GREMLIN Database
ATOC - Acetoacetate metabolism regulatory protein AtoC
UniProt: Q06065 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11668
Length: 461 (438)
Sequences: 10198 (7143)
Seq/√Len: 341.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
292_M297_T3.9271.00
218_E228_L3.7441.00
174_E317_R3.7441.00
429_Q439_M3.3661.00
32_H49_P3.2121.00
203_A255_A3.0961.00
232_L267_E3.0941.00
291_A295_E2.9561.00
234_E268_R2.7361.00
265_E274_T2.7171.00
159_T182_I2.6741.00
62_D65_K2.5501.00
266_F277_V2.5311.00
37_G61_M2.5251.00
333_K366_S2.4931.00
265_E276_K2.4911.00
287_R292_M2.4641.00
36_N39_T2.4451.00
419_K423_M2.4421.00
435_R438_L2.4381.00
17_R35_N2.4341.00
207_E252_V2.4171.00
429_Q436_T2.4131.00
233_F260_I2.3981.00
324_S350_M2.2031.00
100_F119_A2.2021.00
242_L284_A2.2001.00
288_D291_A2.1981.00
346_D382_F2.1951.00
421_I425_V2.1821.00
17_R33_C2.1631.00
345_I369_I2.1591.00
35_N39_T2.1191.00
161_K377_S2.0981.00
327_A345_I2.0781.00
267_E274_T2.0631.00
358_W368_V2.0541.00
10_V40_A2.0371.00
6_R30_E2.0331.00
182_I313_L2.0301.00
292_M295_E2.0281.00
8_L34_A2.0261.00
68_K97_C2.0261.00
218_E271_G1.9311.00
238_E278_D1.9291.00
428_Q439_M1.9271.00
262_Q366_S1.9201.00
324_S354_T1.9081.00
248_E287_R1.8891.00
291_A294_K1.8571.00
356_W359_P1.8191.00
261_L281_I1.7971.00
38_R60_E1.7691.00
51_V116_V1.7661.00
233_F241_L1.7441.00
320_R324_S1.7421.00
192_R278_D1.7281.00
172_S312_I1.7271.00
148_N325_L1.7071.00
177_T313_L1.6881.00
218_E268_R1.6731.00
125_M129_I1.6731.00
418_E450_K1.6591.00
328_N350_M1.6461.00
415_K453_E1.6261.00
327_A369_I1.6261.00
320_R323_I1.6121.00
329_H333_K1.6121.00
283_A306_L1.6021.00
147_T152_M1.6001.00
160_A189_N1.5911.00
21_S33_C1.5901.00
320_R357_S1.5891.00
445_R449_Y1.5801.00
344_D380_I1.5761.00
271_G275_I1.5731.00
346_D349_A1.5711.00
41_L69_E1.5621.00
45_A73_H1.5611.00
349_A353_L1.5571.00
149_S321_E1.5531.00
237_N277_V1.5411.00
6_R32_H1.5381.00
44_F70_M1.5371.00
21_S25_A1.5231.00
260_I266_F1.5171.00
425_V429_Q1.5121.00
32_H43_L1.5101.00
348_M383_S1.5021.00
69_E72_S1.4981.00
349_A383_S1.4701.00
211_E256_K1.4671.00
230_Q234_E1.4591.00
54_M66_A1.4591.00
172_S310_H1.4541.00
312_I318_D1.4521.00
326_L330_F1.4511.00
74_E77_T1.4471.00
289_L298_F1.4421.00
350_M354_T1.4421.00
167_A370_E1.4411.00
34_A43_L1.4381.00
247_G285_T1.4271.00
52_V70_M1.4181.00
152_M156_C1.4161.00
352_L383_S1.4141.00
217_H222_F1.4131.00
381_I386_L1.4111.00
162_I309_I1.4001.00
155_I311_L1.3971.00
80_I115_I1.3951.00
337_E370_E1.3781.00
58_M61_M1.3761.00
180_E259_R1.3711.00
356_W364_E1.3701.00
382_F385_D1.3681.00
237_N278_D1.3651.00
156_C159_T1.3541.00
166_Q337_E1.3541.00
54_M81_L1.3461.00
53_L116_V1.3401.00
229_R272_H1.3301.00
266_F276_K1.3281.00
195_G238_E1.3241.00
157_K160_A1.3221.00
93_E97_C1.3141.00
