GREMLIN Database
PHYDA - D-phenylhydantoinase
UniProt: Q46806 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13056
Length: 461 (418)
Sequences: 9700 (6435)
Seq/√Len: 314.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_I46_A4.6331.00
429_L434_T3.8821.00
49_C426_V3.8711.00
228_Q255_N3.6471.00
8_G51_V3.3961.00
399_S420_T3.3871.00
427_R434_T3.2861.00
361_R364_E3.2651.00
24_E29_R3.2621.00
10_V19_Q3.2331.00
42_E437_C3.1491.00
8_G46_A3.0821.00
21_L51_V3.0081.00
32_G35_I2.9821.00
383_L391_V2.9001.00
30_Q385_P2.8161.00
6_K43_E2.7681.00
358_T361_R2.7341.00
292_V296_D2.7151.00
380_K388_D2.5991.00
382_L387_S2.5361.00
3_V429_L2.5251.00
404_H417_E2.4891.00
369_M372_R2.4741.00
49_C393_I2.4661.00
46_A393_I2.3881.00
83_A120_I2.3751.00
403_Q406_H2.3521.00
23_I391_V2.3451.00
220_I245_G2.2941.00
4_L22_L2.2821.00
51_V393_I2.2461.00
52_F394_I2.2331.00
121_D431_R2.1821.00
9_T18_K2.1371.00
54_G88_T2.1341.00
263_T267_Y2.1081.00
292_V295_Q2.0791.00
84_C436_F2.0531.00
402_I421_C2.0431.00
253_R308_D2.0281.00
258_P373_L1.9861.00
384_A387_S1.9291.00
236_Y260_W1.9271.00
58_V374_F1.9211.00
27_I379_Q1.9051.00
49_C395_D1.9021.00
353_M422_Q1.8931.00
364_E369_M1.8911.00
31_L385_P1.8731.00
108_E112_G1.8361.00
171_R174_E1.8271.00
83_A435_I1.8171.00
372_R382_L1.8141.00
26_G388_D1.8091.00
84_C408_H1.7991.00
329_D332_R1.7881.00
399_S422_Q1.7751.00
400_Q424_A1.7721.00
10_V21_L1.7621.00
138_E141_M1.7551.00
50_Y359_P1.7501.00
243_G293_R1.7361.00
7_N45_D1.7261.00
395_D398_Q1.7191.00
427_R437_C1.7181.00
350_S354_T1.7171.00
224_I259_V1.6991.00
364_E368_A1.6941.00
89_T123_S1.6821.00
109_V113_Y1.6811.00
44_I429_L1.6681.00
217_A244_L1.6651.00
398_Q426_V1.6551.00
19_Q31_L1.6501.00
221_A248_Y1.6411.00
6_K20_D1.6371.00
22_L41_Y1.6311.00
16_Q360_E1.6241.00
20_D35_I1.6221.00
398_Q424_A1.6131.00
52_F363_V1.6131.00
251_L255_N1.6131.00
172_L179_T1.6101.00
3_V23_I1.6091.00
401_Q420_T1.6081.00
227_A235_L1.6041.00
76_F80_R1.5961.00
347_L366_T1.5911.00
62_F78_G1.5731.00
224_I248_Y1.5621.00
347_L362_F1.5621.00
166_L229_I1.5591.00
87_T343_R1.5491.00
8_G393_I1.5421.00
143_V177_A1.5421.00
434_T437_C1.5401.00
264_C267_Y1.5361.00
55_G344_M1.4911.00
271_D292_V1.4711.00
250_R304_D1.4651.00
309_V373_L1.4591.00
240_L249_L1.4561.00
352_V362_F1.4491.00
395_D426_V1.4441.00
221_A225_N1.4421.00
247_D251_L1.4411.00
378_P387_S1.4381.00
161_N164_E1.4381.00
22_L30_Q1.4321.00
27_I388_D1.4291.00
51_V391_V1.4231.00
21_L383_L1.4181.00
363_V367_S1.4171.00
361_R365_L1.4061.00
5_I393_I1.3961.00
71_S318_S1.3781.00
428_T436_F1.3751.00
140_P171_R1.3731.00
5_I23_I1.3591.00
74_D410_N1.3571.00
270_L346_L1.3561.00
