GREMLIN Database
YGEW - Uncharacterized protein YgeW
UniProt: Q46803 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13053
Length: 396 (303)
Sequences: 6368 (3180)
Seq/√Len: 182.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_E348_G4.2321.00
190_K221_D3.7561.00
190_K223_T3.3531.00
327_Y345_V3.3211.00
56_K59_N3.3201.00
258_E319_L3.1281.00
192_A264_A3.0531.00
114_F359_K2.8791.00
176_L266_I2.7741.00
113_S149_V2.7141.00
326_L356_A2.6721.00
179_H356_A2.6361.00
46_K178_E2.5751.00
256_S259_E2.5191.00
265_D321_R2.4611.00
43_A177_R2.4051.00
41_V373_L2.3781.00
40_D177_R2.3721.00
106_R136_E2.3611.00
64_I116_A2.3551.00
26_L164_D2.3481.00
328_M356_A2.2981.00
118_A372_I2.2021.00
82_L87_L2.1811.00
169_S214_L2.1751.00
63_G82_L2.1721.00
228_E255_T2.1411.00
225_A260_A2.1121.00
43_A174_A2.0731.00
234_P238_E2.0281.00
180_F324_E2.0251.00
36_K177_R2.0241.00
173_L214_L2.0181.00
334_D343_G1.9541.00
317_M325_A1.9481.00
231_D255_T1.9481.00
261_F267_V1.9481.00
221_D252_R1.9281.00
215_M222_V1.9071.00
314_E318_E1.8981.00
130_G133_Y1.8741.00
114_F362_S1.8561.00
179_H359_K1.7911.00
32_P36_K1.7461.00
254_V259_E1.7021.00
221_D250_S1.6841.00
120_G159_L1.6761.00
31_T34_E1.6581.00
267_V312_C1.6441.00
325_A354_R1.6411.00
76_F112_I1.6381.00
37_Q374_S1.6351.00
230_Y306_Q1.6271.00
38_V374_S1.6081.00
93_D96_K1.6051.00
83_N88_A1.5991.00
180_F189_K1.5861.00
223_T254_V1.5711.00
321_R324_E1.5541.00
118_A376_K1.5491.00
45_L373_L1.5491.00
315_E318_E1.5421.00
110_N351_E1.5391.00
211_I268_Y1.5361.00
84_L369_A1.5311.00
68_R133_Y1.5271.00
257_M316_M1.5021.00
192_A223_T1.5001.00
22_K34_E1.4851.00
41_V374_S1.4761.00
192_A225_A1.4601.00
266_I326_L1.4521.00
32_P187_K1.4471.00
42_A174_A1.4291.00
194_T261_F1.4241.00
228_E231_D1.4241.00
28_W239_V1.4221.00
263_D321_R1.4181.00
167_T368_I1.4061.00
182_S189_K1.3981.00
32_P217_R1.3961.00
57_V373_L1.3791.00
24_F170_M1.3741.00
320_T325_A1.3701.00
268_Y360_E1.3501.00
164_D213_G1.3451.00
313_T346_T1.3381.00
39_L177_R1.3201.00
311_H346_T1.3101.00
317_M327_Y1.3001.00
258_E316_M1.3001.00
72_T102_G1.2901.00
72_T108_T1.2841.00
44_A48_L1.2771.00
119_I137_V1.2761.00
135_R139_A1.2721.00
72_T98_Q1.2601.00
182_S187_K1.2341.00
170_M371_M1.2311.00
63_G120_G1.2301.00
63_G118_A1.2231.00
48_L53_I1.2081.00
317_M354_R1.2051.00
278_M284_L1.1991.00
36_K218_F1.1991.00
254_V260_A1.1981.00
49_R84_L1.1951.00
226_H231_D1.1861.00
27_T214_L1.1831.00
366_Y369_A1.1741.00
23_D138_G1.1641.00
