GREMLIN Database
PBL - Putative peptidoglycan-binding-like protein
UniProt: Q46790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13040
Length: 158 (133)
Sequences: 661 (488)
Seq/√Len: 42.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_I110_T3.8161.00
141_K145_Y3.6441.00
114_Y118_S3.3701.00
73_Y83_I3.2761.00
49_V148_K3.1121.00
28_C103_C2.9331.00
76_M109_G2.8691.00
145_Y149_Y2.8621.00
116_H129_T2.8421.00
63_D70_S2.7751.00
124_W127_L2.5981.00
72_D79_N2.5741.00
74_W105_N2.4151.00
33_G40_P2.3121.00
35_M107_K1.9940.99
71_L93_K1.8210.98
120_C126_C1.7700.98
54_K57_S1.7590.98
33_G38_I1.7290.98
47_A76_M1.7180.97
70_S79_N1.6690.97
141_K149_Y1.6360.97
85_L115_N1.5690.96
61_N72_D1.5630.96
27_S106_I1.5480.95
73_Y93_K1.5330.95
48_L53_L1.5200.95
48_L52_N1.5120.95
133_G145_Y1.4920.94
29_S106_I1.4640.94
138_N142_R1.4580.94
82_H112_I1.4250.93
142_R145_Y1.4240.93
145_Y148_K1.4030.92
61_N79_N1.3990.92
49_V149_Y1.3840.92
32_A110_T1.2800.88
124_W128_G1.2680.88
103_C124_W1.2670.88
61_N70_S1.2380.86
82_H116_H1.2190.85
82_H86_L1.1790.83
19_T24_A1.1680.83
63_D79_N1.1620.83
135_A141_K1.1580.82
29_S43_I1.1570.82
29_S47_A1.1360.81
18_I22_S1.1310.81
59_G80_Q1.1250.80
116_H133_G1.1210.80
14_F17_F1.1190.80
142_R146_A1.1170.80
83_I108_I1.0960.79
28_C124_W1.0890.78
70_S81_M1.0760.77
27_S44_K1.0700.77
138_N141_K1.0560.76
126_C129_T1.0360.75
42_L131_N1.0330.74
133_G137_D1.0010.72
60_K71_L0.9990.72
128_G132_A0.9930.71
14_F19_T0.9820.71
132_A141_K0.9680.69
63_D72_D0.9490.68
46_I113_L0.9470.68
43_I109_G0.9400.67
28_C32_A0.9390.67
125_Q138_N0.9390.67
132_A135_A0.9360.67
143_Q147_P0.9280.66
29_S39_E0.9180.65
98_L126_C0.9150.65
63_D81_M0.9030.64
134_F141_K0.9000.64
29_S33_G0.8930.63
73_Y80_Q0.8910.63
116_H126_C0.8870.63
47_A75_L0.8850.62
110_T113_L0.8790.62
32_A106_I0.8760.62
76_M106_I0.8700.61
128_G142_R0.8660.61
17_F20_K0.8540.60
59_G73_Y0.8530.60
29_S44_K0.8520.60
117_F123_T0.8520.60
20_K23_F0.8510.59
104_L108_I0.8510.59
29_S105_N0.8490.59
36_F107_K0.8460.59
97_D111_E0.8420.59
111_E124_W0.8380.58
32_A103_C0.8340.58
82_H85_L0.8300.57
50_E72_D0.8210.57
58_I99_L0.8140.56
49_V144_Q0.8130.56
12_F15_C0.7980.55
59_G71_L0.7910.54
51_S57_S0.7870.53
15_C18_I0.7790.53
59_G62_R0.7640.51
26_N30_N0.7640.51
60_K135_A0.7530.50
86_L91_I0.7480.50
18_I23_F0.7400.49
88_K140_K0.7360.49
140_K144_Q0.7360.49
146_A149_Y0.7290.48
129_T132_A0.7250.48
51_S123_T0.7220.47
49_V152_Y0.7190.47
61_N103_C0.7180.47
17_F24_A0.7180.47
32_A107_K0.7110.46
49_V52_N0.7090.46
97_D101_N0.7050.46
125_Q143_Q0.7040.46
116_H120_C0.7030.46
51_S59_G0.6990.45
93_K108_I0.6830.44
17_F21_M0.6800.43
22_S25_S0.6770.43
58_I131_N0.6770.43
141_K146_A0.6620.42
83_I149_Y0.6600.42
109_G113_L0.6580.41
27_S30_N0.6550.41
136_M140_K0.6540.41
37_R114_Y0.6470.40
82_H104_L0.6460.40
92_I97_D0.6460.40
89_R125_Q0.6460.40
18_I93_K0.6410.40
40_P128_G0.6410.40
116_H131_N0.6400.40
49_V145_Y0.6390.40
16_I22_S0.6390.40
12_F16_I0.6350.39
87_K92_I0.6300.39
144_Q147_P0.6280.39
14_F56_D0.6250.38
37_R151_L0.6190.38
32_A78_I0.6140.37
18_I58_I0.6040.37
114_Y131_N0.6040.37
22_S96_R0.6010.36
124_W146_A0.5950.36
106_I142_R0.5930.36
13_T16_I0.5910.35
72_D131_N0.5910.35
39_E122_V0.5900.35
13_T17_F0.5890.35
103_C128_G0.5880.35
83_I91_I0.5870.35
78_I108_I0.5850.35
12_F18_I0.5840.35
39_E123_T0.5830.35
45_A127_L0.5780.34
63_D135_A0.5740.34
88_K96_R0.5730.34
15_C20_K0.5720.34
117_F126_C0.5670.33
13_T19_T0.5660.33
46_I75_L0.5590.33
57_S77_Q0.5560.32
134_F137_D0.5550.32
27_S31_E0.5540.32
117_F122_V0.5530.32
14_F20_K0.5520.32
31_E106_I0.5500.32
18_I21_M0.5480.32
105_N150_I0.5410.31
32_A128_G0.5400.31
44_K128_G0.5390.31
149_Y152_Y0.5380.31
109_G131_N0.5370.31
41_N44_K0.5350.31
33_G37_R0.5330.31
109_G114_Y0.5320.31
17_F22_S0.5290.30
36_F109_G0.5280.30
116_H127_L0.5280.30
117_F150_I0.5210.30
15_C21_M0.5210.30
132_A137_D0.5210.30
64_K79_N0.5190.29
55_K121_G0.5170.29
19_T26_N0.5160.29
82_H108_I0.5150.29
64_K134_F0.5150.29
106_I139_Q0.5140.29
28_C128_G0.5110.29
116_H119_R0.5080.29
139_Q143_Q0.5030.28
112_I131_N0.5030.28
39_E131_N0.5010.28
13_T21_M0.5010.28
14_F23_F0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lsgA 1 0.7595 99.9 0.51 Contact Map
4xp8A 1 0.5443 99.9 0.552 Contact Map
1gbsA 1 0.8987 99.9 0.557 Contact Map
3w6bA 1 0.8481 99.9 0.559 Contact Map
3b72A 1 0.7152 99.9 0.564 Contact Map
3gxrA 1 0.8987 99.9 0.565 Contact Map
4hjzA 1 0.8861 99.9 0.567 Contact Map
4g9sA 1 0.8987 99.9 0.572 Contact Map
1qsaA 1 0.9367 99.8 0.582 Contact Map
4cfpA 1 0.9304 99.8 0.592 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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