426_V438_D1.3451.00
403_Q417_E1.3451.00
4_L40_P1.3381.00
58_V309_V1.3301.00
368_A372_R1.3161.00
379_Q388_D1.3081.00
251_L254_A1.3011.00
44_I427_R1.3001.00
249_L261_V1.3001.00
285_L337_L1.2981.00
22_L40_P1.2921.00
225_N229_I1.2851.00
228_Q257_Q1.2791.00
271_D274_S1.2741.00
73_D78_G1.2691.00
50_Y396_P1.2621.00
268_L298_L1.2571.00
42_E434_T1.2541.00
388_D431_R1.2301.00
357_I365_L1.2191.00
52_F392_V1.2181.00
180_T238_V1.2001.00
172_L177_A1.1991.00
80_R408_H1.1941.00
230_A233_A1.1941.00
95_G98_P1.1901.00
112_G116_H1.1851.00
213_L244_L1.1821.00
32_G36_S1.1821.00
100_G103_L1.1731.00
52_F55_G1.1711.00
250_R306_A1.1651.00
261_V307_I1.1611.00
291_N294_E1.1611.00
169_L233_A1.1571.00
227_A257_Q1.1561.00
40_P43_E1.1541.00
243_G297_K1.1491.00
3_V42_E1.1451.00
109_V112_G1.1391.00
269_L346_L1.1351.00
56_V371_A1.1331.00
402_I407_L1.1331.00
55_G366_T1.1321.00
171_R175_S1.1281.00
17_A33_N1.1271.00
199_A203_A1.1251.00
62_F90_I1.1231.00
205_R276_D1.1211.00
224_I252_A1.1171.00
393_I427_R1.1141.00
430_S435_I1.1091.00
185_N218_E1.0981.00
240_L245_G1.0791.00
300_C304_D1.0681.00
195_E199_A1.0681.00
220_I237_I1.0661.00
18_K47_T1.0651.00
302_I365_L1.0651.00
5_I51_V1.0641.00
296_D300_C1.0621.00
46_A51_V1.0621.00
132_N135_I1.0461.00
10_V17_A1.0441.00
79_T118_A1.0411.00
10_V383_L1.0371.00
11_V50_Y1.0331.00
338_P411_A1.0331.00
102_R105_H1.0301.00
349_S422_Q1.0281.00
328_G332_R1.0171.00
349_S353_M1.0161.00
74_D77_T1.0151.00
176_G375_G1.0131.00
20_D32_G1.0101.00
169_L179_T1.0091.00
284_I333_C1.0061.00
242_N245_G1.0051.00
30_Q35_I0.9981.00
58_V370_P0.9971.00
19_Q33_N0.9951.00
22_L35_I0.9911.00
150_F177_A0.9891.00
11_V363_V0.9861.00
5_I429_L0.9811.00
91_I125_H0.9801.00
161_N187_A0.9791.00
5_I391_V0.9711.00
8_G391_V0.9711.00
9_T50_Y0.9661.00
170_R174_E0.9641.00
371_A381_G0.9551.00
349_S419_F0.9541.00
62_F79_T0.9541.00
223_M235_L0.9531.00
224_I257_Q0.9481.00
393_I429_L0.9451.00
125_H149_S0.9431.00
167_Q170_R0.9431.00
91_I123_S0.9421.00
359_P396_P0.9391.00
94_M98_P0.9371.00
14_D382_L0.9361.00
19_Q383_L0.9341.00
310_V347_L0.9341.00
362_F366_T0.9331.00
178_L234_P0.9321.00
345_Q400_Q0.9301.00
381_G390_D0.9271.00
248_Y251_L0.9261.00
121_D380_K0.9231.00
11_V16_Q0.9201.00
83_A428_T0.9201.00
297_K301_G0.9181.00
318_S321_Q0.9181.00
195_E198_A0.9171.00
140_P144_E0.9131.00
4_L20_D0.9091.00
74_D117_K0.9081.00
130_H135_I0.9081.00
391_V429_L0.9051.00
234_P258_P0.9041.00
136_L145_E0.8961.00
164_E167_Q0.8901.00
344_M348_F0.8821.00
23_I429_L0.8821.00
165_V181_V0.8811.00
342_N402_I0.8811.00
55_G87_T0.8731.00
15_G360_E0.8721.00
94_M97_G0.8701.00
140_P174_E0.8661.00
250_R254_A0.8651.00
120_I430_S0.8641.00
