ATOS - ECOLI - GREMLIN Contacts

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ATOS - Signal transduction histidine-protein kinase AtoS

UniProt:	Q06067	Sequences: MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQALGDRYDLYIDLPREERIRALNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALYQNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSMLPIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLPGEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQTV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11667
Length:	608 (569)
Sequences:	8021 (7109)
Seq/√Len:	298.0

ECOLI - ATOS DCUS DPIB RCSC BARA RCSD NARX ARCB NARQ TORS EVGS PHOR CREC ZRAS PHOQ GLRK QSEC CUSS BAES YEDV NTRB ENVZ
BACSU - YYCG PHOR RESE DCTS CITS MALK KINE KINA KINC YCLK YVRG KIND CSSS YKOH
HALSA - Q9HQ16 O51970 Q9HR10 Q9HQG5 Q9HRE4 Q9HRG1 Q9HNM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_L	244_G	4.975	1.00
227_T	231_N	4.915	1.00
587_L	590_Y	4.705	1.00
538_E	593_T	4.236	1.00
241_G	244_G	3.743	1.00
411_V	430_V	3.664	1.00
515_I	540_N	3.239	1.00
15_Q	241_G	3.226	1.00
235_R	258_R	3.150	1.00
549_Q	584_V	3.133	1.00
459_S	462_A	3.054	1.00
485_E	524_Q	2.939	1.00
235_R	251_N	2.884	1.00
583_R	595_T	2.879	1.00
503_V	574_I	2.826	1.00
584_V	594_F	2.808	1.00
279_D	283_D	2.780	1.00
535_I	596_L	2.745	1.00
483_I	520_K	2.739	1.00
273_D	368_S	2.671	1.00
225_L	253_L	2.650	1.00
524_Q	536_S	2.638	1.00
522_R	538_E	2.609	1.00
305_Q	309_M	2.574	1.00
105_N	109_D	2.531	1.00
458_V	495_A	2.528	1.00
495_A	578_H	2.497	1.00
575_I	596_L	2.488	1.00
572_Q	576_N	2.473	1.00
373_R	377_Q	2.457	1.00
532_Q	597_I	2.437	1.00
520_K	540_N	2.433	1.00
536_S	593_T	2.399	1.00
324_L	327_G	2.377	1.00
483_I	522_R	2.370	1.00
524_Q	538_E	2.310	1.00
503_V	575_I	2.280	1.00
228_L	253_L	2.247	1.00
306_P	309_M	2.235	1.00
526_W	534_A	2.226	1.00
571_S	582_I	2.225	1.00
261_R	265_D	2.153	1.00
574_I	578_H	2.147	1.00
575_I	580_G	2.108	1.00
11_R	14_N	2.107	1.00
534_A	597_I	2.091	1.00
515_I	519_G	2.087	1.00
289_P	293_V	2.076	1.00
461_N	525_T	2.059	1.00
585_A	593_T	2.013	1.00
290_A	293_V	2.003	1.00
536_S	595_T	1.992	1.00
251_N	254_A	1.990	1.00
235_R	255_Q	1.983	1.00
481_D	520_K	1.978	1.00
586_S	592_A	1.956	1.00
221_I	247_S	1.954	1.00
289_P	292_E	1.950	1.00
544_I	548_L	1.938	1.00
225_L	246_I	1.938	1.00
207_I	211_S	1.933	1.00
514_A	558_T	1.913	1.00
250_V	253_L	1.912	1.00
334_E	374_K	1.911	1.00
485_E	522_R	1.906	1.00
495_A	500_L	1.899	1.00
456_Q	497_R	1.891	1.00
260_T	263_L	1.846	1.00
235_R	254_A	1.844	1.00
317_Y	320_V	1.827	1.00
318_S	322_D	1.823	1.00
226_S	245_Q	1.804	1.00
407_I	411_V	1.801	1.00
472_Q	476_V	1.793	1.00
