GREMLIN Database
YGEG - Uncharacterized protein YgeG
UniProt: Q46787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13037
Length: 163 (128)
Sequences: 34056 (30059)
Seq/√Len: 2656.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_I131_C2.7711.00
89_K92_Q2.7321.00
43_I62_Y2.5781.00
124_N127_N2.5691.00
55_N58_D2.4921.00
77_L96_L2.4571.00
81_A97_Y2.4501.00
47_A63_Y2.4431.00
116_G132_F2.3391.00
115_M131_C2.2941.00
46_Y62_Y2.2671.00
98_K115_M2.2101.00
80_F96_L2.0181.00
21_H24_S2.0051.00
64_K80_F1.9721.00
84_C96_L1.9641.00
63_Y79_D1.9471.00
84_C92_Q1.9091.00
29_L45_A1.8981.00
119_Q131_C1.8531.00
50_Y58_D1.8061.00
97_Y114_R1.7781.00
119_Q127_N1.7691.00
50_Y62_Y1.7601.00
60_E64_K1.5631.00
94_Y98_K1.5121.00
60_E87_K1.5041.00
30_A46_Y1.4561.00
60_E84_C1.4101.00
129_M133_Y1.3941.00
94_Y119_Q1.3851.00
94_Y122_A1.3041.00
67_C77_L1.2921.00
100_S111_V1.2801.00
77_L99_L1.2711.00
115_M119_Q1.2491.00
119_Q124_N1.2491.00
26_G30_A1.2411.00
66_L76_Y1.2371.00
80_F84_C1.2231.00
26_G53_K1.2211.00
50_Y55_N1.2111.00
32_L42_R1.1961.00
101_Y112_I1.1851.00
84_C89_K1.1701.00
108_D111_V1.1691.00
39_I42_R1.1671.00
82_S114_R1.1631.00
43_I65_F1.1601.00
46_Y50_Y1.1581.00
139_C142_D1.1461.00
26_G50_Y1.1261.00
112_I134_H1.1251.00
73_N76_Y1.1001.00
105_P108_D1.0991.00
33_H43_I1.0931.00
94_Y115_M1.0581.00
142_D145_K1.0581.00
60_E80_F1.0441.00
113_Y117_Q1.0261.00
51_H79_D1.0231.00
48_F79_D1.0061.00
134_H138_N0.9961.00
101_Y111_V0.9951.00
92_Q95_D0.9941.00
99_L103_Y0.9851.00
44_Y48_F0.9571.00
78_K114_R0.9481.00
81_A93_A0.9361.00
33_H46_Y0.9341.00
67_C76_Y0.9341.00
70_A73_N0.9311.00
109_Y139_C0.9281.00
114_R117_Q0.9271.00
112_I135_I0.9271.00
65_F69_Y0.9131.00
36_T39_I0.9051.00
60_E83_V0.9041.00
43_I66_L0.9031.00
116_G128_A0.9001.00
127_N130_Q0.8971.00
78_K82_S0.8941.00
116_G135_I0.8901.00
85_Q114_R0.8901.00
94_Y118_C0.8861.00
44_Y76_Y0.8831.00
91_Q122_A0.8801.00
57_T87_K0.8771.00
58_D61_I0.8581.00
90_Y118_C0.8551.00
74_H100_S0.8521.00
40_L66_L0.8441.00
47_A59_A0.8431.00
28_N31_L0.8401.00
77_L100_S0.8391.00
131_C134_H0.8361.00
99_L102_N0.8351.00
82_S85_Q0.8301.00
85_Q121_G0.8281.00
120_I125_I0.8241.00
51_H86_P0.8211.00
44_Y79_D0.8171.00
48_F51_H0.8151.00
109_Y135_I0.8141.00
33_H42_R0.8101.00
56_I83_V0.8041.00
135_I145_K0.7991.00
56_I86_P0.7981.00
117_Q120_I0.7971.00
51_H83_V0.7941.00
90_Y121_G0.7941.00
83_V87_K0.7921.00
49_D53_K0.7881.00
62_Y65_F0.7741.00
96_L99_L0.7641.00
32_L35_L0.7611.00
118_C122_A0.7581.00
134_H137_N0.7481.00
117_Q121_G0.7481.00
78_K108_D0.7431.00
74_H105_P0.7341.00
94_Y124_N0.7341.00
120_I132_F0.7281.00
48_F52_E0.7281.00
44_Y73_N0.7251.00
17_N45_A0.7241.00
43_I69_Y0.7231.00
127_N131_C0.7221.00
60_E89_K0.7191.00
112_I138_N0.7071.00
97_Y118_C0.7051.00
45_A48_F0.7021.00
113_Y135_I0.7021.00
85_Q93_A0.6991.00
67_C80_F0.6881.00
26_G46_Y0.6811.00
40_L70_A0.6761.00
23_L53_K0.6731.00
82_S86_P0.6681.00
77_L103_Y0.6501.00
26_G49_D0.6491.00
74_H108_D0.6471.00
31_L35_L0.6451.00
85_Q90_Y0.6401.00
22_A49_D0.6301.00
24_S27_E0.6301.00
56_I87_K0.6261.00
47_A66_L0.6251.00
85_Q118_C0.6221.00
29_L46_Y0.6211.00
100_S103_Y0.6121.00
81_A100_S0.6111.00
65_F68_I0.6111.00
98_K131_C0.6041.00
90_Y122_A0.6021.00
64_K96_L0.6001.00
58_D62_Y0.5961.00
27_E31_L0.5951.00
98_K119_Q0.5891.00
119_Q122_A0.5881.00
51_H56_I0.5871.00
113_Y142_D0.5841.00
28_N32_L0.5811.00
79_D82_S0.5801.00
59_A83_V0.5791.00
136_I145_K0.5761.00
130_Q134_H0.5711.00
120_I128_A0.5681.00
40_L47_A0.5631.00
78_K111_V0.5631.00
125_I129_M0.5611.00
92_Q96_L0.5481.00
59_A63_Y0.5391.00
51_H59_A0.5331.00
133_Y136_I0.5301.00
130_Q133_Y0.5291.00
101_Y115_M0.5281.00
85_Q117_Q0.5251.00
95_D99_L0.5211.00
133_Y137_N0.5181.00
51_H63_Y0.5181.00
25_K32_L0.5181.00
61_I65_F0.5181.00
78_K110_S0.5151.00
93_A97_Y0.5091.00
24_S28_N0.5061.00
66_L69_Y0.5031.00
17_N22_A0.5031.00
22_A52_E0.5021.00
93_A118_C0.5021.00
82_S97_Y0.5011.00
98_K101_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pziA 1 0.9571 99.8 0.133 Contact Map
4l9pA 1 0.9939 99.8 0.167 Contact Map
3dssA 1 0.9816 99.8 0.17 Contact Map
3q7aA 1 0.9755 99.8 0.173 Contact Map
2h6fA 1 0.9939 99.7 0.177 Contact Map
2e2eA 2 0.9632 99.7 0.179 Contact Map
1dceA 1 0.9939 99.7 0.181 Contact Map
2vsyA 1 0.7669 99.7 0.184 Contact Map
3urzA 1 0.9509 99.7 0.187 Contact Map
4gywA 2 0.9816 99.7 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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