424_E428_Q1.3111.00
27_Q113_N1.2961.00
88_V92_V1.2961.00
425_V439_M1.2911.00
331_L373_V1.2801.00
154_D157_K1.2791.00
423_M427_E1.2781.00
331_L345_I1.2711.00
67_L79_V1.2681.00
69_E73_H1.2671.00
445_R448_M1.2661.00
425_V440_L1.2621.00
443_S446_A1.2501.00
432_N444_R1.2481.00
207_E250_P1.2471.00
349_A381_I1.2461.00
37_G66_A1.2451.00
334_F373_V1.2411.00
335_S343_I1.2341.00
43_L49_P1.2321.00
446_A450_K1.2321.00
345_I350_M1.2271.00
147_T156_C1.2251.00
7_I29_F1.2241.00
435_R439_M1.2171.00
268_R271_G1.2161.00
234_E275_I1.2161.00
343_I379_P1.2141.00
434_T438_L1.2131.00
324_S327_A1.2091.00
159_T185_A1.2051.00
210_L253_L1.2011.00
166_Q192_R1.2011.00
174_E315_P1.1991.00
37_G58_M1.1931.00
264_R276_K1.1901.00
351_S355_A1.1871.00
330_F334_F1.1821.00
23_A109_L1.1821.00
346_D380_I1.1811.00
90_T102_Y1.1741.00
217_H221_A1.1731.00
29_F117_Q1.1731.00
410_L413_E1.1721.00
52_V77_T1.1721.00
167_A338_N1.1721.00
213_E229_R1.1671.00
433_R448_M1.1661.00
146_L329_H1.1641.00
376_N385_D1.1591.00
36_N60_E1.1571.00
413_E417_V1.1571.00
155_I182_I1.1551.00
203_A248_E1.1551.00
159_T311_L1.1511.00
330_F366_S1.1481.00
155_I313_L1.1451.00
67_L81_L1.1451.00
248_E286_N1.1441.00
158_D375_M1.1421.00
212_S217_H1.1411.00
334_F369_I1.1401.00
11_D17_R1.1381.00
184_R199_K1.1281.00
171_I182_I1.1271.00
247_G289_L1.1271.00
145_I181_L1.1261.00
449_Y453_E1.1251.00
432_N435_R1.1251.00
145_I156_C1.1231.00
41_L61_M1.1231.00
201_N248_E1.1191.00
197_F239_G1.1181.00
171_I282_I1.1181.00
294_K300_E1.1101.00
387_P390_I1.1071.00
422_I447_L1.1071.00
56_I90_T1.0961.00
159_T186_I1.0961.00
11_D58_M1.0961.00
210_L214_L1.0941.00
330_F369_I1.0931.00
210_L249_M1.0931.00
409_N412_E1.0911.00
290_Q294_K1.0911.00
321_E354_T1.0901.00
421_I440_L1.0901.00
414_I417_V1.0891.00
37_G41_L1.0741.00
335_S341_D1.0741.00
443_S449_Y1.0741.00
410_L414_I1.0711.00
144_H188_Y1.0711.00
426_L451_L1.0671.00
32_H47_I1.0671.00
57_R85_Y1.0671.00
145_I182_I1.0661.00
6_R47_I1.0591.00
348_M382_F1.0561.00
434_T444_R1.0561.00
234_E266_F1.0461.00
219_K227_T1.0431.00
93_E96_R1.0361.00
64_I94_A1.0361.00
65_K68_K1.0361.00
372_A376_N1.0341.00
34_A40_A1.0321.00
164_L191_R1.0231.00
328_N332_Q1.0221.00
51_V120_L1.0201.00
170_L283_A1.0191.00
240_T282_I1.0171.00
332_Q336_S1.0171.00
54_M79_V1.0151.00
185_A189_N1.0101.00
425_V436_T1.0081.00
417_V421_I1.0071.00
281_I306_L1.0061.00
168_S264_R1.0041.00
6_R49_P1.0011.00
53_L112_L1.0001.00
320_R354_T1.0001.00
125_M128_E1.0001.00
221_A269_I0.9981.00
9_I31_T0.9931.00
323_I327_A0.9901.00
167_A308_V0.9881.00
27_Q117_Q0.9781.00
420_R424_E0.9781.00
436_T439_M0.9781.00
237_N279_I0.9771.00
222_F225_A0.9761.00
54_M58_M0.9711.00
174_E177_T0.9661.00
180_E199_K0.9651.00
217_H269_I0.9631.00
335_S342_I0.9621.00
212_S222_F0.9561.00
307_N310_H0.9471.00
