GREMLIN Database
XDHB - Xanthine dehydrogenase FAD-binding subunit
UniProt: Q46800 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13050
Length: 292 (275)
Sequences: 5984 (4116)
Seq/√Len: 248.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_R231_E3.6591.00
134_K145_F3.6451.00
70_R168_A3.3141.00
136_E170_H3.2531.00
136_E168_A2.9651.00
137_I146_V2.9501.00
144_R164_E2.6981.00
60_G75_T2.6451.00
136_E143_V2.6161.00
116_C166_L2.4931.00
20_L28_L2.4191.00
212_E235_Q2.3711.00
145_F170_H2.2521.00
68_S170_H2.1841.00
147_P150_G2.1451.00
249_E273_Q2.1161.00
59_R79_Q2.0991.00
63_L173_P2.0861.00
138_H143_V1.9881.00
204_R211_S1.9451.00
75_T80_L1.9201.00
9_R54_N1.8831.00
135_L166_L1.8551.00
8_H48_H1.8511.00
12_T15_D1.8461.00
136_E145_F1.8351.00
69_L86_T1.8051.00
204_R212_E1.7971.00
78_T107_N1.7911.00
146_V159_S1.7831.00
137_I160_L1.7821.00
132_D149_N1.7741.00
11_A15_D1.7661.00
138_H167_V1.7541.00
76_T79_Q1.7231.00
206_D211_S1.7191.00
233_T250_S1.7061.00
70_R170_H1.6941.00
18_N22_D1.6921.00
14_A138_H1.6881.00
64_A67_G1.6851.00
52_I74_A1.6781.00
210_F213_L1.6601.00
186_Y271_L1.6401.00
245_E277_K1.6331.00
134_K170_H1.6251.00
63_L89_H1.6201.00
112_G166_L1.6131.00
198_G218_G1.6121.00
179_A202_H1.5981.00
8_H19_L1.5831.00
123_D185_K1.5821.00
64_A70_R1.5681.00
62_T70_R1.5521.00
71_I80_L1.5481.00
78_T82_E1.5461.00
134_K147_P1.5101.00
229_H254_D1.4981.00
184_F282_E1.4891.00
118_G158_V1.4841.00
217_F227_C1.4821.00
28_L165_I1.4781.00
141_R163_D1.4661.00
232_Q235_Q1.4501.00
20_L50_V1.4441.00
239_L244_L1.4401.00
141_R161_E1.4401.00
68_S173_P1.4391.00
143_V167_V1.4381.00
28_L52_I1.4381.00
241_L281_S1.4341.00
180_G283_A1.4151.00
233_T243_T1.4051.00
135_L148_I1.3831.00
149_N228_Q1.3751.00
153_T159_S1.3651.00
25_Q47_R1.3521.00
179_A204_R1.3481.00
19_L50_V1.3401.00
16_A165_I1.3351.00
29_L49_I1.3311.00
203_C213_L1.3281.00
126_T218_G1.3001.00
17_I139_S1.2991.00
13_L165_I1.2941.00
270_H274_T1.2941.00
30_A74_A1.2911.00
217_F272_I1.2901.00
229_H232_Q1.2871.00
20_L163_D1.2721.00
201_A279_V1.2691.00
129_L148_I1.2641.00
201_A215_L1.2601.00
182_A282_E1.2501.00
64_A68_S1.2411.00
184_F278_K1.2381.00
77_F109_A1.2351.00
241_L245_E1.2281.00
13_L138_H1.2271.00
6_S48_H1.2211.00
27_K44_D1.2161.00
53_H76_T1.2071.00
77_F124_S1.1971.00
227_C230_A1.1931.00
259_S266_E1.1881.00
61_I83_D1.1851.00
115_I169_F1.1781.00
122_A125_A1.1741.00
89_H173_P1.1731.00
237_A246_A1.1711.00
71_I171_F1.1561.00
10_A52_I1.1551.00
111_Y169_F1.1531.00
67_G173_P1.1521.00
70_R136_E1.1481.00
246_A249_E1.1471.00
228_Q232_Q1.1441.00
17_I138_H1.1421.00
9_R51_D1.1401.00
229_H253_Q1.1391.00
17_I140_P1.1351.00
203_C210_F1.1311.00
7_Y51_D1.1301.00
59_R76_T1.1291.00
26_A50_V1.1271.00
186_Y275_M1.1241.00
187_A193_D1.1221.00
277_K281_S1.1191.00
17_I165_I1.1111.00
15_D18_N1.1101.00
130_I216_A1.1061.00
252_L273_Q1.1031.00
153_T157_K1.0971.00
240_N243_T1.0961.00
213_L235_Q1.0851.00
96_A127_P1.0821.00
244_L248_S1.0801.00