322_D	326_H	1.770	1.00
534_A	595_T	1.767	1.00
228_L	254_A	1.765	1.00
526_W	536_S	1.747	1.00
539_D	543_G	1.745	1.00
323_T	327_G	1.736	1.00
211_S	215_S	1.732	1.00
51_L	55_V	1.729	1.00
504_L	535_I	1.724	1.00
307_Y	310_L	1.720	1.00
545_D	548_L	1.715	1.00
166_G	170_G	1.714	1.00
447_F	451_R	1.686	1.00
586_S	590_Y	1.686	1.00
319_P	322_D	1.678	1.00
225_L	249_S	1.669	1.00
415_R	428_S	1.668	1.00
100_G	113_T	1.666	1.00
457_Q	494_N	1.643	1.00
186_W	189_D	1.638	1.00
374_K	377_Q	1.637	1.00
297_Y	301_E	1.622	1.00
221_I	225_L	1.614	1.00
271_A	275_V	1.614	1.00
402_N	405_T	1.613	1.00
499_L	502_Q	1.608	1.00
170_G	177_L	1.603	1.00
459_S	492_P	1.601	1.00
581_D	597_I	1.593	1.00
222_T	245_Q	1.586	1.00
461_N	465_E	1.586	1.00
428_S	432_K	1.583	1.00
246_I	253_L	1.574	1.00
586_S	589_G	1.570	1.00
519_G	540_N	1.567	1.00
135_R	139_R	1.563	1.00
511_A	521_I	1.547	1.00
321_L	325_E	1.541	1.00
287_M	291_A	1.539	1.00
265_D	269_E	1.536	1.00
580_G	598_L	1.535	1.00
225_L	250_V	1.533	1.00
221_I	250_V	1.533	1.00
274_G	294_I	1.530	1.00
486_L	525_T	1.526	1.00
372_A	375_E	1.526	1.00
227_T	234_T	1.523	1.00
337_F	340_R	1.521	1.00
276_I	291_A	1.509	1.00
261_R	264_N	1.505	1.00
77_R	81_L	1.491	1.00
331_V	334_E	1.488	1.00
323_T	326_H	1.482	1.00
259_E	263_L	1.470	1.00
31_I	35_V	1.465	1.00
522_R	540_N	1.451	1.00
276_I	284_V	1.446	1.00
553_F	582_I	1.446	1.00
226_S	252_N	1.446	1.00
509_I	513_Q	1.443	1.00
576_N	581_D	1.442	1.00
310_L	313_N	1.441	1.00
504_L	537_I	1.431	1.00
496_D	499_L	1.428	1.00
545_D	588_P	1.423	1.00
132_H	136_E	1.419	1.00
466_E	501_K	1.414	1.00
583_R	597_I	1.411	1.00
224_G	236_L	1.409	1.00
110_A	113_T	1.389	1.00
311_F	314_T	1.386	1.00
415_R	424_Q	1.381	1.00
549_Q	586_S	1.373	1.00
212_R	216_A	1.371	1.00
585_A	595_T	1.368	1.00
499_L	574_I	1.358	1.00
226_S	230_Q	1.357	1.00
96_F	99_I	1.357	1.00
307_Y	314_T	1.357	1.00
298_Q	301_E	1.356	1.00
33_Y	37_T	1.356	1.00
546_L	587_L	1.354	1.00
319_P	323_T	1.352	1.00
158_S	161_P	1.351	1.00
503_V	571_S	1.346	1.00
465_E	469_V	1.342	1.00
544_I	552_I	1.337	1.00
320_V	327_G	1.336	1.00
290_A	294_I	1.334	1.00
320_V	324_L	1.333	1.00
288_N	291_A	1.333	1.00
316_F	320_V	1.328	1.00
291_A	294_I	1.319	1.00
471_V	505_L	1.312	1.00
13_R	17_I	1.309	1.00
136_E	140_T	1.288	1.00
316_F	323_T	1.286	1.00
504_L	508_L	1.286	1.00
515_I	521_I	1.285	1.00
308_S	312_D	1.276	1.00
464_V	525_T	1.272	1.00
394_A	399_E	1.272	1.00
321_L	328_T	1.265	1.00
190_V	194_I	1.263	1.00
148_G	151_V	1.262	1.00
224_G	250_V	1.262	1.00
203_S	207_I	1.257	1.00
250_V	254_A	1.255	1.00
13_R	212_R	1.250	1.00
186_W	190_V	1.250	1.00
240_P	244_G	1.247	1.00
260_T	264_N	1.244	1.00
355_N	359_E	1.244	1.00
303_V	310_L	1.240	1.00