323_I353_L0.9461.00
241_L281_I0.9391.00
423_M456_I0.9361.00
56_I81_L0.9361.00
290_Q389_Q0.9311.00
66_A70_M0.9291.00
152_M155_I0.9261.00
235_R272_H0.9241.00
371_R375_M0.9231.00
70_M79_V0.9231.00
68_K93_E0.9221.00
424_E427_E0.9191.00
147_T325_L0.9061.00
422_I440_L0.9011.00
166_Q191_R0.9001.00
123_Q127_K0.8921.00
147_T182_I0.8871.00
53_L80_I0.8861.00
198_I235_R0.8851.00
409_N441_G0.8851.00
433_R451_L0.8851.00
169_V186_I0.8851.00
426_L436_T0.8831.00
345_I381_I0.8831.00
155_I159_T0.8831.00
366_S370_E0.8821.00
16_V107_F0.8811.00
39_T42_H0.8781.00
233_F279_I0.8761.00
150_P154_D0.8761.00
420_R423_M0.8751.00
241_L260_I0.8731.00
50_D123_Q0.8721.00
168_S283_A0.8711.00
10_V66_A0.8701.00
217_H229_R0.8681.00
36_N58_M0.8661.00
121_Q124_S0.8661.00
415_K454_Y0.8651.00
351_S354_T0.8641.00
172_S290_Q0.8611.00
156_C182_I0.8591.00
199_K259_R0.8581.00
217_H228_L0.8571.00
24_F116_V0.8571.00
308_V367_N0.8571.00
446_A449_Y0.8571.00
184_R188_Y0.8561.00
43_L47_I0.8551.00
345_I349_A0.8531.00
249_M253_L0.8491.00
422_I450_K0.8441.00
42_H46_D0.8401.00
268_R275_I0.8381.00
167_A374_V0.8351.00
14_D17_R0.8341.00
151_A154_D0.8331.00
198_I236_A0.8331.00
266_F275_I0.8321.00
42_H45_A0.8321.00
433_R445_R0.8301.00
11_D16_V0.8301.00
444_R448_M0.8271.00
431_G451_L0.8261.00
217_H225_A0.8251.00
328_N344_D0.8201.00
372_A381_I0.8191.00
147_T159_T0.8181.00
54_M70_M0.8181.00
433_R440_L0.8161.00
387_P391_R0.8121.00
171_I313_L0.8111.00
235_R271_G0.8111.00
39_T43_L0.8081.00
37_G60_E0.8071.00
12_D55_D0.8041.00
114_L118_R0.8041.00
448_M452_Q0.8031.00
96_R101_D0.8031.00
43_L46_D0.8021.00
9_I20_L0.8011.00
443_S448_M0.8011.00
146_L325_L0.8001.00
61_M65_K0.8001.00
121_Q126_K0.7991.00
201_N249_M0.7981.00
171_I183_A0.7921.00
307_N371_R0.7911.00
347_P350_M0.7911.00
148_N153_M0.7901.00
323_I354_T0.7901.00
153_M156_C0.7891.00
153_M157_K0.7881.00
419_K454_Y0.7861.00
340_R373_V0.7851.00
41_L66_A0.7851.00
206_P269_I0.7851.00
145_I152_M0.7851.00
53_L82_M0.7821.00
142_W185_A0.7821.00
51_V78_P0.7801.00
162_I169_V0.7781.00
38_R42_H0.7781.00
230_Q235_R0.7771.00
426_L433_R0.7741.00
65_K69_E0.7721.00
167_A309_I0.7721.00
422_I451_L0.7721.00
44_F52_V0.7711.00
34_A39_T0.7691.00
340_R343_I0.7691.00
290_Q303_F0.7671.00
414_I421_I0.7651.00
7_I24_F0.7631.00
54_M67_L0.7621.00
343_I373_V0.7621.00
230_Q272_H0.7621.00
440_L450_K0.7611.00
205_L214_L0.7601.00
34_A37_G0.7601.00
12_D105_K0.7571.00
293_V303_F0.7561.00
61_M69_E0.7541.00
121_Q125_M0.7511.00
92_V96_R0.7501.00
10_V52_V0.7481.00
233_F277_V0.7420.99
82_M107_F0.7420.99
413_E416_R0.7390.99
327_A350_M0.7390.99
447_L451_L0.7370.99
68_K72_S0.7370.99
228_L268_R0.7360.99
20_L112_L0.7360.99
368_V372_A0.7350.99
228_L273_Q0.7330.99
233_F266_F0.7330.99
433_R444_R0.7320.99
108_D111_E0.7320.99
442_I446_A0.7310.99
