GREMLIN Database
YGER - Uncharacterized lipoprotein YgeR
UniProt: Q46798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13048
Length: 251 (204)
Sequences: 6709 (5589)
Seq/√Len: 391.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_V198_M3.6031.00
195_N213_A3.5061.00
152_A215_M3.2871.00
217_S221_A3.2731.00
158_I195_N3.0081.00
184_H190_T2.8501.00
199_L214_T2.7901.00
157_P211_K2.7741.00
128_W150_I2.6451.00
137_P239_L2.6241.00
135_I151_S2.6231.00
211_K214_T2.3371.00
163_A207_K2.2771.00
127_L208_A2.2391.00
165_K205_S2.1721.00
176_Y193_A2.1101.00
154_R223_V2.0471.00
149_D226_H2.0231.00
200_V204_Q2.0231.00
181_M191_A1.9891.00
161_A227_F1.9811.00
167_V189_I1.8591.00
154_R196_D1.8541.00
133_K151_S1.8461.00
195_N198_M1.8211.00
196_D214_T1.8191.00
161_A190_T1.7951.00
197_T214_T1.7931.00
138_Y235_A1.7821.00
152_A156_T1.7761.00
160_A182_I1.7471.00
215_M223_V1.7431.00
42_Y48_D1.6851.00
181_M189_I1.6621.00
159_Y211_K1.6531.00
190_T229_I1.6381.00
179_L191_A1.5961.00
167_V183_K1.5511.00
90_S94_R1.5261.00
207_K210_Q1.4851.00
158_I215_M1.4741.00
182_I212_I1.4491.00
201_N204_Q1.4431.00
188_Y231_Y1.4381.00
230_R235_A1.4301.00
132_G150_I1.4271.00
153_P156_T1.4141.00
162_G208_A1.4011.00
78_V82_L1.3921.00
171_N178_N1.3811.00
136_M141_A1.3791.00
42_Y57_T1.3751.00
149_D224_R1.3611.00
146_K228_Q1.3531.00
148_I239_L1.3471.00
237_D240_R1.3421.00
89_S93_T1.3251.00
168_Y179_L1.2901.00
145_N149_D1.2881.00
141_A144_G1.2841.00
98_A102_T1.2811.00
46_R49_T1.2641.00
97_T101_T1.2521.00
88_K92_I1.2481.00
180_I195_N1.2381.00
99_K103_K1.2381.00
97_T100_S1.2291.00
93_T97_T1.2171.00
95_K99_K1.2141.00
180_I212_I1.2101.00
145_N224_R1.2071.00
131_T159_Y1.1791.00
86_G90_S1.1671.00
95_K98_A1.1421.00
63_E67_L1.1291.00
164_G182_I1.1281.00
57_T60_S1.1201.00
199_L211_K1.1191.00
199_L213_A1.1161.00
179_L193_A1.1141.00
130_T152_A1.1021.00
92_I96_S1.0881.00
86_G89_S1.0851.00
188_Y229_I1.0811.00
157_P214_T1.0771.00
91_S95_K1.0741.00
44_V47_G1.0671.00
96_S100_S1.0601.00
88_K91_S1.0591.00
130_T156_T1.0571.00
148_I238_P1.0531.00
168_Y181_M1.0511.00
161_A192_Y1.0351.00
91_S94_R1.0271.00
98_A101_T1.0161.00
165_K183_K1.0161.00
215_M225_L1.0131.00
36_T39_G1.0111.00
154_R217_S1.0101.00
100_S103_K1.0061.00
42_Y45_K1.0011.00
87_A91_S0.9961.00
92_I95_K0.9951.00
77_E80_Q0.9911.00
79_G82_L0.9891.00
94_R98_A0.9881.00
96_S99_K0.9881.00
33_D37_Y0.9861.00
236_I241_Y0.9831.00
94_R97_T0.9821.00
43_T47_G0.9781.00
70_I73_P0.9711.00
231_Y236_I0.9691.00
40_S44_V0.9621.00
193_A228_Q0.9621.00
200_V210_Q0.9601.00
52_R56_T0.9601.00
76_I80_Q0.9591.00
137_P237_D0.9571.00
89_S92_I0.9541.00
136_M145_N0.9531.00
130_T215_M0.9471.00
134_V148_I0.9391.00
75_T79_G0.9381.00
178_N218_T0.9321.00
128_W242_L0.9291.00
32_S35_G0.9261.00
82_L86_G0.9261.00
61_V65_A0.9251.00
39_G43_T0.9221.00
176_Y230_R0.9071.00
194_H219_D0.9061.00
163_A208_A0.8961.00
49_T52_R0.8881.00
90_S93_T0.8851.00
183_K187_D0.8841.00
99_K102_T0.8821.00
126_W188_Y0.8811.00
57_T61_V0.8711.00
191_A230_R0.8691.00
135_I222_S0.8671.00
189_I230_R0.8671.00
74_Y78_V0.8661.00
74_Y77_E0.8651.00
151_S222_S0.8641.00
148_I242_L0.8621.00
30_K33_D0.8571.00
100_S104_T0.8471.00
146_K235_A0.8421.00
36_T40_S0.8401.00
195_N215_M0.8321.00
166_V200_V0.8321.00
101_T104_T0.8321.00
178_N198_M0.8311.00
44_V48_D0.8301.00
176_Y191_A0.8301.00
54_S57_T0.8301.00
87_A90_S0.8271.00
68_N71_S0.8241.00