475_G	521_I	1.229	1.00
317_Y	327_G	1.228	1.00
408_R	434_I	1.223	1.00
178_T	182_R	1.223	1.00
76_E	80_A	1.222	1.00
77_R	80_A	1.220	1.00
375_E	378_R	1.216	1.00
408_R	435_D	1.216	1.00
489_E	527_Q	1.215	1.00
415_R	431_L	1.212	1.00
317_Y	324_L	1.210	1.00
297_Y	340_R	1.210	1.00
532_Q	581_D	1.208	1.00
224_G	234_T	1.207	1.00
316_F	321_L	1.206	1.00
291_A	295_T	1.198	1.00
15_Q	213_R	1.198	1.00
347_S	373_R	1.197	1.00
31_I	34_I	1.195	1.00
434_I	437_I	1.194	1.00
551_K	554_D	1.189	1.00
552_I	584_V	1.175	1.00
276_I	365_V	1.173	1.00
414_L	423_H	1.157	1.00
438_N	442_Q	1.145	1.00
288_N	295_T	1.139	1.00
110_A	114_Y	1.136	1.00
236_L	251_N	1.131	1.00
247_S	251_N	1.130	1.00
461_N	486_L	1.129	1.00
319_P	324_L	1.127	1.00
287_M	292_E	1.127	1.00
500_L	578_H	1.125	1.00
242_E	246_I	1.124	1.00
513_Q	560_K	1.124	1.00
434_I	447_F	1.124	1.00
318_S	321_L	1.123	1.00
347_S	368_S	1.118	1.00
464_V	504_L	1.116	1.00
59_N	63_G	1.114	1.00
79_R	82_N	1.114	1.00
222_T	249_S	1.111	1.00
12_L	214_L	1.111	1.00
46_E	50_K	1.111	1.00
303_V	306_P	1.110	1.00
253_L	257_L	1.109	1.00
303_V	313_N	1.108	1.00
460_L	535_I	1.108	1.00
365_V	369_D	1.100	1.00
319_P	327_G	1.094	1.00
317_Y	323_T	1.093	1.00
410_Y	426_Y	1.087	1.00
104_Y	110_A	1.086	1.00
468_L	484_S	1.083	1.00
445_L	449_R	1.082	1.00
318_S	323_T	1.080	1.00
151_V	157_N	1.079	1.00
214_L	217_N	1.077	1.00
37_T	41_S	1.077	1.00
425_E	428_S	1.073	1.00
287_M	295_T	1.072	1.00
10_R	15_Q	1.071	1.00
189_D	193_I	1.069	1.00
485_E	526_W	1.067	1.00
170_G	174_A	1.066	1.00
32_G	36_E	1.064	1.00
55_V	59_N	1.058	1.00
75_E	80_A	1.056	1.00
148_G	155_I	1.054	1.00
338_P	341_D	1.054	1.00
339_G	343_T	1.053	1.00
157_N	160_L	1.049	1.00
584_V	592_A	1.046	1.00
236_L	247_S	1.045	1.00
63_G	67_D	1.043	1.00
167_E	170_G	1.043	1.00
144_L	148_G	1.042	1.00
24_V	203_S	1.039	1.00
370_L	374_K	1.038	1.00
380_M	401_R	1.038	1.00
439_K	498_E	1.038	1.00
274_G	367_F	1.038	1.00
83_A	86_A	1.034	1.00
404_L	407_I	1.027	1.00
78_I	82_N	1.026	1.00
546_L	549_Q	1.023	1.00
462_A	466_E	1.022	1.00
553_F	584_V	1.021	1.00
431_L	435_D	1.020	1.00
170_G	173_W	1.017	1.00
548_L	559_T	1.015	1.00
254_A	257_L	1.014	1.00
446_E	453_S	1.014	1.00
439_K	442_Q	1.010	1.00
48_E	51_L	1.009	1.00
399_E	403_P	1.006	1.00
467_T	508_L	1.003	1.00
177_L	180_D	1.002	1.00
37_T	40_R	1.002	1.00
307_Y	311_F	1.000	1.00
471_V	512_V	1.000	1.00
89_T	93_T	1.000	1.00
323_T	328_T	0.994	1.00
287_M	294_I	0.989	1.00
575_I	598_L	0.988	1.00
80_A	84_E	0.982	1.00
306_P	313_N	0.971	1.00
90_E	94_H	0.970	1.00
268_I	288_N	0.969	1.00
529_S	534_A	0.967	1.00
222_T	226_S	0.967	1.00
310_L	314_T	0.964	1.00
101_A	105_N	0.964	1.00
463_L	467_T	0.962	1.00
292_E	302_L	0.962	1.00
