GREMLIN Database
XDHC - Xanthine dehydrogenase iron-sulfur-binding subunit
UniProt: Q46801 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13051
Length: 159 (146)
Sequences: 6749 (3811)
Seq/√Len: 315.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_S154_D4.1091.00
128_I153_L3.6581.00
26_T35_Q3.2281.00
89_S115_T2.7871.00
12_T75_E2.6361.00
127_T130_E2.5701.00
20_L31_L2.5471.00
39_S79_L2.5231.00
131_I153_L2.4081.00
57_D74_K2.3211.00
93_Q97_K2.2411.00
98_S150_N2.1791.00
114_T152_V2.0521.00
10_E19_Q2.0241.00
29_S42_Q2.0231.00
47_G65_L1.9981.00
53_T60_A1.9871.00
115_T119_A1.9261.00
12_T17_P1.9201.00
56_V61_I1.8791.00
31_L68_A1.8621.00
26_T31_L1.8561.00
91_V111_I1.8431.00
97_K154_D1.8431.00
10_E17_P1.8121.00
37_L40_V1.8091.00
55_L112_M1.7261.00
121_P130_E1.7221.00
56_V66_Y1.7211.00
132_R149_V1.6931.00
42_Q45_C1.6291.00
79_L111_I1.6281.00
39_S80_E1.4951.00
67_L70_W1.4851.00
14_N80_E1.4301.00
60_A116_A1.4011.00
91_V115_T1.3861.00
55_L116_A1.3681.00
14_N37_L1.3601.00
77_R81_G1.3041.00
11_C18_F1.2861.00
117_M134_G1.2841.00
116_A120_K1.2661.00
135_L152_V1.2561.00
55_L115_T1.2491.00
53_T112_M1.2461.00
28_L54_V1.2451.00
128_I150_N1.2271.00
110_L135_L1.2181.00
22_A68_A1.2051.00
84_K87_K1.2041.00
66_Y71_A1.2001.00
61_I66_Y1.1941.00
91_V114_T1.1891.00
100_A151_T1.1811.00
95_Y107_T1.1721.00
56_V76_I1.1721.00
146_Q150_N1.1721.00
88_L92_Q1.1611.00
56_V74_K1.1411.00
13_I18_F1.1271.00
28_L76_I1.1001.00
121_P125_P1.0921.00
113_A137_G1.0871.00
147_M150_N1.0771.00
9_I72_E1.0661.00
128_I132_R1.0531.00
83_A88_L1.0391.00
91_V155_C1.0391.00
82_E115_T1.0251.00
29_S40_V1.0111.00
23_A26_T1.0081.00
28_L71_A0.9881.00
89_S92_Q0.9721.00
109_G138_N0.9651.00
128_I149_V0.9631.00
56_V71_A0.9571.00
27_P30_E0.9501.00
22_A35_Q0.9461.00
40_V79_L0.9331.00
87_K93_Q0.9181.00
59_T120_K0.9091.00
60_A113_A0.9071.00
95_Y111_I0.9001.00
77_R119_A0.8961.00
37_L80_E0.8891.00
54_V63_S0.8871.00
125_P156_E0.8781.00
90_H155_C0.8691.00
32_L54_V0.8551.00
118_L156_E0.8421.00
100_A107_T0.8421.00
94_A154_D0.8421.00
149_V153_L0.8401.00
71_A74_K0.8401.00
13_I37_L0.8381.00
117_M121_P0.8311.00
91_V118_L0.8181.00
114_T135_L0.8161.00
10_E72_E0.8101.00
55_L77_R0.8091.00
82_E111_I0.8081.00
15_G75_E0.7931.00
129_T132_R0.7931.00
85_G88_L0.7921.00
15_G18_F0.7831.00
83_A87_K0.7751.00
110_L148_I0.7751.00
120_K134_G0.7720.99
95_Y114_T0.7700.99
94_A155_C0.7650.99
83_A86_G0.7600.99
66_Y70_W0.7590.99
83_A92_Q0.7560.99
121_P134_G0.7540.99
