GREMLIN Database
ARCL - Carbamate kinase-like protein YqeA
UniProt: Q46807 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13057
Length: 310 (296)
Sequences: 1302 (833)
Seq/√Len: 48.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_E139_E6.4051.00
256_E281_R6.3861.00
250_L255_A4.2331.00
236_A246_W3.6841.00
4_K41_E3.6811.00
238_N243_N3.6361.00
134_T137_E3.3421.00
247_L250_L3.3011.00
234_K248_D3.2971.00
32_I42_V3.0221.00
45_T214_S2.9591.00
75_S205_S2.9351.00
197_E202_R2.6111.00
257_R261_E2.5771.00
238_N263_H2.4911.00
234_K246_W2.3961.00
287_E307_V2.3421.00
55_I81_S2.3341.00
249_R309_C2.3201.00
30_Q96_E2.2821.00
291_T299_G2.2481.00
135_E156_Y2.2311.00
187_V213_A2.2031.00
90_Q108_T2.1631.00
6_V223_A2.1081.00
7_L32_I2.0761.00
295_K298_E2.0661.00
164_K278_S2.0511.00
216_R220_M2.0361.00
146_Y158_R2.0331.00
187_V217_L1.9870.99
280_A288_A1.9670.99
227_I296_A1.9460.99
229_L296_A1.9160.99
237_I245_Q1.8740.99
114_E196_R1.8300.99
124_N149_K1.8210.99
280_A284_A1.8160.99
114_E167_D1.8040.99
33_V93_L1.8030.99
140_Q143_K1.7900.99
214_S226_L1.7810.99
233_E236_A1.7520.99
117_A197_E1.7460.99
252_L277_A1.7410.99
237_I263_H1.7150.98
298_E303_K1.7110.98
167_D220_M1.7040.98
132_F154_R1.6890.98
57_Q133_F1.6830.98
258_F261_E1.6450.98
222_D286_R1.6440.98
291_T304_T1.6430.98
255_A308_I1.6110.98
233_E304_T1.5960.97
215_A219_E1.5560.97
41_E181_G1.5320.97
225_M289_L1.5080.96
251_S254_D1.5070.96
43_I221_I1.4840.96
34_D297_K1.4770.96
212_W274_E1.4760.96
238_N245_Q1.4670.96
5_I40_H1.4540.95
197_E200_H1.4460.95
266_K270_L1.4370.95
219_E278_S1.4290.95
34_D37_A1.3990.94
142_T148_L1.3920.94
167_D196_R1.3890.94
128_P149_K1.3800.94
74_M78_V1.3780.94
139_E156_Y1.3760.94
58_A84_Y1.3750.94
176_A180_A1.3580.93
171_K221_I1.3430.93
175_K179_D1.3420.93
167_D171_K1.3420.93
105_P172_E1.3280.93
240_G244_E1.3210.93
234_K304_T1.3150.92
107_A173_T1.3110.92
114_E169_I1.3100.92
76_V88_D1.3070.92
16_D20_G1.2880.92
245_Q254_D1.2830.91
289_L299_G1.2800.91
58_A80_L1.2510.90
96_E99_S1.2470.90
57_Q131_S1.2460.90
94_R106_V1.2410.90
276_A288_A1.2410.90
265_A270_L1.2410.90
254_D257_R1.2310.90
238_N241_K1.2270.89
173_T182_Q1.2250.89
236_A239_F1.2210.89
15_G20_G1.2210.89
215_A278_S1.2130.89
97_L106_V1.2100.89
43_I178_V1.2090.89
36_I183_V1.2050.89
14_L54_M1.1910.88
236_A244_E1.1860.88
227_I289_L1.1840.88
132_F150_E1.1840.88