342_E347_E1.1631.00
269_P312_C1.1631.00
39_L174_A1.1621.00
197_Y226_H1.1581.00
237_V253_Q1.1541.00
312_C327_Y1.1501.00
109_A137_V1.1431.00
119_I150_L1.1431.00
180_F265_D1.1421.00
174_A367_I1.1351.00
333_A350_F1.1341.00
81_A372_I1.1341.00
41_V44_A1.1331.00
223_T252_R1.1331.00
335_I351_E1.1321.00
352_K355_I1.1291.00
24_F371_M1.1251.00
261_F316_M1.1241.00
28_W213_G1.1181.00
24_F30_Q1.1101.00
167_T371_M1.0971.00
110_N358_Y1.0931.00
75_R79_A1.0921.00
306_Q309_D1.0901.00
82_L89_Q1.0891.00
83_N89_Q1.0891.00
46_K363_W1.0841.00
262_K319_L1.0781.00
35_L217_R1.0751.00
26_L29_E1.0681.00
189_K266_I1.0651.00
47_A51_E1.0631.00
173_L218_F1.0621.00
212_I224_L1.0571.00
180_F326_L1.0551.00
169_S207_V1.0351.00
132_A136_E1.0311.00
111_M361_A1.0301.00
76_F92_L1.0291.00
39_L43_A1.0291.00
350_F357_T1.0200.99
191_I215_M1.0150.99
36_K40_D1.0140.99
191_I211_I1.0120.99
283_E306_Q1.0000.99
35_L218_F0.9960.99
259_E262_K0.9890.99
225_A257_M0.9770.99
134_M161_C0.9760.99
23_D113_S0.9750.99
150_L155_A0.9750.99
26_L213_G0.9730.99
79_A91_D0.9700.99
215_M220_M0.9630.99
169_S211_I0.9460.99
157_V371_M0.9440.99
255_T310_W0.9380.99
123_D161_C0.9370.99
98_Q108_T0.9360.99
347_E351_E0.9340.99
136_E139_A0.9330.99
180_F356_A0.9300.99
43_A178_E0.9240.99
106_R351_E0.9200.99
39_L367_I0.9190.99
118_A157_V0.9180.99
362_S366_Y0.9120.99
82_L372_I0.9090.99
273_A281_R0.9090.99
258_E262_K0.9080.99
44_A47_A0.9070.99
131_N135_R0.9060.99
170_M367_I0.9050.99
314_E352_K0.9050.99
176_L189_K0.9020.99
84_L365_P0.8930.99
359_K362_S0.8910.99
317_M349_V0.8860.99
62_L84_L0.8840.99
225_A264_A0.8810.99
279_E282_T0.8810.99
194_T316_M0.8750.98
106_R110_N0.8720.98
312_C345_V0.8650.98
225_A254_V0.8650.98
175_W356_A0.8640.98
197_Y208_P0.8620.98
32_P247_S0.8620.98
315_E319_L0.8610.98
68_R99_I0.8600.98
113_S150_L0.8580.98
178_E363_W0.8530.98
280_E284_L0.8510.98
335_I350_F0.8470.98
163_I233_I0.8450.98
98_Q101_H0.8440.98
121_I137_V0.8410.98
190_K264_A0.8380.98
62_L88_A0.8380.98
347_E350_F0.8240.98
106_R347_E0.8230.98
27_T35_L0.8220.98
78_Y167_T0.8200.98
130_G162_D0.8200.98
116_A150_L0.8190.98
190_K263_D0.8190.98
70_N100_A0.8160.98
194_T267_V0.8120.97
373_L377_Y0.8100.97
349_V352_K0.8090.97
176_L180_F0.8080.97
63_G87_L0.8080.97
164_D210_G0.8080.97
267_V317_M0.8070.97
209_Q236_V0.8050.97
48_L51_E0.8000.97
181_G186_L0.7930.97
43_A47_A0.7920.97
317_M345_V0.7890.97
226_H232_L0.7880.97
79_A89_Q0.7860.97
208_P224_L0.7850.97