58_G75_E0.7500.99
98_S151_T0.7500.99
129_T133_R0.7440.99
27_P42_Q0.7320.99
95_Y100_A0.7310.99
11_C20_L0.7260.99
30_E42_Q0.7260.99
121_P124_K0.7250.99
113_A134_G0.7240.99
45_C48_E0.7240.99
29_S43_G0.7230.99
60_A134_G0.7230.99
99_G144_G0.7140.99
41_K108_P0.7140.99
130_E134_G0.7060.99
150_N154_D0.7060.99
99_G143_T0.7040.99
25_G69_A0.7010.99
26_T34_E0.7000.99
101_V107_T0.7000.99
95_Y110_L0.6980.99
31_L35_Q0.6970.99
117_M131_I0.6950.99
110_L144_G0.6940.99
22_A31_L0.6890.99
95_Y101_V0.6870.99
14_N81_G0.6870.99
55_L60_A0.6800.99
11_C31_L0.6770.99
118_L125_P0.6750.99
38_L108_P0.6740.99
77_R115_T0.6690.99
27_P67_L0.6630.98
30_E34_E0.6600.98
62_D66_Y0.6590.98
82_E112_M0.6580.98
131_I149_V0.6570.98
57_D75_E0.6560.98
113_A138_N0.6480.98
20_L35_Q0.6450.98
110_L138_N0.6450.98
26_T68_A0.6410.98
9_I22_A0.6400.98
88_L96_A0.6300.98
13_I32_L0.6280.98
117_M125_P0.6260.98
143_T146_Q0.6240.98
86_G92_Q0.6240.98
131_I152_V0.6200.98
99_G147_M0.6180.98
58_G119_A0.6170.98
18_F31_L0.6140.97
86_G90_H0.6050.97
49_C52_C0.6030.97
48_E62_D0.6010.97
96_A101_V0.6010.97
66_Y74_K0.5990.97
38_L41_K0.5980.97
55_L58_G0.5970.97
118_L121_P0.5960.97
58_G77_R0.5930.97
118_L155_C0.5930.97
53_T113_A0.5920.97
44_C49_C0.5900.97
46_V62_D0.5820.97
34_E38_L0.5780.96
32_L40_V0.5770.96
32_L38_L0.5760.96
41_K62_D0.5720.96
44_C52_C0.5720.96
82_E89_S0.5670.96
9_I68_A0.5600.96
27_P46_V0.5560.96
86_G89_S0.5540.95
137_G145_Y0.5530.95
55_L119_A0.5520.95
117_M123_E0.5490.95
93_Q96_A0.5480.95
24_P69_A0.5480.95
53_T138_N0.5420.95
42_Q48_E0.5410.95
68_A71_A0.5380.95
26_T30_E0.5370.95
27_P45_C0.5370.95
125_P134_G0.5350.95
88_L93_Q0.5310.94
112_M134_G0.5280.94
25_G67_L0.5270.94
62_D113_A0.5260.94
84_K88_L0.5250.94
22_A26_T0.5240.94
42_Q62_D0.5210.94
42_Q105_F0.5170.93
28_L66_Y0.5170.93
11_C71_A0.5150.93
9_I69_A0.5120.93
89_S93_Q0.5120.93
29_S45_C0.5110.93
101_V144_G0.5070.93
110_L137_G0.5060.93
40_V80_E0.5060.93
46_V65_L0.5050.93
62_D65_L0.5040.93
96_A99_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.9371 100 0.047 Contact Map
3zyvA 3 0.9434 100 0.056 Contact Map
2w3sA 1 0.9245 100 0.094 Contact Map
3nvwA 1 0.9497 100 0.095 Contact Map
1dgjA 1 0.956 100 0.121 Contact Map
4usaA 2 0.956 100 0.133 Contact Map
1n62A 1 0.956 100 0.182 Contact Map
3hrdD 1 0.9686 100 0.189 Contact Map
1rm6C 1 0.9623 100 0.236 Contact Map
1t3qA 1 0.9686 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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