56_A59_R1.0751.00
61_I75_T1.0671.00
80_L111_Y1.0641.00
77_F100_I1.0581.00
115_I128_T1.0511.00
10_A15_D1.0461.00
139_S142_G1.0441.00
237_A243_T1.0441.00
73_S112_G1.0381.00
93_L124_S1.0341.00
63_L85_I1.0331.00
209_N238_P1.0321.00
116_C151_F1.0311.00
28_L50_V1.0301.00
100_I109_A1.0221.00
230_A250_S1.0201.00
233_T237_A1.0201.00
257_P269_L1.0201.00
95_A282_E1.0121.00
15_D19_L1.0021.00
137_I164_E1.0021.00
210_F239_L0.9991.00
60_G168_A0.9911.00
29_L32_G0.9901.00
30_A110_T0.9871.00
230_A254_D0.9841.00
251_V276_T0.9771.00
93_L127_P0.9671.00
125_A152_H0.9631.00
78_T81_I0.9601.00
217_F220_A0.9591.00
92_A181_S0.9581.00
234_A247_I0.9571.00
13_L17_I0.9531.00
215_L230_A0.9481.00
202_H214_R0.9451.00
128_T135_L0.9411.00
274_T278_K0.9391.00
246_A250_S0.9381.00
242_Q246_A0.9341.00
161_E164_E0.9281.00
250_S253_Q0.9241.00
195_S198_G0.9101.00
248_S277_K0.9061.00
14_A57_E0.9011.00
59_R74_A0.8991.00
233_T246_A0.8991.00
68_S172_P0.8931.00
257_P266_E0.8911.00
76_T110_T0.8861.00
178_H204_R0.8841.00
85_I89_H0.8751.00
184_F279_V0.8720.99
279_V283_A0.8720.99
213_L234_A0.8710.99
265_K269_L0.8710.99
63_L69_L0.8710.99
23_N48_H0.8670.99
238_P243_T0.8670.99
71_I111_Y0.8640.99
77_F97_A0.8600.99
34_D117_N0.8580.99
11_A54_N0.8540.99
259_S265_K0.8530.99
270_H273_Q0.8500.99
129_L149_N0.8490.99
135_L151_F0.8480.99
128_T133_A0.8470.99
111_Y124_S0.8460.99
21_A163_D0.8360.99
149_N226_R0.8320.99
78_T103_P0.8290.99
181_S202_H0.8270.99
129_L152_H0.8240.99
52_I165_I0.8230.99
244_L280_I0.8200.99
211_S235_Q0.8160.99
263_A268_R0.8150.99
64_A170_H0.8100.99
220_A272_I0.8090.99
53_H74_A0.8060.99
128_T171_F0.8030.99
13_L57_E0.7970.99
139_S164_E0.7970.99
217_F276_T0.7950.99
199_C275_M0.7910.99
97_A100_I0.7910.99
84_P88_R0.7870.99
132_D226_R0.7850.99
183_H198_G0.7850.99
79_Q83_D0.7840.99
249_E253_Q0.7840.99
13_L58_L0.7830.99
14_A18_N0.7830.99
114_N124_S0.7820.99
16_A55_L0.7820.99
126_T198_G0.7790.99
136_E167_V0.7760.99
230_A247_I0.7710.99
148_I152_H0.7670.99
228_Q231_E0.7670.99
189_R193_D0.7650.99
69_L173_P0.7630.99
245_E249_E0.7620.99
81_I98_T0.7580.99
175_P179_A0.7570.99
63_L68_S0.7560.99
151_F159_S0.7550.99
32_G36_L0.7520.99
75_T111_Y0.7470.98
248_S276_T0.7440.98
58_L74_A0.7430.98
175_P204_R0.7410.98
21_A140_P0.7390.98
132_D214_R0.7340.98
184_F275_M0.7300.98
85_I88_R0.7290.98
216_A226_R0.7260.98
80_L124_S0.7250.98
34_D119_A0.7210.98
144_R161_E0.7200.98
205_L208_G0.7150.98
88_R91_P0.7130.98
215_L227_C0.7110.98
137_I144_R0.7080.98
95_A182_A0.7040.98
90_L171_F0.6960.98
269_L273_Q0.6960.98
60_G79_Q0.6950.98
16_A28_L0.6950.98
151_F160_L0.6940.97
29_L36_L0.6940.97
265_K268_R0.6900.97
197_I220_A0.6860.97
29_L35_V0.6840.97
77_F101_A0.6840.97
239_L243_T0.6830.97
117_N122_A0.6810.97
149_N214_R0.6810.97
174_Q179_A0.6780.97
237_A240_N0.6770.97
75_T79_Q0.6760.97
115_I148_I0.6750.97
221_A225_I0.6720.97
87_Q94_C0.6690.97
243_T246_A0.6690.97
10_A13_L0.6680.97
227_C251_V0.6620.97
131_Y171_F0.6610.97