156_T215_M0.8231.00
194_H218_T0.8211.00
85_G88_K0.8171.00
125_C162_G0.8141.00
221_A224_R0.8111.00
35_G38_S0.7991.00
176_Y228_Q0.7961.00
168_Y173_L0.7961.00
130_T150_I0.7941.00
64_L68_N0.7931.00
135_I145_N0.7821.00
47_G51_Y0.7811.00
63_E66_R0.7771.00
38_S42_Y0.7771.00
65_A68_N0.7701.00
145_N226_H0.7701.00
60_S63_E0.7681.00
33_D36_T0.7651.00
128_W131_T0.7631.00
80_Q84_L0.7571.00
143_G220_A0.7521.00
217_S223_V0.7461.00
194_H224_R0.7411.00
35_G39_G0.7351.00
195_N225_L0.7341.00
62_K66_R0.7311.00
80_Q83_K0.7311.00
95_K100_S0.7291.00
59_T63_E0.7231.00
64_L67_L0.7221.00
175_G193_A0.7221.00
31_S35_G0.7221.00
101_T105_A0.7161.00
126_W162_G0.7161.00
77_E81_K0.7071.00
173_L179_L0.7031.00
85_G89_S0.7011.00
31_S34_T0.6981.00
126_W229_I0.6981.00
83_K87_A0.6920.99
46_R50_L0.6890.99
49_T53_I0.6840.99
39_G42_Y0.6820.99
92_I99_K0.6780.99
163_A205_S0.6760.99
124_R162_G0.6720.99
155_G196_D0.6700.99
162_G184_H0.6680.99
58_G61_V0.6650.99
40_S43_T0.6650.99
48_D52_R0.6650.99
139_S144_G0.6620.99
93_T96_S0.6580.99
169_V200_V0.6570.99
138_Y234_T0.6570.99
37_Y40_S0.6530.99
45_K49_T0.6530.99
135_I224_R0.6530.99
126_W190_T0.6520.99
176_Y179_L0.6470.99
56_T60_S0.6430.99
62_K65_A0.6420.99
42_Y46_R0.6420.99
134_V137_P0.6410.99
134_V239_L0.6370.99
76_I79_G0.6360.99
127_L161_A0.6360.99
228_Q235_A0.6350.99
51_Y55_R0.6340.99
81_K84_L0.6310.99
95_K103_K0.6300.99
91_S98_A0.6280.99
181_M230_R0.6270.99
149_D194_H0.6270.99
140_T143_G0.6260.99
191_A228_Q0.6230.99
184_H192_Y0.6230.99
127_L159_Y0.6220.99
116_S119_P0.6190.99
34_T37_Y0.6140.99
188_Y241_Y0.6100.99
91_S99_K0.6070.99
30_K34_T0.6070.99
183_K189_I0.6060.99
190_T227_F0.6050.99
121_V125_C0.6030.99
155_G214_T0.6020.99
227_F242_L0.6020.99
58_G62_K0.6020.99
183_K232_R0.5980.99
187_D231_Y0.5910.98
66_R70_I0.5870.98
65_A69_G0.5860.98
83_K86_G0.5820.98
47_G53_I0.5800.98
160_A209_G0.5760.98
155_G215_M0.5710.98
51_Y54_S0.5710.98
43_T81_K0.5690.98
195_N199_L0.5690.98
139_S143_G0.5670.98
180_I200_V0.5670.98
123_Q162_G0.5660.98
140_T144_G0.5650.98
75_T78_V0.5630.98
158_I225_L0.5600.98
119_P122_G0.5570.98
137_P148_I0.5560.98
54_S68_N0.5520.98
145_N194_H0.5520.98
192_Y227_F0.5510.98
39_G46_R0.5480.97
54_S58_G0.5450.97
136_M149_D0.5450.97
32_S36_T0.5440.97
79_G83_K0.5440.97
119_P124_R0.5390.97
140_T146_K0.5390.97
41_V44_V0.5390.97
134_V150_I0.5380.97
152_A155_G0.5370.97
167_V202_N0.5360.97
118_W121_V0.5350.97
122_G162_G0.5350.97
41_V81_K0.5320.97
46_R60_S0.5310.97
99_K104_T0.5310.97
168_Y202_N0.5300.97
187_D232_R0.5300.97
78_V81_K0.5290.97
189_I233_A0.5280.97
41_V45_K0.5230.97
194_H221_A0.5220.97
177_G216_G0.5170.96
239_L242_L0.5160.96
53_I57_T0.5160.96
84_L87_A0.5150.96
145_N219_D0.5140.96
119_P123_Q0.5110.96
158_I213_A0.5100.96
53_I60_S0.5090.96
88_K95_K0.5080.96
102_T105_A0.5070.96
193_A230_R0.5060.96
231_Y240_R0.5010.96
179_L195_N0.5000.96
48_D51_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bh5A 4 0.502 100 0.372 Contact Map
2gu1A 1 0.9641 100 0.373 Contact Map
2hsiA 1 0.8008 100 0.379 Contact Map
3tufB 1 0.5139 100 0.392 Contact Map
1qwyA 1 0.7131 100 0.4 Contact Map
4rnzA 1 0.9562 100 0.41 Contact Map
3sluA 1 0.9761 100 0.413 Contact Map
3nyyA 2 0.8526 100 0.432 Contact Map
4qp5A 1 0.4821 100 0.448 Contact Map
4lxcA 4 0.5219 100 0.456 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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