273_V288_A1.1820.88
55_I58_A1.1740.87
128_P132_F1.1740.87
187_V214_S1.1730.87
59_F80_L1.1600.87
233_E295_K1.1550.86
150_E154_R1.1460.86
225_M287_E1.1360.85
138_A145_G1.1350.85
91_N112_Q1.1330.85
151_D154_R1.1310.85
90_Q112_Q1.1300.85
87_Y203_G1.1180.84
97_L183_V1.1120.84
112_Q201_L1.1060.84
291_T295_K1.1050.84
174_V186_T1.1010.84
256_E277_A1.0930.83
22_M92_A1.0900.83
81_S84_Y1.0840.83
15_G56_N1.0800.82
133_F141_L1.0750.82
87_Y91_N1.0670.82
103_N172_E1.0570.81
216_R219_E1.0560.81
138_A142_T1.0560.81
142_T156_Y1.0400.80
178_V221_I1.0370.80
141_L148_L1.0350.80
116_D166_V1.0340.79
18_L76_V1.0340.79
256_E274_E1.0310.79
78_V113_V1.0300.79
18_L75_S1.0290.79
80_L84_Y1.0270.79
142_T146_Y1.0250.79
90_Q185_I1.0200.79
249_R307_V1.0150.78
168_I217_L1.0110.78
25_V89_L1.0050.78
42_V183_V1.0020.77
38_Q301_E1.0020.77
133_F148_L0.9970.77
5_I35_L0.9950.77
76_V84_Y0.9920.77
173_T176_A0.9770.75
54_M58_A0.9740.75
280_A309_C0.9700.75
5_I293_L0.9670.75
87_Y112_Q0.9640.75
235_V290_I0.9640.75
49_G267_G0.9620.74
4_K40_H0.9600.74
250_L258_F0.9590.74
297_K301_E0.9560.74
59_F69_S0.9480.73
18_L72_L0.9410.73
18_L58_A0.9390.73
164_K274_E0.9390.73
237_I247_L0.9330.72
90_Q110_V0.9290.72
55_I77_C0.9280.72
128_P265_A0.9230.71
54_M59_F0.9230.71
54_M84_Y0.9210.71
18_L88_D0.9210.71
252_L256_E0.9180.71
132_F151_D0.9130.70
41_E104_K0.9120.70
23_K26_K0.9090.70
258_F264_F0.9030.70
139_E142_T0.9020.69
62_A72_L0.9020.69
113_V214_S0.9010.69
4_K178_V0.8990.69
69_S88_D0.8960.69
112_Q169_I0.8950.69
9_L13_A0.8880.68
166_V216_R0.8860.68
59_F84_Y0.8860.68
17_D20_G0.8810.68
149_K156_Y0.8740.67
169_I201_L0.8660.66
248_D307_V0.8640.66
13_A229_L0.8620.66
117_A195_I0.8620.66
62_A68_H0.8610.66
289_L307_V0.8560.65
61_A131_S0.8550.65
121_A126_T0.8530.65
9_L293_L0.8470.65
293_L296_A0.8460.64
14_L85_I0.8380.64
44_V89_L0.8370.64
113_V213_A0.8370.64
174_V187_V0.8340.63
36_I39_G0.8300.63
240_G280_A0.8230.62
25_V92_A0.8220.62
164_K212_W0.8220.62
29_S92_A0.8190.62
75_S87_Y0.8120.61
22_M88_D0.8120.61
29_S89_L0.8060.61
237_I258_F0.8020.60
95_E198_G0.8010.60
95_E187_V0.8000.60
166_V171_K0.7980.60
135_E150_E0.7960.60
59_F81_S0.7930.59
26_K92_A0.7890.59
15_G54_M0.7870.59
94_R201_L0.7860.59
229_L293_L0.7860.59
78_V84_Y0.7840.59
99_S199_N0.7730.57
105_P182_Q0.7720.57
142_T149_K0.7700.57
81_S110_V0.7660.57
111_T168_I0.7660.57
177_L184_V0.7650.57