163_A190_S0.7310.99
448_M451_L0.7260.99
324_S328_N0.7250.99
228_L271_G0.7240.99
290_Q300_E0.7230.99
150_P153_M0.7210.99
334_F366_S0.7170.99
247_G286_N0.7130.99
115_I119_A0.7120.99
13_E16_V0.7100.99
290_Q310_H0.7090.99
8_L49_P0.7080.99
55_D105_K0.7080.99
63_G105_K0.7070.99
327_A372_A0.7040.99
29_F113_N0.7000.99
23_A113_N0.7000.99
71_R78_P0.6990.99
440_L446_A0.6990.99
232_L235_R0.6980.99
320_R325_L0.6970.99
9_I21_S0.6950.99
229_R232_L0.6950.99
44_F74_E0.6930.99
6_R50_D0.6920.99
142_W156_C0.6920.99
249_M257_L0.6920.99
157_K377_S0.6910.99
413_E421_I0.6900.99
38_R61_M0.6900.99
338_N373_V0.6900.99
155_I158_D0.6900.99
206_P209_L0.6900.99
412_E416_R0.6860.99
429_Q435_R0.6860.99
12_D83_T0.6850.99
450_K454_Y0.6840.99
142_W189_N0.6830.99
86_A104_I0.6810.99
161_K375_M0.6800.99
217_H226_Q0.6800.99
447_L450_K0.6790.99
161_K385_D0.6780.99
334_F338_N0.6780.99
12_D63_G0.6770.99
411_K425_V0.6760.99
259_R263_E0.6760.99
10_V58_M0.6760.99
247_G298_F0.6730.99
89_E93_E0.6730.99
151_A318_D0.6720.99
315_P318_D0.6700.99
12_D84_A0.6690.99
372_A386_L0.6680.99
88_V91_A0.6680.99
67_L99_A0.6670.99
156_C185_A0.6660.99
352_L356_W0.6640.99
427_E431_G0.6640.99
331_L369_I0.6630.99
223_T284_A0.6590.99
347_P351_S0.6580.99
56_I62_D0.6560.99
118_R125_M0.6560.99
444_R449_Y0.6550.99
102_Y111_E0.6510.99
91_A99_A0.6480.99
221_A225_A0.6480.99
442_I447_L0.6470.99
219_K228_L0.6470.99
14_D18_R0.6460.99
20_L82_M0.6460.99
158_D161_K0.6440.99
44_F77_T0.6430.99
148_N321_E0.6430.99
78_P126_K0.6400.99
175_S248_E0.6390.99
302_L306_L0.6390.99
229_R235_R0.6370.98
161_K340_R0.6360.98
128_E136_L0.6340.98
117_Q121_Q0.6330.98
247_G287_R0.6300.98
181_L185_A0.6300.98
246_I306_L0.6290.98
303_F307_N0.6290.98
64_I93_E0.6280.98
107_F112_L0.6270.98
247_G284_A0.6270.98
150_P321_E0.6260.98
101_D115_I0.6230.98
352_L386_L0.6230.98
451_L456_I0.6230.98
415_K419_K0.6210.98
219_K226_Q0.6200.98
410_L417_V0.6190.98
290_Q293_V0.6190.98
44_F49_P0.6180.98
426_L431_G0.6170.98
45_A69_E0.6170.98
52_V66_A0.6160.98
200_V232_L0.6150.98
411_K450_K0.6140.98
327_A331_L0.6140.98
114_L125_M0.6140.98
78_P122_L0.6130.98
432_N448_M0.6100.98
416_R420_R0.6070.98
264_R279_I0.6060.98
100_F115_I0.6060.98
335_S340_R0.6050.98
449_Y452_Q0.6040.98
325_L328_N0.6040.98
219_K225_A0.6040.98
233_F281_I0.6030.98
242_L282_I0.6030.98
8_L40_A0.6020.98
412_E420_R0.6020.98
165_S374_V0.6020.98
152_M182_I0.6000.98
331_L335_S0.5990.98
445_R452_Q0.5950.98
76_R130_R0.5950.98
335_S373_V0.5940.98
223_T286_N0.5930.98
232_L274_T0.5910.98
334_F370_E0.5900.97
86_A91_A0.5900.97
432_N436_T0.5860.97
19_M23_A0.5860.97
200_V241_L0.5840.97
86_A102_Y0.5820.97
36_N61_M0.5820.97
163_A189_N0.5810.97
22_T26_L0.5810.97
220_G225_A0.5790.97
214_L253_L0.5780.97
209_L223_T0.5780.97
352_L390_I0.5770.97