295_Q299_W0.8621.00
112_G115_A0.8611.00
139_I175_S0.8591.00
376_L380_K0.8571.00
284_I287_P0.8551.00
343_R366_T0.8521.00
89_T390_D0.8511.00
4_L43_E0.8481.00
166_L170_R0.8421.00
12_N16_Q0.8411.00
246_L301_G0.8401.00
328_G334_P0.8401.00
163_D167_Q0.8371.00
312_T343_R0.8361.00
272_E291_N0.8351.00
17_A31_L0.8351.00
12_N15_G0.8321.00
414_S417_E0.8261.00
95_G99_N0.8241.00
271_D295_Q0.8231.00
166_L230_A0.8201.00
364_E372_R0.8191.00
106_Q109_V0.8181.00
13_A16_Q0.8141.00
7_N47_T0.8121.00
252_A257_Q0.8061.00
300_C303_S0.8051.00
118_A122_Y0.8051.00
146_G150_F0.8041.00
108_E111_R0.8041.00
162_D222_R0.8041.00
274_S283_F0.8031.00
379_Q387_S0.8011.00
83_A430_S0.8001.00
56_V89_T0.7991.00
76_F117_K0.7991.00
50_Y394_I0.7961.00
113_Y116_H0.7961.00
214_E218_E0.7951.00
92_D110_Y0.7941.00
312_T316_T0.7941.00
365_L369_M0.7941.00
344_M394_I0.7941.00
247_D250_R0.7911.00
71_S321_Q0.7901.00
62_F340_V0.7901.00
382_L385_P0.7891.00
225_N228_Q0.7891.00
303_S361_R0.7891.00
102_R106_Q0.7881.00
263_T298_L0.7871.00
152_L168_A0.7871.00
51_V429_L0.7861.00
128_I168_A0.7861.00
7_N18_K0.7851.00
22_L29_R0.7841.00
165_V169_L0.7811.00
105_H108_E0.7791.00
367_S370_P0.7791.00
214_E229_I0.7781.00
348_F353_M0.7761.00
349_S354_T0.7751.00
126_G142_I0.7751.00
369_M373_L0.7720.99
149_S152_L0.7710.99
186_D190_A0.7660.99
239_H313_D0.7630.99
357_I361_R0.7620.99
58_V311_A0.7580.99
108_E145_E0.7580.99
301_G306_A0.7570.99
91_I374_F0.7570.99
76_F119_V0.7560.99
310_V365_L0.7560.99
392_V425_I0.7530.99
107_L111_R0.7520.99
321_Q334_P0.7510.99
218_E221_A0.7510.99
3_V44_I0.7510.99
338_P407_L0.7480.99
176_G234_P0.7450.99
55_G343_R0.7450.99
245_G249_L0.7430.99
110_Y113_Y0.7420.99
100_G110_Y0.7400.99
56_V380_K0.7390.99
26_G431_R0.7380.99
72_C317_F0.7370.99
21_L31_L0.7350.99
106_Q110_Y0.7350.99
273_R292_V0.7320.99
202_T206_Y0.7320.99
114_A118_A0.7310.99
342_N345_Q0.7310.99
296_D299_W0.7300.99
169_L173_H0.7260.99
20_D34_N0.7240.99
299_W356_R0.7240.99
79_T119_V0.7230.99
162_D185_N0.7220.99
137_D142_I0.7220.99
49_C427_R0.7220.99
11_V360_E0.7210.99
303_S306_A0.7210.99
55_G392_V0.7200.99
44_I434_T0.7200.99
57_D60_T0.7190.99
22_L32_G0.7170.99
187_A191_S0.7150.99
105_H109_V0.7120.99
260_W373_L0.7120.99
19_Q32_G0.7110.99
82_A90_I0.7110.99
404_H407_L0.7100.99
350_S353_M0.7100.99
201_L205_R0.7090.99
197_I202_T0.7080.99
58_V91_I0.7080.99
29_R385_P0.7060.99
158_Y161_N0.7060.99
121_D430_S0.7050.99
169_L172_L0.7040.99
137_D140_P0.7040.99
341_E408_H0.7030.99
111_R115_A0.7030.99
201_L206_Y0.7020.99
227_A258_P0.6990.99
339_G342_N0.6980.99
9_T16_Q0.6970.99
266_Q337_L0.6950.99
274_S419_F0.6950.99
68_I71_S0.6950.99