504_L	596_L	0.960	1.00
553_F	594_F	0.960	1.00
307_Y	313_N	0.960	1.00
75_E	79_R	0.960	1.00
427_L	445_L	0.958	1.00
500_L	596_L	0.955	1.00
48_E	52_S	0.954	1.00
398_H	402_N	0.954	1.00
38_E	42_A	0.953	1.00
466_E	497_R	0.950	1.00
444_L	451_R	0.950	1.00
247_S	250_V	0.949	1.00
389_L	393_M	0.947	1.00
271_A	278_I	0.945	1.00
233_P	258_R	0.944	1.00
423_H	427_L	0.943	1.00
482_F	521_I	0.939	1.00
554_D	557_F	0.938	1.00
502_Q	574_I	0.938	1.00
267_I	277_A	0.937	1.00
316_F	319_P	0.936	1.00
191_R	194_I	0.933	1.00
231_N	234_T	0.932	1.00
548_L	557_F	0.928	1.00
389_L	402_N	0.927	1.00
305_Q	308_S	0.924	1.00
34_I	38_E	0.923	1.00
503_V	578_H	0.923	1.00
507_I	537_I	0.921	1.00
81_L	84_E	0.920	1.00
29_L	33_Y	0.918	1.00
84_E	87_P	0.916	1.00
193_I	197_T	0.916	1.00
447_F	450_P	0.916	1.00
287_M	296_G	0.915	1.00
187_K	191_R	0.914	1.00
155_I	158_S	0.911	1.00
306_P	311_F	0.907	1.00
35_V	39_G	0.906	1.00
449_R	453_S	0.905	1.00
254_A	258_R	0.902	1.00
418_T	423_H	0.902	1.00
284_V	288_N	0.902	1.00
246_I	250_V	0.901	1.00
411_V	434_I	0.900	1.00
455_W	494_N	0.898	1.00
308_S	313_N	0.898	1.00
406_A	410_Y	0.894	1.00
292_E	299_R	0.891	1.00
115_A	118_A	0.889	1.00
82_N	86_A	0.889	1.00
426_Y	430_V	0.889	1.00
348_V	352_R	0.888	1.00
294_I	297_Y	0.888	1.00
317_Y	321_L	0.885	1.00
292_E	295_T	0.885	1.00
407_I	430_V	0.884	1.00
424_Q	428_S	0.883	1.00
217_N	242_E	0.882	1.00
221_I	243_M	0.880	1.00
194_I	198_A	0.880	1.00
467_T	501_K	0.879	1.00
102_G	110_A	0.878	1.00
331_V	338_P	0.878	1.00
147_S	150_Q	0.874	1.00
76_E	79_R	0.873	1.00
297_Y	300_H	0.871	1.00
292_E	296_G	0.871	1.00
380_M	398_H	0.871	1.00
321_L	324_L	0.870	1.00
583_R	596_L	0.868	1.00
268_I	275_V	0.868	1.00
465_E	484_S	0.868	1.00
135_R	138_M	0.864	1.00
445_L	451_R	0.863	1.00
337_F	341_D	0.863	1.00
292_E	298_Q	0.863	1.00
13_R	211_S	0.863	1.00
20_A	23_M	0.858	1.00
293_V	296_G	0.858	1.00
421_P	425_E	0.855	1.00
400_V	403_P	0.853	1.00
264_N	268_I	0.850	1.00
285_T	288_N	0.850	1.00
283_D	288_N	0.848	1.00
406_A	433_E	0.847	1.00
464_V	523_I	0.847	1.00
334_E	338_P	0.844	1.00
460_L	533_Q	0.842	1.00
508_L	523_I	0.841	1.00
123_N	126_V	0.841	1.00
307_Y	312_D	0.840	1.00
405_T	408_R	0.838	1.00
201_L	205_L	0.835	1.00
459_S	463_L	0.835	1.00
44_L	48_E	0.834	1.00
65_R	68_L	0.834	1.00
552_I	594_F	0.834	1.00
295_T	298_Q	0.833	1.00
132_H	135_R	0.833	1.00
308_S	311_F	0.833	1.00
397_A	402_N	0.832	1.00
525_T	535_I	0.830	1.00
442_Q	446_E	0.829	1.00
474_A	477_Q	0.829	1.00
110_A	115_A	0.829	1.00
88_I	91_N	0.829	1.00
65_R	69_Y	0.828	1.00
503_V	596_L	0.828	1.00
514_A	560_K	0.828	1.00
392_L	395_G	0.825	1.00
544_I	592_A	0.825	1.00
507_I	594_F	0.824	1.00
131_D	134_G	0.823	1.00
136_E	139_R	0.823	1.00