180_E263_E0.5770.97
237_N264_R0.5770.97
218_E275_I0.5770.97
166_Q338_N0.5750.97
200_V214_L0.5740.97
40_A66_A0.5730.97
192_R195_G0.5720.97
109_L113_N0.5710.97
433_R436_T0.5700.97
228_L275_I0.5690.97
145_I185_A0.5680.97
422_I454_Y0.5680.97
103_V107_F0.5680.97
157_K161_K0.5660.97
238_E279_I0.5650.97
25_A31_T0.5630.97
82_M103_V0.5610.97
159_T189_N0.5600.97
373_V376_N0.5600.97
7_I120_L0.5590.97
410_L440_L0.5590.97
55_D84_A0.5590.97
58_M63_G0.5550.96
177_T181_L0.5540.96
111_E114_L0.5530.96
78_P123_Q0.5520.96
287_R297_T0.5510.96
247_G292_M0.5510.96
120_L123_Q0.5510.96
82_M85_Y0.5510.96
129_I136_L0.5500.96
331_L342_I0.5490.96
158_D309_I0.5480.96
444_R447_L0.5460.96
410_L421_I0.5450.96
144_H185_A0.5440.96
154_D158_D0.5440.96
434_T437_A0.5440.96
418_E422_I0.5440.96
147_T322_D0.5410.96
433_R447_L0.5400.96
309_I374_V0.5400.96
230_Q266_F0.5380.96
52_V79_V0.5380.96
244_D363_R0.5380.96
64_I90_T0.5370.96
232_L272_H0.5350.96
386_L389_Q0.5350.96
111_E115_I0.5340.96
212_S220_G0.5340.96
182_I185_A0.5330.95
49_P77_T0.5330.95
342_I373_V0.5320.95
414_I450_K0.5310.95
168_S308_V0.5300.95
192_R279_I0.5300.95
433_R450_K0.5300.95
368_V390_I0.5300.95
209_L269_I0.5290.95
338_N374_V0.5290.95
164_L190_S0.5290.95
70_M77_T0.5280.95
416_R419_K0.5280.95
83_T105_K0.5280.95
17_R37_G0.5280.95
260_I263_E0.5270.95
12_D58_M0.5270.95
104_I111_E0.5260.95
356_W390_I0.5260.95
364_E389_Q0.5250.95
21_S31_T0.5240.95
442_I450_K0.5240.95
329_H332_Q0.5240.95
196_P235_R0.5220.95
155_I162_I0.5210.95
89_E111_E0.5210.95
264_R277_V0.5210.95
15_N19_M0.5210.95
445_R450_K0.5200.95
201_N255_A0.5190.95
57_R87_E0.5190.95
205_L210_L0.5180.95
227_T272_H0.5170.95
309_I375_M0.5160.95
346_D383_S0.5150.95
218_E221_A0.5140.95
170_L285_T0.5140.95
377_S385_D0.5140.95
237_N276_K0.5130.94
230_Q268_R0.5120.94
292_M298_F0.5120.94
433_R449_Y0.5120.94
100_F122_L0.5120.94
213_E232_L0.5110.94
9_I24_F0.5110.94
190_S280_R0.5100.94
260_I277_V0.5090.94
7_I51_V0.5080.94
352_L387_P0.5070.94
352_L355_A0.5060.94
321_E324_S0.5050.94
183_A197_F0.5040.94
237_N266_F0.5040.94
421_I436_T0.5040.94
222_F229_R0.5030.94
421_I443_S0.5030.94
201_N204_A0.5030.94
162_I311_L0.5020.94
308_V370_E0.5020.94
151_A321_E0.5010.94
142_W160_A0.5010.94
337_E366_S0.5010.94
63_G84_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.833 100 0.104 Contact Map
3dzdA 2 0.7983 100 0.278 Contact Map
1ojlA 3 0.6529 100 0.453 Contact Map
4fwgA 3 0.6334 100 0.625 Contact Map
1r6bX 1 0.8482 100 0.647 Contact Map
3pxiA 3 0.7961 100 0.654 Contact Map
1qvrA 3 0.8286 100 0.654 Contact Map
4qosA 1 0.5206 100 0.666 Contact Map
4qhsA 3 0.5293 100 0.666 Contact Map
4d2uA 3 0.8373 100 0.667 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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