237_I242_E0.7600.56
142_T145_G0.7570.56
212_W275_A0.7550.56
298_E304_T0.7500.55
31_A34_D0.7440.55
129_I160_V0.7430.55
264_F273_V0.7430.55
120_P123_L0.7430.55
19_A23_K0.7410.54
236_A248_D0.7340.54
62_A69_S0.7300.53
176_A182_Q0.7300.53
75_S88_D0.7250.53
58_A88_D0.7230.52
40_H224_D0.7220.52
55_I84_Y0.7190.52
255_A273_V0.7170.52
14_L59_F0.7140.52
45_T187_V0.7140.52
35_L296_A0.7130.51
196_R201_L0.7100.51
75_S131_S0.7090.51
298_E301_E0.7030.50
18_L84_Y0.7010.50
107_A182_Q0.7010.50
44_V183_V0.6980.50
292_V295_K0.6980.50
185_I228_I0.6970.50
75_S84_Y0.6970.50
24_A74_M0.6960.50
56_N75_S0.6950.50
22_M91_N0.6930.49
224_D286_R0.6920.49
195_I204_A0.6910.49
20_G24_A0.6900.49
79_A285_G0.6890.49
245_Q248_D0.6890.49
12_N49_G0.6870.49
167_D216_R0.6840.49
12_N162_S0.6700.47
24_A88_D0.6690.47
89_L93_L0.6680.47
174_V217_L0.6660.47
72_L76_V0.6660.47
47_G209_D0.6660.47
232_V239_F0.6650.47
175_K222_D0.6610.46
95_E112_Q0.6570.46
27_I294_S0.6540.46
129_I156_Y0.6530.45
74_M88_D0.6520.45
11_G47_G0.6520.45
148_L158_R0.6520.45
281_R285_G0.6500.45
169_I194_V0.6490.45
36_I102_I0.6490.45
150_E153_G0.6470.45
225_M296_A0.6460.45
114_E117_A0.6450.45
34_D39_G0.6430.44
74_M205_S0.6420.44
239_F262_G0.6420.44
120_P242_E0.6410.44
11_G209_D0.6410.44
9_L21_Q0.6380.44
132_F155_G0.6380.44
121_A275_A0.6370.44
45_T113_V0.6360.44
37_A239_F0.6310.43
295_K304_T0.6310.43
235_V263_H0.6290.43
63_A131_S0.6290.43
94_R112_Q0.6290.43
114_E201_L0.6250.43
94_R105_P0.6230.42
171_K220_M0.6230.42
212_W278_S0.6220.42
186_T299_G0.6220.42
233_E292_V0.6210.42
95_E199_N0.6210.42
253_S281_R0.6210.42
13_A293_L0.6210.42
56_N74_M0.6200.42
142_T158_R0.6190.42
14_L88_D0.6160.42
251_S255_A0.6150.42
21_Q85_I0.6150.42
18_L73_P0.6140.42
26_K95_E0.6140.42
37_A167_D0.6130.41
138_A156_Y0.6130.41
62_A161_A0.6130.41
146_Y270_L0.6110.41
81_S185_I0.6100.41
107_A177_L0.6080.41
110_V197_E0.6060.41
281_R308_I0.6060.41
32_I234_K0.6060.41
122_F204_A0.6050.41
25_V54_M0.6040.41
84_Y231_A0.6030.41
209_D267_G0.6020.40
124_N266_K0.6020.40
94_R170_E0.6010.40
72_L84_Y0.6000.40
24_A291_T0.5970.40
273_V308_I0.5960.40
154_R231_A0.5960.40
129_I161_A0.5930.40
282_S286_R0.5900.39
144_Q148_L0.5890.39
7_L35_L0.5870.39
174_V208_I0.5850.39
11_G162_S0.5810.38
113_V186_T0.5810.38
144_Q158_R0.5800.38
99_S245_Q0.5790.38
228_I244_E0.5770.38
84_Y88_D0.5770.38
212_W219_E0.5770.38
252_L255_A0.5770.38