437_I	441_I	0.821	1.00
148_G	159_M	0.821	1.00
322_D	327_G	0.819	1.00
536_S	585_A	0.818	1.00
52_S	56_N	0.817	1.00
411_V	431_L	0.816	1.00
21_I	24_V	0.816	1.00
114_Y	117_S	0.815	1.00
166_G	172_I	0.815	1.00
258_R	262_T	0.815	1.00
493_I	598_L	0.813	1.00
146_Y	150_Q	0.811	1.00
12_L	242_E	0.809	1.00
395_G	555_P	0.808	1.00
245_Q	248_Q	0.808	1.00
392_L	397_A	0.807	1.00
161_P	170_G	0.805	1.00
115_A	120_Y	0.804	1.00
75_E	78_I	0.802	1.00
306_P	310_L	0.802	1.00
102_G	113_T	0.800	1.00
105_N	110_A	0.800	1.00
390_G	394_A	0.799	1.00
334_E	337_F	0.798	1.00
252_N	256_A	0.798	1.00
133_P	137_V	0.795	0.99
497_R	501_K	0.795	0.99
54_V	58_L	0.791	0.99
333_L	337_F	0.791	0.99
427_L	451_R	0.789	0.99
501_K	505_L	0.788	0.99
86_A	90_E	0.788	0.99
344_I	369_D	0.785	0.99
350_T	353_I	0.785	0.99
322_D	325_E	0.785	0.99
179_E	183_R	0.783	0.99
144_L	154_D	0.781	0.99
85_L	89_T	0.781	0.99
140_T	143_P	0.780	0.99
445_L	450_P	0.779	0.99
67_D	70_I	0.775	0.99
105_N	108_L	0.775	0.99
399_E	402_N	0.773	0.99
291_A	297_Y	0.769	0.99
467_T	471_V	0.769	0.99
414_L	427_L	0.768	0.99
281_Q	288_N	0.768	0.99
408_R	411_V	0.766	0.99
296_G	299_R	0.765	0.99
514_A	559_T	0.763	0.99
475_G	512_V	0.763	0.99
508_L	521_I	0.761	0.99
271_A	274_G	0.760	0.99
289_P	294_I	0.760	0.99
479_R	517_A	0.759	0.99
410_Y	429_V	0.759	0.99
400_V	440_V	0.756	0.99
49_K	52_S	0.756	0.99
146_Y	155_I	0.754	0.99
542_C	592_A	0.752	0.99
171_Y	175_N	0.751	0.99
40_R	44_L	0.751	0.99
60_Q	63_G	0.750	0.99
153_G	157_N	0.749	0.99
446_E	449_R	0.749	0.99
276_I	288_N	0.749	0.99
80_A	83_A	0.748	0.99
105_N	111_I	0.744	0.99
340_R	343_T	0.744	0.99
401_R	437_I	0.743	0.99
411_V	415_R	0.742	0.99
264_N	267_I	0.742	0.99
174_A	177_L	0.736	0.99
273_D	276_I	0.735	0.99
268_I	274_G	0.735	0.99
253_L	256_A	0.735	0.99
513_Q	558_T	0.734	0.99
222_T	225_L	0.734	0.99
470_L	505_L	0.734	0.99
24_V	207_I	0.733	0.99
290_A	298_Q	0.732	0.99
440_V	451_R	0.732	0.99
455_W	578_H	0.731	0.99
330_H	337_F	0.731	0.99
513_Q	559_T	0.730	0.99
13_R	219_D	0.730	0.99
19_M	23_M	0.730	0.99
218_I	246_I	0.729	0.99
430_V	434_I	0.728	0.99
249_S	253_L	0.727	0.99
100_G	114_Y	0.727	0.99
393_M	396_V	0.727	0.99
166_G	171_Y	0.725	0.99
320_V	323_T	0.725	0.99
423_H	426_Y	0.723	0.99
397_A	513_Q	0.722	0.99
278_I	284_V	0.721	0.99
46_E	49_K	0.721	0.99
507_I	571_S	0.720	0.99
325_E	328_T	0.719	0.99
433_E	436_S	0.719	0.99
399_E	570_L	0.719	0.99
544_I	549_Q	0.718	0.99
147_S	155_I	0.718	0.99
290_A	297_Y	0.715	0.99
170_G	178_T	0.715	0.99
10_R	18_L	0.712	0.99
487_D	526_W	0.711	0.99
287_M	298_Q	0.708	0.99
409_G	413_I	0.708	0.99
174_A	181_I	0.707	0.99
62_L	65_R	0.706	0.99
105_N	112_I	0.705	0.99
316_F	327_G	0.705	0.99
396_V	444_L	0.704	0.99