342_N407_L0.6940.99
12_N17_A0.6920.99
124_F127_V0.6920.99
150_F153_Y0.6920.99
351_G355_G0.6920.99
368_A382_L0.6910.99
352_V355_G0.6900.99
203_A206_Y0.6890.99
338_P413_Y0.6840.99
202_T205_R0.6840.99
424_A438_D0.6830.99
244_L247_D0.6820.99
285_L289_L0.6810.99
348_F359_P0.6810.99
238_V262_E0.6760.99
148_S151_K0.6750.99
56_V370_P0.6750.99
231_G258_P0.6750.99
31_L383_L0.6750.99
243_G247_D0.6740.99
3_V41_Y0.6730.99
394_I425_I0.6700.99
113_Y117_K0.6680.99
138_E142_I0.6680.99
213_L217_A0.6670.99
160_L164_E0.6660.99
136_L140_P0.6650.98
79_T90_I0.6640.98
313_D316_T0.6640.98
20_D36_S0.6630.98
400_Q425_I0.6630.98
146_G151_K0.6620.98
83_A119_V0.6620.98
380_K390_D0.6620.98
91_I376_L0.6610.98
145_E148_S0.6600.98
62_F92_D0.6560.98
344_M362_F0.6550.98
140_P175_S0.6540.98
281_M333_C0.6540.98
184_E188_A0.6540.98
237_I240_L0.6530.98
49_C397_R0.6520.98
345_Q424_A0.6520.98
3_V434_T0.6510.98
293_R296_D0.6510.98
176_G258_P0.6500.98
37_P40_P0.6470.98
80_R119_V0.6450.98
400_Q423_G0.6420.98
196_F206_Y0.6420.98
6_K45_D0.6410.98
330_F336_G0.6400.98
348_F394_I0.6400.98
139_I150_F0.6390.98
294_E297_K0.6380.98
141_M145_E0.6380.98
94_M99_N0.6370.98
5_I44_I0.6370.98
188_A191_S0.6360.98
131_I136_L0.6340.98
162_D165_V0.6330.98
197_I331_S0.6320.98
167_Q171_R0.6310.98
312_T317_F0.6310.98
287_P290_R0.6300.98
103_L106_Q0.6300.98
58_V373_L0.6290.98
60_T87_T0.6270.98
310_V314_H0.6250.98
96_F100_G0.6250.98
221_A251_L0.6240.98
217_A221_A0.6230.98
341_E345_Q0.6220.98
114_A124_F0.6220.98
107_L110_Y0.6220.98
196_F208_A0.6210.98
347_L351_G0.6190.98
95_G100_G0.6190.98
141_M144_E0.6190.98
310_V316_T0.6180.98
72_C321_Q0.6170.98
96_F99_N0.6170.98
121_D124_F0.6150.97
44_I393_I0.6130.97
162_D166_L0.6090.97
217_A248_Y0.6090.97
146_G149_S0.6080.97
406_H417_E0.6070.97
15_G384_A0.6070.97
427_R436_F0.6070.97
42_E427_R0.6070.97
330_F333_C0.6060.97
329_D333_C0.6050.97
9_T17_A0.6050.97
82_A340_V0.6020.97
125_H180_T0.6020.97
220_I224_I0.6000.97
180_T188_A0.6000.97
348_F396_P0.6000.97
205_R209_L0.5980.97
345_Q425_I0.5950.97
125_H128_I0.5950.97
240_L307_I0.5940.97
196_F200_G0.5920.97
213_L291_N0.5920.97
299_W351_G0.5910.97
280_G283_F0.5870.97
350_S419_F0.5870.97
59_H239_H0.5840.97
170_R195_E0.5840.97
68_I72_C0.5840.97
328_G331_S0.5840.97
218_E222_R0.5830.97
344_M347_L0.5830.97
220_I240_L0.5810.96
6_K35_I0.5800.96
160_L165_V0.5780.96
375_G379_Q0.5780.96
422_Q425_I0.5780.96
348_F362_F0.5780.96
252_A256_H0.5770.96
22_L34_N0.5770.96
280_G288_P0.5770.96
180_T374_F0.5770.96
65_D113_Y0.5760.96
344_M392_V0.5760.96
245_G248_Y0.5750.96
237_I249_L0.5750.96
343_R347_L0.5750.96
425_I428_T0.5750.96
34_N37_P0.5740.96
249_L252_A0.5740.96