132_D147_P0.6600.97
189_R194_I0.6600.97
251_V254_D0.6580.97
34_D37_I0.6570.97
160_L163_D0.6560.96
260_S268_R0.6550.96
26_A48_H0.6550.96
130_I200_A0.6550.96
90_L173_P0.6540.96
40_H102_G0.6530.96
115_I125_A0.6530.96
217_F255_V0.6500.96
225_I255_V0.6490.96
20_L162_H0.6480.96
95_A181_S0.6460.96
81_I97_A0.6450.96
248_S251_V0.6430.96
133_A171_F0.6420.96
23_N26_A0.6400.96
210_F244_L0.6390.96
59_R75_T0.6350.96
111_Y128_T0.6350.96
63_L66_D0.6330.96
175_P178_H0.6250.95
119_A194_I0.6230.95
101_A105_I0.6220.95
92_A131_Y0.6210.95
148_I151_F0.6210.95
190_D193_D0.6190.95
62_T168_A0.6190.95
33_T114_N0.6120.95
133_A169_F0.6080.95
69_L90_L0.6060.95
95_A99_S0.6050.95
92_A202_H0.6040.94
34_D193_D0.6030.94
248_S273_Q0.6020.94
152_H224_P0.6010.94
75_T112_G0.6000.94
83_D86_T0.5970.94
252_L272_I0.5970.94
154_G222_P0.5960.94
154_G157_K0.5960.94
30_A52_I0.5830.93
61_I71_I0.5830.93
129_L224_P0.5810.93
255_V272_I0.5800.93
58_L73_S0.5800.93
8_H15_D0.5790.93
170_H173_P0.5790.93
81_I103_P0.5790.93
57_E60_G0.5790.93
192_M195_S0.5780.93
118_G152_H0.5780.93
208_G239_L0.5740.93
214_R226_R0.5730.93
33_T102_G0.5700.93
77_F80_L0.5680.92
244_L281_S0.5670.92
187_A194_I0.5650.92
23_N47_R0.5620.92
135_L146_V0.5610.92
213_L231_E0.5590.92
77_F111_Y0.5590.92
34_D38_Q0.5570.92
137_I159_S0.5560.92
181_S200_A0.5560.92
110_T113_G0.5540.92
102_G185_K0.5520.91
249_E277_K0.5510.91
14_A143_V0.5510.91
101_A192_M0.5510.91
150_G159_S0.5490.91
86_T94_C0.5480.91
34_D194_I0.5460.91
117_N156_G0.5450.91
71_I75_T0.5440.91
146_V151_F0.5440.91
52_I58_L0.5430.91
81_I94_C0.5420.91
239_L283_A0.5420.91
63_L67_G0.5410.91
68_S171_F0.5400.90
274_T277_K0.5400.90
21_A139_S0.5390.90
20_L26_A0.5370.90
266_E270_H0.5370.90
271_L275_M0.5360.90
117_N194_I0.5330.90
139_S161_E0.5330.90
21_A141_R0.5300.90
257_P260_S0.5300.90
252_L269_L0.5270.89
121_S219_V0.5270.89
80_L97_A0.5240.89
221_A224_P0.5230.89
94_C98_T0.5220.89
28_L163_D0.5220.89
227_C254_D0.5210.89
86_T91_P0.5210.89
185_K195_S0.5200.89
205_L210_F0.5190.89
17_I21_A0.5170.88
33_T123_D0.5130.88
86_T90_L0.5120.88
96_A100_I0.5120.88
114_N194_I0.5110.88
18_N140_P0.5110.88
77_F81_I0.5110.88
194_I219_V0.5110.88
122_A194_I0.5100.88
119_A156_G0.5100.88
271_L274_T0.5100.88
215_L247_I0.5090.88
151_F158_V0.5080.88
210_F235_Q0.5080.88
38_Q156_G0.5070.88
102_G192_M0.5070.88
230_A233_T0.5070.88
259_S268_R0.5050.87
20_L27_K0.5030.87
46_Y49_I0.5010.87
38_Q41_H0.5010.87
38_Q117_N0.5000.87
90_L131_Y0.5000.87
154_G223_T0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6B 1 0.9589 100 0.117 Contact Map
1n62C 1 0.9726 100 0.13 Contact Map
1t3qC 1 0.9726 100 0.13 Contact Map
3zyvA 3 0.9829 100 0.139 Contact Map
3hrdC 1 0.976 100 0.148 Contact Map
1ffvC 1 0.976 100 0.162 Contact Map
2w3sA 1 0.9623 100 0.165 Contact Map
3uncA 2 0.9897 100 0.171 Contact Map
3nvzB 1 0.9795 100 0.181 Contact Map
4pytA 1 0.8014 98.1 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.