457_Q	492_P	0.704	0.99
321_L	327_G	0.703	0.99
286_T	291_A	0.702	0.99
507_I	596_L	0.701	0.99
330_H	333_L	0.701	0.99
266_L	269_E	0.699	0.99
402_N	409_G	0.698	0.99
12_L	218_I	0.697	0.99
446_E	451_R	0.695	0.99
102_G	105_N	0.695	0.99
166_G	169_L	0.694	0.99
515_I	558_T	0.693	0.99
76_E	88_I	0.693	0.99
294_I	298_Q	0.693	0.99
239_L	251_N	0.692	0.99
304_G	310_L	0.692	0.99
320_V	325_E	0.690	0.99
156_L	160_L	0.689	0.99
527_Q	530_D	0.688	0.99
397_A	514_A	0.688	0.99
66_Y	69_Y	0.688	0.99
256_A	259_E	0.688	0.99
131_D	135_R	0.687	0.99
53_A	57_L	0.686	0.99
411_V	427_L	0.685	0.99
187_K	190_V	0.685	0.99
284_V	295_T	0.684	0.98
437_I	440_V	0.684	0.98
551_K	557_F	0.684	0.98
434_I	438_N	0.682	0.98
50_K	53_A	0.682	0.98
106_K	110_A	0.681	0.98
439_K	443_Q	0.680	0.98
225_L	229_A	0.678	0.98
134_G	138_M	0.678	0.98
303_V	307_Y	0.677	0.98
101_A	108_L	0.676	0.98
333_L	336_S	0.676	0.98
304_G	311_F	0.675	0.98
404_L	434_I	0.675	0.98
102_G	108_L	0.674	0.98
267_I	270_N	0.673	0.98
305_Q	310_L	0.673	0.98
352_R	362_G	0.672	0.98
106_K	109_D	0.671	0.98
425_E	429_V	0.671	0.98
308_S	314_T	0.670	0.98
324_L	328_T	0.670	0.98
405_T	409_G	0.670	0.98
298_Q	302_L	0.669	0.98
318_S	327_G	0.669	0.98
181_I	185_A	0.668	0.98
49_K	53_A	0.663	0.98
309_M	312_D	0.663	0.98
394_A	400_V	0.662	0.98
290_A	296_G	0.660	0.98
161_P	171_Y	0.660	0.98
190_V	193_I	0.659	0.98
433_E	437_I	0.657	0.98
402_N	406_A	0.656	0.98
225_L	228_L	0.656	0.98
515_I	542_C	0.655	0.98
211_S	214_L	0.655	0.98
262_T	266_L	0.654	0.98
542_C	586_S	0.653	0.98
292_E	297_Y	0.653	0.98
277_A	362_G	0.652	0.98
84_E	88_I	0.652	0.98
78_I	81_L	0.651	0.98
392_L	396_V	0.650	0.98
429_V	433_E	0.650	0.98
546_L	550_K	0.650	0.98
286_T	290_A	0.650	0.98
469_V	472_Q	0.649	0.98
247_S	254_A	0.649	0.98
286_T	295_T	0.646	0.98
402_N	408_R	0.645	0.98
151_V	154_D	0.644	0.98
406_A	429_V	0.643	0.98
10_R	14_N	0.642	0.98
42_A	46_E	0.642	0.98
108_L	112_I	0.639	0.98
544_I	568_L	0.636	0.98
174_A	178_T	0.636	0.98
156_L	159_M	0.636	0.98
41_S	48_E	0.636	0.98
35_V	192_I	0.635	0.98
566_L	570_L	0.634	0.98
290_A	295_T	0.633	0.98
346_L	350_T	0.633	0.98
304_G	308_S	0.633	0.98
471_V	474_A	0.633	0.98
165_N	169_L	0.632	0.97
410_Y	430_V	0.631	0.97
515_I	518_R	0.631	0.97
148_G	157_N	0.631	0.97
287_M	302_L	0.630	0.97
217_N	246_I	0.627	0.97
404_L	410_Y	0.626	0.97
312_D	315_Q	0.626	0.97
83_A	87_P	0.626	0.97
32_G	196_L	0.625	0.97
47_K	50_K	0.624	0.97
406_A	413_I	0.623	0.97
169_L	172_I	0.623	0.97
266_L	270_N	0.623	0.97
133_P	136_E	0.622	0.97
426_Y	434_I	0.621	0.97
403_P	437_I	0.621	0.97
321_L	326_H	0.621	0.97
222_T	246_I	0.620	0.97
242_E	250_V	0.620	0.97
287_M	290_A	0.620	0.97
173_W	177_L	0.619	0.97