196_F199_A0.5730.96
101_C106_Q0.5720.96
89_T371_A0.5720.96
52_F367_S0.5710.96
353_M397_R0.5700.96
281_M284_I0.5690.96
14_D384_A0.5690.96
152_L157_Q0.5690.96
319_M327_K0.5680.96
99_N102_R0.5670.96
89_T121_D0.5660.96
351_G356_R0.5660.96
84_C341_E0.5660.96
162_D187_A0.5660.96
407_L417_E0.5630.96
143_V150_F0.5630.96
81_A340_V0.5590.96
65_D68_I0.5570.96
51_V383_L0.5560.96
197_I203_A0.5560.96
22_L37_P0.5540.95
14_D368_A0.5530.95
346_L421_C0.5520.95
412_D423_G0.5520.95
13_A368_A0.5520.95
181_V223_M0.5500.95
390_D430_S0.5480.95
351_G357_I0.5450.95
7_N20_D0.5420.95
185_N222_R0.5420.95
68_I97_G0.5410.95
103_L108_E0.5400.95
204_P207_H0.5380.95
10_V31_L0.5370.95
253_R306_A0.5360.95
303_S356_R0.5360.95
316_T321_Q0.5350.94
219_A222_R0.5340.94
234_P373_L0.5340.94
72_C318_S0.5340.94
9_T397_R0.5330.94
99_N103_L0.5330.94
296_D356_R0.5320.94
9_T47_T0.5310.94
269_L350_S0.5310.94
30_Q34_N0.5290.94
148_S169_L0.5290.94
246_L307_I0.5290.94
328_G333_C0.5280.94
279_D282_K0.5280.94
346_L350_S0.5280.94
119_V124_F0.5270.94
63_N72_C0.5270.94
55_G367_S0.5260.94
195_E211_R0.5250.94
282_K319_M0.5250.94
246_L261_V0.5250.94
375_G378_P0.5250.94
136_L146_G0.5250.94
9_T19_Q0.5240.94
142_I145_E0.5220.94
60_T340_V0.5220.94
222_R225_N0.5220.94
207_H286_S0.5220.94
94_M100_G0.5210.94
263_T268_L0.5190.94
89_T380_K0.5190.94
13_A360_E0.5190.94
239_H262_E0.5190.94
63_N317_F0.5180.93
246_L250_R0.5180.93
162_D169_L0.5180.93
144_E175_S0.5180.93
213_L242_N0.5180.93
337_L415_P0.5170.93
407_L412_D0.5160.93
240_L261_V0.5160.93
147_L150_F0.5150.93
152_L156_Y0.5150.93
314_H317_F0.5150.93
352_V359_P0.5130.93
268_L347_L0.5130.93
88_T390_D0.5120.93
366_T370_P0.5110.93
172_L233_A0.5110.93
327_K332_R0.5110.93
168_A179_T0.5100.93
90_I120_I0.5100.93
165_V168_A0.5100.93
196_F209_L0.5090.93
136_L139_I0.5090.93
223_M227_A0.5080.93
270_L415_P0.5060.93
135_I138_E0.5050.93
121_D390_D0.5040.93
139_I143_V0.5040.93
32_G37_P0.5030.92
311_A314_H0.5030.92
294_E301_G0.5030.92
158_Y165_V0.5030.92
4_L35_I0.5020.92
197_I200_G0.5010.92
317_F321_Q0.5010.92
119_V125_H0.5010.92
344_M366_T0.5010.92
179_T191_S0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dc8A 3 0.9761 100 0.227 Contact Map
2ftyA 3 0.9957 100 0.239 Contact Map
4lcqA 3 0.9913 100 0.24 Contact Map
2ftwA 3 0.9892 100 0.255 Contact Map
4bknA 3 0.9892 100 0.257 Contact Map
1gkpA 4 0.9848 100 0.258 Contact Map
2vm8A 3 0.987 100 0.261 Contact Map
3sfwA 3 0.9848 100 0.265 Contact Map
1nfgA 3 0.9805 100 0.273 Contact Map
1gkrA 3 0.9566 100 0.28 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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