98_Q102_G0.7820.97
313_T316_M0.7810.97
252_R259_E0.7800.97
77_S115_C0.7770.97
23_D148_G0.7740.97
342_E348_G0.7690.97
27_T169_S0.7660.96
232_L253_Q0.7640.96
282_T305_A0.7640.96
212_I222_V0.7630.96
102_G108_T0.7610.96
42_A370_A0.7590.96
232_L237_V0.7570.96
318_E354_R0.7510.96
30_Q38_V0.7510.96
212_I240_A0.7500.96
77_S368_I0.7480.96
48_L55_T0.7470.96
258_E315_E0.7440.96
37_Q41_V0.7410.96
19_L374_S0.7360.96
110_N140_A0.7360.96
65_S82_L0.7360.96
182_S186_L0.7320.95
61_G117_D0.7310.95
56_K86_G0.7300.95
121_I133_Y0.7290.95
64_I119_I0.7290.95
42_A367_I0.7280.95
181_G188_G0.7240.95
308_K311_H0.7230.95
72_T101_H0.7230.95
223_T264_A0.7220.95
321_R325_A0.7170.95
261_F319_L0.7140.95
132_A135_R0.7140.95
35_L214_L0.7110.95
169_S360_E0.7100.95
223_T263_D0.7070.94
46_K174_A0.7060.94
40_D44_A0.7040.94
179_H326_L0.7040.94
131_N163_I0.7030.94
181_G326_L0.7000.94
24_F375_R0.7000.94
305_A308_K0.6990.94
70_N98_Q0.6950.94
135_R138_G0.6940.94
180_F266_I0.6940.94
186_L218_F0.6890.94
268_Y271_S0.6880.94
79_A83_N0.6840.93
97_S102_G0.6830.93
314_E354_R0.6810.93
65_S89_Q0.6800.93
108_T112_I0.6790.93
45_L52_N0.6790.93
22_K374_S0.6760.93
78_Y368_I0.6690.93
235_D238_E0.6640.92
21_E375_R0.6640.92
278_M281_R0.6630.92
176_L186_L0.6620.92
123_D133_Y0.6610.92
106_R140_A0.6600.92
317_M320_T0.6590.92
214_L218_F0.6560.92
23_D149_V0.6560.92
62_L83_N0.6550.92
58_F372_I0.6530.92
104_T351_E0.6520.92
176_L215_M0.6510.92
217_R247_S0.6510.92
213_G236_V0.6490.92
110_N113_S0.6470.91
231_D253_Q0.6460.91
49_R52_N0.6460.91
27_T30_Q0.6450.91
191_I268_Y0.6450.91
267_V325_A0.6440.91
271_S334_D0.6410.91
109_A148_G0.6410.91
77_S167_T0.6380.91
211_I215_M0.6380.91
221_D249_G0.6370.91
191_I220_M0.6370.91
213_G239_V0.6360.91
356_A359_K0.6350.91
160_Q206_S0.6340.91
192_A260_A0.6340.91
352_K357_T0.6330.90
278_M282_T0.6320.90
72_T97_S0.6320.90
24_F35_L0.6310.90
219_G250_S0.6310.90
333_A345_V0.6300.90
370_A374_S0.6290.90
25_L138_G0.6280.90
192_A254_V0.6260.90
157_V375_R0.6250.90
176_L191_I0.6250.90
176_L326_L0.6240.90
316_M319_L0.6240.90
260_A264_A0.6230.90
45_L57_V0.6210.90
229_G306_Q0.6210.90
212_I232_L0.6190.90
58_F118_A0.6190.90
231_D234_P0.6170.89
174_A178_E0.6170.89
70_N102_G0.6160.89
97_S101_H0.6160.89
157_V372_I0.6110.89
58_F87_L0.6100.89
335_I347_E0.6080.89
38_V367_I0.6050.88
266_I328_M0.6040.88
38_V370_A0.6030.88
41_V45_L0.6030.88
237_V251_F0.6030.88
327_Y349_V0.6020.88
283_E305_A0.6020.88
113_S148_G0.6010.88