399_E	440_V	0.619	0.97
335_I	340_R	0.618	0.97
58_L	61_A	0.618	0.97
172_I	177_L	0.614	0.97
390_G	397_A	0.613	0.97
87_P	90_E	0.613	0.97
514_A	542_C	0.613	0.97
85_L	92_I	0.613	0.97
446_E	450_P	0.613	0.97
468_L	472_Q	0.612	0.97
150_Q	157_N	0.611	0.97
462_A	465_E	0.607	0.97
87_P	91_N	0.607	0.97
239_L	242_E	0.606	0.97
147_S	151_V	0.604	0.97
433_E	445_L	0.603	0.97
390_G	558_T	0.602	0.97
443_Q	564_T	0.602	0.97
216_A	220_I	0.599	0.97
99_I	102_G	0.598	0.97
232_I	251_N	0.597	0.96
500_L	504_L	0.597	0.96
575_I	582_I	0.597	0.96
376_T	380_M	0.596	0.96
467_T	470_L	0.596	0.96
283_D	286_T	0.592	0.96
246_I	257_L	0.592	0.96
404_L	413_I	0.592	0.96
209_L	213_R	0.591	0.96
161_P	168_I	0.590	0.96
395_G	401_R	0.589	0.96
291_A	298_Q	0.587	0.96
45_S	48_E	0.586	0.96
85_L	112_I	0.585	0.96
267_I	271_A	0.584	0.96
286_T	289_P	0.584	0.96
410_Y	558_T	0.584	0.96
303_V	311_F	0.583	0.96
205_L	209_L	0.583	0.96
164_R	167_E	0.582	0.96
277_A	288_N	0.581	0.96
59_N	62_L	0.581	0.96
422_I	425_E	0.581	0.96
437_I	450_P	0.581	0.96
435_D	439_K	0.581	0.96
168_I	172_I	0.581	0.96
24_V	27_P	0.580	0.96
527_Q	531_S	0.579	0.96
36_E	40_R	0.578	0.96
400_V	437_I	0.576	0.96
398_H	401_R	0.576	0.96
102_G	173_W	0.576	0.96
390_G	514_A	0.575	0.96
211_S	218_I	0.575	0.96
395_G	560_K	0.575	0.96
267_I	272_A	0.574	0.96
218_I	243_M	0.574	0.96
109_D	113_T	0.573	0.96
499_L	503_V	0.573	0.96
350_T	363_A	0.572	0.96
291_A	296_G	0.572	0.96
389_L	395_G	0.571	0.95
151_V	158_S	0.569	0.95
402_N	514_A	0.568	0.95
152_R	155_I	0.568	0.95
163_E	170_G	0.568	0.95
437_I	451_R	0.567	0.95
317_Y	326_H	0.566	0.95
288_N	299_R	0.566	0.95
499_L	571_S	0.564	0.95
281_Q	284_V	0.563	0.95
464_V	484_S	0.563	0.95
481_D	518_R	0.563	0.95
289_P	296_G	0.562	0.95
536_S	596_L	0.561	0.95
268_I	286_T	0.561	0.95
461_N	488_N	0.561	0.95
412_Q	416_Q	0.561	0.95
332_A	337_F	0.560	0.95
479_R	518_R	0.560	0.95
251_N	258_R	0.559	0.95
115_A	119_L	0.559	0.95
248_Q	251_N	0.559	0.95
450_P	453_S	0.558	0.95
332_A	336_S	0.557	0.95
113_T	116_P	0.556	0.95
38_E	41_S	0.556	0.95
437_I	444_L	0.556	0.95
458_V	500_L	0.556	0.95
93_T	97_P	0.555	0.95
475_G	482_F	0.555	0.95
393_M	402_N	0.555	0.95
362_G	365_V	0.555	0.95
220_I	223_D	0.554	0.95
17_I	21_I	0.554	0.95
470_L	474_A	0.553	0.95
347_S	350_T	0.553	0.95
268_I	278_I	0.553	0.95
544_I	586_S	0.553	0.95
317_Y	328_T	0.553	0.95
286_T	294_I	0.552	0.95
268_I	272_A	0.551	0.95
43_V	46_E	0.551	0.95
427_L	434_I	0.550	0.94
66_Y	70_I	0.549	0.94
395_G	572_Q	0.549	0.94
400_V	410_Y	0.549	0.94
110_A	117_S	0.549	0.94
399_E	502_Q	0.549	0.94
150_Q	154_D	0.547	0.94
134_G	141_N	0.547	0.94
417_Q	423_H	0.547	0.94
241_G	247_S	0.546	0.94
146_Y	151_V	0.546	0.94
108_L	114_Y	0.545	0.94
