GREMLIN Database
YJHX - UPF0386 protein YjhX
UniProt: Q2EEU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14430
Length: 85 (85)
Sequences: 146 (103)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_C43_L3.4110.98
16_K56_T2.6260.90
1_M7_E2.3940.85
34_E42_L2.2890.82
61_K75_L2.2600.81
73_T77_K2.2560.81
72_T76_N2.0870.75
16_K39_E2.0550.74
10_T46_C1.9770.71
13_V43_L1.9540.70
24_R36_Y1.9540.70
45_D81_Q1.9270.69
61_K71_N1.8870.67
8_Q12_H1.7790.62
71_N75_L1.7260.60
2_N77_K1.7050.59
42_L47_T1.6860.58
27_S47_T1.6170.55
28_G81_Q1.6010.54
22_H71_N1.5910.54
79_R84_N1.4560.47
59_L77_K1.4250.46
3_L81_Q1.4020.44
7_E53_K1.3750.43
9_H65_G1.3120.40
41_L60_I1.2540.37
17_G38_R1.2500.37
24_R66_Q1.2230.36
67_P79_R1.2090.35
13_V41_L1.2060.35
50_V59_L1.1860.34
23_V66_Q1.1800.34
67_P84_N1.1250.32
43_L59_L1.1250.32
10_T85_R1.1160.31
2_N59_L1.0690.30
36_Y42_L1.0630.29
6_Q77_K1.0410.28
28_G47_T1.0260.28
43_L46_C1.0260.28
66_Q72_T1.0130.27
21_A55_K1.0060.27
12_H79_R0.9980.27
22_H30_V0.9980.27
46_C50_V0.9870.26
53_K65_G0.9780.26
13_V59_L0.9720.26
55_K71_N0.9700.26
2_N46_C0.9630.25
5_R81_Q0.9250.24
8_Q79_R0.9230.24
36_Y58_K0.9070.23
58_K81_Q0.8990.23
61_K72_T0.8880.23
25_D52_K0.8870.23
36_Y66_Q0.8870.23
6_Q45_D0.8840.23
26_S33_V0.8790.22
2_N45_D0.8780.22
35_C39_E0.8630.22
3_L71_N0.8600.22
33_V46_C0.8580.22
3_L60_I0.8510.22
41_L71_N0.8490.21
58_K63_V0.8410.21
8_Q67_P0.8130.20
1_M4_S0.8100.20
42_L61_K0.8040.20
31_T85_R0.7870.20
12_H67_P0.7860.19
4_S8_Q0.7820.19
12_H78_V0.7800.19
10_T45_D0.7780.19
7_E78_V0.7770.19
22_H55_K0.7550.19
31_T57_K0.7530.18
22_H33_V0.7430.18
36_Y49_A0.7380.18
45_D50_V0.7350.18
78_V84_N0.7300.18
79_R83_D0.7270.18
29_R49_A0.7250.18
29_R82_L0.7140.17
29_R39_E0.7100.17
5_R33_V0.6990.17
18_R62_S0.6870.17
24_R79_R0.6750.16
21_A31_T0.6720.16
19_R37_S0.6600.16
16_K53_K0.6580.16
5_R56_T0.6580.16
14_L57_K0.6450.16
80_A85_R0.6450.16
16_K85_R0.6420.15
44_T59_L0.6350.15
39_E69_R0.6280.15
10_T43_L0.6260.15
18_R74_E0.6240.15
3_L53_K0.6100.15
3_L61_K0.6060.15
2_N13_V0.6030.14
3_L23_V0.5910.14
8_Q78_V0.5890.14
6_Q10_T0.5880.14
48_L82_L0.5810.14
30_V65_G0.5800.14
62_S74_E0.5740.14
35_C45_D0.5720.14
19_R34_E0.5720.14
75_L79_R0.5670.14
67_P78_V0.5610.14
4_S7_E0.5600.13
47_T50_V0.5600.13
22_H28_G0.5420.13
53_K57_K0.5390.13
5_R20_I0.5370.13
2_N35_C0.5370.13
65_G72_T0.5360.13
5_R25_D0.5360.13
33_V66_Q0.5330.13
37_S42_L0.5270.13
5_R77_K0.5220.13
62_S68_Y0.5160.13
2_N10_T0.5150.13
75_L78_V0.5140.12
5_R82_L0.5110.12
10_T16_K0.5060.12
17_G68_Y0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9176 86.2 0.888 Contact Map
2rkhA 2 0.8118 69.3 0.905 Contact Map
3l9fA 2 0.8941 69.2 0.905 Contact Map
2x4hA 3 0.8588 66.2 0.907 Contact Map
1s3jA 2 0.8706 64.8 0.907 Contact Map
2e1nA 2 0.9294 63.8 0.908 Contact Map
2a61A 2 0.8706 60.3 0.91 Contact Map
2rdpA 2 0.8706 59.8 0.91 Contact Map
3echA 2 0.8353 58.4 0.911 Contact Map
3s2wA 3 0.8706 56.8 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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