111_M358_Y0.6000.88
80_S90_Q0.6000.88
236_V240_A0.5990.88
216_T249_G0.5980.88
33_D37_Q0.5970.88
25_L135_R0.5960.88
65_S91_D0.5940.88
63_G372_I0.5910.87
70_N91_D0.5890.87
281_R334_D0.5890.87
314_E346_T0.5870.87
56_K60_S0.5870.87
70_N97_S0.5840.87
48_L52_N0.5840.87
271_S275_Y0.5830.87
41_V370_A0.5820.86
194_T269_P0.5800.86
81_A368_I0.5790.86
54_S85_L0.5770.86
105_V133_Y0.5760.86
257_M261_F0.5750.86
136_E140_A0.5740.86
35_L170_M0.5730.86
350_F355_I0.5700.85
177_R182_S0.5700.85
281_R284_L0.5700.85
124_D133_Y0.5680.85
169_S173_L0.5670.85
21_E374_S0.5660.85
193_M205_L0.5660.85
34_E37_Q0.5650.85
36_K187_K0.5630.85
207_V268_Y0.5620.85
268_Y328_M0.5620.85
80_S365_P0.5600.84
27_T164_D0.5590.84
279_E283_E0.5590.84
175_W363_W0.5570.84
77_S111_M0.5550.84
105_V121_I0.5530.84
38_V371_M0.5520.83
54_S59_N0.5520.83
173_L177_R0.5510.83
66_V99_I0.5500.83
266_I356_A0.5470.83
194_T309_D0.5450.83
40_D43_A0.5450.83
271_S343_G0.5440.83
186_L220_M0.5440.83
26_L135_R0.5440.83
19_L37_Q0.5410.82
78_Y120_G0.5410.82
324_E354_R0.5400.82
45_L48_L0.5400.82
189_K265_D0.5390.82
119_I148_G0.5380.82
33_D36_K0.5380.82
193_M207_V0.5360.82
205_L270_K0.5350.82
226_H255_T0.5350.82
121_I161_C0.5340.81
84_L366_Y0.5320.81
352_K356_A0.5320.81
176_L328_M0.5310.81
69_D160_Q0.5300.81
349_V354_R0.5290.81
182_S188_G0.5280.81
70_N96_K0.5270.81
65_S120_G0.5270.81
192_A261_F0.5270.81
84_L117_D0.5260.80
181_G189_K0.5240.80
28_W164_D0.5230.80
240_A248_G0.5230.80
261_F320_T0.5220.80
37_Q40_D0.5220.80
207_V360_E0.5210.80
207_V211_I0.5200.80
223_T260_A0.5190.80
312_C317_M0.5180.79
78_Y159_L0.5160.79
254_V257_M0.5160.79
53_I56_K0.5140.79
92_L97_S0.5130.79
99_I108_T0.5120.79
93_D97_S0.5110.79
101_H104_T0.5100.78
62_L80_S0.5100.78
281_R343_G0.5100.78
35_L39_L0.5080.78
230_Y307_H0.5070.78
319_L323_G0.5030.77
62_L90_Q0.5030.77
197_Y224_L0.5030.77
50_A362_S0.5020.77
29_E217_R0.5010.77
209_Q233_I0.5000.77
43_A367_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q98A 3 0.952 100 0.179 Contact Map
2yfkA 3 0.9646 100 0.191 Contact Map
1pvvA 6 0.7904 100 0.207 Contact Map
4nf2A 3 0.7753 100 0.211 Contact Map
2i6uA 3 0.7753 100 0.212 Contact Map
3gd5A 4 0.7197 100 0.212 Contact Map
4oh7A 3 0.7626 100 0.217 Contact Map
1duvG 3 0.798 100 0.217 Contact Map
3tpfA 3 0.7677 100 0.218 Contact Map
4am8A 4 0.8182 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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