144_L	158_S	0.545	0.94
92_I	95_A	0.543	0.94
155_I	160_L	0.542	0.94
440_V	445_L	0.542	0.94
223_D	227_T	0.542	0.94
499_L	577_A	0.542	0.94
356_T	359_E	0.542	0.94
335_I	339_G	0.541	0.94
257_L	260_T	0.541	0.94
345_E	374_K	0.540	0.94
20_A	207_I	0.540	0.94
345_E	370_L	0.539	0.94
427_L	430_V	0.538	0.94
228_L	232_I	0.537	0.94
573_R	576_N	0.535	0.94
170_G	176_E	0.534	0.94
81_L	85_L	0.534	0.94
61_A	65_R	0.533	0.94
463_L	495_A	0.533	0.94
134_G	137_V	0.533	0.94
473_T	477_Q	0.533	0.94
281_Q	285_T	0.533	0.94
76_E	81_L	0.533	0.94
408_R	438_N	0.532	0.93
268_I	277_A	0.532	0.93
150_Q	155_I	0.532	0.93
288_N	292_E	0.532	0.93
157_N	163_E	0.531	0.93
365_V	368_S	0.531	0.93
283_D	287_M	0.531	0.93
213_R	217_N	0.530	0.93
167_E	172_I	0.530	0.93
288_N	369_D	0.529	0.93
434_I	451_R	0.529	0.93
309_M	313_N	0.528	0.93
243_M	247_S	0.527	0.93
556_F	566_L	0.527	0.93
232_I	253_L	0.526	0.93
445_L	448_S	0.526	0.93
299_R	302_L	0.526	0.93
388_T	391_E	0.526	0.93
112_I	115_A	0.525	0.93
555_P	560_K	0.524	0.93
542_C	560_K	0.521	0.93
155_I	161_P	0.521	0.93
370_L	373_R	0.521	0.93
487_D	527_Q	0.520	0.93
388_T	555_P	0.518	0.93
25_I	29_L	0.517	0.92
394_A	397_A	0.516	0.92
395_G	447_F	0.515	0.92
130_A	133_P	0.515	0.92
219_D	222_T	0.515	0.92
392_L	558_T	0.515	0.92
278_I	365_V	0.514	0.92
544_I	594_F	0.514	0.92
56_N	59_N	0.514	0.92
145_V	149_R	0.514	0.92
440_V	448_S	0.513	0.92
393_M	514_A	0.512	0.92
372_A	376_T	0.512	0.92
109_D	112_I	0.512	0.92
575_I	581_D	0.511	0.92
333_L	340_R	0.511	0.92
79_R	84_E	0.510	0.92
159_M	162_I	0.510	0.92
111_I	114_Y	0.510	0.92
20_A	27_P	0.510	0.92
154_D	157_N	0.510	0.92
224_G	253_L	0.510	0.92
394_A	403_P	0.509	0.92
158_S	162_I	0.509	0.92
101_A	110_A	0.509	0.92
284_V	287_M	0.509	0.92
172_I	176_E	0.508	0.92
513_Q	562_S	0.508	0.92
480_V	512_V	0.507	0.92
392_L	400_V	0.506	0.92
227_T	253_L	0.505	0.92
443_Q	449_R	0.505	0.92
300_H	303_V	0.505	0.92
220_I	237_P	0.505	0.92
469_V	473_T	0.505	0.92
509_I	564_T	0.505	0.92
527_Q	533_Q	0.504	0.92
103_Y	108_L	0.504	0.92
185_A	189_D	0.503	0.91
283_D	295_T	0.503	0.91
148_G	152_R	0.501	0.91
116_P	120_Y	0.501	0.91
391_E	395_G	0.500	0.91
284_V	291_A	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.6184	100	0.433	Contact Map
3a0rA	2	0.5428	100	0.479	Contact Map
4gczA	2	0.5855	100	0.48	Contact Map
4r3aA	1	0.5082	100	0.579	Contact Map
4bixA	2	0.3717	100	0.601	Contact Map
4ctiA	2	0.3701	100	0.622	Contact Map
4q20A	2	0.3717	100	0.624	Contact Map
3d36A	2	0.3602	100	0.624	Contact Map
4mpcA	2	0.4967	100	0.627	Contact Map
2c2aA	2	0.3766	100	0.628	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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