R158_L1.1161.00
56_E59_E1.1151.00
120_G137_S1.1101.00
8_I39_A1.1011.00
182_F186_K1.1001.00
183_I186_K1.0881.00
36_I67_I1.0701.00
26_W185_A1.0671.00
25_P30_T1.0661.00
68_T89_A1.0571.00
81_T85_A1.0521.00
8_I35_S1.0471.00
84_K88_P1.0371.00
142_M145_I1.0281.00
111_R115_S1.0271.00
27_E34_T1.0251.00
25_P28_Q1.0201.00
40_L46_I1.0181.00
4_I114_W1.0111.00
80_L147_R1.0041.00
34_T38_N1.0011.00
84_K145_I0.9941.00
7_I49_V0.9791.00
20_W53_R0.9791.00
17_M179_P0.9781.00
50_T54_G0.9741.00
33_D65_S0.9611.00
35_S38_N0.9571.00
96_F135_L0.9501.00
124_P128_G0.9491.00
58_H69_I0.9371.00
176_I182_F0.9361.00
30_T34_T0.9281.00
50_T58_H0.9231.00
51_G76_A0.9151.00
142_M146_Q0.9091.00
143_Q146_Q0.9071.00
38_N41_Q0.8951.00
7_I97_L0.8891.00
50_T71_H0.8871.00
112_K115_S0.8831.00
140_C143_Q0.8811.00
146_Q159_M0.8811.00
14_S22_M0.8761.00
136_V144_A0.8711.00
126_H131_G0.8671.00
31_I100_G0.8621.00
155_Q158_L0.8561.00
130_P164_S0.8541.00
113_I122_I0.8481.00
121_A157_L0.8411.00
96_F114_W0.8401.00
23_M60_R0.8391.00
70_I85_A0.8371.00
139_P142_M0.8281.00
113_I135_L0.8251.00
142_M163_Y0.8221.00
47_I68_T0.8171.00
49_V70_I0.8121.00
112_K116_L0.8121.00
10_A48_L0.7931.00
180_D183_I0.7911.00
51_G75_Y0.7891.00
47_I90_V0.7881.00
24_L179_P0.7861.00
78_G81_T0.7821.00
5_D93_E0.7741.00
14_S19_Q0.7731.00
83_V99_H0.7721.00
121_A124_P0.7701.00
45_R91_Q0.7681.00
125_L130_P0.7651.00
6_C42_F0.7651.00
8_I32_L0.7621.00
93_E137_S0.7531.00
113_I124_P0.7431.00
75_Y81_T0.7371.00
31_I35_S0.7321.00
122_I125_L0.7301.00
27_E186_K0.7211.00
167_I173_I0.7201.00
35_S39_A0.7191.00
60_R63_N0.7141.00
150_V155_Q0.7121.00
39_A43_C0.7121.00
36_I40_L0.7031.00
14_S182_F0.6991.00
95_C141_L0.6991.00
127_N166_E0.6991.00
120_G139_P0.6951.00
59_E62_A0.6951.00
72_N82_S0.6911.00
108_D111_R0.6851.00
126_H129_I0.6831.00
180_D184_T0.6831.00
32_L36_I0.6831.00
171_E174_L0.6771.00
119_D137_S0.6711.00
68_T71_H0.6671.00
43_C96_F0.6641.00
119_D122_I0.6561.00
42_F107_I0.6561.00
58_H62_A0.6551.00
133_P136_V0.6551.00
104_T174_L0.6501.00
5_D91_Q0.6501.00
56_E60_R0.6501.00
25_P29_G0.6471.00
129_I170_A0.6461.00
35_S98_T0.6451.00
130_P133_P0.6381.00
42_F110_F0.6361.00
159_M162_H0.6351.00
26_W186_K0.6341.00
116_L122_I0.6331.00
76_A81_T0.6331.00
136_V139_P0.6311.00
111_R114_W0.6281.00
72_N85_A0.6261.00
32_L48_L0.6211.00
7_I90_V0.6201.00
124_P127_N0.6180.99
37_K40_L0.6180.99
120_G161_D0.6180.99
33_D63_N0.6160.99
80_L84_K0.6110.99
179_P183_I0.6090.99
140_C160_G0.6070.99
14_S20_W0.6050.99
105_L134_I0.6050.99
108_D112_K0.6020.99
93_E138_K0.6010.99
38_N42_F0.5990.99
84_K87_V0.5970.99
50_T57_L0.5920.99
20_W23_M0.5890.99
7_I47_I0.5840.99
118_N137_S0.5810.99
158_L162_H0.5800.99
120_G124_P0.5800.99
144_A156_A0.5800.99
20_W52_Y0.5800.99
151_T155_Q0.5740.99
79_L82_S0.5730.99
123_L164_S0.5700.99
37_K65_S0.5690.99
17_M182_F0.5670.99
99_H134_I0.5670.99
5_D95_C0.5660.99
137_S141_L0.5630.99
48_L61_Y0.5630.99
12_G16_R0.5570.99
99_H136_V0.5570.99
123_L157_L0.5560.99
55_N58_H0.5560.99
11_A82_S0.5540.99
99_H132_H0.5520.99
139_P160_G0.5510.99
92_T141_L0.5460.99
109_I124_P0.5400.99
62_A65_S0.5400.99
11_A79_L0.5400.99
91_Q141_L0.5380.99
72_N75_Y0.5380.99
66_N69_I0.5360.99
102_M173_I0.5340.99
144_A153_M0.5320.98
147_R156_A0.5290.98
94_H134_I0.5290.98
13_L75_Y0.5280.98
153_M156_A0.5280.98
99_H133_P0.5280.98
46_I67_I0.5270.98
51_G54_G0.5270.98
80_L144_A0.5270.98
122_I126_H0.5260.98
170_A173_I0.5210.98
120_G163_Y0.5150.98
92_T138_K0.5130.98
152_N175_D0.5120.98
4_I42_F0.5120.98
20_W57_L0.5110.98
49_V85_A0.5110.98
8_I98_T0.5080.98
6_C35_S0.5040.98
161_D164_S0.5030.98
139_P143_Q0.5030.98
70_I86_A0.5020.98
25_P186_K0.5010.98
9_T99_H0.5010.98
120_G140_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2weeA 1 0.9688 100 0.247 Contact Map
2wawA 1 0.9896 100 0.251 Contact Map
1e5kA 1 0.9323 100 0.283 Contact Map
2e8bA 1 0.8958 100 0.301 Contact Map
3d5nA 2 0.9062 100 0.307 Contact Map
3ngwA 2 0.9479 100 0.321 Contact Map
2px7A 2 0.901 100 0.43 Contact Map
1vpaA 2 0.9635 100 0.433 Contact Map
1i52A 2 0.9792 100 0.436 Contact Map
2xmeA 3 0.9219 100 0.437 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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