234_K250_L0.5760.38
15_G76_V0.5730.38
222_D249_R0.5730.38
219_E282_S0.5720.38
93_L183_V0.5720.38
54_M80_L0.5710.37
108_T185_I0.5700.37
229_L300_I0.5700.37
128_P150_E0.5700.37
95_E200_H0.5690.37
24_A231_A0.5680.37
161_A171_K0.5670.37
277_A281_R0.5650.37
28_T291_T0.5630.37
58_A75_S0.5630.37
45_T186_T0.5620.37
54_M81_S0.5620.37
59_F88_D0.5610.36
56_N59_F0.5600.36
17_D129_I0.5590.36
59_F75_S0.5580.36
256_E261_E0.5580.36
295_K299_G0.5570.36
35_L300_I0.5550.36
14_L84_Y0.5550.36
178_V181_G0.5540.36
141_L146_Y0.5540.36
36_I97_L0.5530.36
36_I104_K0.5510.36
78_V231_A0.5500.35
231_A296_A0.5490.35
120_P253_S0.5480.35
32_I44_V0.5450.35
42_V286_R0.5430.35
35_L102_I0.5430.35
15_G59_F0.5430.35
54_M88_D0.5380.34
14_L56_N0.5370.34
23_K27_I0.5360.34
106_V129_I0.5350.34
90_Q170_E0.5340.34
243_N261_E0.5340.34
238_N261_E0.5330.34
237_I264_F0.5330.34
18_L78_V0.5310.34
49_G162_S0.5310.34
239_F265_A0.5310.34
231_A265_A0.5300.34
90_Q97_L0.5290.34
72_L133_F0.5270.33
63_A68_H0.5270.33
56_N158_R0.5270.33
56_N60_E0.5250.33
94_R98_L0.5250.33
77_C84_Y0.5240.33
105_P173_T0.5220.33
25_V78_V0.5220.33
161_A205_S0.5210.33
78_V82_Q0.5210.33
25_V226_L0.5210.33
72_L77_C0.5210.33
12_N267_G0.5200.33
5_I300_I0.5200.33
248_D255_A0.5200.33
87_Y192_I0.5180.33
25_V88_D0.5170.32
40_H70_P0.5170.32
58_A131_S0.5160.32
276_A308_I0.5160.32
29_S93_L0.5140.32
83_G110_V0.5140.32
24_A58_A0.5140.32
20_G75_S0.5130.32
74_M146_Y0.5120.32
9_L79_A0.5120.32
14_L215_A0.5120.32
82_Q302_G0.5110.32
155_G232_V0.5110.32
137_E140_Q0.5110.32
299_G304_T0.5090.32
72_L81_S0.5090.32
131_S158_R0.5080.32
44_V185_I0.5070.32
289_L300_I0.5060.32
57_Q121_A0.5050.31
22_M74_M0.5040.31
56_N81_S0.5040.31
16_D24_A0.5030.31
57_Q61_A0.5030.31
20_G56_N0.5010.31
7_L42_V0.5010.31
60_E299_G0.5010.31
156_Y273_V0.5010.31
15_G24_A0.5010.31
80_L88_D0.5000.31
109_L174_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e19A 2 0.9903 100 0.486 Contact Map
2e9yA 2 0.9806 100 0.493 Contact Map
4axsA 2 0.9355 100 0.501 Contact Map
2we5A 2 0.9839 100 0.505 Contact Map
4jz8A 2 0.9871 100 0.51 Contact Map
3l86A 1 0.7742 100 0.711 Contact Map
2bufA 3 0.8097 100 0.715 Contact Map
3wwnA 2 0.8097 100 0.715 Contact Map
2rd5A 3 0.8355 100 0.719 Contact Map
2ap9A 3 0.829 100 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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